Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Methysergide: History, Community, Culture & Applications

Methysergide, sold under the brand names Deseril and Sansert, is a monoaminergic medication which is used in the prevention and treatment of migraine and cluster headaches. It has been withdrawn from the market in the United States and Canada due to safety concerns. The drug has also been found to produce psychedelic effects at high doses. It is taken…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Methysergide topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Methysergide.

Related topics
93
Source areas
9
Connected nodes
102
Extracted relationships
88
Concept neighborhoods
32
Bridge connections
102

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 31 topics
Overview · 29 topics
Medical uses · 7 topics
Chemistry · 6 topics
History · 6 topics
Interactions · 6 topics
Side effects · 4 topics
Natural occurrence · 3 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
N02CA04 (WHO)
CAS Number
361-37-5 Y
ChEMBL
ChEMBL1065 Y
ChemSpider
9300 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Interactions

Pharmacology

Chemistry

Natural occurrence

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Methysergide connects Entity context

The extracted context around Methysergide shows recurring relationship patterns in the source. For example, Methysergide → GABA, HT1, HT1A, HT1B, HT1D, HT1E, HT1F, HT2A, HT2B, HT2C, HT3, HT5A, HT6, HT7, It, Methylergonovine, The Another extracted example is Methysergide → Discusses Methysergide, ErowidLSD-25, Isomer Design, Isomer DesignSansert, Koehler, Migraine, NovartisHistory, NovartisSansert, Prescribing Information, PubMedLSD-25, Tfelt-Hansen, TiHKAL. Use these groups to spot repeated connection types before inspecting the individual relationships.

Methysergide

Top relations

related to Pharmacodynamics · 17
Methysergide → GABA, HT1, HT1A, HT1B, HT1D, HT1E, HT1F, HT2A, HT2B, HT2C, HT3, HT5A, HT6, HT7, It, Methylergonovine, The
related to External links · 12
Methysergide → Discusses Methysergide, ErowidLSD-25, Isomer Design, Isomer DesignSansert, Koehler, Migraine, NovartisHistory, NovartisSansert, Prescribing Information, PubMedLSD-25, Tfelt-Hansen, TiHKAL
related to history · 9
Methysergide → Based, Harold Wolff's, HT, In, Less, Serotonin, Sicuteri, The, This
Legal status · 5
Methysergide → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
is a · 4
Methysergide → agonist of 5-HT1 receptors, mixed agonist of some serotonin receptors, partial agonist of the 5-HT2A and 5-HT2B receptors and also interacts with various other targets.Methysergide antagonizes the effects of serotonin in blood vessels and gastroint…, rapidly converted prodrug of methylergometrine
related to Interactions · 4
Methysergide → DMT, However, Pre-treatment, Since
related to Migraine and cluster headaches · 3
Methysergide → European Medicines Agency, International Headache Society, To
related to Natural occurrence · 3
Methysergide → Argyreia, Hawaiian, Previously
related to Pharmacokinetics · 3
Methysergide → As, Levels, The
related to Analogues · 2
Methysergide → D13H, XC101-D13H

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

serotonin migraine effects methylergonovine receptor cluster psychedelic due drug treatment agonist also methylergometrine used receptors united headaches sansert 5-ht2a 5-ht2b

