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ETS1: Interaction with DNA repair promoters and proteins, Interactions & Knockout mice

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS transcription factor family.

Language: English [EN]
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ETS1 topic overview

The analysis highlights Interaction with DNA repair promoters and proteins, Interactions and Knockout mice as prominent areas in the source structure around ETS1.

Related topics
25
Source areas
5
Connected nodes
30
Extracted relationships
222
Concept neighborhoods
10
Bridge connections
30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interaction with DNA repair promoters and proteins · 15 topics
Interactions · 4 topics
Overview · 3 topics
Knockout mice · 2 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ETS1, ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GVJ, 2NNY, 2STT, 2STW, 3MFK, 3RI4, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 3WTZ, 3WU0, 3WU1, 4L0Y, 4L0Z,…
Band
11q24.3 · 9 A4|9 17.97 cM
Bgee
visceral pleura · parietal pleura · tibia · epithelium of nasopharynx · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Knockout mice

Interactions

Interaction with DNA repair promoters and proteins

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ETS1 connects Entity context

The extracted context around ETS1 shows recurring relationship patterns in the source. For example, ETS1 → angiogenesis involved in wound healing, cell differentiation, cell motility, cellular response to hydrogen peroxide, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, estrous cycle, female pregnancy, histone acetyltransferase binding, hypothalamus development, identical protein binding, immune response, immune system process, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of inflammatory response, nucleoplasm Another extracted example is ETS1 → AGGAAG, AP1, C-terminal, CGGAAG, ChIP-Seq, Contrary, DNA, Erk2, ETS, Ets/AP1, Ets1-responsive GGAA/T, First, For, GGAA/T, However, If, It, Many Ras, On, Phosphorylation. Use these groups to spot repeated connection types before inspecting the individual relationships.

ETS1

Top relations

Gene ontology · 56
ETS1 → angiogenesis involved in wound healing, cell differentiation, cell motility, cellular response to hydrogen peroxide, cytoplasm, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, estrous cycle, female pregnancy, histone acetyltransferase binding, hypothalamus development, identical protein binding, immune response, immune system process, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of inflammatory response, nucleoplasm
related to Function · 30
ETS1 → AGGAAG, AP1, C-terminal, CGGAAG, ChIP-Seq, Contrary, DNA, Erk2, ETS, Ets/AP1, Ets1-responsive GGAA/T, First, For, GGAA/T, However, If, It, Many Ras, On, Phosphorylation
Bgee · 20
ETS1 → atrioventricular valve, atrium, blood, endocardial cushion, epithelium of colon, epithelium of nasopharynx, Gonadal ridge, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, parietal pleura, pericardium, right lung lobe, spleen, superficial temporal artery, thymus, tibia, vena cava, visceral pleura
RNA expression pattern · 20
ETS1 → atrioventricular valve, atrium, blood, endocardial cushion, epithelium of colon, epithelium of nasopharynx, Gonadal ridge, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, parietal pleura, pericardium, right lung lobe, spleen, superficial temporal artery, thymus, tibia, vena cava, visceral pleura
related to DNA repair protein interactions · 17
ETS1 → Active PARP1, ADP-ribosylation, As, DNA, DNA-dependent, DNA-PK, DNA-PKcs, In, Ku, Ku70, Ku80, Legrand, PARP1, Such, The Ku80, XRCC5, XRCC6
related to Interactions · 15
ETS1 → Acetyltransferases CBP, Also, AP1, C-terminal, Death-associated, Pax5, Runx1, STAT5, TFE3, Their, TTRAP, UBE2I, USF1, VDR, When Ets1
related to DNA repair promoters · 14
ETS1 → As, BARD1, CpG, DNA, ERCC1, If, Increased ETS1, MUTYH, PARP1, RNA, The, These, Wilson, XPA
related to Knockout mice · 10
ETS1 → Although Ets1, Ets, IL-2, In CD4/CD8, T-cell, Th1, Th17, Th2, There, Treg
related to External links · 7
ETS1 → Drosophila, Medicine, Medicine Medical Subject Headings, MeSH, National Library, The Interactive FlyFactorBookETS1 This, United States National Library
related to Clinical significance · 6
ETS1 → European, Meta-analyses, Mmps, SNPs, Th17, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna protein parp1 gene transcription ets bp binding human factor repair expression chr band promoter bind domain sites interacts chromosome

