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Dopamine receptor D1: Ligands, Tissue distribution & Protein–protein interactions

Dopamine receptor D1, also known as DRD1, is one of the two types of D1-like receptor family—receptors D1 and D5. It is a protein that in humans is encoded by the DRD1 gene.

Language: English [EN]
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Dopamine receptor D1 topic overview

The analysis highlights Ligands, Tissue distribution and Protein–protein interactions as prominent areas in the source structure around Dopamine receptor D1.

Related topics
114
Source areas
6
Connected nodes
120
Extracted relationships
163
Concept neighborhoods
26
Bridge connections
120

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 36 topics
Ligands · 32 topics
Tissue distribution · 17 topics
Protein–protein interactions · 13 topics
Function · 8 topics
Structure · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DRD1, dopamine receptor D1, DADR, DRD1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OZ5
Band
5q35.2 · 13 B1|13 28.4 cM
Bgee
caudate nucleus · nucleus accumbens · putamen · gonad · prefrontal cortex
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tissue distribution

Structure

Function

Ligands

Protein–protein interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dopamine receptor D1 connects Entity context

The extracted context around Dopamine receptor D1 shows recurring relationship patterns in the source. For example, Dopamine receptor D1 → activation of adenylate cyclase activity, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adult walking behavior, associative learning, astrocyte development, behavioral fear response, behavioral response to cocaine, cell projection, cellular response to catecholamine stimulus, cellular response to dopamine, cerebral cortex GABAergic interneuron migration, ciliary membrane, cilium, conditioned taste aversion, dendrite, dendritic spine, dentate gyrus development, dopamine binding, dopamine metabolic process Another extracted example is Dopamine receptor D1 → amygdala, anterior cingulate cortex, Brodmann area 46, Brodmann area 9, caudate nucleus, cingulate gyrus, dorsal striatum, globus pallidus, gonad, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory tubercle, prefrontal cortex, putamen, right frontal lobe, superior frontal gyrus, temporal lobe, urethra. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dopamine receptor D1

Top relations

Gene ontology · 83
Dopamine receptor D1 → activation of adenylate cyclase activity, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adult walking behavior, associative learning, astrocyte development, behavioral fear response, behavioral response to cocaine, cell projection, cellular response to catecholamine stimulus, cellular response to dopamine, cerebral cortex GABAergic interneuron migration, ciliary membrane, cilium, conditioned taste aversion, dendrite, dendritic spine, dentate gyrus development, dopamine binding, dopamine metabolic process
Bgee · 19
Dopamine receptor D1 → amygdala, anterior cingulate cortex, Brodmann area 46, Brodmann area 9, caudate nucleus, cingulate gyrus, dorsal striatum, globus pallidus, gonad, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory tubercle, prefrontal cortex, putamen, right frontal lobe, superior frontal gyrus, temporal lobe, urethra
RNA expression pattern · 19
Dopamine receptor D1 → amygdala, anterior cingulate cortex, Brodmann area 46, Brodmann area 9, caudate nucleus, cingulate gyrus, dorsal striatum, globus pallidus, gonad, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory tubercle, prefrontal cortex, putamen, right frontal lobe, superior frontal gyrus, temporal lobe, urethra
related to Structure · 16
Dopamine receptor D1 → Agonist, Cryo-EM, D1, D1R, G-protein, Gs-coupled GPCR, Gαs, Interactions, S1985, S1995, S2025, The, TM, TM5, TM6, X-ray
related to Protein–protein interactions · 3
Dopamine receptor D1 → COPG2COPGDNAJC14, D1, Dopamine
Band · 2
Dopamine receptor D1 → 13 B1|13 28.4 cM, 5q35.2
Chr. · 2
Dopamine receptor D1 → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Dopamine receptor D1 → 175,444,182 bp, 54,209,724 bp
Aliases · 1
Dopamine receptor D1 → DRD1, dopamine receptor D1, DADR, DRD1A
Available structures · 1
Dopamine receptor D1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OZ5

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

d1 receptor dopamine receptors selective clinical agonists drd1 bp gene human d5 chr band agonist selectivity d2 d1-like also dihydrexidine

