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CRISPR: History & Applications

CRISPR (/ˈkrɪspər/; acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. Each sequence within an individual prokaryotic CRISPR is derived from a DNA fragment of a bacteriophage that had previously infected the prokaryote or one of…

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CRISPR topic overview

The analysis highlights History and Applications as prominent areas in the source structure around CRISPR.

Related topics
118
Source areas
10
Connected nodes
128
Extracted relationships
273
Concept neighborhoods
30
Bridge connections
128

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

CRISPR-associated systems · 42 topics
Overview · 20 topics
Evolution · 14 topics
History · 13 topics
Mechanism · 11 topics
Locus structure · 7 topics
Use by phages · 5 topics
Protein Data Bank · 3 topics
Applications · 2 topics
Identification · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
Entrez
947229
Organism
Escherichia coli
Orthologs
NCBI: entry; OMA: entry
PDB
4QYZ
RefSeq (Prot)
NP_417241.1

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

CRISPR-associated systems

Locus structure

Mechanism

Evolution

Identification

Use by phages

Applications

Protein Data Bank

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CRISPR connects Entity context

The extracted context around CRISPR shows recurring relationship patterns in the source. For example, CRISPR → Another, Cas, CRISPR-Cas, DNA, I-F, ICP1, ICP1 CRISPR-Cas, In, It, LtrC, Moreover, O1, One, PICI, PICI CpmAB, PICI-encoded Ppi, PICI-like, PICIs, PtiA, PtiB Another extracted example is CRISPR → CRISPR-DR19, CRISPR-DR2, CRISPR-DR41, CRISPR-DR5, CRISPR-DR52, CRISPR-DR57, CRISPR-DR6, CRISPR-DR65, CRISPR-DR8, CRISPR-DR9, Family RF01315, Family RF01318, Family RF01319, Family RF01321, Family RF01322, Family RF01332, Family RF01350, Family RF01365, Family RF01370, Family RF01378. Use these groups to spot repeated connection types before inspecting the individual relationships.

CRISPR

Top relations

related to Use by phages · 28
CRISPR → Another, Cas, CRISPR-Cas, DNA, I-F, ICP1, ICP1 CRISPR-Cas, In, It, LtrC, Moreover, O1, One, PICI, PICI CpmAB, PICI-encoded Ppi, PICI-like, PICIs, PtiA, PtiB
related to CRISPR RNA structures · 22
CRISPR → CRISPR-DR19, CRISPR-DR2, CRISPR-DR41, CRISPR-DR5, CRISPR-DR52, CRISPR-DR57, CRISPR-DR6, CRISPR-DR65, CRISPR-DR8, CRISPR-DR9, Family RF01315, Family RF01318, Family RF01319, Family RF01321, Family RF01322, Family RF01332, Family RF01350, Family RF01365, Family RF01370, Family RF01378
related to External links · 21
CRISPR → Advanced Gene Editing, April, Archived, Birth, Breakthrough Technology, Congressional Research Service, CRISPR-Cas9, December, Episode, Genome Engineering, Human Nature, Jennifer Doudna, NOVA, November, October, PBS, PDF, Retrieved, Season, September
related to Cas genes and CRISPR subtypes · 16
CRISPR → Cas, Cas1, Cas9, Class, Classification, Collectively, CRISPR-Cas, Each, II, III, IV, Many, Most CRISPR-Cas, Small, The, VI
related to Cas13 · 15
CRISPR → Cas12, Cas13, Cas9, CRISPR RNA, CRISPR-associated, DNA, It, Its PAM-independent, KRAS-G12D, REPAIR, RNA, SHERLOCK, The, This, Usher
related to Evolution · 15
CRISPR → But, Cas, Cas1-like, CRISPR-Cas, Darwinian, For, However, Indeed, Koonin, Lamarck, Lamarckian, On, The, These, We
related to Protein Data Bank · 15
CRISPR → CasA, CasB, CasC, Cascade, CasD, CasE, Overview, P76632, PDB, PDBe-KB, Q46897, Q46898, Q46899, Q46901, UniProt
related to Biogenesis · 14
CRISPR → Cas, Cas6, Cas6e, Cas6f, Cleavage, CRISPR-Cas, CRISPR-RNA, I-E, I-F, In, The, These Cas, This, Type III
related to Cas12a · 13
CRISPR → Cas12a, Cas9, Class II Type, Cpf1, CRISPR RNA, CRISPR-associated, DNA, G-rich' PAMs, In, NGG-3, PAM, T-rich, TTTV-3
related to CRISPR-associated systems · 11
CRISPR → All, Cas, CRISPR's, CRISPR-associated, CRISPR-cas, DNA, However, In, Jansen's, The, The Cas