Methysergide relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around Methysergide. Examples in this analysis include Methysergide → 3D model (JSmol) → Interactive image and Methysergide → AHFS/Drugs.com → International Drug Names. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Methysergide3D model (JSmol)Interactive image1.00infobox
MethysergideAHFS/Drugs.comInternational Drug Names1.00infobox
MethysergideATC codeN02CA04 (WHO)1.00infobox
MethysergideCAS Number361-37-5 Y1.00infobox
MethysergideChEMBLChEMBL1065 Y1.00infobox
MethysergideChemSpider9300 Y1.00infobox
MethysergideCompTox Dashboard (EPA)DTXSID20233071.00infobox
MethysergideDrug classMonoamine receptor modulator; Antimigraine agent1.00infobox
MethysergideDrugBankDB00247 Y1.00infobox
MethysergideECHA InfoCard100.006.0411.00infobox
MethysergideFormulaC21H27N3O21.00infobox
MethysergideIUPHAR/BPS1341.00infobox
MethysergideKEGGD02357 Y1.00infobox
MethysergideLegal statusAU: S4 (Prescription only)1.00infobox
MethysergideLegal statusBR: Class C1 (Other controlled substances)1.00infobox
MethysergideLegal statusCA: ℞-only1.00infobox
MethysergideLegal statusUK: POM (Prescription only)1.00infobox
MethysergideLegal statusUS: ℞-only1.00infobox
MethysergideMedlinePlusa6030221.00infobox
MethysergideMolar mass353.466 g·mol−11.00infobox
MethysergideOther namesUML-491; 1-Methylmethylergonovine; N-[(2S)-1-Hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8α-carboxamide; N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide1.00infobox
MethysergidePregnancy categoryAU: C1.00infobox
MethysergidePubChem CID96811.00infobox
MethysergideRoutes of administrationOral1.00infobox
MethysergideTrade namesDeseril, Sansert1.00infobox
MethysergideUNIIXZA9HY6Z981.00infobox
Methysergideis amixed agonist of some serotonin receptors0.90text
Methysergideis arapidly converted prodrug of methylergometrine0.90text
Methysergideis aagonist of 5-HT1 receptors0.90text
Methysergideis apartial agonist of the 5-HT2A and 5-HT2B receptors and also interacts with various other targets.Methysergide antagonizes the effects of serotonin in blood vessels and gastroint…0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Methysergide bring nearby vocabulary together. In this analysis, examples include Methylergonovine, Effects and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Methysergide
    • Methylergonovine
    • Effects
    • Receptor
    • Migraine
    • Serotonin
    • Agonist
    • Treatment
    • Methylergometrine
    • Headache
    • Receptors
    • Also
    • Cluster
  • methysergide
    • Methylergonovine
    • Effects
    • Receptor
    • Migraine
    • Serotonin
    • Agonist
    • Treatment
    • Methylergometrine
    • Headache
    • Receptors
    • Also
    • Cluster
  • serotonin receptor agonist
    • Receptors
    • Serotonin
    • 5-ht2a
    • Receptor
    • 5-ht2b
    • Antagonist
    • Doses
    • Methylergometrine
    • Methylergonovine
    • Psychedelic
    • Metabolism
    • Methysergide
  • 5-ht2a receptor
    • 5-ht2b
    • Serotonin
    • Agonist
    • Receptors
    • 5-ht2a
    • Receptor
    • Psychedelic
    • Metabolism
    • Effects
    • Antagonist
    • Doses
    • High
  • side effects
    • Psychedelic
    • Effect
    • Produce
    • Serotonin
    • Methysergide
    • Receptor
    • High
    • Metabolism
    • Side
    • States
    • Use
    • 5-ht2a
  • migraine
    • Treatment
    • Used
    • Headache
    • Use
    • Sansert
    • Drug
    • Side
    • Known
    • Effects
    • Canada
    • Concerns
    • Safety
  • cluster headaches
    • Headache
    • Headaches
    • Migraine
    • Used
    • Sansert
    • Treatment
    • Side
    • Use
    • Canada
    • States
    • United
    • Effects
  • migraine trust
    • Treatment
    • Used
    • Headache
    • Use
    • Sansert
    • Drug
    • Side
    • Known
    • Effects
    • Canada
    • Concerns
    • Safety

Connections between topic areas Semantic bridges

For Methysergide, one of the stronger structural bridges in this analysis connects Methysergide with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Methysergide — Pharmacology · splits 71 ⟂ 32
Methysergide — Overview · splits 73 ⟂ 30
Methysergide — Medical uses · splits 95 ⟂ 8
Methysergide — Interactions · splits 96 ⟂ 7
Methysergide — Chemistry · splits 96 ⟂ 7
Methysergide — History · splits 96 ⟂ 7
Methysergide — Side effects · splits 98 ⟂ 5
Methysergide — Natural occurrence · splits 99 ⟂ 4

Map overview Semantic statistics

Methysergide

Nodes103
Edges102
Triples88
Avg. degree1.98
Density0.019417
Components1

Source & methodology

TTTA analyzes the structure around Methysergide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Methysergide · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.