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Functional selectivity

Functional selectivity (or agonist trafficking, biased agonism, biased signaling, ligand bias, and differential engagement) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor. Functional selectivity can be present when a receptor has…

Examples, Functional vs. traditional selectivity & Overview

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Functional vs. traditional selectivity

Examples

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Functional selectivity

Nodes53
Edges52
Triples24
Avg. degree1.96
Density0.037736
Components1

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Functional selectivity

Top relations

related to Examples · 19
Functional selectivity → A2, Conversely, DOB, However, HT, HT2, HT2A, HT2C, HT2C-VGV, IP3, LSD, MAOIs, Notably, Oligomers, One, Serotonin, SSRIs, This, Tianeptine
related to Functional vs. traditional selectivity · 3
Functional selectivity → Functional, Traditional, While

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Important terminology

receptor functional selectivity biased agonist protein effects signaling ligand receptors example antagonist signal transduction pathways agonists chemokine arm390 mediate tolerance

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DOBinstance ofas do many exogenous hallucinogens0.80text
lysergic acid diethylamideinstance ofas do many exogenous hallucinogens0.80text
Functional selectivityrelated to ExamplesOne0.60section
Functional selectivityrelated to ExamplesHT2A0.60section
Functional selectivityrelated to ExamplesHT2C0.60section
Functional selectivityrelated to ExamplesSerotonin0.60section
Functional selectivityrelated to ExamplesHT0.60section
Functional selectivityrelated to ExamplesA20.60section
Functional selectivityrelated to ExamplesHowever0.60section
Functional selectivityrelated to ExamplesDOB0.60section
Functional selectivityrelated to ExamplesLSD0.60section
Functional selectivityrelated to ExamplesNotably0.60section

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