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DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome.
The analysis highlights Interactions, Function and Clinical significance as prominent areas in the source structure around DNMT3B.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around DNMT3B shows recurring relationship patterns in the source. For example, DNMT3B → C-5 methylation of cytosine, cellular response to dexamethasone stimulus, cellular response to hyperoxia, chromatin binding, cytoplasm, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA methylation, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-methyltransferase activity, histone deacetylase binding, intracellular membrane-bounded organelle, metal ion binding, methylation, methyltransferase activity, negative regulation of gene expression, epigenetic, negative regulation of histone H3-K9 methylation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus Another extracted example is DNMT3B → abdominal wall, body of pancreas, corpus epididymis, ejaculatory duct, embryo, epiblast, epithelium of vagina, ganglionic eminence, gonad, hair follicle, paramesonephric duct, pelvic part of vagina, primitive streak, secondary oocyte, sperm, tail of embryo, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bp dna chr human band chromosome 20 methylation -methyltransferase location function methyltransferase enzyme mouse beta external variants anomalies syndrome
TTTA extracted 111 structured relationships around DNMT3B. Examples in this analysis include DNMT3B → 2.1.1.37 → ↗ and DNMT3B → Aliases → DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| DNMT3B | 2.1.1.37 | ↗ | 1.00 | infobox |
| DNMT3B | Aliases | DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4 | 1.00 | infobox |
| DNMT3B | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QKJ, 3FLG, 5CIU | 1.00 | infobox |
| DNMT3B | Band | 20q11.21 | 1.00 | infobox |
| DNMT3B | Band | 2|2 H1 | 1.00 | infobox |
| DNMT3B | Bgee | secondary oocyte | 1.00 | infobox |
| DNMT3B | Bgee | hair follicle | 1.00 | infobox |
| DNMT3B | Bgee | sperm | 1.00 | infobox |
| DNMT3B | Bgee | embryo | 1.00 | infobox |
| DNMT3B | Bgee | gonad | 1.00 | infobox |
| DNMT3B | Bgee | testicle | 1.00 | infobox |
| DNMT3B | Bgee | ganglionic eminence | 1.00 | infobox |
| DNMT3B | Bgee | body of pancreas | 1.00 | infobox |
| DNMT3B | Bgee | ventricular zone | 1.00 | infobox |
| DNMT3B | Bgee | corpus epididymis | 1.00 | infobox |
| DNMT3B | Bgee | epiblast | 1.00 | infobox |
| DNMT3B | Bgee | primitive streak | 1.00 | infobox |
| DNMT3B | Bgee | pelvic part of vagina | 1.00 | infobox |
| DNMT3B | Bgee | paramesonephric duct | 1.00 | infobox |
| DNMT3B | Bgee | epithelium of vagina | 1.00 | infobox |
| DNMT3B | Bgee | ejaculatory duct | 1.00 | infobox |
| DNMT3B | Bgee | tail of embryo | 1.00 | infobox |
| DNMT3B | Bgee | abdominal wall | 1.00 | infobox |
| DNMT3B | BioGPS | More reference expression data | 1.00 | infobox |
| DNMT3B | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| DNMT3B | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| DNMT3B | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| DNMT3B | End | 32,809,356 bp | 1.00 | infobox |
| DNMT3B | End | 153,529,650 bp | 1.00 | infobox |
| DNMT3B | Ensembl | ENSG00000088305 | 1.00 | infobox |
The concept neighborhoods around DNMT3B bring nearby vocabulary together. In this analysis, examples include Gene, Activity and Cytosine-5-. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For DNMT3B, one of the stronger structural bridges in this analysis connects DNMT3B with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around DNMT3B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — DNMT3B · EN edition · Analysis: TopicsToTalkAbout