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The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin, is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is evolutionarily…
The analysis highlights Discovery, Complexes and Clinical significance as prominent areas in the source structure around MTOR. 2 topics appear in more than one source area, which can help identify connections that are less obvious in a linear reading.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MTOR shows recurring relationship patterns in the source. For example, MTOR → 'de novo' pyrimidine nucleobase biosynthetic process, activation of protein kinase B activity, anoikis, ATP binding, brain development, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to leucine, cellular response to leucine starvation, cellular response to nutrient levels, cellular response to starvation, cytoplasm, cytosol, dendrite Another extracted example is MTOR → Abraham, Brunn, Candace, David, Dumont, FK506, FKBP12, Francis, Francis Dumont, G1, George Livi, Gregory, Gregory Wiederrecht, Hall, Hediye Erdjument-Bromage, IL-2, In, Interest, Jeannette Kunz, Joseph Heitman. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
rapamycin protein activity signaling mtorc1 autophagy activation mtorc2 complex target growth also kinase tor cells cell including ad insulin studies
TTTA extracted 457 structured relationships around MTOR. Examples in this analysis include MTOR → 2.7.10.2 → ↗ and MTOR → Aliases → MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MTOR | 2.7.10.2 | ↗ | 1.00 | infobox |
| MTOR | 2.7.11.1 | ↗ | 1.00 | infobox |
| MTOR | Aliases | MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase | 1.00 | infobox |
| MTOR | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5,… | 1.00 | infobox |
| MTOR | Band | 1p36.22 | 1.00 | infobox |
| MTOR | Band | 4 E2|4 78.76 cM | 1.00 | infobox |
| MTOR | Bgee | gonad | 1.00 | infobox |
| MTOR | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| MTOR | Bgee | left testis | 1.00 | infobox |
| MTOR | Bgee | right testis | 1.00 | infobox |
| MTOR | Bgee | gastrocnemius muscle | 1.00 | infobox |
| MTOR | Bgee | right frontal lobe | 1.00 | infobox |
| MTOR | Bgee | muscle of thigh | 1.00 | infobox |
| MTOR | Bgee | testicle | 1.00 | infobox |
| MTOR | Bgee | ventricular zone | 1.00 | infobox |
| MTOR | Bgee | apex of heart | 1.00 | infobox |
| MTOR | Bgee | spermatid | 1.00 | infobox |
| MTOR | Bgee | spermatocyte | 1.00 | infobox |
| MTOR | Bgee | right kidney | 1.00 | infobox |
| MTOR | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| MTOR | Bgee | superior frontal gyrus | 1.00 | infobox |
| MTOR | Bgee | genital tubercle | 1.00 | infobox |
| MTOR | Bgee | primary visual cortex | 1.00 | infobox |
| MTOR | Bgee | neural layer of retina | 1.00 | infobox |
| MTOR | BioGPS | More reference expression data | 1.00 | infobox |
| MTOR | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| MTOR | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| MTOR | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MTOR | End | 11,262,551 bp | 1.00 | infobox |
| MTOR | End | 148,642,140 bp | 1.00 | infobox |
The concept neighborhoods around MTOR bring nearby vocabulary together. In this analysis, examples include Protein, Rapamycin and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MTOR, one of the stronger structural bridges in this analysis connects MTOR with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MTOR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Discovery, Complexes & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MTOR · EN edition · Analysis: TopicsToTalkAbout