Mismatch repair endonuclease PMS2

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Explore the main themes, entities and connections around Mismatch repair endonuclease PMS2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Clinical significance

Mismatch repair Melanoma Cancer immunotherapy Germline mutations Nuclei

22 related topics

Function

Chromosome 7 DNA mismatch repair MLH1 MSH2 Hereditary nonpolyposis colorectal cancer

8 related topics

Interactions

Interact Leucine zipper Cell cycle P53 P73

8 related topics

Overview

Enzyme Gene

2 related topics

Key facts & relationships

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Aliases: PMS2, HNPCC4, PMS2CL, PMSL2, MLH4, PMS1 homolog 2, mismatch repair system component, MMRCS4, PMS-2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EA6, 1H7S, 1H7U
Band: 7p22.1
Bgee: thymus · prefrontal cortex · testicle · superior frontal gyrus · corpus callosum
BioGPS: More reference expression data
Chr.: Chromosome 7 (human)

Topics to explore

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Overview

Function

Chromosome 7
DNA mismatch repair
MLH1
MSH2
Hereditary nonpolyposis colorectal cancer
Turcot syndrome
Primitive neuroectodermal tumors Primitive neuroectodermal tumor
Endonuclease

Interactions

Clinical significance

Mismatch repair
Melanoma
Cancer immunotherapy
Germline mutations Germline mutation
Nuclei Cell nucleus
Colon Large intestine
ERCC1
ERCC4
Field defects Neoplasm
Lumen Lumen (anatomy)
Stem cells Stem cell
Immunostaining Immunohistochemistry
Counterstained Counterstain
Hematoxylin Haematoxylin
Lamina propria
Epigenetic Epigenetics
Promoter methylation DNA methylation
Selected for Natural selection
Ultraviolet
Mutation
Wild type
Genome instability

Advanced semantic analysis

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Map overview Semantic statistics

Nodes45

Edges44

Triples63

Avg. degree1.96

Density0.044444

Components1

How this topic connects Entity context

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Mismatch repair endonuclease PMS2

Top relations

Gene ontology · 24

Mismatch repair endonuclease PMS2 → ATP binding, ATPase activity, cellular response to DNA damage stimulus, cytoplasmic ribonucleoprotein granule, cytosol, DNA binding, DNA mismatch repair, DNA repair, endonuclease activity, hydrolase activity, microtubule cytoskeleton, mismatch repair complex, mismatched DNA binding, MutLalpha complex, MutSalpha complex binding, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleoplasm, nucleus, plasma membrane

Bgee · 10

Mismatch repair endonuclease PMS2 → cerebellar cortex, cerebellar hemisphere, corpus callosum, endometrium, prefrontal cortex, stromal cell of endometrium, superior frontal gyrus, testicle, thymus, ventricular zone

RNA expression pattern · 10

Aliases · 1

Mismatch repair endonuclease PMS2 → PMS2, HNPCC4, PMS2CL, PMSL2, MLH4, PMS1 homolog 2, mismatch repair system component, MMRCS4, PMS-2

Available structures · 1

Mismatch repair endonuclease PMS2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EA6, 1H7S, 1H7U

Band · 1

Mismatch repair endonuclease PMS2 → 7p22.1

BioGPS · 1

Mismatch repair endonuclease PMS2 → More reference expression data

Chr. · 1

Mismatch repair endonuclease PMS2 → Chromosome 7 (human)

Databases · 1

Mismatch repair endonuclease PMS2 → NCBI: entry; OMA: entry

End · 1

Mismatch repair endonuclease PMS2 → 6,009,106 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pms2 dna repair mlh1 mismatch ercc1 cells gene ercc4 expression mutations xpf damage p73 human endonuclease syndrome also cell p53

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Mismatch repair endonuclease PMS2	Aliases	PMS2, HNPCC4, PMS2CL, PMSL2, MLH4, PMS1 homolog 2, mismatch repair system component, MMRCS4, PMS-2	1.00	infobox
Mismatch repair endonuclease PMS2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EA6, 1H7S, 1H7U	1.00	infobox
Mismatch repair endonuclease PMS2	Band	7p22.1	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	thymus	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	prefrontal cortex	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	testicle	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	superior frontal gyrus	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	corpus callosum	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	endometrium	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	ventricular zone	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	stromal cell of endometrium	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	cerebellar cortex	1.00	infobox
Mismatch repair endonuclease PMS2	Bgee	cerebellar hemisphere	1.00	infobox
Mismatch repair endonuclease PMS2	BioGPS	More reference expression data	1.00	infobox
Mismatch repair endonuclease PMS2	Chr.	Chromosome 7 (human)	1.00	infobox
Mismatch repair endonuclease PMS2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Mismatch repair endonuclease PMS2	End	6,009,106 bp	1.00	infobox
Mismatch repair endonuclease PMS2	Ensembl	ENSG00000122512	1.00	infobox
Mismatch repair endonuclease PMS2	Entrez	5395	1.00	infobox
Mismatch repair endonuclease PMS2	External IDs	OMIM: 600259; MGI: 104288; GeneCards: PMS2	1.00	infobox
Mismatch repair endonuclease PMS2	Gene location (Human)	Gene location (Human)Chr.Chromosome 7 (human)Band7p22.1Start5,970,925 bpEnd6,009,106 bp	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	endonuclease activity	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	single-stranded DNA binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	ATP binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	mismatched DNA binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	DNA binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	MutSalpha complex binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	nuclease activity	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	protein binding	1.00	infobox
Mismatch repair endonuclease PMS2	Gene ontology	single base insertion or deletion binding	1.00	infobox

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