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Amitriptyline

Amitriptyline, formerly sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. Due to the frequency and prominence of side effects, amitriptyline is generally considered a…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA09 (WHO)
Bioavailability
45–53%
CAS Number
50-48-6 Y 549-18-8 (hydrochloride) 17086-03-2 (embonate)
ChEBI
CHEBI:2666 Y

Topics to explore

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Overview

Medical uses

Contraindications and precautions

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Amitriptyline

Nodes201
Edges200
Triples188
Avg. degree1.99
Density0.00995
Components1

How this topic connects Entity context

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Amitriptyline

Top relations

related to Names · 24
Amitriptyline → Amitriptylin, BANM, BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, Elavil, Endep, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Other, Spanish, The
related to Further reading · 16
Amitriptyline → Amitriptyline Therapy, Biotechnology Information, CYP2C19 Genotype, CYP2D6, Dean, Dean LC, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA
related to history · 12
Amitriptyline → American, Ayd, Drug Administration, Following, Frank Ayd, In, In Europe, Lundbeck, Merck, One, Roche, US Food
related to Interactions · 11
Amitriptyline → According, CYP2C19, CYP2D6, CYP3A4, However, John's Wort, On, P450, Similar, Since, St
related to Overdose · 10
Amitriptyline → Activated, Benzodiazepines, Body, Cardiac, Dialysis, ECG, If, TCAs, The, The British National Formulary
related to Pain · 9
Amitriptyline → Association, Combination, Combinations, European League Against Rheumatism, Germany, Here, It, Low, Scientific Medical Societies
related to Pharmacogenetics · 9
Amitriptyline → CYP2C19, CYP2D6, Increased, Individuals, Most, Poor, Since, These, Ultrarapid
related to Contraindications and precautions · 8
Amitriptyline → Being, Cautious, History, However, MAOI, MAOIs, TCAs, The
related to Mechanism of action · 7
Amitriptyline → Amitriptyline's, Increased, Inhibition, Neuropathic, NMDA, Since, The
related to Other indications · 7
Amitriptyline → After, IBS, In, Still, The, There, These

Important terminology Word statistics

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Important terminology

effects may nortriptyline pain patients side drug cyp2d6 used depression cyp2c19 treatment recommended also antidepressant serotonin level metabolizers due however

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amitriptyline3D model (JSmol)Interactive image1.00infobox
AmitriptylineAHFS/Drugs.comMonograph1.00infobox
AmitriptylineATC codeN06AA09 (WHO)1.00infobox
AmitriptylineBioavailability45–53%1.00infobox
AmitriptylineCAS Number50-48-6 Y 549-18-8 (hydrochloride) 17086-03-2 (embonate)1.00infobox
AmitriptylineChEBICHEBI:2666 Y1.00infobox
AmitriptylineChEMBLChEMBL629 Y1.00infobox
AmitriptylineChemSpider2075 Y1.00infobox
AmitriptylineCompTox Dashboard (EPA)DTXSID70225941.00infobox
AmitriptylineDrug classTricyclic antidepressant (TCA)1.00infobox
AmitriptylineDrugBankDB00321 Y1.00infobox
AmitriptylineECHA InfoCard100.000.0381.00infobox
AmitriptylineElimination half-life21 hours1.00infobox
AmitriptylineExcretionUrine: 12–80% after 48 hours; feces: not studied1.00infobox
AmitriptylineFormulaC20H23N1.00infobox
AmitriptylineIUPHAR/BPS2001.00infobox
AmitriptylineKEGGD07448 Y1.00infobox
AmitriptylineLegal statusAU: S4 (Prescription only)1.00infobox
AmitriptylineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
AmitriptylineLegal statusCA: ℞-only1.00infobox
AmitriptylineLegal statusUK: POM (Prescription only)1.00infobox
AmitriptylineLegal statusUS: ℞-only1.00infobox
AmitriptylineLicense dataUS DailyMed: Amitriptyline1.00infobox
AmitriptylineMedlinePlusa6823881.00infobox
AmitriptylineMelting point197.5 °C (387.5 °F)1.00infobox
AmitriptylineMetabolismLiver (CYP2D6, CYP2C19, CYP3A4)1.00infobox
AmitriptylineMetabolitesnortriptyline, (E)-10-hydroxynortriptyline1.00infobox
AmitriptylineMolar mass277.411 g·mol−11.00infobox
AmitriptylinePregnancy categoryAU: C1.00infobox
AmitriptylinePronunciation/ˌæmɪˈtrɪptɪliːn/1.00infobox

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