Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

DNMT1: Art, Interactions & Clinical significance

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

DNMT1 topic overview

The analysis highlights Art, Interactions and Clinical significance as prominent areas in the source structure around DNMT1.

Related topics
29
Source areas
4
Connected nodes
33
Extracted relationships
135
Concept neighborhoods
15
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 12 topics
Clinical significance · 8 topics
Overview · 8 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.1.1.37
Aliases
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YOC, 3EPZ, 3PTA, 3SWR, 4WXX
Band
19p13.2 · 9 A3|9 7.66 cM
Bgee
oocyte · secondary oocyte · sural nerve · ventricular zone · ganglionic eminence
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DNMT1 connects Entity context

The extracted context around DNMT1 shows recurring relationship patterns in the source. For example, DNMT1 → C-5 methylation of cytosine, cellular response to amino acid stimulus, chromatin binding, chromatin organization, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA methylation involved in embryo development, DNA methylation on cytosine, DNA methylation on cytosine within a CG sequence, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, heterochromatin, maintenance of DNA methylation, metal ion binding, methyl-CpG binding, methylation, methyltransferase activity, negative regulation of gene expression, negative regulation of gene expression, epigenetic Another extracted example is DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

DNMT1

Top relations

Gene ontology · 43
DNMT1 → C-5 methylation of cytosine, cellular response to amino acid stimulus, chromatin binding, chromatin organization, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA methylation involved in embryo development, DNA methylation on cytosine, DNA methylation on cytosine within a CG sequence, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, heterochromatin, maintenance of DNA methylation, metal ion binding, methyl-CpG binding, methylation, methyltransferase activity, negative regulation of gene expression, negative regulation of gene expression, epigenetic
Bgee · 19
DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote
RNA expression pattern · 19
DNMT1 → Achilles tendon, appendix, bone marrow cell, cerebellar hemisphere, ganglionic eminence, genital tubercle, oocyte, Paneth cell, paramesonephric duct, primary oocyte, right hemisphere of cerebellum, secondary oocyte, somite, sural nerve, tail of embryo, tibiofemoral joint, urethra, ventricular zone, zygote
related to Clinical significance · 11
DNMT1 → Conditional, DNA, Dysregulation, Hematopoietic, HSC, HSCs, Intestinal, ISCs, It, Mammary, MaSCs
related to Function · 6
DNMT1 → Aberrant, CpGs, DNA, However, In, This
related to Interactions · 5
DNMT1 → DNMT3ADNMT3B, HDAC2, PCNA, RB1, UHRF1DMAP1
related to External links · 4
DNMT1 → Deafness, DNMT1-Related Dementia, GeneReviews/NCBI/NIH/UW, Sensory Neuropathy
Band · 2
DNMT1 → 19p13.2, 9 A3|9 7.66 cM
Chr. · 2
DNMT1 → Chromosome 19 (human), Chromosome 9 (mouse)
End · 2
DNMT1 → 10,231,286 bp, 20,871,184 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

methylation dna gene bp human chr band cell methyltransferase chromosome 19 enzyme patterns cancer -methyltransferase mouse expression location epigenetic role

DNMT1 relationships Subject–Predicate–Object triples

TTTA extracted 135 structured relationships around DNMT1. Examples in this analysis include DNMT1 → 2.1.1.37 → ↗ and DNMT1 → Aliases → DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DNMT12.1.1.371.00infobox
DNMT1AliasesDNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 11.00infobox
DNMT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YOC, 3EPZ, 3PTA, 3SWR, 4WXX1.00infobox
DNMT1Band19p13.21.00infobox
DNMT1Band9 A3|9 7.66 cM1.00infobox
DNMT1Bgeeoocyte1.00infobox
DNMT1Bgeesecondary oocyte1.00infobox
DNMT1Bgeesural nerve1.00infobox
DNMT1Bgeeventricular zone1.00infobox
DNMT1Bgeeganglionic eminence1.00infobox
DNMT1Bgeebone marrow cell1.00infobox
DNMT1Bgeeappendix1.00infobox
DNMT1Bgeecerebellar hemisphere1.00infobox
DNMT1Bgeeright hemisphere of cerebellum1.00infobox
DNMT1BgeeAchilles tendon1.00infobox
DNMT1Bgeeprimary oocyte1.00infobox
DNMT1Bgeetail of embryo1.00infobox
DNMT1Bgeegenital tubercle1.00infobox
DNMT1Bgeezygote1.00infobox
DNMT1Bgeeurethra1.00infobox
DNMT1Bgeeparamesonephric duct1.00infobox
DNMT1BgeePaneth cell1.00infobox
DNMT1Bgeesomite1.00infobox
DNMT1Bgeetibiofemoral joint1.00infobox
DNMT1BioGPSMore reference expression data1.00infobox
DNMT1Chr.Chromosome 19 (human)1.00infobox
DNMT1Chr.Chromosome 9 (mouse)1.00infobox
DNMT1DatabasesNCBI: entry; OMA: entry1.00infobox
DNMT1End10,231,286 bp1.00infobox
DNMT1End20,871,184 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DNMT1 bring nearby vocabulary together. In this analysis, examples include Methylation, Gene and Methyltransferase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DNMT1
    • Methylation
    • Gene
    • Methyltransferase
    • Cancer
    • Cell
    • Patterns
    • Maintaining
    • Maintenance
    • Enzyme
    • Expression
    • Role
    • Activity
  • dnmt1
    • Methylation
    • Gene
    • Methyltransferase
    • Cancer
    • Cell
    • Patterns
    • Maintaining
    • Maintenance
    • Enzyme
    • Expression
    • Role
    • Activity
  • enzyme
    • Activity
    • Cytosine-5-
    • Function
    • Process
    • Search
    • Development
    • Location
    • Mouse
    • Chromosome
    • Methyltransferase
    • Bp
    • Chr
  • dna
    • Dnmt1
    • Methylation
    • Methyltransferase
    • Maintaining
    • Gene
    • Enzyme
    • Role
    • Cell
    • Patterns
    • Activity
    • Cytosine-5-
    • Dnmt3a
  • dna methylation
    • Dnmt1
    • Methylation
    • Patterns
    • Methyltransferase
    • Expression
    • Gene
    • Cancer
    • Maintaining
    • Enzyme
    • Role
    • Cell
    • Development
  • dna methyltransferase
    • Dnmt1
    • Search
    • Methylation
    • Location
    • Methyltransferase
    • Maintaining
    • Cell
    • Gene
    • Human
    • Enzyme
    • Role
    • Patterns
  • cell cycle
    • Maintenance
    • Methyltransferase
    • Shown
    • Dna
    • Dnmt1
    • Methylation
    • Cytosine-5-
    • Dnmt3a
    • Dnmt3b
    • Epigenetic
    • Function
    • Process
  • hematopoietic stem cell
    • Maintenance
    • Methyltransferase
    • Shown
    • Dna
    • Dnmt1
    • Methylation
    • Cytosine-5-
    • Dnmt3a
    • Dnmt3b
    • Epigenetic
    • Function
    • Process

Connections between topic areas Semantic bridges

For DNMT1, one of the stronger structural bridges in this analysis connects DNMT1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DNMT1Interactions · splits 21 ⟂ 13
DNMT1Overview · splits 25 ⟂ 9
DNMT1Clinical significance · splits 25 ⟂ 9

Map overview Semantic statistics

DNMT1

Nodes34
Edges33
Triples135
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around DNMT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DNMT1 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.