DNA ligase

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DNA ligase topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around DNA ligase.

Related topics: 63
Source areas: 7
Connected nodes: 70
Extracted relationships: 124
Concept neighborhoods: 30
Bridge connections: 70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Types · 30 topics

Overview · 9 topics

Enzymatic mechanism · 8 topics

Research applications · 7 topics

Disorders · 6 topics

As a drug target · 2 topics

History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA: enzyme data
CAS no.: 9015-85-4
EC no.: 6.5.1.1
ExPASy: NiceZyme view
Gene Ontology: AmiGO / QuickGO
KEGG: enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

DNA
Phosphodiester bond
DNA ligase IV LIG4
Complementary Complementarity (molecular biology)
DNA repair
DNA replication
Research applications DNA ligase
Molecular biology
Recombinant DNA

Enzymatic mechanism

Disorders

As a drug target

Computer-aided drug design
Eukaryotic Eukaryote

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DNA ligase connects Entity context

The extracted context around DNA ligase shows recurring relationship patterns in the source. For example, DNA ligase → ATP, Bacteriophage T4, DNA, Escherichia, However, It, NAD, NF-kB, RNA, RNA-DNA, Some, T4, T4 DNA, The, The DNA, The T4, Unlike, UV Another extracted example is DNA ligase → ATP, DEAE, Diethylaminoethyl, DNA, Gellert, Hurwitz, It, Lehman, Mg, Richardson, T4, The, Weiss. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to T4 · 18

DNA ligase → ATP, Bacteriophage T4, DNA, Escherichia, However, It, NAD, NF-kB, RNA, RNA-DNA, Some, T4, T4 DNA, The, The DNA, The T4, Unlike, UV

related to history · 13

DNA ligase → ATP, DEAE, Diethylaminoethyl, DNA, Gellert, Hurwitz, It, Lehman, Mg, Richardson, T4, The, Weiss

measured by · 10

DNA ligase → A-T, ATP, DNA, III, Many, Modrich-Lehman, There, These, This, Weiss

related to As a drug target · 10

DNA ligase → ATP, ATP-dependent, Computer-aided, DNA, Furthermore, In, NAD, Previous, Since, The

related to External links · 10

DNA ligase → College General Information, DNA, LigaseOpenWetWare DNA Ligation ProtocolOverview, Overview, P00970, P18858, P49916, PDB, PDBe-KB, UniProt

related to Mammalian · 10

DNA ligase → DNA, In, It, Of, Okazaki, Ribonuclease, RNA, T-cell, XRCC1, XRCC4

has application · 9

DNA ligase → Controlling, DNA, For, However, Most, T4, T4 DNA Ligase, The, Tm

related to Enzymatic mechanism · 9

DNA ligase → Adenylylation, AMP, DNA, Formation, Okazaki, Reorganization, The, Transfer, Two ATP

related to E. coli · 8

DNA ligase → DNA, Enhancement, It, NAD, Pol, RNA, The, When

related to Thermostable · 6

DNA ligase → Ampligase DNA Ligase, C/80, Derived, DNA, Its, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna ligase repair ligases ends used also ligation coli t4 activity enzyme fragments phosphodiester active bond research gene reaction nad

DNA ligase relationships Subject–Predicate–Object triples

TTTA extracted 124 structured relationships around DNA ligase. Examples in this analysis include DNA ligase → BRENDA → enzyme data and DNA ligase → CAS no. → 9015-85-4. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
DNA ligase	BRENDA	enzyme data	1.00	infobox
DNA ligase	CAS no.	9015-85-4	1.00	infobox
DNA ligase	EC no.	6.5.1.1	1.00	infobox
DNA ligase	ExPASy	NiceZyme view	1.00	infobox
DNA ligase	Gene Ontology	AmiGO / QuickGO	1.00	infobox
DNA ligase	KEGG	enzyme entry	1.00	infobox
DNA ligase	MetaCyc	metabolic pathway	1.00	infobox
DNA ligase	NCBI	proteins	1.00	infobox
DNA ligase	PDB structures	RCSB PDB PDBe PDBsum	1.00	infobox
DNA ligase	PMC	articles	1.00	infobox
DNA ligase	PubMed	articles	1.00	infobox
DNA ligase	Rhea	reactions	1.00	infobox
DNA ligase	Search	SearchPMCarticlesPubMedarticlesNCBIproteins	1.00	infobox
DNA ligase	is a	type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around DNA ligase bring nearby vocabulary together. In this analysis, examples include Ligase, Ligases and Repair. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

DNA ligase
- Ligase
- Ligases
- Repair
- Coli
- T4
- Nad
- Use
- Activity
- Fragments
- Active
- Used
- Ligation
dna ligase
- Ligase
- Ligases
- T4
- Repair
- Coli
- Ends
- Activity
- Used
- Nad
- Use
- Fragments
- Active
dna
- Ligase
- Ligases
- Repair
- Coli
- T4
- Nad
- Activity
- Fragments
- Active
- Used
- Ligation
- Bacteriophage
dna ligase iv
- Ligase
- Ligases
- T4
- Repair
- Coli
- Ends
- Activity
- Used
- Nad
- Use
- Fragments
- Active
dna repair
- Ligase
- Protein
- Strands
- Ligases
- Final
- Repair
- Coli
- T4
- Nad
- Activity
- Fragments
- Mammalian
dna replication
- Ligase
- Ligases
- Repair
- Coli
- T4
- Nad
- Activity
- Fragments
- Active
- Used
- Ligation
- Bacteriophage
recombinant dna
- Ligase
- Research
- Ligases
- See
- Together
- Repair
- Protein
- Coli
- T4
- Gene
- Use
- Nad
dna polymerase
- Ligase
- Ligases
- Repair
- Coli
- T4
- Nad
- Activity
- Fragments
- Active
- Used
- Ligation
- Bacteriophage

Connections between topic areas Semantic bridges

For DNA ligase, one of the stronger structural bridges in this analysis connects DNA ligase with Types. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

DNA ligase — Types · splits 40 ⟂ 31

DNA ligase — Overview · splits 61 ⟂ 10

DNA ligase — Enzymatic mechanism · splits 62 ⟂ 9

DNA ligase — Research applications · splits 63 ⟂ 8

DNA ligase — Disorders · splits 64 ⟂ 7

DNA ligase — As a drug target · splits 68 ⟂ 3

Map overview Semantic statistics

DNA ligase

Nodes71

Edges70

Triples124

Avg. degree1.97

Density0.028169

Components1

Source & methodology

TTTA analyzes the structure around DNA ligase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DNA ligase · EN edition · Analysis: TopicsToTalkAbout