Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Dopamine receptor D2: Ligands, Genetics & Protein–protein interactions

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Dopamine receptor D2 topic overview

The analysis highlights Ligands, Genetics and Protein–protein interactions as prominent areas in the source structure around Dopamine receptor D2.

Related topics
128
Source areas
7
Connected nodes
135
Extracted relationships
221
Concept neighborhoods
28
Bridge connections
135

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligands · 64 topics
Genetics · 15 topics
Protein–protein interactions · 15 topics
Function · 12 topics
Overview · 10 topics
Active and inactive forms · 7 topics
Isoforms · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DRD2, D2DR, D2R, dopamine receptor D2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4
Band
11q23.2 · 9 A5.3|9 26.72 cM
Bgee
putamen · nucleus accumbens · testicle · pituitary gland · caudate nucleus
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Isoforms

Active and inactive forms

Genetics

Ligands

Protein–protein interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dopamine receptor D2 connects Entity context

The extracted context around Dopamine receptor D2 shows recurring relationship patterns in the source. For example, Dopamine receptor D2 → acid secretion, acrosomal vesicle, activation of protein kinase activity, adenohypophysis development, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor activity, adrenergic receptor signaling pathway, adult behavior, adult walking behavior, arachidonic acid secretion, associative learning, auditory behavior, autophagy, axon, axon terminus, axonogenesis, behavioral response to cocaine, behavioral response to ethanol Another extracted example is Dopamine receptor D2 → ankle joint, anterior pituitary, caudate nucleus, dorsal striatum, embryo, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory epithelium, olfactory tubercle, pars compacta, pars reticulata, pituitary gland, putamen, striatum of neuraxis, superior frontal gyrus, testicle, triceps brachii muscle, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dopamine receptor D2

Top relations

Gene ontology · 144
Dopamine receptor D2 → acid secretion, acrosomal vesicle, activation of protein kinase activity, adenohypophysis development, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor activity, adrenergic receptor signaling pathway, adult behavior, adult walking behavior, arachidonic acid secretion, associative learning, auditory behavior, autophagy, axon, axon terminus, axonogenesis, behavioral response to cocaine, behavioral response to ethanol
Bgee · 19
Dopamine receptor D2 → ankle joint, anterior pituitary, caudate nucleus, dorsal striatum, embryo, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory epithelium, olfactory tubercle, pars compacta, pars reticulata, pituitary gland, putamen, striatum of neuraxis, superior frontal gyrus, testicle, triceps brachii muscle, ventral tegmental area
RNA expression pattern · 19
Dopamine receptor D2 → ankle joint, anterior pituitary, caudate nucleus, dorsal striatum, embryo, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory epithelium, olfactory tubercle, pars compacta, pars reticulata, pituitary gland, putamen, striatum of neuraxis, superior frontal gyrus, testicle, triceps brachii muscle, ventral tegmental area
related to Protein–protein interactions · 5
Dopamine receptor D2 → D2, EPB41L1, NCS-1, PPP1R9B, The
Band · 2
Dopamine receptor D2 → 11q23.2, 9 A5.3|9 26.72 cM
Chr. · 2
Dopamine receptor D2 → Chromosome 11 (human), Chromosome 9 (mouse)
End · 2
Dopamine receptor D2 → 113,475,691 bp, 49,319,477 bp
Aliases · 1
Dopamine receptor D2 → DRD2, D2DR, D2R, dopamine receptor D2
Available structures · 1
Dopamine receptor D2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4
BioGPS · 1
Dopamine receptor D2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dopamine d2 receptor d2r agonist also antipsychotic antagonist receptors gene drd2 bp form selective chr protein human band ligands active

