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MTOR

The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin, is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is evolutionarily…

Discovery, Complexes & Clinical significance

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2.7.10.2
2.7.11.1
Aliases
MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5,…
Band
1p36.22 · 4 E2|4 78.76 cM
Bgee
gonad · right hemisphere of cerebellum · left testis · right testis · gastrocnemius muscle

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Overview

Discovery

Function

In plants

Complexes

Gene deletion experiments

Clinical significance

MTOR inhibitors as therapies

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

MTOR

Nodes245
Edges244
Triples457
Avg. degree1.99
Density0.008163
Components1

How this topic connects Entity context

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MTOR

Top relations

Gene ontology · 152
MTOR → 'de novo' pyrimidine nucleobase biosynthetic process, activation of protein kinase B activity, anoikis, ATP binding, brain development, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to leucine, cellular response to leucine starvation, cellular response to nutrient levels, cellular response to starvation, cytoplasm, cytosol, dendrite
related to history · 48
MTOR → Abraham, Brunn, Candace, David, Dumont, FK506, FKBP12, Francis, Francis Dumont, G1, George Livi, Gregory, Gregory Wiederrecht, Hall, Hediye Erdjument-Bromage, IL-2, In, Interest, Jeannette Kunz, Joseph Heitman
related to Lysosomal damage inhibits mTOR and induces autophagy · 32
MTOR → Active, Alzheimer's, AMPK, At, ATG13's HORMA, ATG14, ATG16L1, ATG16L1-ATG5-ATG12, Beclin, During, FIP200/RB1CC1, Following, GALTOR, III PI3K, III PI3K Beclin, LAMTOR1, LAMTOR1-5, LC3B/GABARAP, PI3P, Ragulator's
related to Gene deletion experiments · 24
MTOR → AKT, AKT1, AKT1/AKT2, AKT2, AKT3, Amino-1-isopropyl-1H-pyrazolo, Constitutive, Decreased Rictor, G1, Genetic, Inhibition, Knockdown, Knockout, Mice, NIP7, Overexpression, PDK1, PKC-phosphorylation, PP242, RICTOR
related to mTORC2 · 21
MTOR → Akt, Akt's, Akt/PKB, Cdc42, Complex, F-actin, IGF-1R, IGF-IR, In, InsR, MLST8, PDK1, Phosphorylation, PKCα, Rac1, RhoA, RICTOR, Ser473, Thr308, Tyr1131/1136
related to Cancer · 20
MTOR → Additionally, Akt, Akt2, Also, Among, BP1, Constitutively, HIF1A, Increasing, Moreover, Over-activation, PI3K, PKM2, PTEN, Reasons, S6K1, S6K2, Similarly, TSC, Warburg
Bgee · 18
MTOR → apex of heart, dentate gyrus of hippocampal formation granule cell, gastrocnemius muscle, genital tubercle, gonad, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, spermatid, spermatocyte, superior frontal gyrus, testicle, ventricular zone
RNA expression pattern · 18
MTOR → apex of heart, dentate gyrus of hippocampal formation granule cell, gastrocnemius muscle, genital tubercle, gonad, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, spermatid, spermatocyte, superior frontal gyrus, testicle, ventricular zone
related to External links · 14
MTOR → Archived, Medicine Medical Subject Headings, MeSH, National Cancer Institute, National Library, Overview, P42345, Pathway Interaction Database, PDB, PDBe-KB, Retrieved, Serine/threonine-protein, Signaling Pathway, UniProt
related to In plants · 9
MTOR → FKBP-rapamycin, FRB, In, Plant, Plants, Role, TOR, TORC1, TORC2

Important terminology Word statistics

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Important terminology

rapamycin protein activity signaling mtorc1 autophagy activation mtorc2 complex target growth also kinase tor cells cell including ad insulin studies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MTOR2.7.10.21.00infobox
MTOR2.7.11.11.00infobox
MTORAliasesMTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase1.00infobox
MTORAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5,…1.00infobox
MTORBand1p36.221.00infobox
MTORBand4 E2|4 78.76 cM1.00infobox
MTORBgeegonad1.00infobox
MTORBgeeright hemisphere of cerebellum1.00infobox
MTORBgeeleft testis1.00infobox
MTORBgeeright testis1.00infobox
MTORBgeegastrocnemius muscle1.00infobox
MTORBgeeright frontal lobe1.00infobox
MTORBgeemuscle of thigh1.00infobox
MTORBgeetesticle1.00infobox
MTORBgeeventricular zone1.00infobox
MTORBgeeapex of heart1.00infobox
MTORBgeespermatid1.00infobox
MTORBgeespermatocyte1.00infobox
MTORBgeeright kidney1.00infobox
MTORBgeedentate gyrus of hippocampal formation granule cell1.00infobox
MTORBgeesuperior frontal gyrus1.00infobox
MTORBgeegenital tubercle1.00infobox
MTORBgeeprimary visual cortex1.00infobox
MTORBgeeneural layer of retina1.00infobox
MTORBioGPSMore reference expression data1.00infobox
MTORChr.Chromosome 1 (human)1.00infobox
MTORChr.Chromosome 4 (mouse)1.00infobox
MTORDatabasesNCBI: entry; OMA: entry1.00infobox
MTOREnd11,262,551 bp1.00infobox
MTOREnd148,642,140 bp1.00infobox

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