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Amphetamine: History, Community, Culture & Applications

Amphetamine is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy; it is also used to treat binge eating disorder in the form of lisdexamfetamine. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic…

Language: English [EN]
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Amphetamine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Amphetamine. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
582
Source areas
9
Connected nodes
592
Extracted relationships
303
Concept neighborhoods
66
Bridge connections
592

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 270 topics
Pharmacology · 102 topics
Chemistry · 70 topics
Adverse effects · 40 topics
History, society, and culture · 27 topics
Drug interactions · 22 topics
Uses · 20 topics
Contraindications · 19 topics
Overdose · 13 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Moderate
AHFS/Drugs.com
Monograph
ATC code
N06BA01 (WHO) N06BA02 (WHO) N06BA12 (WHO)
Bioavailability
Oral: ~90%
Boiling point
203 °C (397 °F) at 760 mmHg

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Uses

Contraindications

Adverse effects

Overdose

Drug interactions

Pharmacology

Chemistry

History, society, and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Amphetamine connects Entity context

The extracted context around Amphetamine shows recurring relationship patterns in the source. For example, Amphetamine → Adderall, Adderall XR, Adzenys XR-ODT, Adzenys ER, As, Benzedrine, Cydril, Dexedrine, Dextroamphetamine, Dyanavel XR, Evekeo, Evekeo ODT, However, Levoamphetamine, Many, Mydayis, ODT, Of, Psychedrine, Several Another extracted example is Amphetamine → Allied, Among European Union, As, Axis, Benzedrine, Controlled Substances Act, During, During World War II, EU, European, For, French, Germany, Gordon Alles, II, In, Kline, Lazăr Edeleanu, MDMA, Outside Europe. Use these groups to spot repeated connection types before inspecting the individual relationships.

Amphetamine

Top relations

related to Pharmaceutical products · 25
Amphetamine → Adderall, Adderall XR, Adzenys XR-ODT, Adzenys ER, As, Benzedrine, Cydril, Dexedrine, Dextroamphetamine, Dyanavel XR, Evekeo, Evekeo ODT, However, Levoamphetamine, Many, Mydayis, ODT, Of, Psychedrine, Several
related to history · 23
Amphetamine → Allied, Among European Union, As, Axis, Benzedrine, Controlled Substances Act, During, During World War II, EU, European, For, French, Germany, Gordon Alles, II, In, Kline, Lazăr Edeleanu, MDMA, Outside Europe
related to Legal status · 19
Amphetamine → A3, As, Australia, Brazil, Canada, Consequently, Convention, II, In, Japan, List, Netherlands, Psychotropic Substances, Some, South Korea, Thailand, United Kingdom, United Nations, United States
related to Pharmacodynamics · 15
Amphetamine → As, Ca2, CaMKII, DAT, Depending, II, January, NET, Once, PKA, PKC, Ras, RhoA, SERT, The
related to Contraindications · 14
Amphetamine → According, Chemical Safety, Drug Administration, Due, Evidence, FDA, Food, International Programme, IPCS, It, MAOIs, Raynaud's, These, Tourette
related to Drug interactions · 13
Amphetamine → Acidic, ADHD, CYP2D6, Due, FMO3, H2, In, Inhibitors, Many, MAOIs, Norepinephrine, NRIs, Zinc
related to Recreational · 13
Amphetamine → Andrew Wilson, Chronic, Dextroamphetamine, Dextroamphetamine's, Dr, Immediate-release, Injection, Large, Manchester's Twisted Wheel, Mods, Newspaper, Recreational, UK
related to Detection in body fluids · 12
Amphetamine → Chiral, Chromatographic, EMIT, For, Gas, GC, Hence, Mosher's, MS, Several, Techniques, These
related to Physical · 10
Amphetamine → Cardiovascular, Dangerous, Gastrointestinal, If, In, Other, Raynaud's, Sexual, The, This
related to Synthesis · 10
Amphetamine → Chiral, Cleavage, For, In, Leuckart, N-formylamphetamine, Schiff, Since, The, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects dextroamphetamine dopamine also use doses drug therapeutic lisdexamfetamine may monoamine used adhd treatment addiction taar1 brain norepinephrine symptoms high

