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5-HT2B receptor

5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. 5-HT2B is a member of the 5-HT2 receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, the 5-HT2B receptor is Gq/G11-protein coupled, leading to downstream…

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Aliases
HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NC3, 4IB4
Band
2q37.1 · 1|1 C5
Bgee
decidua · tail of epididymis · stromal cell of endometrium · caput epididymis · corpus epididymis
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

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5-HT2B receptor

Nodes218
Edges217
Triples151
Avg. degree1.99
Density0.009174
Components1

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5-HT2B receptor

Top relations

Gene ontology · 61
5-HT2B receptor → activation of phospholipase C activity, animal behavior, calcium-mediated signaling, cardiac muscle hypertrophy, cell junction, cellular calcium ion homeostasis, cellular response to temperature stimulus, cGMP biosynthetic process, cGMP-mediated signaling, chemical synaptic transmission, cytoplasm, dendrite, development of the heart, embryonic morphogenesis, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity
Bgee · 19
5-HT2B receptor → calvaria, caput epididymis, corpus epididymis, decidua, embryo, genital tubercle, left adrenal cortex, left adrenal gland, morula, neural fold, neural groove, right adrenal cortex, right kidney, right lung lobe, smooth muscle tissue, stromal cell of endometrium, tail of embryo, tail of epididymis, testicle
RNA expression pattern · 19
5-HT2B receptor → calvaria, caput epididymis, corpus epididymis, decidua, embryo, genital tubercle, left adrenal cortex, left adrenal gland, morula, neural fold, neural groove, right adrenal cortex, right kidney, right lung lobe, smooth muscle tissue, stromal cell of endometrium, tail of embryo, tail of epididymis, testicle
related to Tissue distribution and function · 9
5-HT2B receptor → Cardiovascular, CNS, First, However, HT2, HT2B, HT2C, PNS, The
has application · 6
5-HT2B receptor → Antagonism, HT2B, More, Phase, Research, RS-127
related to Ligands · 5
5-HT2B receptor → As, HT2B, HT2C, Research, The
related to Migraines · 4
5-HT2B receptor → HT2, HT2B, Serotonin, The
related to Valvular heart disease · 3
5-HT2B receptor → HT2B, The Fen-Phen, Today
Band · 2
5-HT2B receptor → 1|1 C5, 2q37.1
Chr. · 2
5-HT2B receptor → Chromosome 1 (mouse), Chromosome 2 (human)

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Important terminology

5-ht2b receptor serotonin receptors human bp 5-ht2 gene antagonists chr band htr2b development 5-hydroxytryptamine heart chromosome selective non-selective also cardiac

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
5-HT2B receptorAliasesHTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B1.00infobox
5-HT2B receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NC3, 4IB41.00infobox
5-HT2B receptorBand2q37.11.00infobox
5-HT2B receptorBand1|1 C51.00infobox
5-HT2B receptorBgeedecidua1.00infobox
5-HT2B receptorBgeetail of epididymis1.00infobox
5-HT2B receptorBgeestromal cell of endometrium1.00infobox
5-HT2B receptorBgeecaput epididymis1.00infobox
5-HT2B receptorBgeecorpus epididymis1.00infobox
5-HT2B receptorBgeeleft adrenal gland1.00infobox
5-HT2B receptorBgeeleft adrenal cortex1.00infobox
5-HT2B receptorBgeeright adrenal cortex1.00infobox
5-HT2B receptorBgeesmooth muscle tissue1.00infobox
5-HT2B receptorBgeetesticle1.00infobox
5-HT2B receptorBgeemorula1.00infobox
5-HT2B receptorBgeeneural groove1.00infobox
5-HT2B receptorBgeeneural fold1.00infobox
5-HT2B receptorBgeeembryo1.00infobox
5-HT2B receptorBgeetail of embryo1.00infobox
5-HT2B receptorBgeegenital tubercle1.00infobox
5-HT2B receptorBgeecalvaria1.00infobox
5-HT2B receptorBgeeright lung lobe1.00infobox
5-HT2B receptorBgeeright kidney1.00infobox
5-HT2B receptorBioGPSMore reference expression data1.00infobox
5-HT2B receptorChr.Chromosome 2 (human)1.00infobox
5-HT2B receptorChr.Chromosome 1 (mouse)1.00infobox
5-HT2B receptorDatabasesNCBI: entry; OMA: entry1.00infobox
5-HT2B receptorEnd231,125,042 bp1.00infobox
5-HT2B receptorEnd86,039,692 bp1.00infobox
5-HT2B receptorEnsemblENSG000001359141.00infobox

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