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Sirtuin 1

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.

Yeast homolog, Selective ligands & Function

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2.3.1.286
Aliases
SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR
Band
10q21.3 · 10|10 B4
Bgee
Achilles tendon · ganglionic eminence · ventricular zone · gonad · testicle
BioGPS
More reference expression data

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Overview

Function

Selective ligands

Interactions

Yeast homolog

Inhibition of SIRT1

Homologous recombination

Advanced semantic analysis

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Map overview Semantic statistics

Sirtuin 1

Nodes72
Edges71
Triples258
Avg. degree1.97
Density0.027778
Components1

How this topic connects Entity context

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Sirtuin 1

Top relations

Gene ontology · 160
Sirtuin 1 → angiogenesis, apoptotic process, behavioral response to starvation, bHLH transcription factor binding, cell differentiation, cellular glucose homeostasis, cellular response to DNA damage stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to leukemia inhibitory factor, cellular response to starvation, cellular response to tumor necrosis factor, cellular triglyceride homeostasis, cholesterol homeostasis, chromatin, chromatin organization, chromatin silencing complex, circadian regulation of gene expression, circadian rhythm
Bgee · 20
Sirtuin 1 → Achilles tendon, ciliary body, cumulus cell, epiblast, ganglionic eminence, gastric mucosa, genital tubercle, gonad, Gonadal ridge, hair follicle, left adrenal cortex, monocyte, primitive streak, right adrenal cortex, spermatocyte, superior cervical ganglion, tail of embryo, testicle, ventricular zone, white blood cell
RNA expression pattern · 20
Sirtuin 1 → Achilles tendon, ciliary body, cumulus cell, epiblast, ganglionic eminence, gastric mucosa, genital tubercle, gonad, Gonadal ridge, hair follicle, left adrenal cortex, monocyte, primitive streak, right adrenal cortex, spermatocyte, superior cervical ganglion, tail of embryo, testicle, ventricular zone, white blood cell
related to Activators · 20
Sirtuin 1 → AMP-activated, AMPK, Elevating NAD, However, In, Lamin, Metformin, Methylene, Myricanol, NAD, NADH/NAD, NAMPT, PRKA, Resveratrol, SIRT1, SIRT1 Although, Sirtuin, SRT-1720, SRT1720, SRT2104
related to Function · 7
Sirtuin 1 → Furthermore, Members, PGC1-alpha/ERR-alpha, Sir2, SIRT1, Sirtuin, The
related to Interactions · 4
Sirtuin 1 → AIRE, ERR-alpha, Human Sirt1, Sirtuin
Band · 2
Sirtuin 1 → 10q21.3, 10|10 B4
Chr. · 2
Sirtuin 1 → Chromosome 10 (human), Chromosome 10 (mouse)
End · 2
Sirtuin 1 → 63,217,483 bp, 67,918,390 bp
2.3.1.286 · 1
Sirtuin 1 → ↗

Important terminology Word statistics

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Important terminology

sirt1 gene sirtuin sir2 activity human protein yeast nad bp resveratrol transcription chr homolog enzyme band rdna silencing chromosome 10

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Sirtuin 12.3.1.2861.00infobox
Sirtuin 1AliasesSIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 11.00infobox
Sirtuin 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR1.00infobox
Sirtuin 1Band10q21.31.00infobox
Sirtuin 1Band10|10 B41.00infobox
Sirtuin 1BgeeAchilles tendon1.00infobox
Sirtuin 1Bgeeganglionic eminence1.00infobox
Sirtuin 1Bgeeventricular zone1.00infobox
Sirtuin 1Bgeegonad1.00infobox
Sirtuin 1Bgeetesticle1.00infobox
Sirtuin 1Bgeegastric mucosa1.00infobox
Sirtuin 1Bgeeright adrenal cortex1.00infobox
Sirtuin 1Bgeeleft adrenal cortex1.00infobox
Sirtuin 1Bgeewhite blood cell1.00infobox
Sirtuin 1Bgeemonocyte1.00infobox
Sirtuin 1Bgeespermatocyte1.00infobox
Sirtuin 1Bgeeprimitive streak1.00infobox
Sirtuin 1Bgeesuperior cervical ganglion1.00infobox
Sirtuin 1Bgeeepiblast1.00infobox
Sirtuin 1Bgeehair follicle1.00infobox
Sirtuin 1BgeeGonadal ridge1.00infobox
Sirtuin 1Bgeeciliary body1.00infobox
Sirtuin 1Bgeetail of embryo1.00infobox
Sirtuin 1Bgeegenital tubercle1.00infobox
Sirtuin 1Bgeecumulus cell1.00infobox
Sirtuin 1BioGPSMore reference expression data1.00infobox
Sirtuin 1Chr.Chromosome 10 (human)1.00infobox
Sirtuin 1Chr.Chromosome 10 (mouse)1.00infobox
Sirtuin 1DatabasesNCBI: entry; OMA: entry1.00infobox
Sirtuin 1End67,918,390 bp1.00infobox

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