Amphetamine relationships Subject–Predicate–Object triples

TTTA extracted 303 structured relationships around Amphetamine. Examples in this analysis include Amphetamine → 3D model (JSmol) → Interactive image and Amphetamine → Addiction liability → Moderate. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Amphetamine3D model (JSmol)Interactive image1.00infobox
AmphetamineAddiction liabilityModerate1.00infobox
AmphetamineAHFS/Drugs.comMonograph1.00infobox
AmphetamineATC codeN06BA01 (WHO) N06BA02 (WHO) N06BA12 (WHO)1.00infobox
AmphetamineBioavailabilityOral: ~90%1.00infobox
AmphetamineBoiling point203 °C (397 °F) at 760 mmHg1.00infobox
AmphetamineCAS Number300-62-9 Y1.00infobox
AmphetamineChEBICHEBI:2679 Y1.00infobox
AmphetamineChEMBLChEMBL405 Y1.00infobox
AmphetamineChemSpider13852819 Y1.00infobox
AmphetamineChiralityRacemic mixture1.00infobox
AmphetamineCompTox Dashboard (EPA)DTXSID40226001.00infobox
AmphetamineDensity.936 g/cm3 at 25 °C1.00infobox
AmphetamineDependence liabilityPhysical: None Psychological: Moderate1.00infobox
AmphetamineDrug classStimulant; anorectic; norepinephrine-dopamine releasing agent1.00infobox
AmphetamineDrugBankDB00182 Y1.00infobox
AmphetamineDuration of actionIR dosing: 3–6 hours XR dosing: 8–12 hours1.00infobox
AmphetamineECHA InfoCard100.005.5431.00infobox
AmphetamineElimination half-lifeD-amph: 9–11 hours L-amph: 11–14 hours pH-dependent: 7–34 hours1.00infobox
AmphetamineExcretionPrimarily renal; pH-dependent range: 1–75%1.00infobox
AmphetamineFormulaC9H13N1.00infobox
AmphetamineIUPHAR/BPS48041.00infobox
AmphetamineKEGGD07445 Y1.00infobox
AmphetamineLegal statusAU: S8 (Controlled drug)1.00infobox
AmphetamineLegal statusBR: Class A3 (Psychoactive drugs)1.00infobox
AmphetamineLegal statusCA: Schedule I1.00infobox
AmphetamineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
AmphetamineLegal statusNZ: Class B1.00infobox
AmphetamineLegal statusUK: Class B1.00infobox
AmphetamineLegal statusUS: Schedule II1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Amphetamine bring nearby vocabulary together. In this analysis, examples include Also, Effects and Doses. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Amphetamine
    • Also
    • Effects
    • Doses
    • Drug
    • Use
    • Dopamine
    • May
    • Used
    • Therapeutic
    • Increase
    • Addiction
    • High
  • amphetamine
    • Also
    • Effects
    • Doses
    • Drug
    • Use
    • Dopamine
    • May
    • Used
    • Therapeutic
    • Increase
    • Addiction
    • High
  • stimulant
    • Use
    • Recreational
    • Treatment
    • Used
    • Symptoms
    • Narcolepsy
    • Medical
    • Effects
    • Norepinephrine
    • Addiction
    • Review
    • Lisdexamfetamine
  • lisdexamfetamine
    • Dextroamphetamine
    • Cognitive
    • Treatment
    • Narcolepsy
    • Medical
    • Stimulant
    • Effect
    • Review
    • Effects
    • Used
    • May
    • Therapeutic
  • cognitive enhancer
    • Effect
    • Therapeutic
    • Dextroamphetamine
    • Lisdexamfetamine
    • Medical
    • Dopaminergic
    • May
    • Doses
    • Treatment
    • Used
    • Dopamine
    • Narcolepsy
  • prescription drug
    • Use
    • Recreational
    • May
    • Symptoms
    • Effects
    • Δfosb
    • Used
    • Ph
    • Addiction
    • High
    • Dextroamphetamine
    • Treatment
  • dextroamphetamine
    • Lisdexamfetamine
    • Dopaminergic
    • Treatment
    • Narcolepsy
    • Recreational
    • Effects
    • Drug
    • High
    • Taar1
    • Used
    • May
    • Therapeutic
  • pharmaceutical amphetamine
    • Also
    • Effects
    • Doses
    • Drug
    • Use
    • Dopamine
    • May
    • Used
    • Therapeutic
    • Increase
    • Addiction
    • High

Connections between topic areas Semantic bridges

For Amphetamine, one of the stronger structural bridges in this analysis connects Amphetamine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Amphetamine — Overview · splits 322 ⟂ 271
Amphetamine — Pharmacology · splits 490 ⟂ 103
Amphetamine — Chemistry · splits 522 ⟂ 71
Amphetamine — Adverse effects · splits 552 ⟂ 41
Amphetamine — History, society, and culture · splits 565 ⟂ 28
Amphetamine — Drug interactions · splits 570 ⟂ 23
Amphetamine — Uses · splits 572 ⟂ 21
Amphetamine — Contraindications · splits 573 ⟂ 20
Amphetamine — Overdose · splits 579 ⟂ 14

Map overview Semantic statistics

Amphetamine

Nodes593
Edges592
Triples303
Avg. degree2
Density0.003373
Components1

Source & methodology

TTTA analyzes the structure around Amphetamine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Amphetamine · EN edition · Analysis: TopicsToTalkAbout

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