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Nortriptyline

Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety. Its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in…

History, Community, Culture & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA10 (WHO)
Bioavailability
32–79%
CAS Number
72-69-5 Y · 894-71-3
ChEBI
CHEBI:7640 Y

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

  • Generic name Generic term
  • INN International Nonproprietary Name
  • BANM British Approved Name
  • DCF Dénomination Commune Française
  • USAN United States Adopted Name
  • USP United States Pharmacopeia
  • JAN Japanese Accepted Name
  • DCIT Denominazione Comune Italiana

Research

Advanced semantic analysis

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Map overview Semantic statistics

Nortriptyline

Nodes105
Edges104
Triples108
Avg. degree1.98
Density0.019048
Components1

How this topic connects Entity context

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Nortriptyline

Top relations

related to Generic names · 14
Nortriptyline → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Research · 11
Nortriptyline → Although, Cochrane, Drug Administration, FDA, However, In, International Association, It, Pain, Study, US Food
related to Brand names · 10
Nortriptyline → Allegron, Aventyl, Brand, Noritren, Norpress, Nortrilen, Norventyl, Norzepine, Pamelor, Sensival
related to Chemistry · 7
Nortriptyline → C19H21N1, N-methyl-1-propanamine, N-methylated, N-methylnortriptyline, Other, The, The CAS Registry Number
related to Contraindications · 7
Nortriptyline → Closer, However, It, MAOI, MAOIs, Product, The
related to Pharmacogenetics · 7
Nortriptyline → CYP2D6, Increased, Individuals, Most, Poor, These, Ultrarapid
Legal status · 4
Nortriptyline → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, US: ℞-only
related to Pharmacodynamics · 4
Nortriptyline → Chemically, H1, HT2A, In
related to history · 3
Nortriptyline → Geigy, It, The
related to Overdose · 3
Nortriptyline → Symptoms, TCAs, The

Important terminology Word statistics

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Important terminology

tricyclic may side effects drug include antidepressants treatment use antidepressant serotonin metabolizers increased name cyp2d6 mouth used pain risk states

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Nortriptyline3D model (JSmol)Interactive image1.00infobox
NortriptylineAHFS/Drugs.comMonograph1.00infobox
NortriptylineATC codeN06AA10 (WHO)1.00infobox
NortriptylineBioavailability32–79%1.00infobox
NortriptylineCAS Number72-69-5 Y1.00infobox
NortriptylineCAS Number894-71-31.00infobox
NortriptylineChEBICHEBI:7640 Y1.00infobox
NortriptylineChEMBLChEMBL445 Y1.00infobox
NortriptylineChemSpider4384 Y1.00infobox
NortriptylineCompTox Dashboard (EPA)DTXSID90233841.00infobox
NortriptylineDrug classTricyclic antidepressant (TCA)1.00infobox
NortriptylineDrugBankDB00540 Y1.00infobox
NortriptylineECHA InfoCard100.000.7171.00infobox
NortriptylineElimination half-life18–44 hours (mean 30 hours)1.00infobox
NortriptylineExcretionUrine: 40% Feces: minor1.00infobox
NortriptylineFormulaC19H21N1.00infobox
NortriptylineIUPHAR/BPS24041.00infobox
NortriptylineKEGGD08288 Y1.00infobox
NortriptylineLegal statusAU: S4 (Prescription only)1.00infobox
NortriptylineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
NortriptylineLegal statusCA: ℞-only1.00infobox
NortriptylineLegal statusUS: ℞-only1.00infobox
NortriptylineLicense dataUS DailyMed: Nortriptyline1.00infobox
NortriptylineMedlinePlusa6826201.00infobox
NortriptylineMetabolismLiver1.00infobox
NortriptylineMetabolites10-E-Hydroxynortriptyline1.00infobox
NortriptylineMolar mass263.384 g·mol−11.00infobox
NortriptylineOther namesDesitriptyline; ELF-101; E.L.F. 101; N-70481.00infobox
NortriptylinePregnancy categoryAU: C1.00infobox
NortriptylineProtein binding92%1.00infobox

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