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Amphetamine

Amphetamine is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy; it is also used to treat binge eating disorder in the form of lisdexamfetamine. Historically, it has been used to treat nasal congestion and depression.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Moderate
AHFS/Drugs.com
Monograph
ATC code
N06BA01 (WHO) N06BA02 (WHO) N06BA12 (WHO)
Bioavailability
Oral: ~90%
Boiling point
203 °C (397 °F) at 760 mmHg

Topics to explore

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Overview

Uses

Contraindications

Adverse effects

Overdose

Drug interactions

Pharmacology

Chemistry

History, society, and culture

Advanced semantic analysis

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Map overview Semantic statistics

Amphetamine

Nodes593
Edges592
Triples303
Avg. degree2
Density0.003373
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Amphetamine

Top relations

related to Pharmaceutical products · 25
Amphetamine → Adderall, Adderall XR, Adzenys XR-ODT, Adzenys ER, As, Benzedrine, Cydril, Dexedrine, Dextroamphetamine, Dyanavel XR, Evekeo, Evekeo ODT, However, Levoamphetamine, Many, Mydayis, ODT, Of, Psychedrine, Several
related to history · 23
Amphetamine → Allied, Among European Union, As, Axis, Benzedrine, Controlled Substances Act, During, During World War II, EU, European, For, French, Germany, Gordon Alles, II, In, Kline, Lazăr Edeleanu, MDMA, Outside Europe
related to Legal status · 19
Amphetamine → A3, As, Australia, Brazil, Canada, Consequently, Convention, II, In, Japan, List, Netherlands, Psychotropic Substances, Some, South Korea, Thailand, United Kingdom, United Nations, United States
related to Pharmacodynamics · 15
Amphetamine → As, Ca2, CaMKII, DAT, Depending, II, January, NET, Once, PKA, PKC, Ras, RhoA, SERT, The
related to Contraindications · 14
Amphetamine → According, Chemical Safety, Drug Administration, Due, Evidence, FDA, Food, International Programme, IPCS, It, MAOIs, Raynaud's, These, Tourette
related to Drug interactions · 13
Amphetamine → Acidic, ADHD, CYP2D6, Due, FMO3, H2, In, Inhibitors, Many, MAOIs, Norepinephrine, NRIs, Zinc
related to Recreational · 13
Amphetamine → Andrew Wilson, Chronic, Dextroamphetamine, Dextroamphetamine's, Dr, Immediate-release, Injection, Large, Manchester's Twisted Wheel, Mods, Newspaper, Recreational, UK
related to Detection in body fluids · 12
Amphetamine → Chiral, Chromatographic, EMIT, For, Gas, GC, Hence, Mosher's, MS, Several, Techniques, These
related to Physical · 10
Amphetamine → Cardiovascular, Dangerous, Gastrointestinal, If, In, Other, Raynaud's, Sexual, The, This
related to Synthesis · 10
Amphetamine → Chiral, Cleavage, For, In, Leuckart, N-formylamphetamine, Schiff, Since, The, This

Important terminology Word statistics

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Important terminology

effects dextroamphetamine dopamine also use doses drug therapeutic lisdexamfetamine may monoamine used adhd treatment addiction taar1 brain norepinephrine symptoms high

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amphetamine3D model (JSmol)Interactive image1.00infobox
AmphetamineAddiction liabilityModerate1.00infobox
AmphetamineAHFS/Drugs.comMonograph1.00infobox
AmphetamineATC codeN06BA01 (WHO) N06BA02 (WHO) N06BA12 (WHO)1.00infobox
AmphetamineBioavailabilityOral: ~90%1.00infobox
AmphetamineBoiling point203 °C (397 °F) at 760 mmHg1.00infobox
AmphetamineCAS Number300-62-9 Y1.00infobox
AmphetamineChEBICHEBI:2679 Y1.00infobox
AmphetamineChEMBLChEMBL405 Y1.00infobox
AmphetamineChemSpider13852819 Y1.00infobox
AmphetamineChiralityRacemic mixture1.00infobox
AmphetamineCompTox Dashboard (EPA)DTXSID40226001.00infobox
AmphetamineDensity.936 g/cm3 at 25 °C1.00infobox
AmphetamineDependence liabilityPhysical: None Psychological: Moderate1.00infobox
AmphetamineDrug classStimulant; anorectic; norepinephrine-dopamine releasing agent1.00infobox
AmphetamineDrugBankDB00182 Y1.00infobox
AmphetamineDuration of actionIR dosing: 3–6 hours XR dosing: 8–12 hours1.00infobox
AmphetamineECHA InfoCard100.005.5431.00infobox
AmphetamineElimination half-lifeD-amph: 9–11 hours L-amph: 11–14 hours pH-dependent: 7–34 hours1.00infobox
AmphetamineExcretionPrimarily renal; pH-dependent range: 1–75%1.00infobox
AmphetamineFormulaC9H13N1.00infobox
AmphetamineIUPHAR/BPS48041.00infobox
AmphetamineKEGGD07445 Y1.00infobox
AmphetamineLegal statusAU: S8 (Controlled drug)1.00infobox
AmphetamineLegal statusBR: Class A3 (Psychoactive drugs)1.00infobox
AmphetamineLegal statusCA: Schedule I1.00infobox
AmphetamineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
AmphetamineLegal statusNZ: Class B1.00infobox
AmphetamineLegal statusUK: Class B1.00infobox
AmphetamineLegal statusUS: Schedule II1.00infobox

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