NMDA receptor

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NMDA receptor topic overview

The analysis highlights History, Art and Measurement as prominent areas in the source structure around NMDA receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics: 300
Source areas: 10
Connected nodes: 312
Extracted relationships: 227
Related term clusters: 35
Bridge connections: 312

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 182 topics

Clinical significance · 26 topics

Ligands · 19 topics

Variants · 17 topics

Gating · 16 topics

Role in excitotoxicity · 11 topics

History · 10 topics

Receptor modulation · 9 topics

Structure · 7 topics

Mechanism of action · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore different angles and find fresh ideas to shape your next piece of content.

NMDA receptor

16Glutamate receptor · Ion channel · Neuron

6Ionotropic · Agonist · N-methyl-D-aspartate

13Psychoactive · Phencyclidine · Alcohol (drug)

5Excitotoxicity · Glutathione · NMDA receptor antagonist

21Invertebrate · Organism · Vertebrate

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Gating

Mechanism of action

Variants

Role in excitotoxicity

Ligands

Receptor modulation

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How NMDA receptor connects Entity context

The extracted context around NMDA receptor shows recurring relationship patterns in the source. For example, NMDA receptor → A-D, Activation, Allosteric, AMPA, C-terminus, Ca2, D-serine, Figure, GluN1, GluN1-linked, GluN1/GluN2, GluN2, GluN3, GRIN1, Mg2, N-terminus, Na, NMDA, The GluN1, The NMDA Another extracted example is NMDA receptor → A-B, A-D, All NMDARs, Functional NMDA, GluN1, GluN1-2A-1-2A, GluN1-2A-1-2B, GluN1-2A-3A-2A, GluN2, GluN3, Grin1-Grin3, GRIN1GluN2GluN2A, GRIN2AGluN2B, GRIN2BGluN2C, GRIN2CGluN2D, GRIN2DGluN3GluN3A, GRIN3AGluN3B, GRIN3B, NMDARs, Triheteromeric NMDARs. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Gating · 20

NMDA receptor → A-D, Activation, Allosteric, AMPA, C-terminus, Ca2, D-serine, Figure, GluN1, GluN1-linked, GluN1/GluN2, GluN2, GluN3, GRIN1, Mg2, N-terminus, Na, NMDA, The GluN1, The NMDA

related to Structure · 20

NMDA receptor → A-B, A-D, All NMDARs, Functional NMDA, GluN1, GluN1-2A-1-2A, GluN1-2A-1-2B, GluN1-2A-3A-2A, GluN2, GluN3, Grin1-Grin3, GRIN1GluN2GluN2A, GRIN2AGluN2B, GRIN2BGluN2C, GRIN2CGluN2D, GRIN2DGluN3GluN3A, GRIN3AGluN3B, GRIN3B, NMDARs, Triheteromeric NMDARs

related to Clinical significance · 18

NMDA receptor → Aberrant NMDAR, AGN-241751, AMPA, AV-101, BDNFTooltip, CERC-301, GLYX-13, Grin, JNJ-54135419, MK-0657, Mutations, NMDA, NMDAR, NMDAR-targeting, NMDARs, NRX-1074, Research, Tianeptine

related to history · 14

NMDA receptor → Alzheimer's, CNS, Extrasynaptic NMDA, Hilmar Bading, Huntington's, Jeff Watkins, N-methyl-D-aspartic, NMDA, NMDAR/TRPM4, NR2B, Parkinson's, Receptor, Synaptic NMDA, TRPM4

related to GluN2 · 12

NMDA receptor → C-terminal, GluN2, GluN2A, GluN2B, GluN2D, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NMDA, Strong, Unlike GluN1

related to Excitotoxicity in a clinical setting · 10

NMDA receptor → Alzheimer's, D-serine, Excitotoxicity, GRIN1, GRIN2B, Huntington's, NMDA, One, Treating, Treatment

related to Receptor modulation · 10

NMDA receptor → Ca2, EPSP, LTP, Magnesium, Mg2, Na, NMDA, The Ca2, The NMDA, Therefore

related to Role of differing subunits · 10

NMDA receptor → Although, Another, Despite, GluN1, GluN2A, GluN2B, NMDA, NMDAR, NMDARs, Two

related to Structure activity relationship (SAR) · 10

NMDA receptor → CH3, Figure, Memantine, NH2, NH2The, NH3, NMDA, SAR, Three-ring, Two

related to Differing cascade pathways · 9

NMDA receptor → ERK1/2, Experiments, Extrasynaptic, Jacob, Many, NMDA, NMDARs, Phosphorylation, Two

