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5-HT2B receptor: Applications, Overview & Possible applications
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. 5-HT2B is a member of the 5-HT2 receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, the 5-HT2B receptor is Gq/G11-protein coupled, leading to downstream…
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5-HT2B receptor topic overview
The analysis highlights Applications, Overview and Possible applications as prominent areas in the source structure around 5-HT2B receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Related topics
212
Source areas
4
Connected nodes
217
Extracted relationships
151
Concept neighborhoods
17
Bridge connections
217
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 202 topics
Tissue distribution and function · 5 topics
Clinical significance · 4 topics
Possible applications · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How 5-HT2B receptor connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around 5-HT2B receptor shows recurring relationship patterns in the source. For example, 5-HT2B receptor → activation of phospholipase C activity, animal behavior, calcium-mediated signaling, cardiac muscle hypertrophy, cell junction, cellular calcium ion homeostasis, cellular response to temperature stimulus, cGMP biosynthetic process, cGMP-mediated signaling, chemical synaptic transmission, cytoplasm, dendrite, development of the heart, embryonic morphogenesis, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity Another extracted example is 5-HT2B receptor → calvaria, caput epididymis, corpus epididymis, decidua, embryo, genital tubercle, left adrenal cortex, left adrenal gland, morula, neural fold, neural groove, right adrenal cortex, right kidney, right lung lobe, smooth muscle tissue, stromal cell of endometrium, tail of embryo, tail of epididymis, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.
5-HT2B receptor
Top relations
Gene ontology· 61
5-HT2B receptor → activation of phospholipase C activity, animal behavior, calcium-mediated signaling, cardiac muscle hypertrophy, cell junction, cellular calcium ion homeostasis, cellular response to temperature stimulus, cGMP biosynthetic process, cGMP-mediated signaling, chemical synaptic transmission, cytoplasm, dendrite, development of the heart, embryonic morphogenesis, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity
Bgee· 19
5-HT2B receptor → calvaria, caput epididymis, corpus epididymis, decidua, embryo, genital tubercle, left adrenal cortex, left adrenal gland, morula, neural fold, neural groove, right adrenal cortex, right kidney, right lung lobe, smooth muscle tissue, stromal cell of endometrium, tail of embryo, tail of epididymis, testicle
RNA expression pattern· 19
5-HT2B receptor → calvaria, caput epididymis, corpus epididymis, decidua, embryo, genital tubercle, left adrenal cortex, left adrenal gland, morula, neural fold, neural groove, right adrenal cortex, right kidney, right lung lobe, smooth muscle tissue, stromal cell of endometrium, tail of embryo, tail of epididymis, testicle
related to Tissue distribution and function· 9
5-HT2B receptor → Cardiovascular, CNS, First, However, HT2, HT2B, HT2C, PNS, The
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 151 structured relationships around 5-HT2B receptor. Examples in this analysis include 5-HT2B receptor → Aliases → HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B and 5-HT2B receptor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NC3, 4IB4. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NC3, 4IB4
1.00
infobox
5-HT2B receptor
Band
2q37.1
1.00
infobox
5-HT2B receptor
Band
1|1 C5
1.00
infobox
5-HT2B receptor
Bgee
decidua
1.00
infobox
5-HT2B receptor
Bgee
tail of epididymis
1.00
infobox
5-HT2B receptor
Bgee
stromal cell of endometrium
1.00
infobox
5-HT2B receptor
Bgee
caput epididymis
1.00
infobox
5-HT2B receptor
Bgee
corpus epididymis
1.00
infobox
5-HT2B receptor
Bgee
left adrenal gland
1.00
infobox
5-HT2B receptor
Bgee
left adrenal cortex
1.00
infobox
5-HT2B receptor
Bgee
right adrenal cortex
1.00
infobox
5-HT2B receptor
Bgee
smooth muscle tissue
1.00
infobox
5-HT2B receptor
Bgee
testicle
1.00
infobox
5-HT2B receptor
Bgee
morula
1.00
infobox
5-HT2B receptor
Bgee
neural groove
1.00
infobox
5-HT2B receptor
Bgee
neural fold
1.00
infobox
5-HT2B receptor
Bgee
embryo
1.00
infobox
5-HT2B receptor
Bgee
tail of embryo
1.00
infobox
5-HT2B receptor
Bgee
genital tubercle
1.00
infobox
5-HT2B receptor
Bgee
calvaria
1.00
infobox
5-HT2B receptor
Bgee
right lung lobe
1.00
infobox
5-HT2B receptor
Bgee
right kidney
1.00
infobox
5-HT2B receptor
BioGPS
More reference expression data
1.00
infobox
5-HT2B receptor
Chr.
Chromosome 2 (human)
1.00
infobox
5-HT2B receptor
Chr.
Chromosome 1 (mouse)
1.00
infobox
5-HT2B receptor
Databases
NCBI: entry; OMA: entry
1.00
infobox
5-HT2B receptor
End
231,125,042 bp
1.00
infobox
5-HT2B receptor
End
86,039,692 bp
1.00
infobox
5-HT2B receptor
Ensembl
ENSG00000135914
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around 5-HT2B receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Serotonin and Receptors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
5-HT2B receptor
Receptor
Serotonin
Receptors
Antagonists
5-ht2
Development
Heart
Non-selective
Selective
5-ht
Nm
Htr2b
5-ht2b receptor
Receptor
Serotonin
Receptors
5-ht2
Non-selective
Antagonists
Development
5-ht2c
Potent
Selective
Heart
5-ht
protein
Neurotransmitter
Nm
5-ht2c
Htr2b
Humans
Release
Gene
Human
Serotonin
Activation
Function
Mouse
gene
Htr2b
Location
Chromosome
Human
Bp
Chr
Function
Mouse
Protein
Band
Heart
5-ht
5-ht2 receptor
Serotonin
Receptors
5-ht2
Receptor
Activation
Neurotransmitter
Nm
Non-selective
5-ht2c
5-ht2b
Potent
Development
neurotransmitter
Nm
Protein
5-ht2c
Release
Human
Serotonin
Activation
Function
Mouse
Selectivity
Receptors
Agonists
serotonin
Receptor
5-ht2b
5-ht2
Receptors
Release
Development
Neurotransmitter
Nm
Protein
5-ht2c
Humans
Potent
a1 receptor
Serotonin
5-ht2
Non-selective
5-ht2c
Potent
Receptors
Selective
Development
5-ht
Activation
Neurotransmitter
Nm
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For 5-HT2B receptor, one of the stronger structural bridges in this analysis connects 5-HT2B receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
5-HT2B receptor
Nodes218
Edges217
Triples151
Avg. degree1.99
Density0.009174
Components1
Source & methodology
TTTA analyzes the structure around 5-HT2B receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Overview & Possible applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
