Orexin

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Orexin topic overview

The analysis highlights Applications and Regions as prominent areas in the source structure around Orexin.

Related topics: 110
Source areas: 8
Connected nodes: 118
Extracted relationships: 217
Concept neighborhoods: 41
Bridge connections: 118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 45 topics

Overview · 18 topics

Orexin neurons · 14 topics

Discovery · 11 topics

Isoforms · 10 topics

Clinical uses · 7 topics

Orexin system dysfunction · 4 topics

Evolution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02
Band: 17q21.2 · 11 D|11 63.6 cM
Bgee: hypothalamus · pancreatic ductal cell · gonad · granulocyte · nucleus accumbens
BioGPS: n/a
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Isoforms

Orexin-B
Amino acid
Pre-pro-peptide
Chromosome 17
Disulfide bonds Disulfide bond
Hypothalamus
G-protein coupled G-protein coupled receptor
Orexin receptors Orexin receptor
OX1 Hypocretin (orexin) receptor 1
OX2 Hypocretin (orexin) receptor 2

Function

Orexin neurons

Metabotropic glutamate receptors
Cannabinoid receptor 1
Receptor heterodimers GPCR oligomer
Adenosine A1 receptors Adenosine A1 receptor
Muscarinic M3 receptors Muscarinic acetylcholine receptor M3
5-HT1A receptors 5-HT1A receptor
Neuropeptide Y
Cholecystokinin A receptors Cholecystokinin A receptor
Catecholamines
Serotonin
Noradrenaline
Conditioned place preference
Ventral tegmental area
Ventromedial prefrontal cortex

Orexin system dysfunction

Takotsubo syndrome Takotsubo cardiomyopathy
ADHD
Developmental coordination disorder
Autism spectrum disorder

Clinical uses

Evolution

Vertebrates Vertebrate

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Orexin connects Entity context

The extracted context around Orexin shows recurring relationship patterns in the source. For example, Orexin → cell junction, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, eating behavior, endoplasmic reticulum, excitatory postsynaptic potential, extracellular region, feeding behavior, G protein-coupled receptor signaling pathway, negative regulation of DNA replication, negative regulation of potassium ion transport, negative regulation of transmission of nerve impulse, neuropeptide hormone activity, neuropeptide signaling pathway, perinuclear region of cytoplasm, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium ion transport, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration Another extracted example is Orexin → Breakthrough Prize, Dallas, DNA, Emmanuel Mignot, In, Lecea, Luis, Masashi Yanagisawa, Masashi Yanagisawa's, Neurotransmitters, One, OX1, OX1R, OX2, OX2R, Scripps Research Institute, Takeshi Sakurai, Texas Southwestern Medical Center, The, Their. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 34

Orexin → cell junction, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, eating behavior, endoplasmic reticulum, excitatory postsynaptic potential, extracellular region, feeding behavior, G protein-coupled receptor signaling pathway, negative regulation of DNA replication, negative regulation of potassium ion transport, negative regulation of transmission of nerve impulse, neuropeptide hormone activity, neuropeptide signaling pathway, perinuclear region of cytoplasm, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium ion transport, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration

related to Discovery · 24

Orexin → Breakthrough Prize, Dallas, DNA, Emmanuel Mignot, In, Lecea, Luis, Masashi Yanagisawa, Masashi Yanagisawa's, Neurotransmitters, One, OX1, OX1R, OX2, OX2R, Scripps Research Institute, Takeshi Sakurai, Texas Southwestern Medical Center, The, Their

Bgee · 19

Orexin → axial skeleton, blastocyst, caudate nucleus, cerebellum, dorsomedial hypothalamic nucleus, embryo, gonad, granulocyte, hypothalamus, lumbar spinal ganglion, meninges, morula, muscle tissue, nucleus accumbens, nucleus of stria terminalis, pancreatic ductal cell, putamen, spermatocyte, substantia nigra

RNA expression pattern · 19

related to Clinical uses · 10

Orexin → Belsomra, Dayvigo, Drug Administration, FDA, FDA-approved, III, Quviviq, Suvorexant, The, US Food

related to Food intake · 10

Orexin → Ghrelin, However, In, Leptin, Orexin-producing, Other, Review, Sleep, Such, To

related to Isoforms · 10

Orexin → Although, G-protein, HRCT, Orexin-A, OX1, OX2, The, There, They, This

related to Wakefulness · 10

Orexin → Doberman Pinschers, Dogs, Genetic, Narcolepsy, Organisms, REM, Researchers, Studies, The, Transitioning

related to Neurotransmitters · 9

Orexin → A1, CB1, Group III, HT1A, M3, Orexinergic, OX1, The, These

related to Lipid metabolism · 8

Orexin → It, L1, LY294002, Orexin-A, OXA, PI3K, The, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

neurons system sleep narcolepsy hypocretin also receptor wakefulness brain orexin-a hypothalamus human energy discovery found two gene food peptide receptors