Dopamine receptor D1 relationships Subject–Predicate–Object triples

TTTA extracted 163 structured relationships around Dopamine receptor D1. Examples in this analysis include Dopamine receptor D1 → Aliases → DRD1, dopamine receptor D1, DADR, DRD1A and Dopamine receptor D1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OZ5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dopamine receptor D1AliasesDRD1, dopamine receptor D1, DADR, DRD1A1.00infobox
Dopamine receptor D1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OZ51.00infobox
Dopamine receptor D1Band5q35.21.00infobox
Dopamine receptor D1Band13 B1|13 28.4 cM1.00infobox
Dopamine receptor D1Bgeecaudate nucleus1.00infobox
Dopamine receptor D1Bgeenucleus accumbens1.00infobox
Dopamine receptor D1Bgeeputamen1.00infobox
Dopamine receptor D1Bgeegonad1.00infobox
Dopamine receptor D1Bgeeprefrontal cortex1.00infobox
Dopamine receptor D1BgeeBrodmann area 91.00infobox
Dopamine receptor D1Bgeecingulate gyrus1.00infobox
Dopamine receptor D1Bgeeanterior cingulate cortex1.00infobox
Dopamine receptor D1Bgeeright frontal lobe1.00infobox
Dopamine receptor D1BgeeBrodmann area 461.00infobox
Dopamine receptor D1Bgeedorsal striatum1.00infobox
Dopamine receptor D1Bgeeolfactory tubercle1.00infobox
Dopamine receptor D1Bgeeglobus pallidus1.00infobox
Dopamine receptor D1Bgeesuperior frontal gyrus1.00infobox
Dopamine receptor D1Bgeetemporal lobe1.00infobox
Dopamine receptor D1Bgeeamygdala1.00infobox
Dopamine receptor D1Bgeeneural layer of retina1.00infobox
Dopamine receptor D1Bgeeurethra1.00infobox
Dopamine receptor D1Bgeelumbar subsegment of spinal cord1.00infobox
Dopamine receptor D1BioGPSMore reference expression data1.00infobox
Dopamine receptor D1Chr.Chromosome 5 (human)1.00infobox
Dopamine receptor D1Chr.Chromosome 13 (mouse)1.00infobox
Dopamine receptor D1DatabasesNCBI: entry; OMA: entry1.00infobox
Dopamine receptor D1End175,444,182 bp1.00infobox
Dopamine receptor D1End54,209,724 bp1.00infobox
Dopamine receptor D1EnsemblENSG000001848451.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dopamine receptor D1 bring nearby vocabulary together. In this analysis, examples include Receptors, D1 and Dopamine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dopamine receptor D1
    • Receptors
    • D1
    • Dopamine
    • Receptor
    • D2
    • Selectivity
    • Selective
    • Also
    • D5
    • Clinically
    • Drd1
    • Used
  • dopamine receptor d1
    • Receptor
    • Receptors
    • D1
    • Dopamine
    • D2
    • Selectivity
    • Used
    • Selective
    • D5
    • Also
    • Agonists
    • Clinically
  • dopamine receptor
    • Receptors
    • D1
    • Receptor
    • D2
    • Selectivity
    • Selective
    • Also
    • D5
    • Agonists
    • Clinically
    • Drd1
    • Used
  • dopamine
    • Receptors
    • D1
    • Receptor
    • D2
    • Selectivity
    • Also
    • D5
    • Drd1
    • Used
    • Function
    • Location
    • Positive
  • dopamine receptor d2
    • Selectivity
    • Receptors
    • D1
    • Dihydrexidine
    • Receptor
    • Used
    • D2
    • Dopamine
    • Selective
    • Also
    • D5
    • Agonists
  • d2-like receptor
    • Receptors
    • Selective
    • Agonists
    • Clinically
    • Used
    • D2
    • Function
    • Positive
    • Activity
    • Antagonist
    • Human
    • Location
  • d1-like receptor
    • Clinically
    • Dihydrexidine
    • Agonist
    • D2
    • Selectivity
    • Antagonist
    • Receptors
    • Selective
    • Humans
    • Agonists
    • Used
    • Receptor
  • histamine h3 receptor
    • Receptors
    • Selective
    • Agonists
    • Clinically
    • Used
    • D2
    • Function
    • Positive
    • Activity
    • Antagonist
    • Human
    • Location

Connections between topic areas Semantic bridges

For Dopamine receptor D1, one of the stronger structural bridges in this analysis connects Dopamine receptor D1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dopamine receptor D1Overview · splits 84 ⟂ 37
Dopamine receptor D1Ligands · splits 88 ⟂ 33
Dopamine receptor D1Tissue distribution · splits 103 ⟂ 18
Dopamine receptor D1Protein–protein interactions · splits 107 ⟂ 14
Dopamine receptor D1Structure · splits 112 ⟂ 9
Dopamine receptor D1Function · splits 112 ⟂ 9

Map overview Semantic statistics

Dopamine receptor D1

Nodes121
Edges120
Triples163
Avg. degree1.98
Density0.016529
Components1

Source & methodology

TTTA analyzes the structure around Dopamine receptor D1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ligands, Tissue distribution & Protein–protein interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dopamine receptor D1 · EN edition · Analysis: TopicsToTalkAbout

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