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Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.
The analysis highlights Products, Interactions and Clinical as prominent areas in the source structure around CHD4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CHD4 shows recurring relationship patterns in the source. For example, CHD4 → ATP binding, centrosome, chromatin organization, cytoplasm, cytoskeleton, DNA binding, DNA duplex unwinding, DNA helicase activity, helicase activity, histone deacetylase activity, histone deacetylase binding, histone deacetylation, hydrolase activity, membrane, metal ion binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleosomal DNA binding, nucleotide binding Another extracted example is CHD4 → anterior pituitary, apex of heart, choroid plexus of fourth ventricle, entorhinal cortex, epithelium of colon, ganglionic eminence, genital tubercle, Ileal epithelium, left lobe of thyroid gland, neural layer of retina, perirhinal cortex, right adrenal cortex, right coronary artery, right lobe of thyroid gland, Rostral migratory stream, sural nerve, tail of embryo, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bp human chr band protein chromosome 12 deacetylase location component complex helicase nurd mouse function external nucleosome dna binding
TTTA extracted 103 structured relationships around CHD4. Examples in this analysis include CHD4 → Aliases → CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES and CHD4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CHD4 | Aliases | CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES | 1.00 | infobox |
| CHD4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N | 1.00 | infobox |
| CHD4 | Band | 12p13.31 | 1.00 | infobox |
| CHD4 | Band | 6 F2|6 59.28 cM | 1.00 | infobox |
| CHD4 | Bgee | ventricular zone | 1.00 | infobox |
| CHD4 | Bgee | ganglionic eminence | 1.00 | infobox |
| CHD4 | Bgee | epithelium of colon | 1.00 | infobox |
| CHD4 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| CHD4 | Bgee | anterior pituitary | 1.00 | infobox |
| CHD4 | Bgee | sural nerve | 1.00 | infobox |
| CHD4 | Bgee | apex of heart | 1.00 | infobox |
| CHD4 | Bgee | right adrenal cortex | 1.00 | infobox |
| CHD4 | Bgee | left lobe of thyroid gland | 1.00 | infobox |
| CHD4 | Bgee | right coronary artery | 1.00 | infobox |
| CHD4 | Bgee | Ileal epithelium | 1.00 | infobox |
| CHD4 | Bgee | Rostral migratory stream | 1.00 | infobox |
| CHD4 | Bgee | choroid plexus of fourth ventricle | 1.00 | infobox |
| CHD4 | Bgee | tail of embryo | 1.00 | infobox |
| CHD4 | Bgee | genital tubercle | 1.00 | infobox |
| CHD4 | Bgee | entorhinal cortex | 1.00 | infobox |
| CHD4 | Bgee | perirhinal cortex | 1.00 | infobox |
| CHD4 | Bgee | neural layer of retina | 1.00 | infobox |
| CHD4 | Bgee | yolk sac | 1.00 | infobox |
| CHD4 | BioGPS | More reference expression data | 1.00 | infobox |
| CHD4 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| CHD4 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| CHD4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CHD4 | End | 6,614,524 bp | 1.00 | infobox |
| CHD4 | End | 125,107,554 bp | 1.00 | infobox |
| CHD4 | Ensembl | ENSG00000111642 | 1.00 | infobox |
The concept neighborhoods around CHD4 bring nearby vocabulary together. In this analysis, examples include Gene, Deacetylase and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CHD4, one of the stronger structural bridges in this analysis connects CHD4 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CHD4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Interactions & Clinical, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CHD4 · EN edition · Analysis: TopicsToTalkAbout