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DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.
The analysis highlights Art, Interactions and Clinical significance as prominent areas in the source structure around DNMT1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around DNMT1 shows recurring relationship patterns in the source. For example, DNMT1 → C-5 methylation of cytosine, cellular response to amino acid stimulus, chromatin binding, chromatin organization, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA methylation involved in embryo development, DNA methylation on cytosine, DNA methylation on cytosine within a CG sequence, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, heterochromatin, maintenance of DNA methylation, metal ion binding, methyl-CpG binding, methylation, methyltransferase activity, negative regulation of gene expression, negative regulation of gene expression, epigenetic Another extracted example is DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
methylation dna gene bp human chr band cell methyltransferase chromosome 19 enzyme patterns cancer -methyltransferase mouse expression location epigenetic role
TTTA extracted 135 structured relationships around DNMT1. Examples in this analysis include DNMT1 → 2.1.1.37 → ↗ and DNMT1 → Aliases → DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| DNMT1 | 2.1.1.37 | ↗ | 1.00 | infobox |
| DNMT1 | Aliases | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1 | 1.00 | infobox |
| DNMT1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YOC, 3EPZ, 3PTA, 3SWR, 4WXX | 1.00 | infobox |
| DNMT1 | Band | 19p13.2 | 1.00 | infobox |
| DNMT1 | Band | 9 A3|9 7.66 cM | 1.00 | infobox |
| DNMT1 | Bgee | oocyte | 1.00 | infobox |
| DNMT1 | Bgee | secondary oocyte | 1.00 | infobox |
| DNMT1 | Bgee | sural nerve | 1.00 | infobox |
| DNMT1 | Bgee | ventricular zone | 1.00 | infobox |
| DNMT1 | Bgee | ganglionic eminence | 1.00 | infobox |
| DNMT1 | Bgee | bone marrow cell | 1.00 | infobox |
| DNMT1 | Bgee | appendix | 1.00 | infobox |
| DNMT1 | Bgee | cerebellar hemisphere | 1.00 | infobox |
| DNMT1 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| DNMT1 | Bgee | Achilles tendon | 1.00 | infobox |
| DNMT1 | Bgee | primary oocyte | 1.00 | infobox |
| DNMT1 | Bgee | tail of embryo | 1.00 | infobox |
| DNMT1 | Bgee | genital tubercle | 1.00 | infobox |
| DNMT1 | Bgee | zygote | 1.00 | infobox |
| DNMT1 | Bgee | urethra | 1.00 | infobox |
| DNMT1 | Bgee | paramesonephric duct | 1.00 | infobox |
| DNMT1 | Bgee | Paneth cell | 1.00 | infobox |
| DNMT1 | Bgee | somite | 1.00 | infobox |
| DNMT1 | Bgee | tibiofemoral joint | 1.00 | infobox |
| DNMT1 | BioGPS | More reference expression data | 1.00 | infobox |
| DNMT1 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| DNMT1 | Chr. | Chromosome 9 (mouse) | 1.00 | infobox |
| DNMT1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| DNMT1 | End | 10,231,286 bp | 1.00 | infobox |
| DNMT1 | End | 20,871,184 bp | 1.00 | infobox |
The concept neighborhoods around DNMT1 bring nearby vocabulary together. In this analysis, examples include Methylation, Gene and Methyltransferase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For DNMT1, one of the stronger structural bridges in this analysis connects DNMT1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around DNMT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — DNMT1 · EN edition · Analysis: TopicsToTalkAbout