Orexin relationships Subject–Predicate–Object triples

TTTA extracted 217 structured relationships around Orexin. Examples in this analysis include Orexin → Aliases → HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1 and Orexin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Orexin	Aliases	HCRT, OX, PPOX, hypocretin neuropeptide precursor, NRCLP1	1.00	infobox
Orexin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CQ0, 1WSO, 1UVQ, 1R02	1.00	infobox
Orexin	Band	17q21.2	1.00	infobox
Orexin	Band	11 D\|11 63.6 cM	1.00	infobox
Orexin	Bgee	hypothalamus	1.00	infobox
Orexin	Bgee	pancreatic ductal cell	1.00	infobox
Orexin	Bgee	gonad	1.00	infobox
Orexin	Bgee	granulocyte	1.00	infobox
Orexin	Bgee	nucleus accumbens	1.00	infobox
Orexin	Bgee	putamen	1.00	infobox
Orexin	Bgee	caudate nucleus	1.00	infobox
Orexin	Bgee	muscle tissue	1.00	infobox
Orexin	Bgee	substantia nigra	1.00	infobox
Orexin	Bgee	cerebellum	1.00	infobox
Orexin	Bgee	dorsomedial hypothalamic nucleus	1.00	infobox
Orexin	Bgee	morula	1.00	infobox
Orexin	Bgee	nucleus of stria terminalis	1.00	infobox
Orexin	Bgee	blastocyst	1.00	infobox
Orexin	Bgee	embryo	1.00	infobox
Orexin	Bgee	lumbar spinal ganglion	1.00	infobox
Orexin	Bgee	spermatocyte	1.00	infobox
Orexin	Bgee	axial skeleton	1.00	infobox
Orexin	Bgee	meninges	1.00	infobox
Orexin	BioGPS	n/a	1.00	infobox
Orexin	Chr.	Chromosome 17 (human)	1.00	infobox
Orexin	Chr.	Chromosome 11 (mouse)	1.00	infobox
Orexin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Orexin	End	42,185,452 bp	1.00	infobox
Orexin	End	100,653,757 bp	1.00	infobox
Orexin	Ensembl	ENSG00000161610	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Orexin bring nearby vocabulary together. In this analysis, examples include System, Receptor and Neurons. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Orexin
- System
- Receptor
- Neurons
- Sleep
- Receptors
- Narcolepsy
- Food
- Brain
- Addiction
- Function
- Peptide
- Two
orexin
- System
- Receptor
- Neurons
- Sleep
- Receptors
- Narcolepsy
- Food
- Brain
- Addiction
- Function
- Peptide
- Two
wakefulness
- Neuropeptide
- Function
- Sleep
- Energy
- Neurons
- Hypocretin
- Narcolepsy
- Orexin
- Hcrt
- Bp
- Chr
- Chromosome
orexin receptor type 1
- System
- Discovery
- Receptors
- Receptor
- Neurons
- Sleep
- Two
- Narcolepsy
- Food
- Brain
- Addiction
- Function
orexin receptor type 2
- System
- Discovery
- Receptors
- Receptor
- Neurons
- Sleep
- Two
- Narcolepsy
- Food
- Brain
- Addiction
- Function
orexin receptors
- System
- Receptor
- Neurons
- Sleep
- Two
- Receptors
- Narcolepsy
- Food
- Brain
- Addiction
- Function
- Orexin-b
human leukocyte antigen
- Bp
- Chr
- Chromosome
- Band
- Gene
- Hcrt
- Neuropeptide
- Potential
- Function
- Discovery
- Hypothalamus
- Hypocretin
orexin antagonist
- System
- Receptor
- Neurons
- Sleep
- Receptors
- Narcolepsy
- Food
- Brain
- Addiction
- Function
- Peptide
- Two

Connections between topic areas Semantic bridges

For Orexin, one of the stronger structural bridges in this analysis connects Orexin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Orexin — Function · splits 73 ⟂ 46

Orexin — Overview · splits 100 ⟂ 19

Orexin — Orexin neurons · splits 104 ⟂ 15

Orexin — Discovery · splits 107 ⟂ 12

Orexin — Isoforms · splits 108 ⟂ 11

Orexin — Clinical uses · splits 111 ⟂ 8

Orexin — Orexin system dysfunction · splits 114 ⟂ 5

Map overview Semantic statistics

Orexin

Nodes119

Edges118

Triples217

Avg. degree1.98

Density0.016807

Components1

Source & methodology

TTTA analyzes the structure around Orexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Orexin · EN edition · Analysis: TopicsToTalkAbout