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Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to…
The analysis highlights Applications and Regions as prominent areas in the source structure around Orexin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Orexin shows recurring relationship patterns in the source. For example, Orexin → cell junction, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, eating behavior, endoplasmic reticulum, excitatory postsynaptic potential, extracellular region, feeding behavior, G protein-coupled receptor signaling pathway, negative regulation of DNA replication, negative regulation of potassium ion transport, negative regulation of transmission of nerve impulse, neuropeptide hormone activity, neuropeptide signaling pathway, perinuclear region of cytoplasm, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium ion transport, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration Another extracted example is Orexin → axial skeleton, blastocyst, caudate nucleus, cerebellum, dorsomedial hypothalamic nucleus, embryo, gonad, granulocyte, hypothalamus, lumbar spinal ganglion, meninges, morula, muscle tissue, nucleus accumbens, nucleus of stria terminalis, pancreatic ductal cell, putamen, spermatocyte, substantia nigra. Use these groups to spot repeated connection types before inspecting the individual relationships.
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neurons system sleep narcolepsy hypocretin also receptor wakefulness brain orexin-a hypothalamus human energy discovery found two gene food peptide receptors
TTTA extracted 182 structured relationships around Orexin. Examples in this analysis include Orexin → Aliases → HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1 and Orexin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Orexin | Aliases | HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1 | 1.00 | infobox |
| Orexin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02 | 1.00 | infobox |
| Orexin | Band | 17q21.2 | 1.00 | infobox |
| Orexin | Band | 11 D|11 63.6 cM | 1.00 | infobox |
| Orexin | Bgee | hypothalamus | 1.00 | infobox |
| Orexin | Bgee | pancreatic ductal cell | 1.00 | infobox |
| Orexin | Bgee | gonad | 1.00 | infobox |
| Orexin | Bgee | granulocyte | 1.00 | infobox |
| Orexin | Bgee | nucleus accumbens | 1.00 | infobox |
| Orexin | Bgee | putamen | 1.00 | infobox |
| Orexin | Bgee | caudate nucleus | 1.00 | infobox |
| Orexin | Bgee | muscle tissue | 1.00 | infobox |
| Orexin | Bgee | substantia nigra | 1.00 | infobox |
| Orexin | Bgee | cerebellum | 1.00 | infobox |
| Orexin | Bgee | dorsomedial hypothalamic nucleus | 1.00 | infobox |
| Orexin | Bgee | morula | 1.00 | infobox |
| Orexin | Bgee | nucleus of stria terminalis | 1.00 | infobox |
| Orexin | Bgee | blastocyst | 1.00 | infobox |
| Orexin | Bgee | embryo | 1.00 | infobox |
| Orexin | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| Orexin | Bgee | spermatocyte | 1.00 | infobox |
| Orexin | Bgee | axial skeleton | 1.00 | infobox |
| Orexin | Bgee | meninges | 1.00 | infobox |
| Orexin | BioGPS | n/a | 1.00 | infobox |
| Orexin | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| Orexin | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| Orexin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Orexin | End | 42,185,452 bp | 1.00 | infobox |
| Orexin | End | 100,653,757 bp | 1.00 | infobox |
| Orexin | Ensembl | ENSG00000161610 | 1.00 | infobox |
The concept neighborhoods around Orexin bring nearby vocabulary together. In this analysis, examples include System, Receptor and Neurons. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Orexin, one of the stronger structural bridges in this analysis connects Orexin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Orexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Orexin · EN edition · Analysis: TopicsToTalkAbout