ETS1 relationships Subject–Predicate–Object triples

TTTA extracted 222 structured relationships around ETS1. Examples in this analysis include ETS1 → Aliases → ETS1, ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor and ETS1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GVJ, 2NNY, 2STT, 2STW, 3MFK, 3RI4, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 3WTZ, 3WU0, 3WU1, 4L0Y, 4L0Z,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ETS1AliasesETS1, ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor1.00infobox
ETS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GVJ, 2NNY, 2STT, 2STW, 3MFK, 3RI4, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 3WTZ, 3WU0, 3WU1, 4L0Y, 4L0Z,…1.00infobox
ETS1Band11q24.31.00infobox
ETS1Band9 A4|9 17.97 cM1.00infobox
ETS1Bgeevisceral pleura1.00infobox
ETS1Bgeeparietal pleura1.00infobox
ETS1Bgeetibia1.00infobox
ETS1Bgeeepithelium of nasopharynx1.00infobox
ETS1Bgeelower lobe of lung1.00infobox
ETS1Bgeesuperficial temporal artery1.00infobox
ETS1Bgeeepithelium of colon1.00infobox
ETS1Bgeepericardium1.00infobox
ETS1Bgeevena cava1.00infobox
ETS1Bgeelymph node1.00infobox
ETS1Bgeeleft lung lobe1.00infobox
ETS1Bgeethymus1.00infobox
ETS1Bgeemesenteric lymph nodes1.00infobox
ETS1Bgeeblood1.00infobox
ETS1Bgeespleen1.00infobox
ETS1BgeeGonadal ridge1.00infobox
ETS1Bgeeright lung lobe1.00infobox
ETS1Bgeeatrium1.00infobox
ETS1Bgeeatrioventricular valve1.00infobox
ETS1Bgeeendocardial cushion1.00infobox
ETS1BioGPSMore reference expression data1.00infobox
ETS1Chr.Chromosome 11 (human)1.00infobox
ETS1Chr.Chromosome 9 (mouse)1.00infobox
ETS1DatabasesNCBI: entry; OMA: entry1.00infobox
ETS1End128,587,558 bp1.00infobox
ETS1End32,757,820 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ETS1 bring nearby vocabulary together. In this analysis, examples include Dna, Protein and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ETS1
    • Dna
    • Protein
    • Transcription
    • Parp1
    • Interacts
    • Promoter
    • Repair
    • Binding
    • Causes
    • Shown
    • Factor
    • Sites
  • ets1
    • Dna
    • Protein
    • Transcription
    • Parp1
    • Interacts
    • Promoter
    • Repair
    • Binding
    • Causes
    • Shown
    • Factor
    • Sites
  • protein
    • Factor
    • Repair
    • Dna
    • Transcription
    • Human
    • Interacts
    • Location
    • Chromosome
    • Proteins
    • Bp
    • Chr
    • Mice
  • gene
    • Location
    • Chromosome
    • Ets
    • Bp
    • Chr
    • Human
    • Mice
    • Factor
    • Mouse
    • Protein
    • Humans
    • Transcription
  • ets transcription factor family
    • Factor
    • Transcription
    • Gene
    • Promoter
    • Binding
    • Ets
    • Protein
    • Genes
    • Mice
    • Location
    • Chromosome
    • Differentiation
  • death-associated protein 6
    • Factor
    • Repair
    • Dna
    • Transcription
    • Human
    • Interacts
    • Location
    • Chromosome
    • Proteins
    • Bp
    • Chr
    • Mice
  • ku (protein)
    • Factor
    • Repair
    • Dna
    • Transcription
    • Human
    • Interacts
    • Location
    • Chromosome
    • Proteins
    • Bp
    • Chr
    • Mice
  • interaction with dna repair promoters and proteins
    • Repair
    • Binding
    • Expression
    • Protein
    • Ets1
    • Levels
    • Transcription
    • Causes
    • Genes
    • Location
    • Proteins
    • Interacts

Connections between topic areas Semantic bridges

For ETS1, one of the stronger structural bridges in this analysis connects ETS1 with Interaction with DNA repair promoters and proteins. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ETS1Interaction with DNA repair promoters and proteins · splits 15 ⟂ 16
ETS1Interactions · splits 26 ⟂ 5
ETS1Overview · splits 27 ⟂ 4
ETS1Knockout mice · splits 28 ⟂ 3

Map overview Semantic statistics

ETS1

Nodes31
Edges30
Triples222
Avg. degree1.94
Density0.064516
Components1

Source & methodology

TTTA analyzes the structure around ETS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interaction with DNA repair promoters and proteins, Interactions & Knockout mice, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ETS1 · EN edition · Analysis: TopicsToTalkAbout

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