Tumor necrosis factor

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Explore the main themes, entities and connections around Tumor necrosis factor. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Gene

Gene Chromosome 6p Class III Major histocompatibility complex HLA-DR

22 related topics

Function

Innate immune system TNFR1 TNFR2 Cell death Apoptosis

83 related topics

Clinical significance

Autoimmune diseases Psoriatic arthritis Noninfectious uveitis Sarcomas Immunocytokines

40 related topics

Overview

Immune system Macrophages Tumor necrosis factor superfamily Transmembrane proteins Cytokines

24 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
Band: 6p21.33 · 17 B1|17 18.59 cM
Bgee: granulocyte · testicle · bone marrow · monocyte · bone marrow cell
BioGPS: More reference expression data
Chr.: Chromosome 6 (human) · Chromosome 17 (mouse)

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History

William Coley
Endotoxin
Anti-TNF TNF inhibitor
Lymphotoxin Lymphotoxin alpha
Lymphotoxin-β Lymphotoxin beta

Evolution

Gene

Gene
Chromosome 6p Chromosome 6
Class III MHC class III
Major histocompatibility complex
HLA-DR
HLA-B
Fibroblasts
Interleukin-1
Interleukin-2
Interferon-γ
Enhanceosome
Nuclear factor of activated T-cells
Histones
Acetylation Histone acetylation and deacetylation
Methylation Histone methylation
CREB-binding protein
Exons
Introns
Primary transcript
5′ untranslated region Five prime untranslated region
3′ untranslated region Three prime untranslated region
AU-rich element

Protein

Function

Clinical significance

Autoimmune diseases
Psoriatic arthritis
Noninfectious uveitis Uveitis
Sarcomas
Immunocytokines Immunocytokines?action=edit&redlink=1
Remission Remission (medicine)
Metastasis
Infliximab
Etanercept
Varicella-zoster virus
Epstein–Barr virus
Cytomegalovirus
HIV
Sepsis
Hepatic stellate cells Hepatic stellate cell
Alpha-1 type-1 collagen Collagen, type I, alpha 1
Hepatocyte
Hepatitis C virus
Insulin resistance
Insulin receptor substrate 1
Obesity
Type II Diabetes
Adipose
Nonalcoholic fatty liver disease
Muscle wasting
Ubiquitin–proteasome Proteasome
Satellite cells
IL-10 Interleukin 10
Neuroinflammation
Excitotoxic Excitotoxicity

Pharmacology

Advanced semantic analysis

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Map overview Semantic statistics

Nodes201

Edges200

Triples250

Avg. degree1.99

Density0.00995

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Tumor necrosis factor

Top relations

Gene ontology · 144

Tumor necrosis factor → activation of cysteine-type endopeptidase activity involved in apoptotic process, animal organ morphogenesis, apoptotic signaling pathway, cell surface, cellular extravasation, cellular response to amino acid stimulus, cellular response to lipopolysaccharide, cellular response to nicotine, cellular response to organic cyclic compound, chronic inflammatory response to antigenic stimulus, cortical actin cytoskeleton organization, cytokine activity, cytokine-mediated signaling pathway, death-inducing signaling complex assembly, defense response, defense response to bacterium, defense response to Gram-positive bacterium, embryonic digestive tract development, endothelial cell apoptotic process, epithelial cell proliferation involved in salivary gland morphogenesis

Bgee · 17

Tumor necrosis factor → appendix, blood, bone marrow, bone marrow cell, duodenum, embryo, endometrium, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus, wall of uterus

RNA expression pattern · 17

related to External links · 10

Tumor necrosis factor → Medicine Medical Subject Headings, MeSH, National Library, Overview, P01375, PDB, PDBe-KB, Tumor, Tumor Necrosis Factor-alpha, UniProt

related to history · 9

Tumor necrosis factor → Carswell, Coley's, In, Studies, These, This, TNF, TNF's, William Coley

Band · 2

Tumor necrosis factor → 17 B1|17 18.59 cM, 6p21.33

Chr. · 2

Tumor necrosis factor → Chromosome 17 (mouse), Chromosome 6 (human)

End · 2

Tumor necrosis factor → 31,578,336 bp, 35,420,983 bp

Aliases · 1

Tumor necrosis factor → TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha

Available structures · 1

Tumor necrosis factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tnf cell tnfr1 cells inflammatory tnfr2 death also tmtnf immune gene activation response complex nf-κb pathways pathway role tumor cytokines

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Tumor necrosis factor	Aliases	TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha	1.00	infobox
Tumor necrosis factor	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW	1.00	infobox
Tumor necrosis factor	Band	6p21.33	1.00	infobox
Tumor necrosis factor	Band	17 B1\|17 18.59 cM	1.00	infobox
Tumor necrosis factor	Bgee	granulocyte	1.00	infobox
Tumor necrosis factor	Bgee	testicle	1.00	infobox
Tumor necrosis factor	Bgee	bone marrow	1.00	infobox
Tumor necrosis factor	Bgee	monocyte	1.00	infobox
Tumor necrosis factor	Bgee	bone marrow cell	1.00	infobox
Tumor necrosis factor	Bgee	blood	1.00	infobox
Tumor necrosis factor	Bgee	lymph node	1.00	infobox
Tumor necrosis factor	Bgee	spleen	1.00	infobox
Tumor necrosis factor	Bgee	appendix	1.00	infobox
Tumor necrosis factor	Bgee	duodenum	1.00	infobox
Tumor necrosis factor	Bgee	stroma of bone marrow	1.00	infobox
Tumor necrosis factor	Bgee	embryo	1.00	infobox
Tumor necrosis factor	Bgee	wall of uterus	1.00	infobox
Tumor necrosis factor	Bgee	endometrium	1.00	infobox
Tumor necrosis factor	Bgee	subcutaneous adipose tissue	1.00	infobox
Tumor necrosis factor	Bgee	thymus	1.00	infobox
Tumor necrosis factor	Bgee	mesenteric lymph nodes	1.00	infobox
Tumor necrosis factor	BioGPS	More reference expression data	1.00	infobox
Tumor necrosis factor	Chr.	Chromosome 6 (human)	1.00	infobox
Tumor necrosis factor	Chr.	Chromosome 17 (mouse)	1.00	infobox
Tumor necrosis factor	Databases	NCBI: entry; OMA: entry	1.00	infobox
Tumor necrosis factor	End	31,578,336 bp	1.00	infobox
Tumor necrosis factor	End	35,420,983 bp	1.00	infobox
Tumor necrosis factor	Ensembl	ENSG00000228978 ENSG00000230108 ENSG00000223952 ENSG00000204490 ENSG00000228321 ENSG00000232810 ENSG00000228849 ENSG00000206439	1.00	infobox
Tumor necrosis factor	Entrez	7124	1.00	infobox
Tumor necrosis factor	External IDs	OMIM: 191160; MGI: 104798; GeneCards: TNF	1.00	infobox

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