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Ku80

Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the…

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4.2.99.18
↗
5.6.2.4
↗
Aliases
XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Band
2q35 · 1 C3|1 36.5 cM
Bgee
embryo · ganglionic eminence · ventricular zone · islet of Langerhans · stromal cell of endometrium

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Map overview Semantic statistics

Ku80

Nodes41
Edges40
Triples166
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

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Ku80

Top relations

Gene ontology · 69
Ku80 → 5'-deoxyribose-5-phosphate lyase activity, activation of innate immune response, ATP binding, brain development, cell population proliferation, cellular hyperosmotic salinity response, cellular response to DNA damage stimulus, cellular response to fatty acid, cellular response to gamma radiation, cellular response to leukemia inhibitory factor, cellular response to X-ray, chromosome, cytoplasm, cytosol, damaged DNA binding, DNA binding, DNA duplex unwinding, DNA end binding, DNA helicase activity, DNA recombination
Bgee · 19
Ku80 → Achilles tendon, bone marrow, bone marrow cell, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, islet of Langerhans, otic placode, otic vesicle, primary oocyte, primitive streak, right kidney, saccule, smooth muscle tissue, stromal cell of endometrium, tail of embryo, ventricular zone
RNA expression pattern · 19
Ku80 → Achilles tendon, bone marrow, bone marrow cell, embryo, epiblast, ganglionic eminence, genital tubercle, gonad, islet of Langerhans, otic placode, otic vesicle, primary oocyte, primitive streak, right kidney, saccule, smooth muscle tissue, stromal cell of endometrium, tail of embryo, ventricular zone
related to Interactions · 10
Ku80 → ATP-dependent, DNA-PKcs, GCN5L2, Ku70, NCOA6, PCNA, POU2F1, Telomerase, TERF2IP, Tyrosine
related to Senescence · 8
Ku80 → An, DNA, Furthermore, Ku, Loss, Mouse, NHEJ, These
related to Deficiency in cancer · 5
Ku80 → Cancer, Deficient DNA, DNA, In, XRCC5
related to Epigenetic repression · 5
Ku80 → In, LOH, Low, The, XRCC5
related to Nomenclature · 4
Ku80 → Chinese, DNA, Lupus Ku, XRCC5
Band · 2
Ku80 → 1 C3|1 36.5 cM, 2q35
Chr. · 2
Ku80 → Chromosome 1 (mouse), Chromosome 2 (human)

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Important terminology

gene protein repair xrcc5 human bp ku dna chr chromosome band nhej expression required mouse ku70 x-ray end pathway cancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ku804.2.99.18↗1.00infobox
Ku805.6.2.4↗1.00infobox
Ku80AliasesXRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 51.00infobox
Ku80Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ91.00infobox
Ku80Band2q351.00infobox
Ku80Band1 C3|1 36.5 cM1.00infobox
Ku80Bgeeembryo1.00infobox
Ku80Bgeeganglionic eminence1.00infobox
Ku80Bgeeventricular zone1.00infobox
Ku80Bgeeislet of Langerhans1.00infobox
Ku80Bgeestromal cell of endometrium1.00infobox
Ku80Bgeebone marrow1.00infobox
Ku80Bgeegonad1.00infobox
Ku80BgeeAchilles tendon1.00infobox
Ku80Bgeebone marrow cell1.00infobox
Ku80Bgeesmooth muscle tissue1.00infobox
Ku80Bgeesaccule1.00infobox
Ku80Bgeeotic placode1.00infobox
Ku80Bgeeotic vesicle1.00infobox
Ku80Bgeegenital tubercle1.00infobox
Ku80Bgeetail of embryo1.00infobox
Ku80Bgeeprimary oocyte1.00infobox
Ku80Bgeeepiblast1.00infobox
Ku80Bgeeright kidney1.00infobox
Ku80Bgeeprimitive streak1.00infobox
Ku80BioGPSMore reference expression data1.00infobox
Ku80Chr.Chromosome 2 (human)1.00infobox
Ku80Chr.Chromosome 1 (mouse)1.00infobox
Ku80DatabasesNCBI: entry; OMA: entry1.00infobox
Ku80End216,206,303 bp1.00infobox

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