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MDMA: History, Community, Culture & Applications

3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy in tablet form, and molly in crystal form, is an entactogen with stimulant and minor psychedelic properties.

Language: English [EN]
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MDMA topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around MDMA. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
424
Source areas
10
Connected nodes
435
Extracted relationships
372
Concept neighborhoods
64
Bridge connections
435

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 155 topics
Pharmacology · 77 topics
History · 55 topics
Interactions · 46 topics
Chemistry · 44 topics
Uses · 30 topics
Effects and side effects · 7 topics
Overdose · 6 topics
Research · 4 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Low–moderate
AHFS/Drugs.com
MDMA
ATC code
None
Bioavailability
Oral: Unknown
Boiling point
105 °C (221 °F) at 0.4 mmHg (experimental)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Uses

Effects and side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MDMA connects Entity context

The extracted context around MDMA shows recurring relationship patterns in the source. For example, MDMA → According, After MDMA, American, Baltimore, Barcelona, California Pacific Medical Center, Charles Grob, Chicago, Detroit, European, Ibiza, Illicit MDMA, In, Later, Maastricht University, Netherlands, NIDA, NIH Intramural Program, Psychiatry, San Francisco Another extracted example is MDMA → Along, By, Ca2, CaMKIIα, Conversely, HT1, HT1A, HT1B, HT1D, HT2, HT2A, HT2B, HT2C, I1, In, Induction, It, MAT, MATs, MRA. Use these groups to spot repeated connection types before inspecting the individual relationships.

MDMA

Top relations

related to Post-scheduling · 39
MDMA → According, After MDMA, American, Baltimore, Barcelona, California Pacific Medical Center, Charles Grob, Chicago, Detroit, European, Ibiza, Illicit MDMA, In, Later, Maastricht University, Netherlands, NIDA, NIH Intramural Program, Psychiatry, San Francisco
related to Pharmacodynamics · 30
MDMA → Along, By, Ca2, CaMKIIα, Conversely, HT1, HT1A, HT1B, HT1D, HT2, HT2A, HT2B, HT2C, I1, In, Induction, It, MAT, MATs, MRA
related to Interactions · 29
MDMA → Aurorix, Bupropion, Celexa, Concurrent, Conversely, Cymbalta, CYP2D6, CYP450, Edronax, HT2A, It, Life-threatening, Manerix, MAOIs, MDMA-induced, Nardil, NDRI, Norepinephrine, Norvir, NRIs
related to Shulgin's research · 26
MDMA → Alexander Shulgin, American, Around, Bethesda, Chicago, David, December, Dow Chemical Company, Following, Los Angeles, Maryland, May, MDA, Michigan, Midwest, N-methylated MDA, Nichols, October, San Francisco, San Francisco State University
related to Analogues · 25
MDMA → Analogues, Deuterated, DMMDA, DMMDA-2, FLEA, MAPB, MAPBT, MBDB, MDA, MDAI, MDAT, MDEA, MDMC, MDMOH, MDMPEA, MDOH, MDPEA, MMDA, MMDA-2, MMDPEA
related to Early research and use · 19
MDMA → Alles, Anton Köllisch, At, Bayer, December, French, Gordon, However, In, Kline, Köllisch, MDA, MDMA's, Merck, N-Methyl-a-Methylhomopiperonylamin, On, Otto Wolfes, Smith, Walther Beckh
related to External links · 14
MDMA → Drug Abuse, ErowidMDMA, Isomer DesignA Multi-Site Phase, Isomer DesignMDMA, June, MAPP2, MDMA Facts, MDMA-Assisted Therapy, National Institute, PiHKAL, PsychonautWikiMDMA, PTSD, Statistics, Study
related to Rising recreational use · 14
MDMA → Adam, Between, Boston, Boston Group, By, Early MDMA, Having, Hoping MDMA, In, Into, LSD, New York City, Paradise Garage, Studio
related to Forms · 13
MDMA → MDA, MDEA, MDMA-like, MDPV, Partly, Powdered MDMA, Some, Tablets, The, The UK, These, US, XTC
related to Usage statistics · 13
MDMA → According, Crime World Drug Report, Drug Use, Drugs, Health, In, Mental Health Services Administration, National Survey, Substance Abuse, This, United Nations Office, United States, Usage

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects drug serotonin use mda may ecstasy used also united drugs users receptor increased states dopamine norepinephrine psychedelic amphetamine reported

