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5-HT1A receptor: Function, Ligands & Distribution

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization…

Language: English [EN]
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5-HT1A receptor topic overview

The analysis highlights Function, Ligands and Distribution as prominent areas in the source structure around 5-HT1A receptor.

Related topics
322
Source areas
6
Connected nodes
328
Extracted relationships
166
Concept neighborhoods
34
Bridge connections
328

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 120 topics
Function · 113 topics
Ligands · 58 topics
Distribution · 11 topics
Protein-protein interactions · 11 topics
Genetics · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
Band
5q12.3 · 13 D1|13 56.92 cM
Bgee
entorhinal cortex · middle temporal gyrus · Brodmann area 46 · superior vestibular nucleus · superior frontal gyrus
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Distribution

Function

Ligands

Genetics

Protein-protein interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How 5-HT1A receptor connects Entity context

The extracted context around 5-HT1A receptor shows recurring relationship patterns in the source. For example, 5-HT1A receptor → adenylate cyclase-inhibiting serotonin receptor signaling pathway, animal behavior, behavioral fear response, cell population proliferation, chemical synaptic transmission, dendrite, exploration behavior, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity, integral component of membrane, integral component of plasma membrane, membrane, neurotransmitter receptor activity, plasma membrane, positive regulation of cell population proliferation, protein binding, receptor-receptor interaction, regulation of behavior Another extracted example is 5-HT1A receptor → Brodmann area 23, Brodmann area 46, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, hippocampus proper, lateral habenular nucleus, medial habenular nucleus, middle temporal gyrus, prefrontal cortex, subthalamus, superior frontal gyrus, superior vestibular nucleus, thalamic reticular nucleus, ventral lateral nucleus, ventral nuclear group, ventral nucleus of lateral geniculate body, ventral posterolateral nucleus, ventral posteromedial nucleus, zona incerta. Use these groups to spot repeated connection types before inspecting the individual relationships.

5-HT1A receptor

Top relations

Gene ontology · 29
5-HT1A receptor → adenylate cyclase-inhibiting serotonin receptor signaling pathway, animal behavior, behavioral fear response, cell population proliferation, chemical synaptic transmission, dendrite, exploration behavior, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity, integral component of membrane, integral component of plasma membrane, membrane, neurotransmitter receptor activity, plasma membrane, positive regulation of cell population proliferation, protein binding, receptor-receptor interaction, regulation of behavior
Bgee · 20
5-HT1A receptor → Brodmann area 23, Brodmann area 46, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, hippocampus proper, lateral habenular nucleus, medial habenular nucleus, middle temporal gyrus, prefrontal cortex, subthalamus, superior frontal gyrus, superior vestibular nucleus, thalamic reticular nucleus, ventral lateral nucleus, ventral nuclear group, ventral nucleus of lateral geniculate body, ventral posterolateral nucleus, ventral posteromedial nucleus, zona incerta
RNA expression pattern · 20
5-HT1A receptor → Brodmann area 23, Brodmann area 46, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, hippocampus proper, lateral habenular nucleus, medial habenular nucleus, middle temporal gyrus, prefrontal cortex, subthalamus, superior frontal gyrus, superior vestibular nucleus, thalamic reticular nucleus, ventral lateral nucleus, ventral nuclear group, ventral nucleus of lateral geniculate body, ventral posterolateral nucleus, ventral posteromedial nucleus, zona incerta
related to Genetics · 16
5-HT1A receptor → Arg219Leu, C-1018G, C-1019G, G294A, Gly22Ser, Gly272Asp, HT1A, HTR1A, Ile28Val, Pro16Leu, SNP, SNPs, Some, The, There, These
related to Receptor oligomers · 11
5-HT1A receptor → GABAB2, GPCR26, HT1A, HT1B, HT1D, HT7, LPA1, LPA3, S1P1, S1P3, The
related to Autoreceptors · 10
5-HT1A receptor → As, For, HT1A, SB-649, SSRIs, Stimulation, The, This, Those, Though
related to Neuromodulation · 7
5-HT1A receptor → Activation, Edinger-Westphal, HT1A, The, These, They, Vasodilation
related to Endocrinology · 6
5-HT1A receptor → ACTH, Endorphin, HT1A, HT2, It, The
related to Ligands · 6
5-HT1A receptor → Another PET, For, HT1A, Labeled, The, WAY-100
related to Distribution · 4
5-HT1A receptor → HT, HT1A, In, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

5-ht1a receptor serotonin receptors activation release also gene postsynaptic autoreceptors human agonists inhibition may bp htr1a chr band brain hippocampus

