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Kinase

In biochemistry, a kinase (/ˈkaɪneɪs, ˈkɪneɪs, -eɪz/, EC 2.7.-.-) is a protein enzyme that catalyzes the transfer of phosphate groups to substrates. This process is known as phosphorylation. Typically ATP is the phosphate donor. Kinases are pervasive, the human genome codes for about 500 of these enzymes.

History, Protein kinases & Lipid kinases

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Overview

Biochemistry and functional relevance

History and classification

Protein kinases

Lipid kinases

Carbohydrate kinases

Other kinases

Kinases and health

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Map overview Semantic statistics

Kinase

Nodes140
Edges139
Triples184
Avg. degree1.99
Density0.014286
Components1

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Kinase

Top relations

related to Mitogen-activated protein kinases · 35
Kinase → Activation, ATF-2, Chop, CREB, DPC4, EGF, Elk-1, ERK, Ets1, For, GDP, GTP, It, Its, Jun, MAP, MAPK, MAPKK, MAPKKK, MAPKs
related to history · 33
Kinase → AMP, At, ATP, Calmodulin-dependent, During, Edmond, Edwin, Eugene, Fischer, For, H1, II, In, JAK, Kennedy, Kinases, Krebs, Lester Reed, MAPK/ERK, More
related to Sphingosine kinases · 23
Kinase → AKT/PI3K, ATP, ERKs, GPCR, GTP, HDACs, In, It, Past, PLC, Rac GTPase, Rho GTPase, S1P, SK, SK1, SK2, SKs, Sphingolipids, Sphingosine, The
related to Carbohydrate kinases · 13
Kinase → ADP, ATP, C6, D-glucose, For, Hexokinase, In, It, Kinases, Mutations, The, This, To
related to Cyclin dependent kinases · 13
Kinase → Additionally, Because, Cdc25, CDK, CDK-activating, CDKs, Cyclin, Different, Once, Therefore, These, They, While
related to Phosphatidylinositol kinases · 12
Kinase → ADP, ATP, Here, Metal, Mutations, P2, Phosphatidylinositol, PI, PI3K, PI3P, PIP3, The
related to Protein kinases · 10
Kinase → Edwin Krebs, Hopkins Memorial Lecture, In, It, Phosphorylation, Protein, The, There, These, This
related to Thymidine kinase · 10
Kinase → After, ATP, Because, DNA, It, Nucleoside, Patients, Therefore, This, Thymidine
related to Biochemistry and functional relevance · 9
Kinase → Additionally, Alternatively, ATP, However, Kinases, Mutations, Phosphorylation, Protein, The
related to Riboflavin kinase · 8
Kinase → ATP, Divalent, FAD, FMN, In, It, Riboflavin, The

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Important terminology

kinases protein phosphorylation cell phosphate atp also many thymidine proteins mapk activity regulation riboflavin mutations groups cells important lipid cancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
lipidsinstance ofVarious other kinases act on small molecules0.80text
carbohydratesinstance ofVarious other kinases act on small molecules0.80text
amino acidsinstance ofVarious other kinases act on small molecules0.80text
and nucleotidesinstance ofVarious other kinases act on small molecules0.80text
either for signaling or to prime them for metabolic pathwaysinstance ofVarious other kinases act on small molecules0.80text
phosphatidylinositol 3instance ofto create species0.80text
4-bisphosphateinstance ofto create species0.80text
Kinaserelated to Biochemistry and functional relevanceKinases0.60section
Kinaserelated to Biochemistry and functional relevanceATP0.60section
Kinaserelated to Biochemistry and functional relevanceAdditionally0.60section
Kinaserelated to Biochemistry and functional relevanceAlternatively0.60section
Kinaserelated to Biochemistry and functional relevanceProtein0.60section

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