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MTOR: Complexes, Clinical significance & Discovery

The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin, is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is evolutionarily…

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MTOR topic overview

The analysis highlights Complexes, Clinical significance and Discovery as prominent areas in the source structure around MTOR. 2 topics appear in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
230
Source areas
9
Connected nodes
241
Extracted relationships
418
Related term clusters
41
Bridge connections
241

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 113 topics
Complexes · 31 topics
Discovery · 19 topics
MTOR inhibitors as therapies · 18 topics
Interactions · 16 topics
Overview · 12 topics
Function · 11 topics
Gene deletion experiments · 11 topics
In plants · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2
↗
2.7.11.1
↗
Aliases
MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5,…
Band
1p36.22 · 4 E2|4 78.76 cM
Bgee
gonad · right hemisphere of cerebellum · left testis · right testis · gastrocnemius muscle

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Function

In plants

Complexes

Gene deletion experiments

Clinical significance

MTOR inhibitors as therapies

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How MTOR connects Entity context

The extracted context around MTOR shows recurring relationship patterns in the source. For example, MTOR → 'de novo' pyrimidine nucleobase biosynthetic process, activation of protein kinase B activity, anoikis, ATP binding, brain development, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to leucine, cellular response to leucine starvation, cellular response to nutrient levels, cellular response to starvation, cytoplasm, cytosol, dendrite Another extracted example is MTOR → Abraham, Brunn, Candace, David, Dumont, FK506, FKBP12, Francis, Francis Dumont, G1, George Livi, Gregory, Gregory Wiederrecht, Hall, Hediye Erdjument-Bromage, IL-2, Interest, Jeannette Kunz, Joseph Heitman, Josie. Use these groups to spot repeated connection types before inspecting the individual relationships.

MTOR

Top relations

Gene ontology · 152
MTOR → 'de novo' pyrimidine nucleobase biosynthetic process, activation of protein kinase B activity, anoikis, ATP binding, brain development, cardiac cell development, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, cell projection organization, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to hypoxia, cellular response to leucine, cellular response to leucine starvation, cellular response to nutrient levels, cellular response to starvation, cytoplasm, cytosol, dendrite
related to history · 45
MTOR → Abraham, Brunn, Candace, David, Dumont, FK506, FKBP12, Francis, Francis Dumont, G1, George Livi, Gregory, Gregory Wiederrecht, Hall, Hediye Erdjument-Bromage, IL-2, Interest, Jeannette Kunz, Joseph Heitman, Josie
related to Lysosomal damage inhibits mTOR and induces autophagy · 28
MTOR → Active, Alzheimer's, AMPK, ATG13's HORMA, ATG14, ATG16L1, ATG16L1-ATG5-ATG12, Beclin, FIP200/RB1CC1, Following, GALTOR, III PI3K, III PI3K Beclin, LAMTOR1, LAMTOR1-5, LC3B/GABARAP, PI3P, Ragulator's, RRAGA/RRAGB, SLC38A9
related to Gene deletion experiments · 23
MTOR → AKT, AKT1, AKT1/AKT2, AKT2, AKT3, Amino-1-isopropyl-1H-pyrazolo, Constitutive, Decreased Rictor, G1, Genetic, Inhibition, Knockdown, Knockout, Mice, NIP7, Overexpression, PDK1, PKC-phosphorylation, PP242, RICTOR
related to Cancer · 20
MTOR → Additionally, Akt, Akt2, Also, Among, BP1, Constitutively, HIF1A, Increasing, Moreover, Over-activation, PI3K, PKM2, PTEN, Reasons, S6K1, S6K2, Similarly, TSC, Warburg
related to mTORC2 · 20
MTOR → Akt, Akt's, Akt/PKB, Cdc42, Complex, F-actin, IGF-1R, IGF-IR, InsR, MLST8, PDK1, Phosphorylation, PKCα, Rac1, RhoA, RICTOR, Ser473, Thr308, Tyr1131/1136, Tyr1146/1151
Bgee · 18
MTOR → apex of heart, dentate gyrus of hippocampal formation granule cell, gastrocnemius muscle, genital tubercle, gonad, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, spermatid, spermatocyte, superior frontal gyrus, testicle, ventricular zone
RNA expression pattern · 18
MTOR → apex of heart, dentate gyrus of hippocampal formation granule cell, gastrocnemius muscle, genital tubercle, gonad, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, spermatid, spermatocyte, superior frontal gyrus, testicle, ventricular zone
related to In plants · 8
MTOR → FKBP-rapamycin, FRB, Plant, Plants, Role, TOR, TORC1, TORC2
related to Function · 7
MTOR → FKBP12, FKBP12-Rapamycin Binding, FRB, IGF-1, IGF-2, Rapamycin, The FKBP12

