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Kinase: History, Protein kinases & Lipid kinases

In biochemistry, a kinase (/ˈkaɪneɪs, ˈkɪneɪs, -eɪz/, EC 2.7.-.-) is a protein enzyme that catalyzes the transfer of phosphate groups to substrates. This process is known as phosphorylation. Typically ATP is the phosphate donor. Kinases are pervasive, the human genome codes for about 500 of these enzymes.

Language: English [EN]
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Kinase topic overview

The analysis highlights History, Protein kinases and Lipid kinases as prominent areas in the source structure around Kinase.

Related topics
131
Source areas
8
Connected nodes
139
Extracted relationships
184
Concept neighborhoods
44
Bridge connections
139

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protein kinases · 27 topics
Other kinases · 25 topics
Lipid kinases · 22 topics
Overview · 19 topics
Carbohydrate kinases · 14 topics
Biochemistry and functional relevance · 10 topics
History and classification · 10 topics
Kinases and health · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Biochemistry and functional relevance

History and classification

Protein kinases

Lipid kinases

Carbohydrate kinases

Other kinases

Kinases and health

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Kinase connects Entity context

The extracted context around Kinase shows recurring relationship patterns in the source. For example, Kinase → Activation, ATF-2, Chop, CREB, DPC4, EGF, Elk-1, ERK, Ets1, For, GDP, GTP, It, Its, Jun, MAP, MAPK, MAPKK, MAPKKK, MAPKs Another extracted example is Kinase → AMP, At, ATP, Calmodulin-dependent, During, Edmond, Edwin, Eugene, Fischer, For, H1, II, In, JAK, Kennedy, Kinases, Krebs, Lester Reed, MAPK/ERK, More. Use these groups to spot repeated connection types before inspecting the individual relationships.

Kinase

Top relations

related to Mitogen-activated protein kinases · 35
Kinase → Activation, ATF-2, Chop, CREB, DPC4, EGF, Elk-1, ERK, Ets1, For, GDP, GTP, It, Its, Jun, MAP, MAPK, MAPKK, MAPKKK, MAPKs
related to history · 33
Kinase → AMP, At, ATP, Calmodulin-dependent, During, Edmond, Edwin, Eugene, Fischer, For, H1, II, In, JAK, Kennedy, Kinases, Krebs, Lester Reed, MAPK/ERK, More
related to Sphingosine kinases · 23
Kinase → AKT/PI3K, ATP, ERKs, GPCR, GTP, HDACs, In, It, Past, PLC, Rac GTPase, Rho GTPase, S1P, SK, SK1, SK2, SKs, Sphingolipids, Sphingosine, The
related to Carbohydrate kinases · 13
Kinase → ADP, ATP, C6, D-glucose, For, Hexokinase, In, It, Kinases, Mutations, The, This, To
related to Cyclin dependent kinases · 13
Kinase → Additionally, Because, Cdc25, CDK, CDK-activating, CDKs, Cyclin, Different, Once, Therefore, These, They, While
related to Phosphatidylinositol kinases · 12
Kinase → ADP, ATP, Here, Metal, Mutations, P2, Phosphatidylinositol, PI, PI3K, PI3P, PIP3, The
related to Protein kinases · 10
Kinase → Edwin Krebs, Hopkins Memorial Lecture, In, It, Phosphorylation, Protein, The, There, These, This
related to Thymidine kinase · 10
Kinase → After, ATP, Because, DNA, It, Nucleoside, Patients, Therefore, This, Thymidine
related to Biochemistry and functional relevance · 9
Kinase → Additionally, Alternatively, ATP, However, Kinases, Mutations, Phosphorylation, Protein, The
related to Riboflavin kinase · 8
Kinase → ATP, Divalent, FAD, FMN, In, It, Riboflavin, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinases protein phosphorylation cell phosphate atp also many thymidine proteins mapk activity regulation riboflavin mutations groups cells important lipid cancer