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna systems phage system rna sequence spacer spacers cas crispr-cas crrna type repeats sequences cas9 proteins mechanism evolution cas1 protein

CRISPR relationships Subject–Predicate–Object triples

TTTA extracted 273 structured relationships around CRISPR. Examples in this analysis include CRISPR → Domains → InterPro and CRISPR → Entrez → 947229. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CRISPRDomainsInterPro1.00infobox
CRISPREntrez9472291.00infobox
CRISPROrganismEscherichia coli1.00infobox
CRISPROrthologsNCBI: entry; OMA: entry1.00infobox
CRISPRPDB4QYZ1.00infobox
CRISPRRefSeq (Prot)NP_417241.11.00infobox
CRISPRSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
CRISPRStructuresSwiss-model1.00infobox
CRISPRSymbolCRISPR1.00infobox
CRISPRUniProtP380361.00infobox
bacteriainstance ofis a family of DNA sequences found in the genomes of prokaryotic organisms0.80text
archaeainstance ofis a family of DNA sequences found in the genomes of prokaryotic organisms0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around CRISPR bring nearby vocabulary together. In this analysis, examples include Sequence, Spacers and Dna. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CRISPR
    • Sequence
    • Spacers
    • Dna
    • Spacer
    • System
    • Sequences
    • Genomes
    • Repeats
    • Cas
    • Phage
    • Crrna
    • Rna
  • crispr
    • Sequence
    • Spacers
    • Dna
    • Spacer
    • System
    • Sequences
    • Genomes
    • Repeats
    • Cas
    • Phage
    • Crrna
    • Rna
  • dna
    • Cas9
    • Rna
    • Sequences
    • Phage
    • Systems
    • Repeats
    • Crrna
    • Genomes
    • Protein
    • Target
    • Spacers
    • Mechanism
  • bacteria
    • Found
    • Crispr-cas
    • Mechanism
    • Sequences
    • System
    • Repeats
    • Genomes
    • Phage
    • Spacers
    • Genes
    • Acquisition
    • Pam
  • cas9
    • Rna
    • Dna
    • Protein
    • Sequences
    • Crrna
    • Genes
    • Pam
    • Thermophilus
    • Target
    • Gene
    • Crispr
    • Cas
  • direct repeats
    • Sequences
    • Genomes
    • Repeat
    • Type
    • Spacers
    • Protein
    • Systems
    • Crrna
    • Proteins
    • Rna
    • Cas
    • Sequence
  • extrachromosomal dna
    • Cas9
    • Rna
    • Sequences
    • Phage
    • Systems
    • Repeats
    • Crrna
    • Genomes
    • Protein
    • Target
    • Spacers
    • Mechanism
  • rna interference
    • Crrna
    • Target
    • Mechanism
    • Systems
    • Cas
    • Crispr-cas
    • Pam
    • Sequence
    • Structure
    • System
    • Gene
    • Repeat

Connections between topic areas Semantic bridges

For CRISPR, one of the stronger structural bridges in this analysis connects CRISPR with CRISPR-associated systems. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CRISPR — CRISPR-associated systems · splits 86 ⟂ 43
CRISPR — Overview · splits 108 ⟂ 21
CRISPR — Evolution · splits 114 ⟂ 15
CRISPR — History · splits 115 ⟂ 14
CRISPR — Mechanism · splits 117 ⟂ 12
CRISPR — Locus structure · splits 121 ⟂ 8
CRISPR — Use by phages · splits 123 ⟂ 6
CRISPR — Protein Data Bank · splits 125 ⟂ 4
CRISPR — Applications · splits 126 ⟂ 3

Map overview Semantic statistics

CRISPR

Nodes129
Edges128
Triples273
Avg. degree1.98
Density0.015504
Components1

Source & methodology

TTTA analyzes the structure around CRISPR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CRISPR · EN edition · Analysis: TopicsToTalkAbout

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