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nmda receptor receptors memantine channel subunit glutamate synaptic also glun2b glun1 activity antagonists subunits site antagonist binding cell glycine two

NMDA receptor relationships Subject–Predicate–Object triples

TTTA extracted 227 structured relationships around NMDA receptor. Examples in this analysis include NMDA receptor → is a → glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it and NMDA receptor → is a → non-specific cation channel that can allow the passage of Ca2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
NMDA receptor	is a	glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it	0.90	text
NMDA receptor	is a	non-specific cation channel that can allow the passage of Ca2	0.90	text
phencyclidine	instance of	ions.Activity of the NMDA receptor is blocked by many psychoactive drugs	0.80	text
epilepsy	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
Parkinson's	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
Alzheimer's	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
Huntington's	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
other CNS disorders.In 2002	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
it was discovered by Hilmar Bading	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
co-workers that the cellular consequences of NMDA receptor stimulation depend on the receptor's location on the neuronal cell surface	instance of	From this it was considered that NMDA receptors were associated with a variety of neurological disorders	0.80	text
learning	instance of	proteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity	0.80	text
memory	instance of	proteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity	0.80	text

Related concept clusters Related term clusters

The concept neighborhoods around NMDA receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Receptors and Channel. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

NMDA receptor
- Receptor
- Receptors
- Channel
- Antagonists
- Site
- Activity
- Synaptic
- Glutamate
- Memantine
- Glun1
- Effects
- Subunit
nmda receptor
- Receptor
- Receptors
- Antagonists
- Channel
- Site
- Memantine
- Activity
- Effects
- Synaptic
- Glutamate
- Glycine
- Antagonist
glutamate receptors
- Glycine
- Agonist
- Site
- D-serine
- Channel
- Receptor
- Synaptic
- Antagonists
- Activation
- Ion
- Block
- Extrasynaptic
ion channel
- Channel
- Ion
- Mg2
- Receptor
- Nmda
- Glutamate
- Ions
- Blocking
- Memantine
- Site
- Glycine
- Membrane
ionotropic glutamate receptors
- Glycine
- Agonist
- Site
- D-serine
- Channel
- Receptor
- Synaptic
- Antagonists
- Activation
- Ion
- Block
- Extrasynaptic
kainate receptors
- Synaptic
- Extrasynaptic
- Excitotoxicity
- Blocking
- Cell
- Subunits
- Two
- Glun2b
- Activity
- D-serine
- Memory
- Physiological
glutamate
- Glycine
- Agonist
- Site
- D-serine
- Channel
- Receptor
- Antagonists
- Activation
- Ion
- Block
- Binding
- Nmda
glycine
- D-serine
- Site
- Agonist
- Ion
- Binding
- Glun1
- Antagonists
- Receptor
- Activation
- Antagonist
- Glun2b
- Nmda

Connections between topic areas Semantic bridges

For NMDA receptor, one of the stronger structural bridges in this analysis connects NMDA receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

NMDA receptor — Overview · splits 129 ⟂ 184

NMDA receptor — Clinical significance · splits 286 ⟂ 27

NMDA receptor — Ligands · splits 293 ⟂ 20

NMDA receptor — Variants · splits 295 ⟂ 18

NMDA receptor — Gating · splits 296 ⟂ 17

NMDA receptor — Role in excitotoxicity · splits 301 ⟂ 12

NMDA receptor — History · splits 302 ⟂ 11

NMDA receptor — Receptor modulation · splits 303 ⟂ 10

NMDA receptor — Structure · splits 305 ⟂ 8

NMDA receptor — Mechanism of action · splits 308 ⟂ 5

Map overview Semantic statistics

NMDA receptor

Nodes313

Edges312

Triples227

Avg. degree1.99

Density0.00639

Components1

Source & methodology

TTTA analyzes the structure around NMDA receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Art & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NMDA receptor · EN edition · Analysis: TopicsToTalkAbout

NMDA receptor: History, Art & Measurement

NMDA receptor topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

History

Structure

Gating

Mechanism of action

Variants

Role in excitotoxicity

Ligands

Receptor modulation

Clinical significance

For the semantics nerds

Advanced semantic analysis

How NMDA receptor connects Entity context

NMDA receptor

Top relations

Important terminology

Important terminology

NMDA receptor relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

NMDA receptor

Source & methodology