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Mescaline: History, Community, Culture & Applications

Mescaline, also known in chemical terms as 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic drug and alkaloid of the phenethylamine and scaline families found in certain cacti like peyote (Lophophora williamsii) and the San Pedro cactus (Echinopsis pachanoi, others).

Language: English [EN]
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Mescaline topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Mescaline. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
447
Source areas
12
Connected nodes
460
Extracted relationships
372
Concept neighborhoods
44
Bridge connections
460

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 144 topics
History · 44 topics
Use and effects · 41 topics
Chemistry · 40 topics
Society and culture · 40 topics
Pharmacology · 39 topics
Natural occurrence · 36 topics
Adverse effects · 22 topics
Interactions · 19 topics
Contraindications · 10 topics
Overdose · 10 topics
Research · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
mescaline
ATC code
None
Bioavailability
Unknown (but ≥53%)
Boiling point
180 °C (356 °F) at 12 mmHg
CAS Number
54-04-6 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Use and effects

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

Natural occurrence

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mescaline connects Entity context

The extracted context around Mescaline shows recurring relationship patterns in the source. For example, Mescaline → Aldous Huxley, Alexander Shulgin, Allen Ginsberg, Antonin Artaud, Arthur Heffter, Arthur Kleps, Bryan Wynter, Carlos Santana, Comanche Nation, Crystal Fairy, Cuckoo's Nest, Dalí, Delta Chemical Company, Dick, Disney, Doomed, Fear, First Visit, Flow My Tears, For Another extracted example is Mescaline → Archaeological, Arthur Heffter, Aztec Empire, Bernardino, Botanical, Canada, Comanche, Ecuador, Ernst Späth, Europeans, Francis, Francisco Hernández, German, He, However, Huichol, In, It, John Raleigh Briggs, Kiowa. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mescaline

Top relations

related to Notable individuals · 75
Mescaline → Aldous Huxley, Alexander Shulgin, Allen Ginsberg, Antonin Artaud, Arthur Heffter, Arthur Kleps, Bryan Wynter, Carlos Santana, Comanche Nation, Crystal Fairy, Cuckoo's Nest, Dalí, Delta Chemical Company, Dick, Disney, Doomed, Fear, First Visit, Flow My Tears, For
related to history · 43
Mescaline → Archaeological, Arthur Heffter, Aztec Empire, Bernardino, Botanical, Canada, Comanche, Ecuador, Ernst Späth, Europeans, Francis, Francisco Hernández, German, He, However, Huichol, In, It, John Raleigh Briggs, Kiowa
has effect · 21
Mescaline → Alexander Shulgin, Buttons, Doses, Have Known, High, However, In, It, Loved, Low, LSD, Microdosing, Nausea, On, Phenethylamines, PiHKAL, San Pedro, Side, Some, The
related to Pharmacodynamics · 19
Mescaline → Besides, DAT, DOx, EC50Tooltip, HIAA, How, However, HT2A, HT2B, HT2C, In, Its EC50Tooltip, Ki, NET, Other, SERT, The, This, TMA
related to Synthesis · 19
Mescaline → Alexander Shulgin, Amide, Cyanohydrin, Ernst Späth's, Ester, Eudesmic, Have Known, Henry, Hofmann, Kolbe, Loved, Ozonolysis, Phenethylamines, PiHKAL, Reduction, Several, THF, This, Treatment
related to Religious use · 15
Mescaline → Comanche, Huichol, Kiowa, Latin American, Mescaline-containing, Mexican, Mexico, Native American, Native American Church, Peru, San Pedro, South American, The, The Huichol, Wixárika
related to Analogues · 13
Mescaline → Deuterated, DOM, DOx, Examples, FLY, N-dimethylmescaline, N-methylmescaline, NBOMe-mescaline, Other, Pachycereus, These, TMA, TMA-1
related to Biosynthesis · 13
Mescaline → COMT, DOPA, In Lophophora, L-DOPA, O-methylation, O-methyltransferase, S-adenosyl, SAM, SAM-dependent, The, These, This, Tyrosine
related to Monoamine oxidase inhibitors · 13
Mescaline → Accordingly, Daniel Trachsel, However, In, It, MAO, MAOI, MAOIs, No, On, RIMA, RIMAs, SSAO
related to Natural occurrence · 13
Mescaline → As, Echinopsis, Gymnocalycium, It, Levels, Lophophora, Moreover, Opuntia, San Pedro, Stenocereus, The, Trichocereus, Turbinicarpus

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

peyote effects psychedelic use serotonin however cacti first cactus drug also lsd religious mg doses receptor like 5-ht2a may san

