Amoxapine, sold under the brand name Asendin among others, is a tricyclic antidepressant (TCA). It is the N-demethylated metabolite of loxapine. Amoxapine first received marketing approval in the United States in 1980, approximately 10 to 20 years after most of the other TCAs were introduced in the United States.
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Amoxapine topic overview
The analysis highlights Community, Culture, Applications and Measurement as prominent areas in the source structure around Amoxapine.
Related topics
126
Source areas
7
Connected nodes
133
Extracted relationships
88
Concept neighborhoods
14
Bridge connections
133
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Side effects · 51 topics
Pharmacology · 41 topics
Contraindications · 11 topics
Society and culture · 11 topics
Overview · 5 topics
Medical uses · 4 topics
Overdose · 3 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA17 (WHO)
Bioavailability
>60%
CAS Number
14028-44-5 Y
ChEBI
CHEBI:2675 Y
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Amoxapine connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Amoxapine shows recurring relationship patterns in the source. For example, Amoxapine → Adisen, Amolife, Amoxan, Asendin, Asendis, Brand, CA, Demolox, DK, Défanyl, ES, FR, IE, IN, JP, KR, NZ, Oxamine, Oxcap, UK Another extracted example is Amoxapine → D1, D2, D3, D4, EC50, GABAA, GlyT2, H1, H4, HT1A, HT1B, HT2A, HT2B, HT2C, HT3, HT6, HT7, Hydroxyamoxapine, It, Ki. Use these groups to spot repeated connection types before inspecting the individual relationships.
Amoxapine
Top relations
related to Brand names· 21
Amoxapine → Adisen, Amolife, Amoxan, Asendin, Asendis, Brand, CA, Demolox, DK, Défanyl, ES, FR, IE, IN, JP, KR, NZ, Oxamine, Oxcap, UK
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 88 structured relationships around Amoxapine. Examples in this analysis include Amoxapine → 3D model (JSmol) → Interactive image and Amoxapine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Amoxapine
3D model (JSmol)
Interactive image
1.00
infobox
Amoxapine
AHFS/Drugs.com
Monograph
1.00
infobox
Amoxapine
ATC code
N06AA17 (WHO)
1.00
infobox
Amoxapine
Bioavailability
>60%
1.00
infobox
Amoxapine
CAS Number
14028-44-5 Y
1.00
infobox
Amoxapine
ChEBI
CHEBI:2675 Y
1.00
infobox
Amoxapine
ChEMBL
ChEMBL1113 Y
1.00
infobox
Amoxapine
ChemSpider
2085 Y
1.00
infobox
Amoxapine
CompTox Dashboard (EPA)
DTXSID7022598
1.00
infobox
Amoxapine
DrugBank
DB00543 Y
1.00
infobox
Amoxapine
ECHA InfoCard
100.034.411
1.00
infobox
Amoxapine
Elimination half-life
8–10 hours (30 hours for chief active metabolite)
1.00
infobox
Amoxapine
Excretion
Renal (60%), feces (18%)
1.00
infobox
Amoxapine
Formula
C17H16ClN3O
1.00
infobox
Amoxapine
IUPHAR/BPS
201
1.00
infobox
Amoxapine
KEGG
D00228 Y
1.00
infobox
Amoxapine
Legal status
AU: S4 (Prescription only)
1.00
infobox
Amoxapine
Legal status
BR: Class C1 (Other controlled substances)
1.00
infobox
Amoxapine
Legal status
US: ℞-only
1.00
infobox
Amoxapine
License data
US FDA: Amoxapine
1.00
infobox
Amoxapine
MedlinePlus
a682202
1.00
infobox
Amoxapine
Metabolism
Hepatic (cytochrome P450 system)
1.00
infobox
Amoxapine
Molar mass
313.79 g·mol−1
1.00
infobox
Amoxapine
Pronunciation
A-mox-a-peen
1.00
infobox
Amoxapine
Protein binding
90%
1.00
infobox
Amoxapine
PubChem CID
2170
1.00
infobox
Amoxapine
Routes of administration
Oral
1.00
infobox
Amoxapine
Trade names
Asendin, others
1.00
infobox
Amoxapine
UNII
R63VQ857OT
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Amoxapine bring nearby vocabulary together. In this analysis, examples include Active, Asendin and Brand. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
extrapyramidal side effects
Extrapyramidal
Side
Adverse
Status
Incidence
Treatment
Changes
Include
Active
Metabolite
Often
Days
anticholinergic effects
Adverse
Incidence
Side
Changes
Extrapyramidal
Include
Treatment
Days
Increased
One
Status
Life-threatening
side effects
Extrapyramidal
Adverse
Status
Incidence
Side
Treatment
Changes
Include
Active
Metabolite
Days
Increased
Amoxapine
Active
Asendin
Brand
Oral
Also
Name
Names
Others
Metabolite
Receptor
Treatment
Effects
amoxapine
Active
Asendin
Brand
Oral
Also
Name
Names
Others
Metabolite
Receptor
Treatment
Effects
active metabolite
Metabolite
Amoxapine
Name
Names
Others
Asendin
Brand
Oral
Overdose
Status
Receptor
Side
overdose
Status
Names
Others
Active
Cardiotoxic
Days
Metabolite
Oral
Tcas
Less
Side
Treatment
metabolite
Name
Names
Others
Oral
Overdose
Status
Receptor
Side
Treatment
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Amoxapine, one of the stronger structural bridges in this analysis connects Amoxapine with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Amoxapine
Nodes134
Edges133
Triples88
Avg. degree1.99
Density0.014925
Components1
Source & methodology
TTTA analyzes the structure around Amoxapine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture, Applications & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