Kinase relationships Subject–Predicate–Object triples

TTTA extracted 184 structured relationships around Kinase. Examples in this analysis include lipids → instance of → Various other kinases act on small molecules and phosphatidylinositol 3 → instance of → to create species. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
lipidsinstance ofVarious other kinases act on small molecules0.80text
carbohydratesinstance ofVarious other kinases act on small molecules0.80text
amino acidsinstance ofVarious other kinases act on small molecules0.80text
and nucleotidesinstance ofVarious other kinases act on small molecules0.80text
either for signaling or to prime them for metabolic pathwaysinstance ofVarious other kinases act on small molecules0.80text
phosphatidylinositol 3instance ofto create species0.80text
4-bisphosphateinstance ofto create species0.80text
Kinaserelated to Biochemistry and functional relevanceKinases0.60section
Kinaserelated to Biochemistry and functional relevanceATP0.60section
Kinaserelated to Biochemistry and functional relevanceAdditionally0.60section
Kinaserelated to Biochemistry and functional relevanceAlternatively0.60section
Kinaserelated to Biochemistry and functional relevanceProtein0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Kinase bring nearby vocabulary together. In this analysis, examples include Thymidine, Phosphate and Atp. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Kinase
    • Thymidine
    • Phosphate
    • Atp
    • Riboflavin
    • Protein
    • Catalyzes
    • Molecule
    • Kinases
    • Also
    • Group
    • One
    • Used
  • kinase
    • Thymidine
    • Phosphate
    • Atp
    • Riboflavin
    • Protein
    • Catalyzes
    • Molecule
    • Kinases
    • Also
    • Group
    • One
    • Used
  • cell signalling
    • Cdks
    • Regulation
    • Different
    • Kinases
    • Role
    • Cells
    • Mutations
    • Enzyme
    • Metabolism
    • Phosphorylation
    • Cancer
    • Important
  • calmodulin-dependent protein kinases
    • Protein
    • Many
    • Proteins
    • Cell
    • One
    • First
    • Act
    • Different
    • Regulation
    • Phosphate
    • Important
    • Thymidine
  • jak kinases
    • Protein
    • Many
    • Cell
    • One
    • Act
    • Different
    • Phosphate
    • Important
    • Regulation
    • Thymidine
    • Proteins
    • Phosphatidylinositol
  • cyclin dependent kinases
    • Protein
    • Many
    • Cell
    • One
    • Act
    • Different
    • Phosphate
    • Important
    • Regulation
    • Thymidine
    • Proteins
    • Phosphatidylinositol
  • cell cycle
    • Cdks
    • Regulation
    • Different
    • Kinases
    • Role
    • Cells
    • Mutations
    • Enzyme
    • Metabolism
    • Phosphorylation
    • Cancer
    • Important
  • cdk-activating kinase
    • Thymidine
    • Phosphate
    • Atp
    • Riboflavin
    • Protein
    • Catalyzes
    • Molecule
    • Kinases
    • Also
    • Group
    • One
    • Used

Connections between topic areas Semantic bridges

For Kinase, one of the stronger structural bridges in this analysis connects Kinase with Protein kinases. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Kinase — Protein kinases · splits 112 ⟂ 28
Kinase — Other kinases · splits 114 ⟂ 26
Kinase — Lipid kinases · splits 117 ⟂ 23
Kinase — Overview · splits 120 ⟂ 20
Kinase — Carbohydrate kinases · splits 125 ⟂ 15
Kinase — Biochemistry and functional relevance · splits 129 ⟂ 11
Kinase — History and classification · splits 129 ⟂ 11
Kinase — Kinases and health · splits 135 ⟂ 5

Map overview Semantic statistics

Kinase

Nodes140
Edges139
Triples184
Avg. degree1.99
Density0.014286
Components1

Source & methodology

TTTA analyzes the structure around Kinase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Protein kinases & Lipid kinases, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Kinase · EN edition · Analysis: TopicsToTalkAbout

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