Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

5-HT2A receptor: History, Gene & Tissue distribution

The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades. Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the Gq/G11 signaling pathway. It is the primary…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

5-HT2A receptor topic overview

The analysis highlights History, Gene and Tissue distribution as prominent areas in the source structure around 5-HT2A receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
357
Source areas
9
Connected nodes
367
Extracted relationships
301
Concept neighborhoods
39
Bridge connections
367

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 152 topics
Ligands · 86 topics
Gene · 30 topics
Function · 27 topics
Tissue distribution · 24 topics
Structure · 16 topics
History · 11 topics
Clinical significance · 7 topics
Methods to analyse the receptor · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
Band
13q14.2
Bgee
buccal mucosa cell · middle temporal gyrus · frontal pole · Brodmann area 23 · Brodmann area 10
BioGPS
More reference expression data
Chr.
Chromosome 13 (human)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Gene

Tissue distribution

Structure

Function

Ligands

Methods to analyse the receptor

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How 5-HT2A receptor connects Entity context

The extracted context around 5-HT2A receptor shows recurring relationship patterns in the source. For example, 5-HT2A receptor → 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, activation of phospholipase C activity, ageing, animal behavior, artery smooth muscle contraction, axon, behavioral response to cocaine, caveola, cell body fiber, cell death, cell projection, cellular calcium ion homeostasis, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dendritic shaft, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain Another extracted example is 5-HT2A receptor → Gaddum, HT, HT1, HT1C, HT2, HT2A, HT2B, HT2C, HT2F, HT3, In, John Gaddum, Later, LSD, Picarelli, The, Thus. Use these groups to spot repeated connection types before inspecting the individual relationships.

5-HT2A receptor

Top relations

Gene ontology · 67
5-HT2A receptor → 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, activation of phospholipase C activity, ageing, animal behavior, artery smooth muscle contraction, axon, behavioral response to cocaine, caveola, cell body fiber, cell death, cell projection, cellular calcium ion homeostasis, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dendritic shaft, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain
related to history · 17
5-HT2A receptor → Gaddum, HT, HT1, HT1C, HT2, HT2A, HT2B, HT2C, HT2F, HT3, In, John Gaddum, Later, LSD, Picarelli, The, Thus
related to Structure · 17
5-HT2A receptor → BOL-148, Bryan Roth, D155, DMT, EBP, EM, GPCR, H8, HT2A, Its, Ligands, LSD, OBP, RS130-180, Structural, The, These
related to Tissue distribution · 17
5-HT2A receptor → A1, Additionally, AMPA, BAT, Cimbi-36, CNS, Especially, GABAA, Golgi, HT1A, HT2A, HT2A/2C, In, It, OX2, Purkinje, Whole-body
related to Positive allosteric modulators · 16
5-HT2A receptor → AB0124, Another, CTW0404, CTW0419, DOI, DOI-induced, HT2A, HT2B, HT2C, Instead, JPC0323, Positive, The, These, They, Unlike
has effect · 15
5-HT2A receptor → ACTH, Activation, Alzheimer's, CNS, DMT, DOI, HT2A, LSD, Other, Physiological, Primarily, Probable, Role, Smooth, TNF-alpha-induced
related to Gene · 14
5-HT2A receptor → A-1438G, C102T, His452Tyr, HT2A, HTR2, HTR2A, HTR2B, HTR2C, In, Many, Probable, Several, T102C, The
related to Agonists · 12
5-HT2A receptor → Activation, Agonists, Both, However, HPPD, HT2A, LSD, On, PFC, Psychedelics, Serotonin, Some
related to Function · 12
5-HT2A receptor → Activation, Additionally, Dysregulation, Functionally, GPCR, GPCRs, HT2A, IP3, It, Notably, PLC, The
related to Serotonin-elevating drugs · 12
5-HT2A receptor → Besides, Examples, HT2A, HTP, In, MAOIs, MDMA, Serotonin, Serotonin-elevating, SNRIs, SRAs, SSRIs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor 5-ht2a serotonin receptors effects agonists htr2a gene agonist anti-inflammatory selective also 5-ht2c potent psychedelics 5-ht2 psychedelic studies lsd human

