Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Amitriptyline: History, Community, Culture & Applications

Amitriptyline, formerly sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. Due to the frequency and prominence of side effects, amitriptyline is generally considered a…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Amitriptyline topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Amitriptyline.

Related topics
189
Source areas
11
Connected nodes
200
Extracted relationships
188
Concept neighborhoods
32
Bridge connections
200

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Medical uses · 50 topics
Pharmacology · 39 topics
Contraindications and precautions · 22 topics
Interactions · 22 topics
Overview · 20 topics
Side effects · 11 topics
Society and culture · 11 topics
Chemistry · 5 topics
History · 4 topics
Overdose · 4 topics
Research · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA09 (WHO)
Bioavailability
45–53%
CAS Number
50-48-6 Y 549-18-8 (hydrochloride) 17086-03-2 (embonate)
ChEBI
CHEBI:2666 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications and precautions

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Amitriptyline connects Entity context

The extracted context around Amitriptyline shows recurring relationship patterns in the source. For example, Amitriptyline → Amitriptylin, BANM, BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, Elavil, Endep, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Other, Spanish, The Another extracted example is Amitriptyline → Amitriptyline Therapy, Biotechnology Information, CYP2C19 Genotype, CYP2D6, Dean, Dean LC, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA. Use these groups to spot repeated connection types before inspecting the individual relationships.

Amitriptyline

Top relations

related to Names · 24
Amitriptyline → Amitriptylin, BANM, BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, Elavil, Endep, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Other, Spanish, The
related to Further reading · 16
Amitriptyline → Amitriptyline Therapy, Biotechnology Information, CYP2C19 Genotype, CYP2D6, Dean, Dean LC, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA
related to history · 12
Amitriptyline → American, Ayd, Drug Administration, Following, Frank Ayd, In, In Europe, Lundbeck, Merck, One, Roche, US Food
related to Interactions · 11
Amitriptyline → According, CYP2C19, CYP2D6, CYP3A4, However, John's Wort, On, P450, Similar, Since, St
related to Overdose · 10
Amitriptyline → Activated, Benzodiazepines, Body, Cardiac, Dialysis, ECG, If, TCAs, The, The British National Formulary
related to Pain · 9
Amitriptyline → Association, Combination, Combinations, European League Against Rheumatism, Germany, Here, It, Low, Scientific Medical Societies
related to Pharmacogenetics · 9
Amitriptyline → CYP2C19, CYP2D6, Increased, Individuals, Most, Poor, Since, These, Ultrarapid
related to Contraindications and precautions · 8
Amitriptyline → Being, Cautious, History, However, MAOI, MAOIs, TCAs, The
related to Mechanism of action · 7
Amitriptyline → Amitriptyline's, Increased, Inhibition, Neuropathic, NMDA, Since, The
related to Other indications · 7
Amitriptyline → After, IBS, In, Still, The, There, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects may nortriptyline pain patients side drug cyp2d6 used depression cyp2c19 treatment recommended also antidepressant serotonin level metabolizers due however

