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Doxepin is a medication belonging to the tricyclic antidepressant (TCA) class of drugs used to treat major depressive disorder, anxiety disorders, difficult-to-treat chronic urticaria, and insomnia. For hives it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness…
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Explore the main themes, entities and connections around Doxepin. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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effects insomnia doses may treatment cyp2d6 side mg nordoxepin metabolism h1 serotonin used anticholinergic extensive receptor drug also metabolizers low
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Doxepin | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Doxepin | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Doxepin | ATC code | D04AX01 (WHO) N06AA12 (WHO) | 1.00 | infobox |
| Doxepin | Bioavailability | 13–45% (mean 29%) | 1.00 | infobox |
| Doxepin | CAS Number | 1668-19-5 Y 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin) | 1.00 | infobox |
| Doxepin | ChEBI | CHEBI:4710 Y | 1.00 | infobox |
| Doxepin | ChEMBL | ChEMBL1628227 Y | 1.00 | infobox |
| Doxepin | ChemSpider | 3046 Y | 1.00 | infobox |
| Doxepin | CompTox Dashboard (EPA) | DTXSID7022966 | 1.00 | infobox |
| Doxepin | Drug class | Tricyclic antidepressant (TCA) | 1.00 | infobox |
| Doxepin | DrugBank | DB01142 Y | 1.00 | infobox |
| Doxepin | Elimination half-life | Doxepin: 8–24 hours (mean 17 hours) Nordoxepin: 28–31 hours | 1.00 | infobox |
| Doxepin | Excretion | Kidney: ~50% Feces: minor | 1.00 | infobox |
| Doxepin | Formula | C19H21NO | 1.00 | infobox |
| Doxepin | IUPHAR/BPS | 1225 | 1.00 | infobox |
| Doxepin | KEGG | D07875 Y | 1.00 | infobox |
| Doxepin | KEGG | as HCl: D00814 Y | 1.00 | infobox |
| Doxepin | Legal status | AU: S4 (Prescription only) | 1.00 | infobox |
| Doxepin | Legal status | BR: Class C1 (Other controlled substances) | 1.00 | infobox |
| Doxepin | Legal status | CA: ℞-only | 1.00 | infobox |
| Doxepin | Legal status | NZ: Prescription only | 1.00 | infobox |
| Doxepin | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Doxepin | Legal status | US: ℞-only | 1.00 | infobox |
| Doxepin | License data | US DailyMed: Doxepin | 1.00 | infobox |
| Doxepin | MedlinePlus | a682390 | 1.00 | infobox |
| Doxepin | Metabolism | Liver (CYP2D6, CYP2C19) | 1.00 | infobox |
| Doxepin | Metabolites | Nordoxepin, glucuronide conjugates | 1.00 | infobox |
| Doxepin | Molar mass | 279.383 g·mol−1 | 1.00 | infobox |
| Doxepin | Other names | NSC-108160 | 1.00 | infobox |
| Doxepin | PDB ligand | 5EH (PDBe, RCSB PDB) | 1.00 | infobox |
These clusters group vocabulary that occurs around closely connected concepts in the source material.
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