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Doxepin: Community, Culture, Applications & Research

Doxepin is a medication belonging to the tricyclic antidepressant (TCA) class of drugs used to treat major depressive disorder, anxiety disorders, difficult-to-treat chronic urticaria, and insomnia. For hives it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness…

Language: English [EN]
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Doxepin topic overview

The analysis highlights Community, Culture, Applications and Research as prominent areas in the source structure around Doxepin.

Related topics
243
Source areas
10
Connected nodes
253
Extracted relationships
235
Concept neighborhoods
38
Bridge connections
253

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 99 topics
Pharmacology · 41 topics
Side effects · 23 topics
Interactions · 22 topics
Chemistry · 17 topics
Society and culture · 13 topics
Medical uses · 11 topics
Overdose · 6 topics
Research · 6 topics
Contraindications · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D04AX01 (WHO) N06AA12 (WHO)
Bioavailability
13–45% (mean 29%)
CAS Number
1668-19-5 Y 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)
ChEBI
CHEBI:4710 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Doxepin connects Entity context

The extracted context around Doxepin shows recurring relationship patterns in the source. For example, Doxepin → Adnor, Anten, Antidoxe, Aponal, Boehringer, Colian, Deptran, Dofu, Doneurin, Dospin, Doxal, Doxepini, Doxesom, Doxiderm, Doxure, Flake, Gilex, Ichderm, It, Li Ke Ning Another extracted example is Doxepin → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, The, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia. Use these groups to spot repeated connection types before inspecting the individual relationships.

Doxepin

Top relations

related to Brand names · 34
Doxepin → Adnor, Anten, Antidoxe, Aponal, Boehringer, Colian, Deptran, Dofu, Doneurin, Dospin, Doxal, Doxepini, Doxesom, Doxiderm, Doxure, Flake, Gilex, Ichderm, It, Li Ke Ning
related to Generic names · 17
Doxepin → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, The, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Insomnia · 16
Doxepin → Agency, American Academy, American College, Benzodiazepines, CI, CITooltip, For, Healthcare Research, In, Physicians, Quality, Sleep Medicine, SMD, SMDs, The, Z-drugs
related to Pharmacodynamics · 16
Doxepin → D2, Extremely, H1, H2, Histamine H1, HT1A, HT2A, HT2C, It, M1, M5, Serotonin, Similarly, SNRI, SSRI, The
related to Interactions · 14
Doxepin → Alcohol, Antihypertensive, Cimetidine, CNS, Co-treatment, Cotreatment, CYP2D6, Hepatic, II, It, MAOI, Sympathomimetic, TCAs, Tolazamide
related to Overdose · 11
Doxepin → Antiarrhythmic, ECG, Haemodialysis, Like, Management, Mild, More, Slow, Supportive, TCAs, Urinary
related to Pharmacogenetics · 11
Doxepin → CYP2C19, CYP2C9, CYP2D6, Increased, Individuals, Most, P450, Poor, Since, These, Ultrarapid
related to Chemistry · 9
Doxepin → C19H21NO, E/Z, It, N-dimethylpropan-1-amine, Other, TCA, TCAs, The, The CAS Registry Number
has effect · 7
Doxepin → Allergic/toxic, Anticholinergic, Central, Doxepin's, Low, May, Others
Legal status · 6
Doxepin → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, NZ: Prescription only, UK: POM (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects insomnia doses may treatment cyp2d6 side mg nordoxepin metabolism h1 serotonin used anticholinergic extensive receptor drug also metabolizers low

