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Doxepin

Doxepin is a medication belonging to the tricyclic antidepressant (TCA) class of drugs used to treat major depressive disorder, anxiety disorders, difficult-to-treat chronic urticaria, and insomnia. For hives it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D04AX01 (WHO) N06AA12 (WHO)
Bioavailability
13–45% (mean 29%)
CAS Number
1668-19-5 Y 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)
ChEBI
CHEBI:4710 Y

Topics to explore

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Doxepin

Nodes254
Edges253
Triples235
Avg. degree1.99
Density0.007874
Components1

How this topic connects Entity context

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Doxepin

Top relations

related to Brand names · 34
Doxepin → Adnor, Anten, Antidoxe, Aponal, Boehringer, Colian, Deptran, Dofu, Doneurin, Dospin, Doxal, Doxepini, Doxesom, Doxiderm, Doxure, Flake, Gilex, Ichderm, It, Li Ke Ning
related to Generic names · 17
Doxepin → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, English, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, The, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Insomnia · 16
Doxepin → Agency, American Academy, American College, Benzodiazepines, CI, CITooltip, For, Healthcare Research, In, Physicians, Quality, Sleep Medicine, SMD, SMDs, The, Z-drugs
related to Pharmacodynamics · 16
Doxepin → D2, Extremely, H1, H2, Histamine H1, HT1A, HT2A, HT2C, It, M1, M5, Serotonin, Similarly, SNRI, SSRI, The
related to Interactions · 14
Doxepin → Alcohol, Antihypertensive, Cimetidine, CNS, Co-treatment, Cotreatment, CYP2D6, Hepatic, II, It, MAOI, Sympathomimetic, TCAs, Tolazamide
related to Overdose · 11
Doxepin → Antiarrhythmic, ECG, Haemodialysis, Like, Management, Mild, More, Slow, Supportive, TCAs, Urinary
related to Pharmacogenetics · 11
Doxepin → CYP2C19, CYP2C9, CYP2D6, Increased, Individuals, Most, P450, Poor, Since, These, Ultrarapid
related to Chemistry · 9
Doxepin → C19H21NO, E/Z, It, N-dimethylpropan-1-amine, Other, TCA, TCAs, The, The CAS Registry Number
has effect · 7
Doxepin → Allergic/toxic, Anticholinergic, Central, Doxepin's, Low, May, Others
Legal status · 6
Doxepin → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, NZ: Prescription only, UK: POM (Prescription only), US: ℞-only

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Important terminology

effects insomnia doses may treatment cyp2d6 side mg nordoxepin metabolism h1 serotonin used anticholinergic extensive receptor drug also metabolizers low

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Doxepin3D model (JSmol)Interactive image1.00infobox
DoxepinAHFS/Drugs.comMonograph1.00infobox
DoxepinATC codeD04AX01 (WHO) N06AA12 (WHO)1.00infobox
DoxepinBioavailability13–45% (mean 29%)1.00infobox
DoxepinCAS Number1668-19-5 Y 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)1.00infobox
DoxepinChEBICHEBI:4710 Y1.00infobox
DoxepinChEMBLChEMBL1628227 Y1.00infobox
DoxepinChemSpider3046 Y1.00infobox
DoxepinCompTox Dashboard (EPA)DTXSID70229661.00infobox
DoxepinDrug classTricyclic antidepressant (TCA)1.00infobox
DoxepinDrugBankDB01142 Y1.00infobox
DoxepinElimination half-lifeDoxepin: 8–24 hours (mean 17 hours) Nordoxepin: 28–31 hours1.00infobox
DoxepinExcretionKidney: ~50% Feces: minor1.00infobox
DoxepinFormulaC19H21NO1.00infobox
DoxepinIUPHAR/BPS12251.00infobox
DoxepinKEGGD07875 Y1.00infobox
DoxepinKEGGas HCl: D00814 Y1.00infobox
DoxepinLegal statusAU: S4 (Prescription only)1.00infobox
DoxepinLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DoxepinLegal statusCA: ℞-only1.00infobox
DoxepinLegal statusNZ: Prescription only1.00infobox
DoxepinLegal statusUK: POM (Prescription only)1.00infobox
DoxepinLegal statusUS: ℞-only1.00infobox
DoxepinLicense dataUS DailyMed: Doxepin1.00infobox
DoxepinMedlinePlusa6823901.00infobox
DoxepinMetabolismLiver (CYP2D6, CYP2C19)1.00infobox
DoxepinMetabolitesNordoxepin, glucuronide conjugates1.00infobox
DoxepinMolar mass279.383 g·mol−11.00infobox
DoxepinOther namesNSC-1081601.00infobox
DoxepinPDB ligand5EH (PDBe, RCSB PDB)1.00infobox

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