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Tryptamine: History, Biological activity & Chemistry

Tryptamine, also known as 2-(3-indolyl)ethylamine, is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the first one being the heterocyclic nitrogen). The structure of tryptamine is a…

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Tryptamine topic overview

The analysis highlights History, Biological activity and Chemistry as prominent areas in the source structure around Tryptamine.

Related topics
200
Source areas
7
Connected nodes
207
Extracted relationships
129
Concept neighborhoods
40
Bridge connections
207

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Biological activity · 84 topics
Chemistry · 53 topics
Overview · 28 topics
History · 13 topics
Natural occurrences · 10 topics
Pharmacokinetics · 10 topics
Metabolism · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
Oral: Very low
Boiling point
137 °C (279 °F) (0.15 mmHg)
CAS Number
61-54-1 Y
ChEBI
CHEBI:16765

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Natural occurrences

Metabolism

Biological activity

Pharmacokinetics

Chemistry

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tryptamine connects Entity context

The extracted context around Tryptamine shows recurring relationship patterns in the source. For example, Tryptamine → Arthur James Ewins, Dilworth Wayne Woolley, DMT, Elliott Shaw, Following, HT, LSD, Maurice, N-methylated, N-methyltryptamine, NMT, Patrick Laidlaw, Rapport, Richard Manske, Stephen Szára, Subsequently, The Another extracted example is Tryptamine → Another, Conversely, Findings, Head, HTP, In, It, LSD, LSD-like, Many, MAO, MAOI, MAOIs, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tryptamine

Top relations

related to history · 17
Tryptamine → Arthur James Ewins, Dilworth Wayne Woolley, DMT, Elliott Shaw, Following, HT, LSD, Maurice, N-methylated, N-methyltryptamine, NMT, Patrick Laidlaw, Rapport, Richard Manske, Stephen Szára, Subsequently, The
has effect · 15
Tryptamine → Another, Conversely, Findings, Head, HTP, In, It, LSD, LSD-like, Many, MAO, MAOI, MAOIs, The, This
related to Analogues and derivatives · 9
Tryptamine → DMT, HT, MeO-DMT, N-acetyltryptamine, N-dimethylserotonin, N-methyltryptamine, NMT, The, These
related to Pharmacokinetics · 9
Tryptamine → Brain, DMT, However, IAA, In, Its, MAO, MAOIs, This
related to Monoaminergic activity enhancer · 8
Tryptamine → BPAP, IPAP, MAE, MAEs, Synthetic, TAAR1, That, The MAE
related to Serotonin receptor agonist · 7
Tryptamine → EC50, EC50Tooltip, Emax, HT1A, HT2A, In, It
related to External links · 5
Tryptamine → ErowidTryptamine, Isomer Design, Isomer DesignTryptamine, TiHKAL, Tryptamine FAQ
related to Monoamine releasing agent · 5
Tryptamine → EC50, It, MRA, SNDRA, That
related to TAAR1 agonist · 5
Tryptamine → GIRKs, GPCR, It, TAAR1, The TAAR1
related to Mammalian gut microbiome · 4
Tryptamine → Clostridium, Commensal, HT4, Ruminococcus

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

serotonin effects monoamine taar1 receptor trace agonist like animals acid tryptophan metabolism derivatives gut brain first including dmt receptors dopamine

