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CHD4

Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.

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Aliases
CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N
Band
12p13.31 · 6 F2|6 59.28 cM
Bgee
ventricular zone · ganglionic eminence · epithelium of colon · right lobe of thyroid gland · anterior pituitary
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

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CHD4

Nodes20
Edges19
Triples103
Avg. degree1.9
Density0.1
Components1

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CHD4

Top relations

Gene ontology · 33
CHD4 → ATP binding, centrosome, chromatin organization, cytoplasm, cytoskeleton, DNA binding, DNA duplex unwinding, DNA helicase activity, helicase activity, histone deacetylase activity, histone deacetylase binding, histone deacetylation, hydrolase activity, membrane, metal ion binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleosomal DNA binding, nucleotide binding
Bgee · 19
CHD4 → anterior pituitary, apex of heart, choroid plexus of fourth ventricle, entorhinal cortex, epithelium of colon, ganglionic eminence, genital tubercle, Ileal epithelium, left lobe of thyroid gland, neural layer of retina, perirhinal cortex, right adrenal cortex, right coronary artery, right lobe of thyroid gland, Rostral migratory stream, sural nerve, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 19
CHD4 → anterior pituitary, apex of heart, choroid plexus of fourth ventricle, entorhinal cortex, epithelium of colon, ganglionic eminence, genital tubercle, Ileal epithelium, left lobe of thyroid gland, neural layer of retina, perirhinal cortex, right adrenal cortex, right coronary artery, right lobe of thyroid gland, Rostral migratory stream, sural nerve, tail of embryo, ventricular zone, yolk sac
related to Interactions · 6
CHD4 → Ataxia, HDAC1, Histone, MTA2, Rad3, SATB1
Band · 2
CHD4 → 12p13.31, 6 F2|6 59.28 cM
Chr. · 2
CHD4 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
CHD4 → 125,107,554 bp, 6,614,524 bp
related to External links · 2
CHD4 → Human CHD4, UCSC Genome Browser
Aliases · 1
CHD4 → CHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES
Available structures · 1
CHD4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N

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Important terminology

gene bp human chr band protein chromosome 12 deacetylase location component complex helicase nurd mouse function external nucleosome dna binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CHD4AliasesCHD4, CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES1.00infobox
CHD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MM2, 1MM3, 2EE1, 2L5U, 2L75, 4O9I, 2N5N1.00infobox
CHD4Band12p13.311.00infobox
CHD4Band6 F2|6 59.28 cM1.00infobox
CHD4Bgeeventricular zone1.00infobox
CHD4Bgeeganglionic eminence1.00infobox
CHD4Bgeeepithelium of colon1.00infobox
CHD4Bgeeright lobe of thyroid gland1.00infobox
CHD4Bgeeanterior pituitary1.00infobox
CHD4Bgeesural nerve1.00infobox
CHD4Bgeeapex of heart1.00infobox
CHD4Bgeeright adrenal cortex1.00infobox
CHD4Bgeeleft lobe of thyroid gland1.00infobox
CHD4Bgeeright coronary artery1.00infobox
CHD4BgeeIleal epithelium1.00infobox
CHD4BgeeRostral migratory stream1.00infobox
CHD4Bgeechoroid plexus of fourth ventricle1.00infobox
CHD4Bgeetail of embryo1.00infobox
CHD4Bgeegenital tubercle1.00infobox
CHD4Bgeeentorhinal cortex1.00infobox
CHD4Bgeeperirhinal cortex1.00infobox
CHD4Bgeeneural layer of retina1.00infobox
CHD4Bgeeyolk sac1.00infobox
CHD4BioGPSMore reference expression data1.00infobox
CHD4Chr.Chromosome 12 (human)1.00infobox
CHD4Chr.Chromosome 6 (mouse)1.00infobox
CHD4DatabasesNCBI: entry; OMA: entry1.00infobox
CHD4End6,614,524 bp1.00infobox
CHD4End125,107,554 bp1.00infobox
CHD4EnsemblENSG000001116421.00infobox

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