5-HT2A receptor relationships Subject–Predicate–Object triples

TTTA extracted 301 structured relationships around 5-HT2A receptor. Examples in this analysis include 5-HT2A receptor → Aliases → HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A and 5-HT2A receptor → Band → 13q14.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
5-HT2A receptorAliasesHTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A1.00infobox
5-HT2A receptorBand13q14.21.00infobox
5-HT2A receptorBgeebuccal mucosa cell1.00infobox
5-HT2A receptorBgeemiddle temporal gyrus1.00infobox
5-HT2A receptorBgeefrontal pole1.00infobox
5-HT2A receptorBgeeBrodmann area 231.00infobox
5-HT2A receptorBgeeBrodmann area 101.00infobox
5-HT2A receptorBgeeBrodmann area 461.00infobox
5-HT2A receptorBgeeendothelial cell1.00infobox
5-HT2A receptorBgeeorbitofrontal cortex1.00infobox
5-HT2A receptorBgeesuperior frontal gyrus1.00infobox
5-HT2A receptorBgeeprimary visual cortex1.00infobox
5-HT2A receptorBioGPSMore reference expression data1.00infobox
5-HT2A receptorChr.Chromosome 13 (human)1.00infobox
5-HT2A receptorDatabasesNCBI: entry; OMA: entry1.00infobox
5-HT2A receptorEnd46,897,076 bp1.00infobox
5-HT2A receptorEnsemblENSG000001024681.00infobox
5-HT2A receptorEntrez33561.00infobox
5-HT2A receptorExternal IDsOMIM: 182135; MGI: 109521; GeneCards: HTR2A1.00infobox
5-HT2A receptorGene location (Human)Gene location (Human)Chr.Chromosome 13 (human)Band13q14.2Start46,831,546 bpEnd46,897,076 bp1.00infobox
5-HT2A receptorGene ontology1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding1.00infobox
5-HT2A receptorGene ontologyG protein-coupled receptor activity1.00infobox
5-HT2A receptorGene ontologyvirus receptor activity1.00infobox
5-HT2A receptorGene ontologysignal transducer activity1.00infobox
5-HT2A receptorGene ontologyG-protein alpha-subunit binding1.00infobox
5-HT2A receptorGene ontologyG protein-coupled serotonin receptor activity1.00infobox
5-HT2A receptorGene ontologyserotonin binding1.00infobox
5-HT2A receptorGene ontologyneurotransmitter receptor activity1.00infobox
5-HT2A receptorGene ontologyprotein binding1.00infobox
5-HT2A receptorGene ontologyprotein-containing complex binding1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around 5-HT2A receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Serotonin and Receptors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • 5-HT2A receptor
    • Receptor
    • Serotonin
    • Receptors
    • Agonists
    • Effects
    • 5-ht2c
    • Agonist
    • Also
    • Selective
    • Potent
    • Antagonist
    • Antagonists
  • 5-ht2a receptor
    • Receptor
    • Serotonin
    • Receptors
    • Agonists
    • Effects
    • 5-ht2c
    • Agonist
    • Also
    • Selective
    • Potent
    • Antagonist
    • Activation
  • 5-ht2 receptor
    • Serotonin
    • Family
    • Receptors
    • Agonists
    • 5-ht2c
    • Effects
    • Activation
    • Psychedelics
    • Positive
    • Antagonists
    • Like
    • Psychedelic
  • serotonin receptor
    • Serotonin
    • Agonists
    • Receptors
    • Effects
    • Psychedelics
    • Serotonergic
    • Activation
    • Positive
    • Antagonists
    • Like
    • Psychedelic
    • Including
  • cell surface receptor
    • Serotonin
    • Agonists
    • Receptors
    • Effects
    • Activation
    • Psychedelics
    • Positive
    • Antagonists
    • Like
    • Psychedelic
    • 5-ht2c
    • Anti-inflammatory
  • σ1 receptor
    • Serotonin
    • Agonists
    • Receptors
    • Effects
    • Activation
    • Psychedelics
    • Positive
    • Antagonists
    • Like
    • Psychedelic
    • 5-ht2c
    • Anti-inflammatory
  • dopamine d2 receptors
    • 5-ht2c
    • Serotonin
    • Also
    • Antagonists
    • Antagonist
    • May
    • Agonist
    • Partial
    • Including
    • Several
    • Effects
    • Signaling
  • anti-inflammatory
    • Effects
    • Potent
    • Psychedelic
    • Psychedelics
    • Lsd
    • Treatment
    • Serotonin
    • Research
    • Drugs
    • Receptor
    • Found
    • Human

Connections between topic areas Semantic bridges

For 5-HT2A receptor, one of the stronger structural bridges in this analysis connects 5-HT2A receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
5-HT2A receptorOverview · splits 215 ⟂ 153
5-HT2A receptorLigands · splits 281 ⟂ 87
5-HT2A receptorGene · splits 337 ⟂ 31
5-HT2A receptorFunction · splits 340 ⟂ 28
5-HT2A receptorTissue distribution · splits 343 ⟂ 25
5-HT2A receptorStructure · splits 351 ⟂ 17
5-HT2A receptorHistory · splits 356 ⟂ 12
5-HT2A receptorClinical significance · splits 360 ⟂ 8
5-HT2A receptorMethods to analyse the receptor · splits 362 ⟂ 6

Map overview Semantic statistics

5-HT2A receptor

Nodes368
Edges367
Triples301
Avg. degree1.99
Density0.005435
Components1

Source & methodology

TTTA analyzes the structure around 5-HT2A receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Gene & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — 5-HT2A receptor · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.