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DDB2: Function, Deficiency in humans & Structure

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.

Language: English [EN]
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DDB2 topic overview

The analysis highlights Function, Deficiency in humans and Structure as prominent areas in the source structure around DDB2.

Related topics
28
Source areas
4
Connected nodes
32
Extracted relationships
149
Concept neighborhoods
10
Bridge connections
32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 17 topics
Deficiency in humans · 7 topics
Overview · 2 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DDB2, DDBB, UV-XPE, damage specific DNA binding protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EI4, 3I7L, 4E54, 4E5Z
Band
11p11.2 · 2|2 E1
Bgee
skin of abdomen · skin of leg · right uterine tube · right adrenal cortex · Descending thoracic aorta
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Deficiency in humans

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DDB2 connects Entity context

The extracted context around DDB2 shows recurring relationship patterns in the source. For example, DDB2 → cell junction, cellular response to DNA damage stimulus, Cul4-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, damaged DNA binding, DNA binding, DNA repair, global genome nucleotide-excision repair, histone H2A monoubiquitination, nucleoplasm, nucleotide-excision repair, nucleotide-excision repair, DNA damage recognition, nucleotide-excision repair, DNA duplex unwinding, nucleotide-excision repair, DNA incision, nucleotide-excision repair, DNA incision, 3'-to lesion, nucleotide-excision repair, DNA incision, 5'-to lesion, nucleotide-excision repair, preincision complex assembly, nucleotide-excision repair, preincision complex stabilization, nucleus, post-translational protein modification Another extracted example is DDB2 → aortic valve, ascending aorta, ciliary body, Descending thoracic aorta, granulocyte, left adrenal cortex, left adrenal gland, medullary collecting duct, olfactory zone of nasal mucosa, otic vesicle, Paneth cell, primary oocyte, right adrenal cortex, right uterine tube, saccule, secondary oocyte, skin of abdomen, skin of leg, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

DDB2

Top relations

Gene ontology · 32
DDB2 → cell junction, cellular response to DNA damage stimulus, Cul4-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, damaged DNA binding, DNA binding, DNA repair, global genome nucleotide-excision repair, histone H2A monoubiquitination, nucleoplasm, nucleotide-excision repair, nucleotide-excision repair, DNA damage recognition, nucleotide-excision repair, DNA duplex unwinding, nucleotide-excision repair, DNA incision, nucleotide-excision repair, DNA incision, 3'-to lesion, nucleotide-excision repair, DNA incision, 5'-to lesion, nucleotide-excision repair, preincision complex assembly, nucleotide-excision repair, preincision complex stabilization, nucleus, post-translational protein modification
Bgee · 19
DDB2 → aortic valve, ascending aorta, ciliary body, Descending thoracic aorta, granulocyte, left adrenal cortex, left adrenal gland, medullary collecting duct, olfactory zone of nasal mucosa, otic vesicle, Paneth cell, primary oocyte, right adrenal cortex, right uterine tube, saccule, secondary oocyte, skin of abdomen, skin of leg, zygote
RNA expression pattern · 19
DDB2 → aortic valve, ascending aorta, ciliary body, Descending thoracic aorta, granulocyte, left adrenal cortex, left adrenal gland, medullary collecting duct, olfactory zone of nasal mucosa, otic vesicle, Paneth cell, primary oocyte, right adrenal cortex, right uterine tube, saccule, secondary oocyte, skin of abdomen, skin of leg, zygote
related to Chromatin remodeling · 15
DDB2 → Action, ADP, ALC1, CUL4A, DDB1, DNA, DNA-based, PARP1, PARylates, The, The PARP1, This, To, UV, UV-induced
related to Deficiency in humans · 14
DDB2 → DNA, If, Mutation, Patients, This, UV, XP, XPA, XPB, XPC, XPD, XPE, XPF, XPG
related to Structure · 10
DDB2 → As, DDB1, Rapić-Otrin, The C-terminal, The DDB2, The WD40, Together, UV-damaged DNA, UV-DDB, WD40
related to Binding to damaged DNA · 9
DDB2 → As, DDB, DDB1, DNA, The, The DDB2, UV, Wittschieben, XP-E
related to Other functions · 8
DDB2 → Decreased, DNA, H3, H3K56Ac, In, UV-induced DNA, Zhu, Zou
Band · 2
DDB2 → 11p11.2, 2|2 E1
Chr. · 2
DDB2 → Chromosome 11 (human), Chromosome 2 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna protein gene chromatin human bp binding repair chr band damage chromosome et al 11 complex uv damaged ddb1 heterodimer

