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NMDA receptor: History, Art & Measurement

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR) is a glutamate receptor and a predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. Depending on its subunit composition, its ligands are glutamate and glycine…

Language: English [EN]
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NMDA receptor topic overview

The analysis highlights History, Art and Measurement as prominent areas in the source structure around NMDA receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
300
Source areas
10
Connected nodes
312
Extracted relationships
292
Concept neighborhoods
35
Bridge connections
312

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 182 topics
Clinical significance · 26 topics
Ligands · 19 topics
Variants · 17 topics
Gating · 16 topics
Role in excitotoxicity · 11 topics
History · 10 topics
Receptor modulation · 9 topics
Structure · 7 topics
Mechanism of action · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Gating

Mechanism of action

Variants

Role in excitotoxicity

Ligands

Receptor modulation

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NMDA receptor connects Entity context

The extracted context around NMDA receptor shows recurring relationship patterns in the source. For example, NMDA receptor → A-D, Activation, All, Allosteric, AMPA, C-terminus, Ca2, D-serine, Figure, GluN1, GluN1-linked, GluN1/GluN2, GluN2, GluN3, GRIN1, Mg2, N-terminus, Na, NMDA, On Another extracted example is NMDA receptor → Aberrant NMDAR, AGN-241751, AMPA, AV-101, BDNFTooltip, CERC-301, For, GLYX-13, Grin, In, JNJ-54135419, MK-0657, Mutations, NMDA, NMDAR, NMDAR-targeting, NMDARs, NRX-1074, Research, These. Use these groups to spot repeated connection types before inspecting the individual relationships.

NMDA receptor

Top relations

related to Gating · 24
NMDA receptor → A-D, Activation, All, Allosteric, AMPA, C-terminus, Ca2, D-serine, Figure, GluN1, GluN1-linked, GluN1/GluN2, GluN2, GluN3, GRIN1, Mg2, N-terminus, Na, NMDA, On
related to Clinical significance · 21
NMDA receptor → Aberrant NMDAR, AGN-241751, AMPA, AV-101, BDNFTooltip, CERC-301, For, GLYX-13, Grin, In, JNJ-54135419, MK-0657, Mutations, NMDA, NMDAR, NMDAR-targeting, NMDARs, NRX-1074, Research, These
related to Structure · 21
NMDA receptor → A-B, A-D, All NMDARs, Functional NMDA, GluN1, GluN1-2A-1-2A, GluN1-2A-1-2B, GluN1-2A-3A-2A, GluN2, GluN3, Grin1-Grin3, GRIN1GluN2GluN2A, GRIN2AGluN2B, GRIN2BGluN2C, GRIN2CGluN2D, GRIN2DGluN3GluN3A, GRIN3AGluN3B, GRIN3B, NMDARs, There
related to history · 19
NMDA receptor → Alzheimer's, CNS, Extrasynaptic NMDA, From, Hilmar Bading, Huntington's, In, Jeff Watkins, N-methyl-D-aspartic, NMDA, NMDAR/TRPM4, NR2B, Parkinson's, Receptor, Synaptic NMDA, The, These, This, TRPM4
related to GluN2 · 18
NMDA receptor → C-terminal, GluN2, GluN2A, GluN2B, GluN2D, GRIN2A, GRIN2B, GRIN2C, GRIN2D, However, In, More, NMDA, Strong, They, This, Unlike GluN1, While
related to Receptor modulation · 14
NMDA receptor → Ca2, EPSP, However, Its, LTP, Magnesium, Mg2, Na, NMDA, The, The Ca2, The NMDA, Therefore, This
related to Role of differing subunits · 14
NMDA receptor → Although, Another, Despite, GluN1, GluN2A, GluN2B, In, NMDA, NMDAR, NMDARs, Some, The, This, Two
related to Differing cascade pathways · 13
NMDA receptor → ERK1/2, Experiments, Extrasynaptic, For, In, Jacob, Many, NMDA, NMDARs, Phosphorylation, These, This, Two
related to External links · 13
NMDA receptor → But Not, Combined Gene Disruption, Discoordination Results, Media, NMDA, NMDA Receptor NR2A, NR2A, NR2C SubunitDrosophila NMDA, NR2C Subunits, Single Disruption, The Interactive Fly, Wikimedia CommonsNMDA, Wiktionary-logo-en-v2
related to Excitotoxicity in a clinical setting · 12
NMDA receptor → Alzheimer's, D-serine, Excitotoxicity, GRIN1, GRIN2B, Huntington's, Most, NMDA, One, These, Treating, Treatment

