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Azacitidine: Applications & Research

Azacitidine, sold under the brand name Vidaza among others, is a medication used for the treatment of myelodysplastic syndrome, myeloid leukemia, and juvenile myelomonocytic leukemia. It is a chemical analog of cytidine, a nucleoside in DNA and RNA.[medical citation needed] Azacitidine and its deoxy derivative, decitabine (also known as…

Language: English [EN]
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Azacitidine topic overview

The analysis highlights Applications and Research as prominent areas in the source structure around Azacitidine.

Related topics
42
Source areas
5
Connected nodes
47
Extracted relationships
68
Concept neighborhoods
16
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Toxicity · 18 topics
Overview · 12 topics
Medical uses · 6 topics
Research · 4 topics
Mechanism of action · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BC07 (WHO)
CAS Number
320-67-2 Y
ChEBI
CHEBI:2038 Y
ChEMBL
ChEMBL1489 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Mechanism of action

Toxicity

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Azacitidine connects Entity context

The extracted context around Azacitidine shows recurring relationship patterns in the source. For example, Azacitidine → Clinical, ClinicalTrials, Diagnosed Advanced Myelodysplastic Syndrome, JMML, Juvenile Myelomonocytic Leukemia, MDS, NCT02447666, Pediatric Subjects With Newly, Study With Azacitidine Another extracted example is Azacitidine → After, As, Azacytosine-guanine, DNA, In, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Azacitidine

Top relations

related to External links · 9
Azacitidine → Clinical, ClinicalTrials, Diagnosed Advanced Myelodysplastic Syndrome, JMML, Juvenile Myelomonocytic Leukemia, MDS, NCT02447666, Pediatric Subjects With Newly, Study With Azacitidine
related to Inhibition of methylation · 7
Azacitidine → After, As, Azacytosine-guanine, DNA, In, The, This
related to Mechanism of action · 7
Azacitidine → Azacitidine's, DNA, In, It, Its, RNA, T-lymphotropic
related to Medical uses · 7
Azacitidine → AML, Drug Administration, FDA, Food, In, May, The
Legal status · 4
Azacitidine → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, US: ℞-only
related to history · 3
Azacitidine → AZA-JMML-001, NCT02447666, The
related to Research · 3
Azacitidine → Certain, DNA, This
related to Toxicity · 2
Azacitidine → It, The
3D model (JSmol) · 1
Azacitidine → Interactive image
AHFS/Drugs.com · 1
Azacitidine → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna patients treatment also leukemia rna juvenile myelomonocytic methylation may myelodysplastic syndrome effects cell used inhibition toxicity medical cytidine decitabine

Azacitidine relationships Subject–Predicate–Object triples

TTTA extracted 68 structured relationships around Azacitidine. Examples in this analysis include Azacitidine → 3D model (JSmol) → Interactive image and Azacitidine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Azacitidine3D model (JSmol)Interactive image1.00infobox
AzacitidineAHFS/Drugs.comMonograph1.00infobox
AzacitidineATC codeL01BC07 (WHO)1.00infobox
AzacitidineCAS Number320-67-2 Y1.00infobox
AzacitidineChEBICHEBI:2038 Y1.00infobox
AzacitidineChEMBLChEMBL1489 Y1.00infobox
AzacitidineChemSpider9072 Y1.00infobox
AzacitidineCompTox Dashboard (EPA)DTXSID90201161.00infobox
AzacitidineDrugBankDB00928 Y1.00infobox
AzacitidineECHA InfoCard100.005.7111.00infobox
AzacitidineElimination half-life4 hr.1.00infobox
AzacitidineFormulaC8H12N4O51.00infobox
AzacitidineIUPHAR/BPS67961.00infobox
AzacitidineKEGGD03021 Y1.00infobox
AzacitidineLegal statusAU: S4 (Prescription only)1.00infobox
AzacitidineLegal statusCA: ℞-only1.00infobox
AzacitidineLegal statusUS: ℞-only1.00infobox
AzacitidineLegal statusEU: Rx-only1.00infobox
AzacitidineLicense dataUS DailyMed: Azacitidine1.00infobox
AzacitidineMedlinePlusa6070681.00infobox
AzacitidineMolar mass244.207 g·mol−11.00infobox
AzacitidineOther names5-Azacytidine, Azacytidine, Ladakamycin, 4-Amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one, U-18496, CC-4861.00infobox
AzacitidinePregnancy categoryAU: X (High risk)1.00infobox
AzacitidinePubChem CID94441.00infobox
AzacitidineRoutes of administrationSubcutaneous, intravenous, by mouth1.00infobox
AzacitidineTrade namesVidaza, Azadine, Onureg1.00infobox
AzacitidineUNIIM801H13NRU1.00infobox
Azacitidineis aribonucleoside0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Azacitidine bring nearby vocabulary together. In this analysis, examples include Patients, Also and Treatment. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Azacitidine
    • Patients
    • Also
    • Treatment
    • Myelodysplastic
    • Syndrome
    • Leukemia
    • Juvenile
    • Myelomonocytic
    • Dna
    • Levels
    • Severe
    • Toxicity
  • azacitidine
    • Patients
    • Also
    • Treatment
    • Myelodysplastic
    • Syndrome
    • Leukemia
    • Juvenile
    • Myelomonocytic
    • Dna
    • Levels
    • Severe
    • Toxicity
  • dna methylation
    • Function
    • Mechanisms
    • Rna
    • Effects
    • Methyltransferases
    • Methylation
    • Decitabine
    • Nucleoside
    • Vidaza
    • Covalent
    • Incorporation
    • Prior
  • dna
    • Rna
    • Methyltransferases
    • Methylation
    • Decitabine
    • Nucleoside
    • Covalent
    • Function
    • Incorporation
    • Mechanisms
    • Medical
    • Cells
    • Death
  • myeloid leukemia
    • Juvenile
    • Myelomonocytic
    • Leukemia
    • Myeloid
    • Name
    • Vidaza
    • Study
    • Treatment
    • Used
    • Myelodysplastic
    • Syndrome
    • Patients
  • juvenile myelomonocytic leukemia
    • Myelomonocytic
    • Juvenile
    • Leukemia
    • Myeloid
    • Study
    • Myelodysplastic
    • Syndrome
    • Treatment
    • Anemia
    • Name
    • Patients
    • Vidaza
  • blood cell counts
    • Counts
    • Low
    • Prior
    • Patients
    • Cells
    • Death
    • Incorporation
    • Mechanisms
    • Study
    • Myelodysplastic
    • Syndrome
    • Juvenile
  • chronic myelogenous leukemia
    • Juvenile
    • Myelomonocytic
    • Myeloid
    • Study
    • Myelodysplastic
    • Syndrome
    • Treatment
    • Patients
    • Anemia
    • Name
    • Vidaza
    • Prior

Connections between topic areas Semantic bridges

For Azacitidine, one of the stronger structural bridges in this analysis connects Azacitidine with Toxicity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Azacitidine — Toxicity · splits 29 ⟂ 19
Azacitidine — Overview · splits 35 ⟂ 13
Azacitidine — Medical uses · splits 41 ⟂ 7
Azacitidine — Research · splits 43 ⟂ 5
Azacitidine — Mechanism of action · splits 45 ⟂ 3

Map overview Semantic statistics

Azacitidine

Nodes48
Edges47
Triples68
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around Azacitidine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Azacitidine · EN edition · Analysis: TopicsToTalkAbout

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