MDMA relationships Subject–Predicate–Object triples

TTTA extracted 372 structured relationships around MDMA. Examples in this analysis include MDMA → 3D model (JSmol) → Interactive image and MDMA → Addiction liability → Low–moderate. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MDMA3D model (JSmol)Interactive image1.00infobox
MDMAAddiction liabilityLow–moderate1.00infobox
MDMAAHFS/Drugs.comMDMA1.00infobox
MDMAATC codeNone1.00infobox
MDMABioavailabilityOral: Unknown1.00infobox
MDMABoiling point105 °C (221 °F) at 0.4 mmHg (experimental)1.00infobox
MDMACAS Number42542-10-9 Y[TOXNET] 64057-70-1 (HCl)1.00infobox
MDMAChEBICHEBI:1391 Y1.00infobox
MDMAChEMBLChEMBL43048 Y1.00infobox
MDMAChemSpider1556 Y1.00infobox
MDMAChiralityRacemic mixture1.00infobox
MDMACompTox Dashboard (EPA)DTXSID908607911.00infobox
MDMADensity1.1 g/cm31.00infobox
MDMADependence liabilityPhysical: Not typical Psychological: Moderate1.00infobox
MDMADrug classEntactogen; Stimulant; Psychedelic; Serotonin–norepinephrine–dopamine releasing agent; 5-HT2 receptor agonist1.00infobox
MDMADrugBankDB01454 Y1.00infobox
MDMADuration of action3–6 hours1.00infobox
MDMAElimination half-lifeMDMA: 8.7 (range 4.6–16) hours1.00infobox
MDMAElimination half-life(S)-MDMA: 5.1 (range 3.5–7.4) hours1.00infobox
MDMAElimination half-life(R)-MDMA: 11 (range 5.1–24) hours1.00infobox
MDMAExcretionKidney1.00infobox
MDMAFormulaC11H15NO21.00infobox
MDMAIUPHAR/BPS45741.00infobox
MDMAKEGGD11172 Y1.00infobox
MDMALegal statusAU: S8 (PTSD)S9 (all other uses)1.00infobox
MDMALegal statusS8 (PTSD)1.00infobox
MDMALegal statusS9 (all other uses)1.00infobox
MDMALegal statusBR: Class F2 (Prohibited psychotropics)1.00infobox
MDMALegal statusCA: Schedule I1.00infobox
MDMALegal statusDE: Anlage I (Authorized scientific use only)1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MDMA bring nearby vocabulary together. In this analysis, examples include Effects, Use and Drug. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MDMA
    • Effects
    • Use
    • Drug
    • Serotonin
    • Mda
    • Also
    • Used
    • May
    • Drugs
    • United
    • Users
    • Increased
  • mdma
    • Effects
    • Use
    • Drug
    • Serotonin
    • Mda
    • Also
    • Used
    • May
    • Drugs
    • United
    • Users
    • Increased
  • psychedelic
    • Stimulant
    • -mdma
    • Mda
    • Methamphetamine
    • Agonist
    • Ptsd
    • Dopamine
    • Norepinephrine
    • Effects
    • Serotonin
    • Receptor
    • Uses
  • dopamine
    • Norepinephrine
    • Serotonin
    • Stimulant
    • Receptor
    • Brain
    • Methamphetamine
    • -mdma
    • Serotonergic
    • Due
    • Psychedelic
    • Effects
    • Uses
  • classes of drugs
    • United
    • Methamphetamine
    • Schedule
    • Substances
    • States
    • Use
    • Mdma
    • Serotonergic
    • Reported
    • Ecstasy
    • Used
    • Stimulant
  • food and drug administration
    • United
    • Use
    • States
    • Ecstasy
    • Mdma
    • Drugs
    • Users
    • Used
    • Schedule
    • Mda
    • Effects
    • Reported
  • drug withdrawal
    • United
    • Use
    • States
    • Ecstasy
    • Mdma
    • Drugs
    • Users
    • Used
    • Schedule
    • Mda
    • Effects
    • Reported
  • drug addiction
    • United
    • Use
    • States
    • Ecstasy
    • Mdma
    • Drugs
    • Users
    • Used
    • Schedule
    • Mda
    • Effects
    • Reported

Connections between topic areas Semantic bridges

For MDMA, one of the stronger structural bridges in this analysis connects MDMA with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MDMAOverview · splits 280 ⟂ 156
MDMAPharmacology · splits 358 ⟂ 78
MDMAHistory · splits 380 ⟂ 56
MDMAInteractions · splits 389 ⟂ 47
MDMAChemistry · splits 391 ⟂ 45
MDMAUses · splits 405 ⟂ 31
MDMAEffects and side effects · splits 428 ⟂ 8
MDMAOverdose · splits 429 ⟂ 7
MDMAResearch · splits 431 ⟂ 5

Map overview Semantic statistics

MDMA

Nodes436
Edges435
Triples372
Avg. degree2
Density0.004587
Components1

Source & methodology

TTTA analyzes the structure around MDMA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MDMA · EN edition · Analysis: TopicsToTalkAbout

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