Mescaline relationships Subject–Predicate–Object triples

TTTA extracted 372 structured relationships around Mescaline. Examples in this analysis include Mescaline → 3D model (JSmol) → Interactive image and Mescaline → AHFS/Drugs.com → mescaline. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mescaline3D model (JSmol)Interactive image1.00infobox
MescalineAHFS/Drugs.commescaline1.00infobox
MescalineATC codeNone1.00infobox
MescalineBioavailabilityUnknown (but ≥53%)1.00infobox
MescalineBoiling point180 °C (356 °F) at 12 mmHg1.00infobox
MescalineCAS Number54-04-6 Y1.00infobox
MescalineChEBICHEBI:28346 Y1.00infobox
MescalineChEMBLChEMBL26687 Y1.00infobox
MescalineChemSpider3934 Y1.00infobox
MescalineCompTox Dashboard (EPA)DTXSID802023031.00infobox
MescalineDensity1.067 g/cm31.00infobox
MescalineDrug classSerotonin receptor agonist; Serotonergic psychedelic; Hallucinogen1.00infobox
MescalineDrugBankDB190831.00infobox
MescalineDuration of action6.4–14 hours (range 3.0–22 hours)1.00infobox
MescalineECHA InfoCard100.000.1741.00infobox
MescalineElimination half-life3.6 hours (range 2.6–5.3 hours)1.00infobox
MescalineExcretionUrine (≥92%; 28–60% unchanged, ≥27–31% as TMPAA, 5% as N-Ac-3,4-DiMeO-5-OH-PEA, <0.1% as NAMTooltip N-acetylmescaline)1.00infobox
MescalineFormulaC11H17NO31.00infobox
MescalineKEGGC06546 Y1.00infobox
MescalineLegal statusAU: S9 (Prohibited substance)1.00infobox
MescalineLegal statusBR: Class F2 (Prohibited psychotropics)1.00infobox
MescalineLegal statusCA: Schedule III , except peyote1.00infobox
MescalineLegal statusDE: Anlage I (Authorized scientific use only)1.00infobox
MescalineLegal statusUK: Class A (Plants containing mescaline legal)1.00infobox
MescalineLegal statusUS: Schedule I (with religious use exceptions)1.00infobox
MescalineLegal statusUN: P I (psychoactive cactus like peyote or san pedro uncontrolled)1.00infobox
MescalineMelting point35 to 36 °C (95 to 97 °F)1.00infobox
MescalineMetabolismOxidative deamination, N-acetylation, O-demethylation, conjugation, other pathways1.00infobox
MescalineMetabolites• 3,4,5-Trimethoxyphenyl-acetaldehyde • 3,4,5-Trimethoxyphenylacetic acid • 3,4,5-Trimethoxyphenylethanol • Others1.00infobox
MescalineMolar mass211.261 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mescaline bring nearby vocabulary together. In this analysis, examples include Effects, Psychedelic and Peyote. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mescaline
    • Effects
    • Psychedelic
    • Peyote
    • Serotonin
    • First
    • Lsd
    • Use
    • Receptor
    • Doses
    • Tmpaa
    • Mg
    • Cactus
  • mescaline
    • Effects
    • Psychedelic
    • Peyote
    • Serotonin
    • First
    • Lsd
    • Use
    • Receptor
    • Doses
    • Tmpaa
    • Mg
    • Cactus
  • psychedelic drug
    • Receptor
    • However
    • Experience
    • Effects
    • First
    • Mg
    • Drugs
    • Psychedelic
    • Serotonin
    • Pedro
    • San
    • 5-ht2a
  • peyote
    • Use
    • San
    • Pedro
    • Religious
    • American
    • Described
    • Psychedelic
    • First
    • However
    • Psychoactive
    • Effects
    • Mg
  • san pedro cactus
    • San
    • Pedro
    • Peyote
    • Use
    • Psychedelic
    • Others
    • Found
    • Psychoactive
    • Appears
    • Mg
    • However
    • Doses
  • psychedelic experience
    • Receptor
    • Experience
    • Psychedelic
    • Effects
    • First
    • Described
    • Drugs
    • Serotonin
    • Pedro
    • San
    • 5-ht2a
    • Doses
  • drug discrimination
    • However
    • Mg
    • Psychedelic
    • Effects
    • Like
    • Peyote
    • Orally
    • Psychoactive
    • Hours
    • Drugs
    • Others
    • Use
  • crystal fairy & the magical cactus
    • Pedro
    • San
    • Peyote
    • Others
    • Found
    • Use
    • Psychoactive
    • However
    • Psychedelic
    • Like
    • Mg
    • Mescaline

Connections between topic areas Semantic bridges

For Mescaline, one of the stronger structural bridges in this analysis connects Mescaline with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MescalineOverview · splits 316 ⟂ 145
MescalineHistory · splits 416 ⟂ 45
MescalineUse and effects · splits 419 ⟂ 42
MescalineChemistry · splits 420 ⟂ 41
MescalineSociety and culture · splits 420 ⟂ 41
MescalinePharmacology · splits 421 ⟂ 40
MescalineNatural occurrence · splits 424 ⟂ 37
MescalineAdverse effects · splits 438 ⟂ 23
MescalineInteractions · splits 441 ⟂ 20
MescalineContraindications · splits 450 ⟂ 11
MescalineOverdose · splits 450 ⟂ 11
MescalineResearch · splits 457 ⟂ 4

Map overview Semantic statistics

Mescaline

Nodes461
Edges460
Triples372
Avg. degree2
Density0.004338
Components1

Source & methodology

TTTA analyzes the structure around Mescaline to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mescaline · EN edition · Analysis: TopicsToTalkAbout

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