DDB2 relationships Subject–Predicate–Object triples

TTTA extracted 149 structured relationships around DDB2. Examples in this analysis include DDB2 → Aliases → DDB2, DDBB, UV-XPE, damage specific DNA binding protein 2 and DDB2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EI4, 3I7L, 4E54, 4E5Z. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DDB2AliasesDDB2, DDBB, UV-XPE, damage specific DNA binding protein 21.00infobox
DDB2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EI4, 3I7L, 4E54, 4E5Z1.00infobox
DDB2Band11p11.21.00infobox
DDB2Band2|2 E11.00infobox
DDB2Bgeeskin of abdomen1.00infobox
DDB2Bgeeskin of leg1.00infobox
DDB2Bgeeright uterine tube1.00infobox
DDB2Bgeeright adrenal cortex1.00infobox
DDB2BgeeDescending thoracic aorta1.00infobox
DDB2Bgeeolfactory zone of nasal mucosa1.00infobox
DDB2Bgeegranulocyte1.00infobox
DDB2Bgeeleft adrenal gland1.00infobox
DDB2Bgeeascending aorta1.00infobox
DDB2Bgeeleft adrenal cortex1.00infobox
DDB2BgeePaneth cell1.00infobox
DDB2Bgeesecondary oocyte1.00infobox
DDB2Bgeezygote1.00infobox
DDB2Bgeemedullary collecting duct1.00infobox
DDB2Bgeeprimary oocyte1.00infobox
DDB2Bgeesaccule1.00infobox
DDB2Bgeeaortic valve1.00infobox
DDB2Bgeeotic vesicle1.00infobox
DDB2Bgeeciliary body1.00infobox
DDB2BioGPSMore reference expression data1.00infobox
DDB2Chr.Chromosome 11 (human)1.00infobox
DDB2Chr.Chromosome 2 (mouse)1.00infobox
DDB2DatabasesNCBI: entry; OMA: entry1.00infobox
DDB2End47,239,217 bp1.00infobox
DDB2End91,067,327 bp1.00infobox
DDB2EnsemblENSG000001345741.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DDB2 bring nearby vocabulary together. In this analysis, examples include Dna, Protein and Al. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DDB2
    • Dna
    • Protein
    • Al
    • Et
    • Ddb1
    • Gene
    • Showed
    • Binding
    • Complex
    • Heterodimer
    • Damage
    • Repair
  • ddb2
    • Dna
    • Protein
    • Al
    • Et
    • Ddb1
    • Gene
    • Showed
    • Binding
    • Complex
    • Heterodimer
    • Damage
    • Repair
  • gene
    • Human
    • Humans
    • Location
    • Chromosome
    • Bp
    • Chr
    • Function
    • Mouse
    • Search
    • Deficiency
    • End
    • Excision
  • chromatin
    • Damage
    • Proteins
    • Uv-induced
    • Dna
    • Damaged
    • Repair
    • Protein
    • External
    • Ddb2
    • Function
    • Search
    • Deficiency
  • deficiency in humans
    • Gene
    • External
    • Human
    • Function
    • Repair
    • Search
    • Protein
    • Cells
    • Deficiency
    • Excision
    • Humans
    • Location
  • nucleotide excision repair
    • Pyrimidine
    • Repair
    • Gene
    • Cells
    • Function
    • Mouse
    • Search
    • Location
    • Proteins
    • Uv
    • Uv-induced
    • Human
  • function
    • Search
    • Location
    • External
    • Human
    • Gene
    • Mouse
    • End
    • Excision
    • Humans
    • Protein
    • Pyrimidine
    • Band
  • protein
    • Complex
    • Ddb1
    • Search
    • Location
    • Mouse
    • End
    • Excision
    • Proteins
    • Pyrimidine
    • Uv-induced
    • Band
    • Uv

Connections between topic areas Semantic bridges

For DDB2, one of the stronger structural bridges in this analysis connects DDB2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DDB2Function · splits 15 ⟂ 18
DDB2Deficiency in humans · splits 25 ⟂ 8
DDB2Overview · splits 30 ⟂ 3
DDB2Structure · splits 30 ⟂ 3

Map overview Semantic statistics

DDB2

Nodes33
Edges32
Triples149
Avg. degree1.94
Density0.060606
Components1

Source & methodology

TTTA analyzes the structure around DDB2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Deficiency in humans & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DDB2 · EN edition · Analysis: TopicsToTalkAbout

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