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Orexin

Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to…

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Aliases
HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02
Band
17q21.2 · 11 D|11 63.6 cM
Bgee
hypothalamus · pancreatic ductal cell · gonad · granulocyte · nucleus accumbens
BioGPS
n/a
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Discovery

Isoforms

Function

Orexin neurons

Orexin system dysfunction

Clinical uses

Evolution

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Map overview Semantic statistics

Orexin

Nodes119
Edges118
Triples217
Avg. degree1.98
Density0.016807
Components1

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Orexin

Top relations

Gene ontology · 34
Orexin → cell junction, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, eating behavior, endoplasmic reticulum, excitatory postsynaptic potential, extracellular region, feeding behavior, G protein-coupled receptor signaling pathway, negative regulation of DNA replication, negative regulation of potassium ion transport, negative regulation of transmission of nerve impulse, neuropeptide hormone activity, neuropeptide signaling pathway, perinuclear region of cytoplasm, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium ion transport, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration
related to Discovery · 24
Orexin → Breakthrough Prize, Dallas, DNA, Emmanuel Mignot, In, Lecea, Luis, Masashi Yanagisawa, Masashi Yanagisawa's, Neurotransmitters, One, OX1, OX1R, OX2, OX2R, Scripps Research Institute, Takeshi Sakurai, Texas Southwestern Medical Center, The, Their
Bgee · 19
Orexin → axial skeleton, blastocyst, caudate nucleus, cerebellum, dorsomedial hypothalamic nucleus, embryo, gonad, granulocyte, hypothalamus, lumbar spinal ganglion, meninges, morula, muscle tissue, nucleus accumbens, nucleus of stria terminalis, pancreatic ductal cell, putamen, spermatocyte, substantia nigra
RNA expression pattern · 19
Orexin → axial skeleton, blastocyst, caudate nucleus, cerebellum, dorsomedial hypothalamic nucleus, embryo, gonad, granulocyte, hypothalamus, lumbar spinal ganglion, meninges, morula, muscle tissue, nucleus accumbens, nucleus of stria terminalis, pancreatic ductal cell, putamen, spermatocyte, substantia nigra
related to Clinical uses · 10
Orexin → Belsomra, Dayvigo, Drug Administration, FDA, FDA-approved, III, Quviviq, Suvorexant, The, US Food
related to Food intake · 10
Orexin → Ghrelin, However, In, Leptin, Orexin-producing, Other, Review, Sleep, Such, To
related to Isoforms · 10
Orexin → Although, G-protein, HRCT, Orexin-A, OX1, OX2, The, There, They, This
related to Wakefulness · 10
Orexin → Doberman Pinschers, Dogs, Genetic, Narcolepsy, Organisms, REM, Researchers, Studies, The, Transitioning
related to Neurotransmitters · 9
Orexin → A1, CB1, Group III, HT1A, M3, Orexinergic, OX1, The, These
related to Lipid metabolism · 8
Orexin → It, L1, LY294002, Orexin-A, OXA, PI3K, The, These

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Important terminology

neurons system sleep narcolepsy hypocretin also receptor wakefulness brain orexin-a hypothalamus human energy discovery found two gene food peptide receptors

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
OrexinAliasesHCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP11.00infobox
OrexinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R021.00infobox
OrexinBand17q21.21.00infobox
OrexinBand11 D|11 63.6 cM1.00infobox
OrexinBgeehypothalamus1.00infobox
OrexinBgeepancreatic ductal cell1.00infobox
OrexinBgeegonad1.00infobox
OrexinBgeegranulocyte1.00infobox
OrexinBgeenucleus accumbens1.00infobox
OrexinBgeeputamen1.00infobox
OrexinBgeecaudate nucleus1.00infobox
OrexinBgeemuscle tissue1.00infobox
OrexinBgeesubstantia nigra1.00infobox
OrexinBgeecerebellum1.00infobox
OrexinBgeedorsomedial hypothalamic nucleus1.00infobox
OrexinBgeemorula1.00infobox
OrexinBgeenucleus of stria terminalis1.00infobox
OrexinBgeeblastocyst1.00infobox
OrexinBgeeembryo1.00infobox
OrexinBgeelumbar spinal ganglion1.00infobox
OrexinBgeespermatocyte1.00infobox
OrexinBgeeaxial skeleton1.00infobox
OrexinBgeemeninges1.00infobox
OrexinBioGPSn/a1.00infobox
OrexinChr.Chromosome 17 (human)1.00infobox
OrexinChr.Chromosome 11 (mouse)1.00infobox
OrexinDatabasesNCBI: entry; OMA: entry1.00infobox
OrexinEnd42,185,452 bp1.00infobox
OrexinEnd100,653,757 bp1.00infobox
OrexinEnsemblENSG000001616101.00infobox

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