5-HT1A receptor relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around 5-HT1A receptor. Examples in this analysis include 5-HT1A receptor → Aliases → HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A and 5-HT1A receptor → Band → 5q12.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
5-HT1A receptorAliasesHTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A1.00infobox
5-HT1A receptorBand5q12.31.00infobox
5-HT1A receptorBand13 D1|13 56.92 cM1.00infobox
5-HT1A receptorBgeeentorhinal cortex1.00infobox
5-HT1A receptorBgeemiddle temporal gyrus1.00infobox
5-HT1A receptorBgeeBrodmann area 461.00infobox
5-HT1A receptorBgeesuperior vestibular nucleus1.00infobox
5-HT1A receptorBgeesuperior frontal gyrus1.00infobox
5-HT1A receptorBgeehippocampus proper1.00infobox
5-HT1A receptorBgeeprefrontal cortex1.00infobox
5-HT1A receptorBgeeendothelial cell1.00infobox
5-HT1A receptorBgeeBrodmann area 231.00infobox
5-HT1A receptorBgeedorsolateral prefrontal cortex1.00infobox
5-HT1A receptorBgeeventral nuclear group1.00infobox
5-HT1A receptorBgeesubthalamus1.00infobox
5-HT1A receptorBgeeventral nucleus of lateral geniculate body1.00infobox
5-HT1A receptorBgeeventral posterolateral nucleus1.00infobox
5-HT1A receptorBgeeventral posteromedial nucleus1.00infobox
5-HT1A receptorBgeemedial habenular nucleus1.00infobox
5-HT1A receptorBgeezona incerta1.00infobox
5-HT1A receptorBgeelateral habenular nucleus1.00infobox
5-HT1A receptorBgeethalamic reticular nucleus1.00infobox
5-HT1A receptorBgeeventral lateral nucleus1.00infobox
5-HT1A receptorBioGPSMore reference expression data1.00infobox
5-HT1A receptorChr.Chromosome 5 (human)1.00infobox
5-HT1A receptorChr.Chromosome 13 (mouse)1.00infobox
5-HT1A receptorDatabasesNCBI: entry; OMA: entry1.00infobox
5-HT1A receptorEnd63,962,507 bp1.00infobox
5-HT1A receptorEnd105,584,630 bp1.00infobox
5-HT1A receptorEnsemblENSG000001783941.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around 5-HT1A receptor bring nearby vocabulary together. In this analysis, examples include 5-ht1a, Receptor and Receptors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • 5-HT1A receptor
    • 5-ht1a
    • Receptor
    • Receptors
    • Activation
    • Serotonin
    • Release
    • Also
    • Agonists
    • Postsynaptic
    • Shown
    • Secretion
    • Gene
  • 5-ht1a receptor
    • 5-ht1a
    • Receptor
    • Receptors
    • Activation
    • Serotonin
    • Also
    • Agonists
    • Release
    • Postsynaptic
    • Effects
    • Shown
    • May
  • serotonin receptors
    • Nucleus
    • Ssris
    • Release
    • Sras
    • Postsynaptic
    • Hippocampus
    • Activation
    • Serotonin
    • Also
    • 5-ht
    • Brain
    • Known
  • g protein-coupled receptor
    • 5-ht1a
    • Chromosome
    • Location
    • Bp
    • Chr
    • Htr1a
    • Serotonin
    • Activation
    • Also
    • Agonists
    • Human
    • Gene
  • receptor
    • 5-ht1a
    • Serotonin
    • Activation
    • Also
    • Agonists
    • Postsynaptic
    • Effects
    • Shown
    • May
    • Receptors
    • Antidepressant
    • Secretion
  • α1-adrenergic receptor
    • 5-ht1a
    • Serotonin
    • Activation
    • Also
    • Agonists
    • Postsynaptic
    • Effects
    • Shown
    • May
    • Receptors
    • Antidepressant
    • Secretion
  • α2-adrenergic receptors
    • Nucleus
    • Release
    • Postsynaptic
    • Hippocampus
    • Activation
    • Serotonin
    • Also
    • 5-ht
    • Brain
    • Known
    • Secretion
    • Agonists
  • nk1 receptor antagonists
    • 5-ht1a
    • Serotonin
    • Activation
    • Also
    • Agonists
    • Postsynaptic
    • Effects
    • Shown
    • May
    • Receptors
    • Antidepressant
    • Secretion

Connections between topic areas Semantic bridges

For 5-HT1A receptor, one of the stronger structural bridges in this analysis connects 5-HT1A receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
5-HT1A receptorOverview · splits 208 ⟂ 121
5-HT1A receptorFunction · splits 215 ⟂ 114
5-HT1A receptorLigands · splits 270 ⟂ 59
5-HT1A receptorDistribution · splits 317 ⟂ 12
5-HT1A receptorProtein-protein interactions · splits 317 ⟂ 12
5-HT1A receptorGenetics · splits 319 ⟂ 10

Map overview Semantic statistics

5-HT1A receptor

Nodes329
Edges328
Triples166
Avg. degree1.99
Density0.006079
Components1

Source & methodology

TTTA analyzes the structure around 5-HT1A receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Ligands & Distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — 5-HT1A receptor · EN edition · Analysis: TopicsToTalkAbout

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