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Pleiotropy

Pleiotropy (from Ancient Greek πλείων (pleíōn) 'more' and τρόπος (trópos) 'turn, way, manner, style') is a condition in which a single gene or genetic variant influences multiple phenotypic traits. A gene that has such multiple effects is referred to as a pleiotropic gene. Mutations in pleiotropic genes can affect several traits simultaneously, often…

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Overview

History

Mechanism

Polygenic risk scores and pleiotropy in complex traits

Models for the origin

Evolution

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Map overview Semantic statistics

Pleiotropy

Nodes157
Edges156
Triples58
Avg. degree1.99
Density0.012739
Components1

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Pleiotropy

Top relations

related to Models for the origin · 9
Pleiotropy → At, But, Eventually, If, It, One, Over, The, This
related to history · 8
Pleiotropy → Festschrift, Gregor Mendel's, He, Ludwig Plate, Mendel, Pleiotropic, The, This
related to Polygenic risk scores and pleiotropy in complex traits · 8
Pleiotropy → Another, CP, Early, GWAS, One, To, Usually, When
related to Antagonistic pleiotropy · 5
Pleiotropy → An, Sometimes, Such, This, Williams
related to Evolution · 4
Pleiotropy → However, In, This, Traditionally
related to Spurious pleiotropy · 4
Pleiotropy → At, Sometimes, Spurious, When
related to Mediated pleiotropy · 3
Pleiotropy → Also, An, LDF
related to Biological pleiotropy · 2
Pleiotropy → Biological, There
is a · 1
Pleiotropy → human disease phenylketonuria
related to Mechanism · 1
Pleiotropy → Recent

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Important terminology

gene traits genes one pleiotropic genetic multiple single also mutations phenotypic mutation effects trait different several body selection phenylalanine biological

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pleiotropyis ahuman disease phenylketonuria0.90text
ageinstance ofdepending on factors0.80text
sexinstance ofdepending on factors0.80text
schizophreniainstance ofIt may be especially useful for explaining multi-dimensional psychiatric disorders0.80text
bipolar disorderinstance ofIt may be especially useful for explaining multi-dimensional psychiatric disorders0.80text
intellectual disabilityinstance ofThis can cause symptoms0.80text
abnormal gaitinstance ofThis can cause symptoms0.80text
postureinstance ofThis can cause symptoms0.80text
and delayed growthinstance ofThis can cause symptoms0.80text
depressioninstance ofGenetic correlations were found between pain susceptibility and conditions0.80text
increase of body mass indexinstance ofGenetic correlations were found between pain susceptibility and conditions0.80text
asthmainstance ofGenetic correlations were found between pain susceptibility and conditions0.80text

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