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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization…

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Aliases
HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
Band
5q12.3 · 13 D1|13 56.92 cM
Bgee
entorhinal cortex · middle temporal gyrus · Brodmann area 46 · superior vestibular nucleus · superior frontal gyrus
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Distribution

Function

Ligands

Genetics

Protein-protein interactions

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Map overview Semantic statistics

5-HT1A receptor

Nodes329
Edges328
Triples166
Avg. degree1.99
Density0.006079
Components1

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5-HT1A receptor

Top relations

Gene ontology · 29
5-HT1A receptor → adenylate cyclase-inhibiting serotonin receptor signaling pathway, animal behavior, behavioral fear response, cell population proliferation, chemical synaptic transmission, dendrite, exploration behavior, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity, integral component of membrane, integral component of plasma membrane, membrane, neurotransmitter receptor activity, plasma membrane, positive regulation of cell population proliferation, protein binding, receptor-receptor interaction, regulation of behavior
Bgee · 20
5-HT1A receptor → Brodmann area 23, Brodmann area 46, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, hippocampus proper, lateral habenular nucleus, medial habenular nucleus, middle temporal gyrus, prefrontal cortex, subthalamus, superior frontal gyrus, superior vestibular nucleus, thalamic reticular nucleus, ventral lateral nucleus, ventral nuclear group, ventral nucleus of lateral geniculate body, ventral posterolateral nucleus, ventral posteromedial nucleus, zona incerta
RNA expression pattern · 20
5-HT1A receptor → Brodmann area 23, Brodmann area 46, dorsolateral prefrontal cortex, endothelial cell, entorhinal cortex, hippocampus proper, lateral habenular nucleus, medial habenular nucleus, middle temporal gyrus, prefrontal cortex, subthalamus, superior frontal gyrus, superior vestibular nucleus, thalamic reticular nucleus, ventral lateral nucleus, ventral nuclear group, ventral nucleus of lateral geniculate body, ventral posterolateral nucleus, ventral posteromedial nucleus, zona incerta
related to Genetics · 16
5-HT1A receptor → Arg219Leu, C-1018G, C-1019G, G294A, Gly22Ser, Gly272Asp, HT1A, HTR1A, Ile28Val, Pro16Leu, SNP, SNPs, Some, The, There, These
related to Receptor oligomers · 11
5-HT1A receptor → GABAB2, GPCR26, HT1A, HT1B, HT1D, HT7, LPA1, LPA3, S1P1, S1P3, The
related to Autoreceptors · 10
5-HT1A receptor → As, For, HT1A, SB-649, SSRIs, Stimulation, The, This, Those, Though
related to Neuromodulation · 7
5-HT1A receptor → Activation, Edinger-Westphal, HT1A, The, These, They, Vasodilation
related to Endocrinology · 6
5-HT1A receptor → ACTH, Endorphin, HT1A, HT2, It, The
related to Ligands · 6
5-HT1A receptor → Another PET, For, HT1A, Labeled, The, WAY-100
related to Distribution · 4
5-HT1A receptor → HT, HT1A, In, The

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Important terminology

5-ht1a receptor serotonin receptors activation release also gene postsynaptic autoreceptors human agonists inhibition may bp htr1a chr band brain hippocampus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
5-HT1A receptorAliasesHTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A1.00infobox
5-HT1A receptorBand5q12.31.00infobox
5-HT1A receptorBand13 D1|13 56.92 cM1.00infobox
5-HT1A receptorBgeeentorhinal cortex1.00infobox
5-HT1A receptorBgeemiddle temporal gyrus1.00infobox
5-HT1A receptorBgeeBrodmann area 461.00infobox
5-HT1A receptorBgeesuperior vestibular nucleus1.00infobox
5-HT1A receptorBgeesuperior frontal gyrus1.00infobox
5-HT1A receptorBgeehippocampus proper1.00infobox
5-HT1A receptorBgeeprefrontal cortex1.00infobox
5-HT1A receptorBgeeendothelial cell1.00infobox
5-HT1A receptorBgeeBrodmann area 231.00infobox
5-HT1A receptorBgeedorsolateral prefrontal cortex1.00infobox
5-HT1A receptorBgeeventral nuclear group1.00infobox
5-HT1A receptorBgeesubthalamus1.00infobox
5-HT1A receptorBgeeventral nucleus of lateral geniculate body1.00infobox
5-HT1A receptorBgeeventral posterolateral nucleus1.00infobox
5-HT1A receptorBgeeventral posteromedial nucleus1.00infobox
5-HT1A receptorBgeemedial habenular nucleus1.00infobox
5-HT1A receptorBgeezona incerta1.00infobox
5-HT1A receptorBgeelateral habenular nucleus1.00infobox
5-HT1A receptorBgeethalamic reticular nucleus1.00infobox
5-HT1A receptorBgeeventral lateral nucleus1.00infobox
5-HT1A receptorBioGPSMore reference expression data1.00infobox
5-HT1A receptorChr.Chromosome 5 (human)1.00infobox
5-HT1A receptorChr.Chromosome 13 (mouse)1.00infobox
5-HT1A receptorDatabasesNCBI: entry; OMA: entry1.00infobox
5-HT1A receptorEnd63,962,507 bp1.00infobox
5-HT1A receptorEnd105,584,630 bp1.00infobox
5-HT1A receptorEnsemblENSG000001783941.00infobox

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