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Arrestin

Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall…

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Alt. symbols
arrestin-1
Domains
InterPro
HGNC
10521
Locus
Chr. 2 q37.1
NCBI gene
6295
OMIM
181031

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Map overview Semantic statistics

Arrestin

Nodes43
Edges42
Triples85
Avg. degree1.95
Density0.046512
Components1

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Arrestin

Top relations

related to Subtypes · 15
Arrestin → Arrestin-1, Arrestin-2, Arrestin-3, Arrestin-4, GPCRs, HUGO, In, It, Mammals, S-antigen, SAG, Systematic, The, This, X-arrestin
related to Mechanism · 14
Arrestin → AP2, Arrestins, Class, First, G-protein, Gi/o, GPCR, GPCRs, Gαi, More, Second, Subsequently, The, These
related to Binding to rhodopsin · 13
Arrestin → Additionally, GRKs, Important, PDB ID, S-arrestin, Ser, Ser-343, The, These, This, Thr, Thr-340, TM7
related to Structure · 12
Arrestin → Active, AP2, Arrestins, C-terminal, GPCRs, Increased, JNK3, Mdm2, Microtubule-bound, Receptor, Their, Unstimulated
related to Application · 8
Arrestin → C-terminal, GPCRs, GRKs, However, It, Rhodopsin, S-Arrestin, The
related to Function · 5
Arrestin → GPCRs, GRK, GRKs, In, The
related to External links · 3
Arrestin → Medicine Medical Subject Headings, MeSH, National Library
related to Tissue distribution · 3
Arrestin → In, Neurons, One
Alt. symbols · 1
Arrestin → arrestin-1
Domains · 1
Arrestin → InterPro

Important terminology Word statistics

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Important terminology

arrestins rhodopsin receptor gpcrs protein receptors binding proteins signaling first arrestin-2 arrestin-3 called non-visual activation s-arrestin visual subtypes gene arrestin-1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ArrestinAlt. symbolsarrestin-11.00infobox
ArrestinDomainsInterPro1.00infobox
ArrestinHGNC105211.00infobox
ArrestinLocusChr. 2 q37.11.00infobox
ArrestinNCBI gene62951.00infobox
ArrestinOMIM1810311.00infobox
ArrestinRefSeqNM_0005411.00infobox
ArrestinSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
ArrestinStructuresSwiss-model1.00infobox
ArrestinSymbolSAG1.00infobox
ArrestinUniProtP105231.00infobox
Arrestinis aprotein found in mice that binds to rhodopsin to stop its activity0.90text

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    Min side: 3
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