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Histone

In biology, histones are highly-basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30-nanometer fibers that form tightly packed chromatin. Histones prevent…

History & Measurement

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Overview

Classes and variants

Structure

Evolution and species distribution

Function

Modification

Histone chaperones

Synthesis

History

Advanced semantic analysis

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Map overview Semantic statistics

Histone

Nodes165
Edges164
Triples186
Avg. degree1.99
Density0.012121
Components1

How this topic connects Entity context

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Histone

Top relations

related to history · 23
Histone → Albrecht Kossel, Ancient Greek, Biology, Bonner, DNA, Emil Smith, For, German, Histone Chemistry, Histone IV, Histones, However, Huang, In, James, James Bonner, Paul T'so, RNA, Ru Chih, The
related to Evolution and species distribution · 17
Histone → AAA, Archaeal, ATPase, C-domain, Clp/Hsp100, Core, Despite, DNA, H1, HC1/HC2, HSH, It, It's, N-terminal, RPS6/RPS15, The, Unlike
related to Beyond eukaryotes · 16
Histone → Additional, Archaeal, Bioinformatic, DNA, DNA-contacting, H3-H4-like, H3/H4-like, MD, Methanothermus, Molecular, More, Most, Such, The, Thermococcus, They
related to Classes and variants · 16
Histone → Angstroms, Around, DNA, During, Five, H1, H1/H5, H2A, H2B, H3, H4, Higher-order, Histones H2A, It, The, This
related to Structure · 12
Histone → C2, DNA, DNA-binding, H2A, H2A-H2B, H2B, H3, H3-H4, H4, The, The H2A-H2B, They
related to Addiction · 11
Histone → After, Cigarette, Delta FosB, Epigenetic, FosB, H3, H4, In, Once, This, US
related to Modification · 11
Histone → ADP-ribosylation, Combinations, DNA, H2A, H2B, H4, Histones, Modifications, SUMOylation, The, The H3
related to Yeast · 10
Histone → Cdc8, G1, G1/S Cdk, Hir, In, SBF, Suppression, This, Whi5, Yeast
related to Chaperone networks · 9
Histone → ASF1, Chaperone, Chromatin, DNA, FACT, For, Once, The, This
related to Histone chaperones · 8
Histone → ASF1, DNA, During DNA, FACT, Moreover, One, These, Unlike

Important terminology Word statistics

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Important terminology

histones dna chromatin transcription also proteins h3 lysine gene genes methylation chaperones core modifications nucleosome structure acetylation nucleosomes h2a cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
transcription factors interact with the nucleosomesinstance ofMethylation can affect how other proteins0.80text
H2A.X are phosphorylated at sites of DNA damageinstance ofVariants0.80text
marking regions for recruitment of repair proteinsinstance ofVariants0.80text
gene regulationinstance ofHistone modifications act in diverse biological processes0.80text
DNA repairinstance ofHistone modifications act in diverse biological processes0.80text
chromosome condensationinstance ofHistone modifications act in diverse biological processes0.80text
neuronsinstance ofhappens in serotonergic cells0.80text
BRCT have been characterised.Effects on transcriptionHistone modifications are involved in control of transcription.Actively transcribed genesTwo histone modifications are particularly associated with active transcriptioninstance ofand binding domains0.80text
histone deacetylasesinstance ofwhich in turn recruits further repressive activities including histone modifiers0.80text
histone methyltransferasesinstance ofwhich in turn recruits further repressive activities including histone modifiers0.80text
the ultraviolet radiation of the sun.Phosphorylation of H2AX at serine 139instance ofDNA would get destroyed by damage accumulated from sources0.80text
BRCT have been characterisedinstance ofand binding domains0.80text

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