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Mefloquine: History, Culture, Applications & Research

Mefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It can be used to treat mild or moderate malaria but is not recommended for severe malaria. It is taken by mouth.

Language: English [EN]
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Mefloquine topic overview

The analysis highlights History, Culture, Applications and Research as prominent areas in the source structure around Mefloquine.

Related topics
109
Source areas
9
Connected nodes
118
Extracted relationships
132
Concept neighborhoods
30
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 39 topics
Adverse effects · 14 topics
Medical uses · 14 topics
History · 13 topics
Pharmacology · 12 topics
Chemistry · 10 topics
Research · 5 topics
Contraindications · 1 topics
In popular culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
P01BC02 (WHO)
CAS Number
53230-10-7 Y
ChEMBL
ChEMBL416956 N
ChemSpider
37171 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

History

Research

In popular culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mefloquine connects Entity context

The extracted context around Mefloquine shows recurring relationship patterns in the source. For example, Mefloquine → Defense, FDA, Hoffman-LaRoche, II, III, Most, PPV, Public-Private Venture, Research, Smith Kline, US Department, Vietnam, Walter Reed Army Institute, WRAIR Another extracted example is Mefloquine → Afghanistan, Australian, Between, Canadian, December, German, Green Berets, In, UK, US Army. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mefloquine

Top relations

related to history · 14
Mefloquine → Defense, FDA, Hoffman-LaRoche, II, III, Most, PPV, Public-Private Venture, Research, Smith Kline, US Department, Vietnam, Walter Reed Army Institute, WRAIR
related to Military · 10
Mefloquine → Afghanistan, Australian, Between, Canadian, December, German, Green Berets, In, UK, US Army
related to Chemistry · 9
Mefloquine → Essentially, Hoffmann-La Roche, However, Mefloquine's, N-tetramethylenetryptamine, Plasma, Specifically, Swiss, The
related to External links · 9
Mefloquine → Archived, Blogger, Drug Information Portal, Hallucinogens You Probably Haven't, Heard, June, Medicine, National Library, Nervewing
has prevention · 8
Mefloquine → America, Disease Control, Doxycycline, If, Infectious Disease Society, It, Prevention, United States Centers
related to Neurologic and psychiatric · 8
Mefloquine → Central, Drug Administration, FDA, In, Neurologic, Psychiatric, US Food, When
has treatment · 5
Mefloquine → Disease Control, It, Plasmodium, Prevention, United States' Centers
related to Pregnancy and breastfeeding · 5
Mefloquine → Available, Compared, In, The World Health Organization, WHO
related to Resistance to mefloquine · 5
Mefloquine → Cambodia, Pfmdr1, Resistance, Southeast Asia, The
Legal status · 4
Mefloquine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects drug malaria side use recommended used health liver include may hallucinations seizures pregnancy one resistance treatment psychiatric prevention lariam

Mefloquine relationships Subject–Predicate–Object triples

TTTA extracted 132 structured relationships around Mefloquine. Examples in this analysis include Mefloquine → 3D model (JSmol) → Interactive image and Mefloquine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mefloquine3D model (JSmol)Interactive image1.00infobox
MefloquineAHFS/Drugs.comMonograph1.00infobox
MefloquineATC codeP01BC02 (WHO)1.00infobox
MefloquineCAS Number53230-10-7 Y1.00infobox
MefloquineChEMBLChEMBL416956 N1.00infobox
MefloquineChemSpider37171 Y1.00infobox
MefloquineChiralityRacemic mixture1.00infobox
MefloquineCompTox Dashboard (EPA)DTXSID508606361.00infobox
MefloquineDrug classAntimalarial1.00infobox
MefloquineDrugBankDB00358 Y1.00infobox
MefloquineElimination half-life2 to 4 weeks1.00infobox
MefloquineExcretionPrimarily bile and feces; urine (9% as unchanged drug, 4% as primary metabolite)1.00infobox
MefloquineFormulaC17H16F6N2O1.00infobox
MefloquineKEGGD04895 Y1.00infobox
MefloquineLegal statusAU: S4 (Prescription only)1.00infobox
MefloquineLegal statusCA: ℞-only1.00infobox
MefloquineLegal statusUK: POM (Prescription only)1.00infobox
MefloquineLegal statusUS: ℞-only1.00infobox
MefloquineLicense dataUS DailyMed: Mefloquine1.00infobox
MefloquineMedlinePlusa6030301.00infobox
MefloquineMetabolismExtensive liver; main metabolite is inactive1.00infobox
MefloquineMolar mass378.318 g·mol−11.00infobox
MefloquineNIAID ChemDB0052181.00infobox
MefloquineOther names2,8-Trifluoromethyl-β-hydroxy-α,N-tetramethylene-quinolinylethylamine1.00infobox
MefloquinePregnancy categoryAU: B31.00infobox
MefloquinePubChem CID406921.00infobox
MefloquineRoutes of administrationOral1.00infobox
MefloquineTrade namesLariam, Mephaquin, Mefliam, others1.00infobox
MefloquineUNIITML814419R1.00infobox
Mefloquineis aquinolinylethylamine0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mefloquine bring nearby vocabulary together. In this analysis, examples include Use, Malaria and Effects. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mefloquine
    • Use
    • Malaria
    • Effects
    • Drug
    • Psychiatric
    • Treatment
    • Used
    • May
    • Also
    • Liver
    • Side
    • History
  • mefloquine
    • Use
    • Malaria
    • Effects
    • Drug
    • Psychiatric
    • Treatment
    • Used
    • May
    • Also
    • Liver
    • Side
    • History
  • malaria
    • Recommended
    • Disease
    • Treatment
    • Used
    • Prevention
    • Resistance
    • Weeks
    • One
    • May
    • Mefloquine
    • Half-life
    • Severe
  • adverse effects
    • Side
    • Include
    • Liver
    • Psychiatric
    • Hallucinations
    • Drug
    • May
    • Anxiety
    • Depression
    • Neurological
    • Potential
    • Seizures
  • centers for disease control and prevention
    • Several
    • Recommended
    • One
    • Malaria
    • Disease
    • Prevention
    • Resistance
    • Weeks
    • Used
    • History
    • Potential
    • Pregnancy
  • food and drug administration
    • Effects
    • Side
    • Soldiers
    • Mefloquine
    • Malaria
    • Potential
    • Disease
    • Half-life
    • Lariam
    • Weeks
    • Liver
    • Psychiatric
  • adverse reactions
    • Liver
    • Psychiatric
    • May
    • History
    • Neurological
    • Pregnancy
    • Serotonin
    • Half-life
    • Hallucinations
    • Lariam
    • Prevention
    • Resistance
  • history
    • Psychiatric
    • Recommended
    • Mental
    • Pregnancy
    • Problems
    • Adverse
    • Half-life
    • Lariam
    • Prevention
    • Resistance
    • Seizures
    • Weeks

Connections between topic areas Semantic bridges

For Mefloquine, one of the stronger structural bridges in this analysis connects Mefloquine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mefloquine — Overview · splits 79 ⟂ 40
Mefloquine — Medical uses · splits 104 ⟂ 15
Mefloquine — Adverse effects · splits 104 ⟂ 15
Mefloquine — History · splits 105 ⟂ 14
Mefloquine — Pharmacology · splits 106 ⟂ 13
Mefloquine — Chemistry · splits 108 ⟂ 11
Mefloquine — Research · splits 113 ⟂ 6

Map overview Semantic statistics

Mefloquine

Nodes119
Edges118
Triples132
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around Mefloquine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mefloquine · EN edition · Analysis: TopicsToTalkAbout

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