Doxepin relationships Subject–Predicate–Object triples

TTTA extracted 235 structured relationships around Doxepin. Examples in this analysis include Doxepin → 3D model (JSmol) → Interactive image and Doxepin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Doxepin3D model (JSmol)Interactive image1.00infobox
DoxepinAHFS/Drugs.comMonograph1.00infobox
DoxepinATC codeD04AX01 (WHO) N06AA12 (WHO)1.00infobox
DoxepinBioavailability13–45% (mean 29%)1.00infobox
DoxepinCAS Number1668-19-5 Y 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)1.00infobox
DoxepinChEBICHEBI:4710 Y1.00infobox
DoxepinChEMBLChEMBL1628227 Y1.00infobox
DoxepinChemSpider3046 Y1.00infobox
DoxepinCompTox Dashboard (EPA)DTXSID70229661.00infobox
DoxepinDrug classTricyclic antidepressant (TCA)1.00infobox
DoxepinDrugBankDB01142 Y1.00infobox
DoxepinElimination half-lifeDoxepin: 8–24 hours (mean 17 hours) Nordoxepin: 28–31 hours1.00infobox
DoxepinExcretionKidney: ~50% Feces: minor1.00infobox
DoxepinFormulaC19H21NO1.00infobox
DoxepinIUPHAR/BPS12251.00infobox
DoxepinKEGGD07875 Y1.00infobox
DoxepinKEGGas HCl: D00814 Y1.00infobox
DoxepinLegal statusAU: S4 (Prescription only)1.00infobox
DoxepinLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DoxepinLegal statusCA: ℞-only1.00infobox
DoxepinLegal statusNZ: Prescription only1.00infobox
DoxepinLegal statusUK: POM (Prescription only)1.00infobox
DoxepinLegal statusUS: ℞-only1.00infobox
DoxepinLicense dataUS DailyMed: Doxepin1.00infobox
DoxepinMedlinePlusa6823901.00infobox
DoxepinMetabolismLiver (CYP2D6, CYP2C19)1.00infobox
DoxepinMetabolitesNordoxepin, glucuronide conjugates1.00infobox
DoxepinMolar mass279.383 g·mol−11.00infobox
DoxepinOther namesNSC-1081601.00infobox
DoxepinPDB ligand5EH (PDBe, RCSB PDB)1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Doxepin bring nearby vocabulary together. In this analysis, examples include Effects, Doses and Insomnia. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Doxepin
    • Effects
    • Doses
    • Insomnia
    • Mg
    • Treatment
    • May
    • Nordoxepin
    • Cyp2d6
    • Metabolism
    • Side
    • Found
    • Dose
  • doxepin
    • Effects
    • Doses
    • Insomnia
    • Mg
    • Treatment
    • May
    • Nordoxepin
    • Cyp2d6
    • Metabolism
    • Side
    • Found
    • Dose
  • insomnia
    • Treatment
    • Doses
    • Low
    • Used
    • Mg
    • Found
    • Effect
    • Effects
    • Drug
    • H1
    • Receptor
    • Overdose
  • side effects
    • Side
    • May
    • Anticholinergic
    • Doses
    • Increased
    • H1
    • Antihistamines
    • Include
    • Tcas
    • Insomnia
    • Low
    • Also
  • rebound insomnia
    • Treatment
    • Doses
    • Low
    • Used
    • Mg
    • Found
    • Effect
    • Effects
    • Drug
    • H1
    • Receptor
    • Overdose
  • extrapyramidal side effects
    • Side
    • May
    • Anticholinergic
    • Doses
    • Increased
    • H1
    • Antihistamines
    • Include
    • Tcas
    • Insomnia
    • Low
    • Also
  • dirty drug
    • Metabolism
    • Increased
    • Insomnia
    • Due
    • Poor
    • Extensive
    • Low
    • Also
    • Metabolizers
    • Used
    • Side
    • Mg
  • combination drug
    • Metabolism
    • Increased
    • Insomnia
    • Due
    • Poor
    • Extensive
    • Low
    • Also
    • Metabolizers
    • Used
    • Side
    • Mg

Connections between topic areas Semantic bridges

For Doxepin, one of the stronger structural bridges in this analysis connects Doxepin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DoxepinOverview · splits 154 ⟂ 100
DoxepinPharmacology · splits 212 ⟂ 42
DoxepinSide effects · splits 230 ⟂ 24
DoxepinInteractions · splits 231 ⟂ 23
DoxepinChemistry · splits 236 ⟂ 18
DoxepinSociety and culture · splits 240 ⟂ 14
DoxepinMedical uses · splits 242 ⟂ 12
DoxepinOverdose · splits 247 ⟂ 7
DoxepinResearch · splits 247 ⟂ 7
DoxepinContraindications · splits 248 ⟂ 6

Map overview Semantic statistics

Doxepin

Nodes254
Edges253
Triples235
Avg. degree1.99
Density0.007874
Components1

Source & methodology

TTTA analyzes the structure around Doxepin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Doxepin · EN edition · Analysis: TopicsToTalkAbout

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