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rapamycin protein activity signaling mtorc1 autophagy activation mtorc2 complex target growth also kinase tor cells cell including insulin studies pathway

MTOR relationships Subject–Predicate–Object triples

TTTA extracted 418 structured relationships around MTOR. Examples in this analysis include MTOR → 2.7.10.2 → ↗ and MTOR → Aliases → MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MTOR2.7.10.2↗1.00infobox
MTOR2.7.11.1↗1.00infobox
MTORAliasesMTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase1.00infobox
MTORAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5,…1.00infobox
MTORBand1p36.221.00infobox
MTORBand4 E2|4 78.76 cM1.00infobox
MTORBgeegonad1.00infobox
MTORBgeeright hemisphere of cerebellum1.00infobox
MTORBgeeleft testis1.00infobox
MTORBgeeright testis1.00infobox
MTORBgeegastrocnemius muscle1.00infobox
MTORBgeeright frontal lobe1.00infobox
MTORBgeemuscle of thigh1.00infobox
MTORBgeetesticle1.00infobox
MTORBgeeventricular zone1.00infobox
MTORBgeeapex of heart1.00infobox
MTORBgeespermatid1.00infobox
MTORBgeespermatocyte1.00infobox
MTORBgeeright kidney1.00infobox
MTORBgeedentate gyrus of hippocampal formation granule cell1.00infobox
MTORBgeesuperior frontal gyrus1.00infobox
MTORBgeegenital tubercle1.00infobox
MTORBgeeprimary visual cortex1.00infobox
MTORBgeeneural layer of retina1.00infobox
MTORBioGPSMore reference expression data1.00infobox
MTORChr.Chromosome 1 (human)1.00infobox
MTORChr.Chromosome 4 (mouse)1.00infobox
MTORDatabasesNCBI: entry; OMA: entry1.00infobox
MTOREnd11,262,551 bp1.00infobox
MTOREnd148,642,140 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around MTOR bring nearby vocabulary together. In this analysis, examples include Protein, Rapamycin and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • serine-threonine protein kinase
    • Plants
    • Growth
    • Tor
    • Protein
    • Target
    • Lysosomal
    • Mtorc1
    • Mtorc2
    • Activity
    • Mammalian
    • Mechanistic
    • Function
  • cell proliferation
    • Activity
    • Human
    • Autophagy
    • Target
    • Kinase
    • Mtorc2
    • Bp
    • Growth
    • Protein
    • Gene
    • Brain
    • Mechanistic
  • protein synthesis
    • Lysosomal
    • Mtorc1
    • Activity
    • Shown
    • Target
    • Complex
    • Rapamycin
    • Function
    • Insulin
    • Activation
    • Disease
    • Mtorc2
  • insulin-like growth factor 1 receptors
    • Kinase
    • Insulin
    • Activation
    • Mtorc2
    • Plants
    • Protein
    • Autophagy
    • Function
    • Cells
    • Tor
    • Activity
    • Bp
  • pi3k/akt pathway
    • Mtorc2
    • Aβ
    • Mice
    • Phosphorylation
    • Shown
    • Signaling
    • Studies
    • Growth
    • Mtorc1
    • Tor
    • Target
    • Brain
  • rapamycin
    • Target
    • Mtor
    • Studies
    • Complex
    • Tor
    • Activity
    • Discovery
    • Protein
    • Plants
    • Mtorc1
    • Gene
    • Function
  • growth factors
    • Kinase
    • Insulin
    • Activation
    • Mtorc2
    • Plants
    • Protein
    • Autophagy
    • Function
    • Cells
    • Tor
    • Activity
    • Bp
  • ragulator-rag complex
    • Plants
    • Kinase
    • Rapamycin
    • Protein
    • Mammalian
    • Target
    • Function
    • Mtor
    • Tor
    • Mechanistic
    • Insulin
    • Lysosomal

Connections between topic areas Semantic bridges

For MTOR, one of the stronger structural bridges in this analysis connects MTOR with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MTOR — Clinical significance · splits 128 ⟂ 114
MTOR — Complexes · splits 210 ⟂ 32
MTOR — Discovery · splits 222 ⟂ 20
MTOR — MTOR inhibitors as therapies · splits 223 ⟂ 19
MTOR — Interactions · splits 225 ⟂ 17
MTOR — Overview · splits 229 ⟂ 13
MTOR — Function · splits 230 ⟂ 12
MTOR — Gene deletion experiments · splits 230 ⟂ 12

Map overview Semantic statistics

MTOR

Nodes242
Edges241
Triples418
Avg. degree1.99
Density0.008264
Components1

Source & methodology

TTTA analyzes the structure around MTOR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Complexes, Clinical significance & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MTOR · EN edition · Analysis: TopicsToTalkAbout

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