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Serotonin transporter: Genetics, Function & Pharmacology

The serotonin transporter (SERT or 5-HTT), also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4, is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a…

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Serotonin transporter topic overview

The analysis highlights Genetics, Function and Pharmacology as prominent areas in the source structure around Serotonin transporter.

Related topics
88
Source areas
7
Connected nodes
95
Extracted relationships
151
Concept neighborhoods
29
Bridge connections
95

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Genetics · 35 topics
Overview · 13 topics
Function · 12 topics
Neuroimaging · 12 topics
Pharmacology · 12 topics
Mechanism of action · 3 topics
Neuroimaging and genetics · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74
Band
17q11.2 · 11 B5|11 46.18 cM
Bgee
right lung · jejunal mucosa · mucosa of ileum · lower lobe of lung · placenta
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanism of action

Function

Pharmacology

Genetics

Neuroimaging

Neuroimaging and genetics

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Serotonin transporter connects Entity context

The extracted context around Serotonin transporter shows recurring relationship patterns in the source. For example, Serotonin transporter → actin filament binding, brain development, brain morphogenesis, cellular response to cGMP, cellular response to organic substance, cellular response to retinoic acid, circadian rhythm, cocaine binding, cytosol, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, ejaculation, endomembrane system, endosome, endosome membrane, focal adhesion, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane Another extracted example is Serotonin transporter → adrenal gland, blood, buccal mucosa cell, central gray substance of midbrain, dorsal tegmental nucleus, duodenum, Ileal epithelium, intestinal villus, jejunal mucosa, jejunum, lower lobe of lung, mucosa of ileum, oral cavity, placenta, right lung, set of raphe nuclei of tegmentum of midbrain, superior vestibular nucleus, upper lobe of left lung, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Serotonin transporter

Top relations

Gene ontology · 62
Serotonin transporter → actin filament binding, brain development, brain morphogenesis, cellular response to cGMP, cellular response to organic substance, cellular response to retinoic acid, circadian rhythm, cocaine binding, cytosol, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, ejaculation, endomembrane system, endosome, endosome membrane, focal adhesion, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane
Bgee · 19
Serotonin transporter → adrenal gland, blood, buccal mucosa cell, central gray substance of midbrain, dorsal tegmental nucleus, duodenum, Ileal epithelium, intestinal villus, jejunal mucosa, jejunum, lower lobe of lung, mucosa of ileum, oral cavity, placenta, right lung, set of raphe nuclei of tegmentum of midbrain, superior vestibular nucleus, upper lobe of left lung, yolk sac
RNA expression pattern · 19
Serotonin transporter → adrenal gland, blood, buccal mucosa cell, central gray substance of midbrain, dorsal tegmental nucleus, duodenum, Ileal epithelium, intestinal villus, jejunal mucosa, jejunum, lower lobe of lung, mucosa of ileum, oral cavity, placenta, right lung, set of raphe nuclei of tegmentum of midbrain, superior vestibular nucleus, upper lobe of left lung, yolk sac
related to Neuroimaging · 10
Serotonin transporter → CIT, DAPP, DASB, Healthy, Journal, Neural Transmission, Revised NEO Personality Inventory, SPECT, The, There
related to Genetics · 7
Serotonin transporter → In, Mutations, SLC6A4, Solute, Some, The, These
related to Mechanism of action · 4
Serotonin transporter → In, Right, Serotonin-reuptake, The
related to Function · 3
Serotonin transporter → Neurons, The, Thus
Band · 2
Serotonin transporter → 11 B5|11 46.18 cM, 17q11.2
Chr. · 2
Serotonin transporter → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Serotonin transporter → 30,236,002 bp, 76,923,166 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

serotonin transporter gene polymorphism 5-httlpr sert found slc6a4 binding human bp variation vntr stin2 protein 17 neurotransmitter reuptake family chr

