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DNMT1

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.

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Interactions

12 related topics

Clinical significance

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Function

1 related topics

Overview

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2.1.1.37
Aliases
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YOC, 3EPZ, 3PTA, 3SWR, 4WXX
Band
19p13.2 · 9 A3|9 7.66 cM
Bgee
oocyte · secondary oocyte · sural nerve · ventricular zone · ganglionic eminence
BioGPS
More reference expression data

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Overview

Function

Interactions

Clinical significance

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Map overview Semantic statistics

DNMT1

Nodes34
Edges33
Triples135
Avg. degree1.94
Density0.058824
Components1

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DNMT1

Top relations

Gene ontology · 43
DNMT1 → C-5 methylation of cytosine, cellular response to amino acid stimulus, chromatin binding, chromatin organization, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA methylation involved in embryo development, DNA methylation on cytosine, DNA methylation on cytosine within a CG sequence, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, heterochromatin, maintenance of DNA methylation, metal ion binding, methyl-CpG binding, methylation, methyltransferase activity, negative regulation of gene expression, negative regulation of gene expression, epigenetic
Bgee · 19
DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote
RNA expression pattern · 19
DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote
related to Clinical significance · 11
DNMT1 → Conditional, DNA, Dysregulation, Hematopoietic, HSC, HSCs, Intestinal, ISCs, It, Mammary, MaSCs
related to Function · 6
DNMT1 → Aberrant, CpGs, DNA, However, In, This
related to Interactions · 5
DNMT1 → DNMT3ADNMT3B, HDAC2, PCNA, RB1, UHRF1DMAP1
related to External links · 4
DNMT1 → Deafness, DNMT1-Related Dementia, GeneReviews/NCBI/NIH/UW, Sensory Neuropathy
Band · 2
DNMT1 → 19p13.2, 9 A3|9 7.66 cM
Chr. · 2
DNMT1 → Chromosome 19 (human), Chromosome 9 (mouse)
End · 2
DNMT1 → 10,231,286 bp, 20,871,184 bp

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Important terminology

methylation dna gene bp human chr band cell methyltransferase chromosome 19 enzyme patterns cancer -methyltransferase mouse expression location epigenetic role

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNMT12.1.1.371.00infobox
DNMT1AliasesDNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 11.00infobox
DNMT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YOC, 3EPZ, 3PTA, 3SWR, 4WXX1.00infobox
DNMT1Band19p13.21.00infobox
DNMT1Band9 A3|9 7.66 cM1.00infobox
DNMT1Bgeeoocyte1.00infobox
DNMT1Bgeesecondary oocyte1.00infobox
DNMT1Bgeesural nerve1.00infobox
DNMT1Bgeeventricular zone1.00infobox
DNMT1Bgeeganglionic eminence1.00infobox
DNMT1Bgeebone marrow cell1.00infobox
DNMT1Bgeeappendix1.00infobox
DNMT1Bgeecerebellar hemisphere1.00infobox
DNMT1Bgeeright hemisphere of cerebellum1.00infobox
DNMT1BgeeAchilles tendon1.00infobox
DNMT1Bgeeprimary oocyte1.00infobox
DNMT1Bgeetail of embryo1.00infobox
DNMT1Bgeegenital tubercle1.00infobox
DNMT1Bgeezygote1.00infobox
DNMT1Bgeeurethra1.00infobox
DNMT1Bgeeparamesonephric duct1.00infobox
DNMT1BgeePaneth cell1.00infobox
DNMT1Bgeesomite1.00infobox
DNMT1Bgeetibiofemoral joint1.00infobox
DNMT1BioGPSMore reference expression data1.00infobox
DNMT1Chr.Chromosome 19 (human)1.00infobox
DNMT1Chr.Chromosome 9 (mouse)1.00infobox
DNMT1DatabasesNCBI: entry; OMA: entry1.00infobox
DNMT1End10,231,286 bp1.00infobox
DNMT1End20,871,184 bp1.00infobox

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