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Amoxapine

Amoxapine, sold under the brand name Asendin among others, is a tricyclic antidepressant (TCA). It is the N-demethylated metabolite of loxapine. Amoxapine first received marketing approval in the United States in 1980, approximately 10 to 20 years after most of the other TCAs were introduced in the United States.

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Side effects

AtaxiaOedemaProlactinHypertensionHypotension
51 related topics

Pharmacology

Reuptake inhibitorSerotoninNorepinephrine5-HT2A5-HT2B
41 related topics

Society and culture

KRINJPCANZ
11 related topics

Contraindications

FDAMyocardial infarctionMonoamine oxidase inhibitorsOndansetronCitalopram
11 related topics

Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA17 (WHO)
Bioavailability
>60%
CAS Number
14028-44-5 Y
ChEBI
CHEBI:2675 Y

Topics to explore

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Overview

Medical uses

Contraindications

Side effects

Overdose

Pharmacology

Society and culture

  • KR South Korea
  • IN India
  • JP Japan
  • CA Canada
  • NZ New Zealand
  • US United States of America
  • IE Ireland
  • UK United Kingdom
  • FR France
  • DK Denmark
  • ES Spain

Advanced semantic analysis

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Map overview Semantic statistics

Amoxapine

Nodes134
Edges133
Triples88
Avg. degree1.99
Density0.014925
Components1

How this topic connects Entity context

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Amoxapine

Top relations

related to Brand names · 21
Amoxapine → Adisen, Amolife, Amoxan, Asendin, Asendis, Brand, CA, Demolox, DK, Défanyl, ES, FR, IE, IN, JP, KR, NZ, Oxamine, Oxcap, UK
related to Pharmacodynamics · 20
Amoxapine → D1, D2, D3, D4, EC50, GABAA, GlyT2, H1, H4, HT1A, HT1B, HT2A, HT2B, HT2C, HT3, HT6, HT7, Hydroxyamoxapine, It, Ki
related to Contraindications · 6
Amoxapine → As, FDA-approved, Its, QT, Severe, Uncorrected
related to Medical uses · 5
Amoxapine → Compared, Despite, In, It, Parkinson's
Legal status · 3
Amoxapine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), US: ℞-only
3D model (JSmol) · 1
Amoxapine → Interactive image
AHFS/Drugs.com · 1
Amoxapine → Monograph
ATC code · 1
Amoxapine → N06AA17 (WHO)
Bioavailability · 1
Amoxapine → 60%
CAS Number · 1
Amoxapine → 14028-44-5 Y

Important terminology Word statistics

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Important terminology

effects blood also treatment adverse life-threatening metabolite side brand asendin 10 names breast incidence include body less often receptor tcas

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amoxapine3D model (JSmol)Interactive image1.00infobox
AmoxapineAHFS/Drugs.comMonograph1.00infobox
AmoxapineATC codeN06AA17 (WHO)1.00infobox
AmoxapineBioavailability>60%1.00infobox
AmoxapineCAS Number14028-44-5 Y1.00infobox
AmoxapineChEBICHEBI:2675 Y1.00infobox
AmoxapineChEMBLChEMBL1113 Y1.00infobox
AmoxapineChemSpider2085 Y1.00infobox
AmoxapineCompTox Dashboard (EPA)DTXSID70225981.00infobox
AmoxapineDrugBankDB00543 Y1.00infobox
AmoxapineECHA InfoCard100.034.4111.00infobox
AmoxapineElimination half-life8–10 hours (30 hours for chief active metabolite)1.00infobox
AmoxapineExcretionRenal (60%), feces (18%)1.00infobox
AmoxapineFormulaC17H16ClN3O1.00infobox
AmoxapineIUPHAR/BPS2011.00infobox
AmoxapineKEGGD00228 Y1.00infobox
AmoxapineLegal statusAU: S4 (Prescription only)1.00infobox
AmoxapineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
AmoxapineLegal statusUS: ℞-only1.00infobox
AmoxapineLicense dataUS FDA: Amoxapine1.00infobox
AmoxapineMedlinePlusa6822021.00infobox
AmoxapineMetabolismHepatic (cytochrome P450 system)1.00infobox
AmoxapineMolar mass313.79 g·mol−11.00infobox
AmoxapinePronunciationA-mox-a-peen1.00infobox
AmoxapineProtein binding90%1.00infobox
AmoxapinePubChem CID21701.00infobox
AmoxapineRoutes of administrationOral1.00infobox
AmoxapineTrade namesAsendin, others1.00infobox
AmoxapineUNIIR63VQ857OT1.00infobox

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