Tryptamine relationships Subject–Predicate–Object triples

TTTA extracted 129 structured relationships around Tryptamine. Examples in this analysis include Tryptamine → 3D model (JSmol) → Interactive image and Tryptamine → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tryptamine3D model (JSmol)Interactive image1.00infobox
TryptamineATC codeNone1.00infobox
TryptamineBioavailabilityOral: Very low1.00infobox
TryptamineBoiling point137 °C (279 °F) (0.15 mmHg)1.00infobox
TryptamineCAS Number61-54-1 Y1.00infobox
TryptamineChEBICHEBI:167651.00infobox
TryptamineChEMBLChEMBL6640 Y1.00infobox
TryptamineChemSpider1118 Y1.00infobox
TryptamineCompTox Dashboard (EPA)DTXSID20753401.00infobox
TryptamineDrug classSerotonin receptor agonist; Trace amine-associated receptor 1 (TAAR1) agonist; Serotonin–norepinephrine–dopamine releasing agent; Serotonergic psychedelic; Hallucinogen1.00infobox
TryptamineDrugBankDB086531.00infobox
TryptamineDuration of actionIVTooltip Intravenous injection: Very short1.00infobox
TryptamineECHA InfoCard100.000.4641.00infobox
TryptamineElimination half-lifeVery short1.00infobox
TryptamineExcretionUrine1.00infobox
TryptamineFormulaC10H12N21.00infobox
TryptamineIUPHAR/BPS1251.00infobox
TryptamineKEGGC003981.00infobox
TryptamineLegal statusLegal or unregulated1.00infobox
TryptamineMelting point118 °C (244 °F)1.00infobox
TryptamineMetabolismVery rapid (oxidative deamination by MAOTooltip monoamine oxidase)1.00infobox
TryptamineMetabolitesIndole-3-acetic acid (IAA)1.00infobox
TryptamineMolar mass160.220 g·mol−11.00infobox
TryptamineOnset of actionIVTooltip Intravenous injection: Very rapid1.00infobox
TryptamineOther namesT; TrpA; Triptamine; 3-(2-Aminoethyl)indole; 2-(3-Indolyl)ethylamine; Indolylethylamine; Indolethylamine; PAL-235; PAL2351.00infobox
TryptaminePubChem CID11501.00infobox
TryptamineRoutes of administrationIntravenous injection1.00infobox
TryptamineSolubility in waterNegligible mg/mL (20 °C)1.00infobox
TryptamineUNII422ZU9N5TV1.00infobox
Tryptamineis ashared feature of certain aminergic neuromodulators including melatonin0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tryptamine bring nearby vocabulary together. In this analysis, examples include Serotonin, Monoamine and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tryptamine
    • Serotonin
    • Monoamine
    • Receptor
    • Effects
    • Oxidase
    • Animals
    • Trace
    • Derivatives
    • Gut
    • Psychedelic
    • Tryptophan
    • Brain
  • tryptamine
    • Serotonin
    • Monoamine
    • Receptor
    • Effects
    • Oxidase
    • Animals
    • Trace
    • Derivatives
    • Gut
    • Psychedelic
    • Tryptophan
    • Brain
  • essential amino acid
    • Tryptophan
    • Oxidase
    • Mg
    • Also
    • Derivatives
    • Monoamine
    • Psychedelic
    • Trace
    • Tryptamine
    • Agent
    • Releasing
    • Effects
  • serotonin
    • Dopamine
    • Receptor
    • Norepinephrine
    • Tryptamine
    • Expressed
    • Structure
    • Derivatives
    • Gut
    • Psychedelic
    • Agonist
    • Brain
    • Trace
  • serotonin receptors
    • Amine-associated
    • Gastrointestinal
    • Gut
    • Dopamine
    • Receptor
    • Norepinephrine
    • Trace
    • Tryptamine
    • Expressed
    • Structure
    • Derivatives
    • Psychedelic
  • trace amine-associated receptors
    • Amine-associated
    • Trace
    • Gastrointestinal
    • Receptors
    • Gut
    • Agonist
    • Brain
    • Taar1
    • Agent
    • Mg
    • Receptor
    • Releasing
  • gut
    • Gastrointestinal
    • Receptors
    • Humans
    • Serotonin
    • Agent
    • Mg
    • Releasing
    • Duration
    • Norepinephrine
    • Dopamine
    • Metabolism
    • Psychedelic
  • gastrointestinal tract
    • Gut
    • Receptors
    • Tryptophan
    • Agent
    • Mg
    • Releasing
    • Duration
    • Norepinephrine
    • Dopamine
    • Humans
    • Metabolism
    • Psychedelic

Connections between topic areas Semantic bridges

For Tryptamine, one of the stronger structural bridges in this analysis connects Tryptamine with Biological activity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tryptamine — Biological activity · splits 123 ⟂ 85
Tryptamine — Chemistry · splits 154 ⟂ 54
Tryptamine — Overview · splits 179 ⟂ 29
Tryptamine — History · splits 194 ⟂ 14
Tryptamine — Natural occurrences · splits 197 ⟂ 11
Tryptamine — Pharmacokinetics · splits 197 ⟂ 11
Tryptamine — Metabolism · splits 205 ⟂ 3

Map overview Semantic statistics

Tryptamine

Nodes208
Edges207
Triples129
Avg. degree1.99
Density0.009615
Components1

Source & methodology

TTTA analyzes the structure around Tryptamine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Biological activity & Chemistry, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tryptamine · EN edition · Analysis: TopicsToTalkAbout

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