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nmda receptor receptors memantine channel subunit glutamate synaptic also glun2b glun1 activity antagonists subunits site antagonist binding cell glycine two

NMDA receptor relationships Subject–Predicate–Object triples

TTTA extracted 292 structured relationships around NMDA receptor. Examples in this analysis include NMDA receptor → is a → glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it and NMDA receptor → is a → non-specific cation channel that can allow the passage of Ca2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NMDA receptoris aglutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it0.90text
NMDA receptoris anon-specific cation channel that can allow the passage of Ca20.90text
phencyclidineinstance ofions.Activity of the NMDA receptor is blocked by many psychoactive drugs0.80text
epilepsyinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Parkinson'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Alzheimer'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
Huntington'sinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
other CNS disorders.In 2002instance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
it was discovered by Hilmar Badinginstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
co-workers that the cellular consequences of NMDA receptor stimulation depend on the receptor's location on the neuronal cell surfaceinstance ofFrom this it was considered that NMDA receptors were associated with a variety of neurological disorders0.80text
learninginstance ofproteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity0.80text
memoryinstance ofproteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels.The GluN2B subunit has been involved in modulating activity0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around NMDA receptor bring nearby vocabulary together. In this analysis, examples include Receptor, Receptors and Channel. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NMDA receptor
    • Receptor
    • Receptors
    • Channel
    • Antagonists
    • Site
    • Activity
    • Synaptic
    • Glutamate
    • Memantine
    • Glun1
    • Effects
    • Subunit
  • nmda receptor
    • Receptor
    • Receptors
    • Antagonists
    • Channel
    • Site
    • Memantine
    • Activity
    • Effects
    • Synaptic
    • Glutamate
    • Glycine
    • Antagonist
  • glutamate receptors
    • Glycine
    • Agonist
    • Site
    • D-serine
    • Channel
    • Receptor
    • Synaptic
    • Antagonists
    • Activation
    • Ion
    • Block
    • Extrasynaptic
  • ion channel
    • Channel
    • Ion
    • Mg2
    • Receptor
    • Nmda
    • Glutamate
    • Ions
    • Blocking
    • Memantine
    • Site
    • Glycine
    • Membrane
  • ionotropic glutamate receptors
    • Glycine
    • Agonist
    • Site
    • D-serine
    • Channel
    • Receptor
    • Synaptic
    • Antagonists
    • Activation
    • Ion
    • Block
    • Extrasynaptic
  • kainate receptors
    • Synaptic
    • Extrasynaptic
    • Excitotoxicity
    • Blocking
    • Cell
    • Subunits
    • Two
    • Glun2b
    • Activity
    • D-serine
    • Memory
    • Physiological
  • glutamate
    • Glycine
    • Agonist
    • Site
    • D-serine
    • Channel
    • Receptor
    • Antagonists
    • Activation
    • Ion
    • Block
    • Binding
    • Nmda
  • glycine
    • D-serine
    • Site
    • Agonist
    • Ion
    • Binding
    • Glun1
    • Antagonists
    • Receptor
    • Activation
    • Antagonist
    • Glun2b
    • Nmda

Connections between topic areas Semantic bridges

For NMDA receptor, one of the stronger structural bridges in this analysis connects NMDA receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NMDA receptor — Overview · splits 129 ⟂ 184
NMDA receptor — Clinical significance · splits 286 ⟂ 27
NMDA receptor — Ligands · splits 293 ⟂ 20
NMDA receptor — Variants · splits 295 ⟂ 18
NMDA receptor — Gating · splits 296 ⟂ 17
NMDA receptor — Role in excitotoxicity · splits 301 ⟂ 12
NMDA receptor — History · splits 302 ⟂ 11
NMDA receptor — Receptor modulation · splits 303 ⟂ 10
NMDA receptor — Structure · splits 305 ⟂ 8
NMDA receptor — Mechanism of action · splits 308 ⟂ 5

Map overview Semantic statistics

NMDA receptor

Nodes313
Edges312
Triples292
Avg. degree1.99
Density0.00639
Components1

Source & methodology

TTTA analyzes the structure around NMDA receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Art & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NMDA receptor · EN edition · Analysis: TopicsToTalkAbout

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