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DNA ligase

DNA ligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role in repairing single-strand breaks in duplex DNA in living organisms, but some forms (such as DNA ligase IV) may specifically repair double-strand breaks (i.e. a break in both complementary strands of…

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BRENDA
enzyme data
CAS no.
9015-85-4
EC no.
6.5.1.1
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

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Overview

Enzymatic mechanism

Types

Research applications

History

Disorders

As a drug target

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Map overview Semantic statistics

DNA ligase

Nodes71
Edges70
Triples124
Avg. degree1.97
Density0.028169
Components1

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DNA ligase

Top relations

related to T4 · 18
DNA ligase → ATP, Bacteriophage T4, DNA, Escherichia, However, It, NAD, NF-kB, RNA, RNA-DNA, Some, T4, T4 DNA, The, The DNA, The T4, Unlike, UV
related to history · 13
DNA ligase → ATP, DEAE, Diethylaminoethyl, DNA, Gellert, Hurwitz, It, Lehman, Mg, Richardson, T4, The, Weiss
measured by · 10
DNA ligase → A-T, ATP, DNA, III, Many, Modrich-Lehman, There, These, This, Weiss
related to As a drug target · 10
DNA ligase → ATP, ATP-dependent, Computer-aided, DNA, Furthermore, In, NAD, Previous, Since, The
related to External links · 10
DNA ligase → College General Information, DNA, LigaseOpenWetWare DNA Ligation ProtocolOverview, Overview, P00970, P18858, P49916, PDB, PDBe-KB, UniProt
related to Mammalian · 10
DNA ligase → DNA, In, It, Of, Okazaki, Ribonuclease, RNA, T-cell, XRCC1, XRCC4
has application · 9
DNA ligase → Controlling, DNA, For, However, Most, T4, T4 DNA Ligase, The, Tm
related to Enzymatic mechanism · 9
DNA ligase → Adenylylation, AMP, DNA, Formation, Okazaki, Reorganization, The, Transfer, Two ATP
related to E. coli · 8
DNA ligase → DNA, Enhancement, It, NAD, Pol, RNA, The, When
related to Thermostable · 6
DNA ligase → Ampligase DNA Ligase, C/80, Derived, DNA, Its, This

Important terminology Word statistics

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Important terminology

dna ligase repair ligases ends used also ligation coli t4 activity enzyme fragments phosphodiester active bond research gene reaction nad

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNA ligaseBRENDAenzyme data1.00infobox
DNA ligaseCAS no.9015-85-41.00infobox
DNA ligaseEC no.6.5.1.11.00infobox
DNA ligaseExPASyNiceZyme view1.00infobox
DNA ligaseGene OntologyAmiGO / QuickGO1.00infobox
DNA ligaseKEGGenzyme entry1.00infobox
DNA ligaseMetaCycmetabolic pathway1.00infobox
DNA ligaseNCBIproteins1.00infobox
DNA ligasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
DNA ligasePMCarticles1.00infobox
DNA ligasePubMedarticles1.00infobox
DNA ligaseRheareactions1.00infobox
DNA ligaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox
DNA ligaseis atype of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond0.90text

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