Serotonin transporter relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around Serotonin transporter. Examples in this analysis include Serotonin transporter → Aliases → SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR and Serotonin transporter → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Serotonin transporterAliasesSLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR1.00infobox
Serotonin transporterAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I741.00infobox
Serotonin transporterBand17q11.21.00infobox
Serotonin transporterBand11 B5|11 46.18 cM1.00infobox
Serotonin transporterBgeeright lung1.00infobox
Serotonin transporterBgeejejunal mucosa1.00infobox
Serotonin transporterBgeemucosa of ileum1.00infobox
Serotonin transporterBgeelower lobe of lung1.00infobox
Serotonin transporterBgeeplacenta1.00infobox
Serotonin transporterBgeeupper lobe of left lung1.00infobox
Serotonin transporterBgeeduodenum1.00infobox
Serotonin transporterBgeebuccal mucosa cell1.00infobox
Serotonin transporterBgeesuperior vestibular nucleus1.00infobox
Serotonin transporterBgeeoral cavity1.00infobox
Serotonin transporterBgeecentral gray substance of midbrain1.00infobox
Serotonin transporterBgeedorsal tegmental nucleus1.00infobox
Serotonin transporterBgeeblood1.00infobox
Serotonin transporterBgeejejunum1.00infobox
Serotonin transporterBgeeyolk sac1.00infobox
Serotonin transporterBgeeset of raphe nuclei of tegmentum of midbrain1.00infobox
Serotonin transporterBgeeadrenal gland1.00infobox
Serotonin transporterBgeeintestinal villus1.00infobox
Serotonin transporterBgeeIleal epithelium1.00infobox
Serotonin transporterBioGPSMore reference expression data1.00infobox
Serotonin transporterChr.Chromosome 17 (human)1.00infobox
Serotonin transporterChr.Chromosome 11 (mouse)1.00infobox
Serotonin transporterDatabasesNCBI: entry; OMA: entry1.00infobox
Serotonin transporterEnd30,236,002 bp1.00infobox
Serotonin transporterEnd76,923,166 bp1.00infobox
Serotonin transporterEnsemblENSG000001085761.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Serotonin transporter bring nearby vocabulary together. In this analysis, examples include Transporter, Binding and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Serotonin transporter
    • Transporter
    • Binding
    • Protein
    • Reuptake
    • Gene
    • Sert
    • Associated
    • Studies
    • Slc6a4
    • Brain
    • Membrane
    • Variation
  • serotonin transporter
    • Transporter
    • Binding
    • Protein
    • Reuptake
    • Gene
    • Sert
    • Associated
    • Studies
    • Slc6a4
    • Membrane
    • Human
    • Brain
  • gene
    • Slc6a4
    • Location
    • Chromosome
    • Human
    • Member
    • 5-httlpr
    • Bp
    • Chr
    • Function
    • Genetic
    • Neurotransmitter
    • Serotonin
  • serotonin
    • Transporter
    • Binding
    • Protein
    • Reuptake
    • Gene
    • Sert
    • Associated
    • Studies
    • Slc6a4
    • Brain
    • Membrane
    • Function
  • transporter protein
    • Brain
    • Neurotransmitter
    • Sert
    • Slc6a4
    • Serotonin
    • Transporter
    • Sodium
    • Gene
    • Membrane
    • Associated
    • Band
    • Location
  • 5-httlpr
    • Polymorphism
    • Short
    • Allele
    • Study
    • Found
    • Gene
    • Slc6a4
    • Variation
    • Associated
    • Meta-analysis
    • Human
    • Stin2
  • serotonin reuptake inhibitors
    • Transporter
    • Tricyclic
    • Binding
    • Antidepressant
    • Sert
    • Protein
    • Reuptake
    • Serotonin
    • Gene
    • Associated
    • Studies
    • Slc6a4
  • selective serotonin reuptake inhibitor
    • Transporter
    • Tricyclic
    • Binding
    • Antidepressant
    • Sert
    • Protein
    • Reuptake
    • Serotonin
    • Gene
    • Associated
    • Studies
    • Slc6a4

Connections between topic areas Semantic bridges

For Serotonin transporter, one of the stronger structural bridges in this analysis connects Serotonin transporter with Genetics. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Serotonin transporter — Genetics · splits 60 ⟂ 36
Serotonin transporter — Overview · splits 82 ⟂ 14
Serotonin transporter — Function · splits 83 ⟂ 13
Serotonin transporter — Pharmacology · splits 83 ⟂ 13
Serotonin transporter — Neuroimaging · splits 83 ⟂ 13
Serotonin transporter — Mechanism of action · splits 92 ⟂ 4

Map overview Semantic statistics

Serotonin transporter

Nodes96
Edges95
Triples151
Avg. degree1.98
Density0.020833
Components1

Source & methodology

TTTA analyzes the structure around Serotonin transporter to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Genetics, Function & Pharmacology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Serotonin transporter · EN edition · Analysis: TopicsToTalkAbout

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