Find related topics. | Discover entities. | See connections. | Build a topical map.
Building topical map: Starting…
EHMT2: Function, EHMT2 in cancer & Interactions
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a deposits the mono- and di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and H3K27me2). The presence of H3K9me1/2 is usually…
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
EHMT2 topic overview
The analysis highlights Function, EHMT2 in cancer and Interactions as prominent areas in the source structure around EHMT2.
Related topics
27
Source areas
4
Connected nodes
31
Extracted relationships
98
Concept neighborhoods
17
Bridge connections
31
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 11 topics
Overview · 9 topics
EHMT2 in cancer · 5 topics
Interactions · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8J, 3DM1, 3K5K, 3RJW, 4NVQ, 5JJ0, 5JHN, 5JIN
Band
6p21.33 · 17 B1|17 18.45 cM
Bgee
nucleus accumbens · ganglionic eminence · putamen · ventricular zone · right frontal lobe
BioGPS
More reference expression data
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How EHMT2 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around EHMT2 shows recurring relationship patterns in the source. For example, EHMT2 → C2H2 zinc finger domain binding, cellular response to starvation, chromatin organization, chromosome, DNA methylation, histone H3-K27 methylation, histone H3-K9 methylation, histone lysine methylation, histone methylation, histone methyltransferase activity (H3-K27 specific), histone methyltransferase activity (H3-K9 specific), histone-lysine N-methyltransferase activity, metal ion binding, methylation, methyltransferase activity, negative regulation of G0 to G1 transition, negative regulation of transcription by RNA polymerase II, nuclear speck, nucleoplasm, nucleus Another extracted example is EHMT2 → amygdala, anterior cingulate cortex, caudate nucleus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, Gonadal ridge, nucleus accumbens, perirhinal cortex, primary visual cortex, putamen, right frontal lobe, right hemisphere of cerebellum, seminiferous tubule, spermatid, spermatocyte, superior frontal gyrus, temporal lobe, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
EHMT2
Top relations
Gene ontology· 29
EHMT2 → C2H2 zinc finger domain binding, cellular response to starvation, chromatin organization, chromosome, DNA methylation, histone H3-K27 methylation, histone H3-K9 methylation, histone lysine methylation, histone methylation, histone methyltransferase activity (H3-K27 specific), histone methyltransferase activity (H3-K9 specific), histone-lysine N-methyltransferase activity, metal ion binding, methylation, methyltransferase activity, negative regulation of G0 to G1 transition, negative regulation of transcription by RNA polymerase II, nuclear speck, nucleoplasm, nucleus
Bgee· 19
EHMT2 → amygdala, anterior cingulate cortex, caudate nucleus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, Gonadal ridge, nucleus accumbens, perirhinal cortex, primary visual cortex, putamen, right frontal lobe, right hemisphere of cerebellum, seminiferous tubule, spermatid, spermatocyte, superior frontal gyrus, temporal lobe, ventricular zone
RNA expression pattern· 19
EHMT2 → amygdala, anterior cingulate cortex, caudate nucleus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, ganglionic eminence, Gonadal ridge, nucleus accumbens, perirhinal cortex, primary visual cortex, putamen, right frontal lobe, right hemisphere of cerebellum, seminiferous tubule, spermatid, spermatocyte, superior frontal gyrus, temporal lobe, ventricular zone
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 98 structured relationships around EHMT2. Examples in this analysis include EHMT2 → 2.1.1.367 → ↗ and EHMT2 → Aliases → EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O8J, 3DM1, 3K5K, 3RJW, 4NVQ, 5JJ0, 5JHN, 5JIN
1.00
infobox
EHMT2
Band
6p21.33
1.00
infobox
EHMT2
Band
17 B1|17 18.45 cM
1.00
infobox
EHMT2
Bgee
nucleus accumbens
1.00
infobox
EHMT2
Bgee
ganglionic eminence
1.00
infobox
EHMT2
Bgee
putamen
1.00
infobox
EHMT2
Bgee
ventricular zone
1.00
infobox
EHMT2
Bgee
right frontal lobe
1.00
infobox
EHMT2
Bgee
right hemisphere of cerebellum
1.00
infobox
EHMT2
Bgee
caudate nucleus
1.00
infobox
EHMT2
Bgee
temporal lobe
1.00
infobox
EHMT2
Bgee
amygdala
1.00
infobox
EHMT2
Bgee
anterior cingulate cortex
1.00
infobox
EHMT2
Bgee
Gonadal ridge
1.00
infobox
EHMT2
Bgee
spermatid
1.00
infobox
EHMT2
Bgee
entorhinal cortex
1.00
infobox
EHMT2
Bgee
seminiferous tubule
1.00
infobox
EHMT2
Bgee
perirhinal cortex
1.00
infobox
EHMT2
Bgee
spermatocyte
1.00
infobox
EHMT2
Bgee
superior frontal gyrus
1.00
infobox
EHMT2
Bgee
dentate gyrus of hippocampal formation granule cell
1.00
infobox
EHMT2
Bgee
primary visual cortex
1.00
infobox
EHMT2
BioGPS
More reference expression data
1.00
infobox
EHMT2
Chr.
Chromosome 6 (human)
1.00
infobox
EHMT2
Chr.
Chromosome 17 (mouse)
1.00
infobox
EHMT2
Databases
NCBI: entry; OMA: entry
1.00
infobox
EHMT2
End
31,897,687 bp
1.00
infobox
EHMT2
End
35,133,028 bp
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around EHMT2 bring nearby vocabulary together. In this analysis, examples include Cancer, Methyltransferase and Histone. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
EHMT2
Cancer
Methyltransferase
Histone
Activity
Enzyme
Euchromatic
Known
Search
Associated
Function
Histone-lysine
Location
ehmt2
Cancer
Methyltransferase
Histone
Activity
Enzyme
Euchromatic
Known
Search
Associated
Function
Histone-lysine
Location
histone methyltransferase
Lysine
Methyltransferase
Activity
Search
Function
Location
N-methyltransferase
Chromosome
Histone-lysine
Bp
Chr
Human
gene
Location
Methyltransferase
Chromosome
Histone
Bp
Chr
Human
Activity
B1
End
Mouse
Search
histone h3
Lysine
Methyltransferase
Activity
Search
Function
Histone-lysine
Location
N-methyltransferase
Chromosome
Bp
Chr
Human
gene silencing
Location
Methyltransferase
Chromosome
Histone
Bp
Chr
Human
Activity
B1
End
Mouse
Search
nucleus accumbens
Nucleus
Development
Expression
Function
G9a
Activity
B1
End
Mouse
Search
Histone-lysine
Location
function
Activity
Search
Location
Lysine
Methyltransferase
Accumbens
Chromosome
Histone
Nucleus
Bp
Chr
Human
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For EHMT2, one of the stronger structural bridges in this analysis connects EHMT2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
EHMT2
Nodes32
Edges31
Triples98
Avg. degree1.94
Density0.0625
Components1
Source & methodology
TTTA analyzes the structure around EHMT2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, EHMT2 in cancer & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — EHMT2 · EN edition · Analysis: TopicsToTalkAbout
For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.