Amitriptyline relationships Subject–Predicate–Object triples

TTTA extracted 188 structured relationships around Amitriptyline. Examples in this analysis include Amitriptyline → 3D model (JSmol) → Interactive image and Amitriptyline → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Amitriptyline3D model (JSmol)Interactive image1.00infobox
AmitriptylineAHFS/Drugs.comMonograph1.00infobox
AmitriptylineATC codeN06AA09 (WHO)1.00infobox
AmitriptylineBioavailability45–53%1.00infobox
AmitriptylineCAS Number50-48-6 Y 549-18-8 (hydrochloride) 17086-03-2 (embonate)1.00infobox
AmitriptylineChEBICHEBI:2666 Y1.00infobox
AmitriptylineChEMBLChEMBL629 Y1.00infobox
AmitriptylineChemSpider2075 Y1.00infobox
AmitriptylineCompTox Dashboard (EPA)DTXSID70225941.00infobox
AmitriptylineDrug classTricyclic antidepressant (TCA)1.00infobox
AmitriptylineDrugBankDB00321 Y1.00infobox
AmitriptylineECHA InfoCard100.000.0381.00infobox
AmitriptylineElimination half-life21 hours1.00infobox
AmitriptylineExcretionUrine: 12–80% after 48 hours; feces: not studied1.00infobox
AmitriptylineFormulaC20H23N1.00infobox
AmitriptylineIUPHAR/BPS2001.00infobox
AmitriptylineKEGGD07448 Y1.00infobox
AmitriptylineLegal statusAU: S4 (Prescription only)1.00infobox
AmitriptylineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
AmitriptylineLegal statusCA: ℞-only1.00infobox
AmitriptylineLegal statusUK: POM (Prescription only)1.00infobox
AmitriptylineLegal statusUS: ℞-only1.00infobox
AmitriptylineLicense dataUS DailyMed: Amitriptyline1.00infobox
AmitriptylineMedlinePlusa6823881.00infobox
AmitriptylineMelting point197.5 °C (387.5 °F)1.00infobox
AmitriptylineMetabolismLiver (CYP2D6, CYP2C19, CYP3A4)1.00infobox
AmitriptylineMetabolitesnortriptyline, (E)-10-hydroxynortriptyline1.00infobox
AmitriptylineMolar mass277.411 g·mol−11.00infobox
AmitriptylinePregnancy categoryAU: C1.00infobox
AmitriptylinePronunciation/ˌæmɪˈtrɪptɪliːn/1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Amitriptyline bring nearby vocabulary together. In this analysis, examples include Patients, May and Nortriptyline. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Amitriptyline
    • Patients
    • May
    • Nortriptyline
    • Pain
    • Effects
    • Drug
    • Cyp2d6
    • Side
    • Due
    • Used
    • Antidepressant
    • However
  • amitriptyline
    • Patients
    • May
    • Nortriptyline
    • Pain
    • Effects
    • Drug
    • Cyp2d6
    • Side
    • Due
    • Used
    • Antidepressant
    • However
  • tricyclic antidepressant
    • Tricyclic
    • Migraine
    • Elavil
    • Name
    • Overdose
    • Also
    • Depression
    • Metabolism
    • Us
    • Pain
    • Used
    • Liver
  • neuropathic pain
    • Reduce
    • Effect
    • Evidence
    • May
    • Also
    • Treatment
    • Tricyclic
    • Syndrome
    • Patients
    • Use
    • Used
    • Effects
  • side effects
    • Side
    • Increased
    • Patients
    • Metabolizers
    • Cyp2d6
    • Reduce
    • Metabolism
    • Liver
    • Treatment
    • May
    • Overdose
    • Syndrome
  • food and drug administration
    • Metabolism
    • Us
    • Also
    • Cyp2c19
    • Metabolizers
    • Patients
    • Cyp2d6
    • Name
    • Nortriptyline
    • Liver
    • Use
    • Level
  • atypical facial pain
    • Reduce
    • Effect
    • Evidence
    • May
    • Also
    • Treatment
    • Tricyclic
    • Syndrome
    • Patients
    • Use
    • Used
    • Effects
  • central post-stroke pain
    • Reduce
    • Effect
    • Evidence
    • May
    • Also
    • Treatment
    • Tricyclic
    • Syndrome
    • Patients
    • Use
    • Used
    • Effects

Connections between topic areas Semantic bridges

For Amitriptyline, one of the stronger structural bridges in this analysis connects Amitriptyline with Medical uses. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AmitriptylineMedical uses · splits 150 ⟂ 51
AmitriptylinePharmacology · splits 161 ⟂ 40
AmitriptylineContraindications and precautions · splits 178 ⟂ 23
AmitriptylineInteractions · splits 178 ⟂ 23
AmitriptylineOverview · splits 180 ⟂ 21
AmitriptylineSide effects · splits 189 ⟂ 12
AmitriptylineSociety and culture · splits 189 ⟂ 12
AmitriptylineChemistry · splits 195 ⟂ 6
AmitriptylineOverdose · splits 196 ⟂ 5
AmitriptylineHistory · splits 196 ⟂ 5

Map overview Semantic statistics

Amitriptyline

Nodes201
Edges200
Triples188
Avg. degree1.99
Density0.00995
Components1

Source & methodology

TTTA analyzes the structure around Amitriptyline to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Amitriptyline · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.