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DNMT3B

DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome.

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2.1.1.37
Aliases
DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QKJ, 3FLG, 5CIU
Band
20q11.21 · 2|2 H1
Bgee
secondary oocyte · hair follicle · sperm · embryo · gonad
BioGPS
More reference expression data

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Map overview Semantic statistics

DNMT3B

Nodes24
Edges23
Triples111
Avg. degree1.92
Density0.083333
Components1

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DNMT3B

Top relations

Gene ontology · 35
DNMT3B → C-5 methylation of cytosine, cellular response to dexamethasone stimulus, cellular response to hyperoxia, chromatin binding, cytoplasm, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, histone deacetylase binding, intracellular membrane-bounded organelle, metal ion binding, methylation, methyltransferase activity, negative regulation of gene expression, epigenetic, negative regulation of histone H3-K9 methylation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus
Bgee · 18
DNMT3B → abdominal wall, body of pancreas, corpus epididymis, ejaculatory duct, embryo, epiblast, epithelium of vagina, ganglionic eminence, gonad, hair follicle, paramesonephric duct, pelvic part of vagina, primitive streak, secondary oocyte, sperm, tail of embryo, testicle, ventricular zone
RNA expression pattern · 18
DNMT3B → abdominal wall, body of pancreas, corpus epididymis, ejaculatory duct, embryo, epiblast, epithelium of vagina, ganglionic eminence, gonad, hair follicle, paramesonephric duct, pelvic part of vagina, primitive streak, secondary oocyte, sperm, tail of embryo, testicle, ventricular zone
related to Interactions · 7
DNMT3B → CBX5, DNMT1, DNMT3A, KIF4A, NCAPG, SMC2, SUMO1
related to Clinical significance · 4
DNMT3B → DNA, ICF, Immunodeficiency-centromeric, Variants
related to External links · 4
DNMT3B → EC2, Medicine Medical Subject Headings, MeSH, National Library
Band · 2
DNMT3B → 20q11.21, 2|2 H1
Chr. · 2
DNMT3B → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
DNMT3B → 153,529,650 bp, 32,809,356 bp
2.1.1.37 · 1
DNMT3B → ↗

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Important terminology

gene bp dna chr human band chromosome 20 methylation -methyltransferase location function methyltransferase enzyme mouse beta external variants anomalies syndrome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNMT3B2.1.1.371.00infobox
DNMT3BAliasesDNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD41.00infobox
DNMT3BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QKJ, 3FLG, 5CIU1.00infobox
DNMT3BBand20q11.211.00infobox
DNMT3BBand2|2 H11.00infobox
DNMT3BBgeesecondary oocyte1.00infobox
DNMT3BBgeehair follicle1.00infobox
DNMT3BBgeesperm1.00infobox
DNMT3BBgeeembryo1.00infobox
DNMT3BBgeegonad1.00infobox
DNMT3BBgeetesticle1.00infobox
DNMT3BBgeeganglionic eminence1.00infobox
DNMT3BBgeebody of pancreas1.00infobox
DNMT3BBgeeventricular zone1.00infobox
DNMT3BBgeecorpus epididymis1.00infobox
DNMT3BBgeeepiblast1.00infobox
DNMT3BBgeeprimitive streak1.00infobox
DNMT3BBgeepelvic part of vagina1.00infobox
DNMT3BBgeeparamesonephric duct1.00infobox
DNMT3BBgeeepithelium of vagina1.00infobox
DNMT3BBgeeejaculatory duct1.00infobox
DNMT3BBgeetail of embryo1.00infobox
DNMT3BBgeeabdominal wall1.00infobox
DNMT3BBioGPSMore reference expression data1.00infobox
DNMT3BChr.Chromosome 20 (human)1.00infobox
DNMT3BChr.Chromosome 2 (mouse)1.00infobox
DNMT3BDatabasesNCBI: entry; OMA: entry1.00infobox
DNMT3BEnd32,809,356 bp1.00infobox
DNMT3BEnd153,529,650 bp1.00infobox
DNMT3BEnsemblENSG000000883051.00infobox

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