Dopamine receptor D2 relationships Subject–Predicate–Object triples

TTTA extracted 221 structured relationships around Dopamine receptor D2. Examples in this analysis include Dopamine receptor D2 → Aliases → DRD2, D2DR, D2R, dopamine receptor D2 and Dopamine receptor D2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dopamine receptor D2AliasesDRD2, D2DR, D2R, dopamine receptor D21.00infobox
Dopamine receptor D2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM41.00infobox
Dopamine receptor D2Band11q23.21.00infobox
Dopamine receptor D2Band9 A5.3|9 26.72 cM1.00infobox
Dopamine receptor D2Bgeeputamen1.00infobox
Dopamine receptor D2Bgeenucleus accumbens1.00infobox
Dopamine receptor D2Bgeetesticle1.00infobox
Dopamine receptor D2Bgeepituitary gland1.00infobox
Dopamine receptor D2Bgeecaudate nucleus1.00infobox
Dopamine receptor D2Bgeeanterior pituitary1.00infobox
Dopamine receptor D2Bgeetriceps brachii muscle1.00infobox
Dopamine receptor D2Bgeepars compacta1.00infobox
Dopamine receptor D2Bgeepars reticulata1.00infobox
Dopamine receptor D2Bgeeventral tegmental area1.00infobox
Dopamine receptor D2Bgeesuperior frontal gyrus1.00infobox
Dopamine receptor D2Bgeestriatum of neuraxis1.00infobox
Dopamine receptor D2Bgeedorsal striatum1.00infobox
Dopamine receptor D2Bgeeolfactory epithelium1.00infobox
Dopamine receptor D2Bgeelumbar subsegment of spinal cord1.00infobox
Dopamine receptor D2Bgeeneural layer of retina1.00infobox
Dopamine receptor D2Bgeeolfactory tubercle1.00infobox
Dopamine receptor D2Bgeeembryo1.00infobox
Dopamine receptor D2Bgeeankle joint1.00infobox
Dopamine receptor D2BioGPSMore reference expression data1.00infobox
Dopamine receptor D2Chr.Chromosome 11 (human)1.00infobox
Dopamine receptor D2Chr.Chromosome 9 (mouse)1.00infobox
Dopamine receptor D2DatabasesNCBI: entry; OMA: entry1.00infobox
Dopamine receptor D2End113,475,691 bp1.00infobox
Dopamine receptor D2End49,319,477 bp1.00infobox
Dopamine receptor D2EnsemblENSG000001492951.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dopamine receptor D2 bring nearby vocabulary together. In this analysis, examples include D2, Dopamine and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dopamine receptor D2
    • D2
    • Dopamine
    • Receptor
    • Receptors
    • Also
    • Antipsychotic
    • Selective
    • Drugs
    • Protein
    • Binding
    • Drd2
    • Gene
  • dopamine receptor d2
    • D2
    • Dopamine
    • Receptor
    • Selective
    • Receptors
    • Also
    • Protein-coupled
    • Agonists
    • Antipsychotic
    • Partial
    • Agonist
    • Drugs
  • dopamine receptors
    • D2
    • Receptor
    • Receptors
    • Selective
    • Also
    • Antagonist
    • Antipsychotic
    • Agonist
    • Drugs
    • Protein
    • Binding
    • Drd2
  • dopamine
    • D2
    • Receptor
    • Receptors
    • Also
    • Antipsychotic
    • Selective
    • Drugs
    • Protein
    • Binding
    • Drd2
    • Gene
    • Location
  • binding affinities
    • Domain
    • Ligands
    • Inactive
    • D2r
    • Receptors
    • Receptor
    • Dopamine
    • Drugs
    • Location
    • Synaptic
    • Chromosome
    • Cytoplasmic
  • allosteric modulator
    • Agonists
    • Negative
    • Selective
    • D2r
    • Location
    • Chromosome
    • Human
    • Protein
    • Bp
    • Chr
    • Ligands
    • Partial
  • d1–d2 dopamine receptor heteromer
    • D2
    • Dopamine
    • Receptor
    • Selective
    • Receptors
    • Also
    • Protein-coupled
    • Agonists
    • Antipsychotic
    • Partial
    • Agonist
    • Drugs
  • active and inactive forms
    • Inactive
    • Agonist
    • Antagonist
    • Full
    • Structure
    • Ligands
    • Studies
    • Binding
    • D2r
    • Location
    • Agonists
    • Allosteric

Connections between topic areas Semantic bridges

For Dopamine receptor D2, one of the stronger structural bridges in this analysis connects Dopamine receptor D2 with Ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dopamine receptor D2 — Ligands · splits 71 ⟂ 65
Dopamine receptor D2 — Genetics · splits 120 ⟂ 16
Dopamine receptor D2 — Protein–protein interactions · splits 120 ⟂ 16
Dopamine receptor D2 — Function · splits 123 ⟂ 13
Dopamine receptor D2 — Overview · splits 125 ⟂ 11
Dopamine receptor D2 — Active and inactive forms · splits 128 ⟂ 8
Dopamine receptor D2 — Isoforms · splits 130 ⟂ 6

Map overview Semantic statistics

Dopamine receptor D2

Nodes136
Edges135
Triples221
Avg. degree1.99
Density0.014706
Components1

Source & methodology

TTTA analyzes the structure around Dopamine receptor D2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Ligands, Genetics & Protein–protein interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dopamine receptor D2 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.