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CYP2D6

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

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Aliases
CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ
Band
22q13.2 · 15|15 E1
Bgee
right lobe of liver · duodenum · sural nerve · right hemisphere of cerebellum · right uterine tube
BioGPS
More reference expression data
Chr.
Chromosome 22 (human) · Chromosome 15 (mouse)

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Overview

Gene

Genotype/phenotype variability

Genetic basis of variability

Ethnic factors in variability

Ligands

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CYP2D6

Nodes59
Edges58
Triples144
Avg. degree1.97
Density0.033898
Components1

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CYP2D6

Top relations

Gene ontology · 31
CYP2D6 → alkaloid catabolic process, alkaloid metabolic process, arachidonic acid metabolic process, aromatase activity, coumarin metabolic process, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, heme binding, heterocycle metabolic process, intracellular membrane-bounded organelle, iron ion binding, isoquinoline alkaloid metabolic process, lipid metabolism, long-chain fatty acid biosynthetic process, membrane, metal ion binding, mitochondrion, monooxygenase activity, monoterpenoid metabolic process
Bgee · 20
CYP2D6 → anterior pituitary, cerebellar cortex, duodenum, extraocular muscle, left lobe of liver, left lobe of thyroid gland, lumbar subsegment of spinal cord, muscle of thigh, neural layer of retina, nucleus accumbens, pituitary gland, primary visual cortex, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, right uterine tube, sciatic nerve, superior frontal gyrus, sural nerve, vestibular membrane of cochlear duct
RNA expression pattern · 20
CYP2D6 → anterior pituitary, cerebellar cortex, duodenum, extraocular muscle, left lobe of liver, left lobe of thyroid gland, lumbar subsegment of spinal cord, muscle of thigh, neural layer of retina, nucleus accumbens, pituitary gland, primary visual cortex, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, right uterine tube, sciatic nerve, superior frontal gyrus, sural nerve, vestibular membrane of cochlear duct
related to External links · 15
CYP2D6 → Annotated PGx Gene Information, CYP2D6Human CYP2D6, CYP2D6Pharmvar Gene, Cytochrome P450, February, Flockhart Lab Cyp2D6 Substrates, IUPUIPharmGKB, Overview, P10635, Page Archived, PDB, PDBe-KB, UCSC Genome Browser, UniProt, Wayback Machine
related to Ethnic factors in variability · 12
CYP2D6 → African Americans, As, Asian, Asians, Caucasians, Ethiopia, Ethnicity, European, In Ethiopia, Middle Eastern, North African, The
related to Gene · 8
CYP2D6 → Alternatively, Among, Catarrhine, CYP2D7P, CYP2D8P, New World, P450, The
related to Genotype/phenotype variability · 5
CYP2D6 → CYPs, However, Pharmacogenomic, The, The CYP2D6
related to Genetic basis of variability · 4
CYP2D6 → Pharmacogenomic, PharmVar, Subjects, The
related to Ligands · 3
CYP2D6 → Following, Inhibitors, Where
Band · 2
CYP2D6 → 15|15 E1, 22q13.2

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Important terminology

may gene enzyme ultrarapid drugs function human metabolism metabolized bp substrates one cytochrome chromosome drug also allele p450 chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CYP2D6AliasesCYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D61.00infobox
CYP2D6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ1.00infobox
CYP2D6Band22q13.21.00infobox
CYP2D6Band15|15 E11.00infobox
CYP2D6Bgeeright lobe of liver1.00infobox
CYP2D6Bgeeduodenum1.00infobox
CYP2D6Bgeesural nerve1.00infobox
CYP2D6Bgeeright hemisphere of cerebellum1.00infobox
CYP2D6Bgeeright uterine tube1.00infobox
CYP2D6Bgeepituitary gland1.00infobox
CYP2D6Bgeeright lobe of thyroid gland1.00infobox
CYP2D6Bgeeleft lobe of thyroid gland1.00infobox
CYP2D6Bgeenucleus accumbens1.00infobox
CYP2D6Bgeeanterior pituitary1.00infobox
CYP2D6Bgeeleft lobe of liver1.00infobox
CYP2D6Bgeeextraocular muscle1.00infobox
CYP2D6Bgeecerebellar cortex1.00infobox
CYP2D6Bgeesciatic nerve1.00infobox
CYP2D6Bgeelumbar subsegment of spinal cord1.00infobox
CYP2D6Bgeesuperior frontal gyrus1.00infobox
CYP2D6Bgeeprimary visual cortex1.00infobox
CYP2D6Bgeevestibular membrane of cochlear duct1.00infobox
CYP2D6Bgeeneural layer of retina1.00infobox
CYP2D6Bgeemuscle of thigh1.00infobox
CYP2D6BioGPSMore reference expression data1.00infobox
CYP2D6Chr.Chromosome 22 (human)1.00infobox
CYP2D6Chr.Chromosome 15 (mouse)1.00infobox
CYP2D6DatabasesNCBI: entry; OMA: entry1.00infobox
CYP2D6End42,130,865 bp1.00infobox
CYP2D6End82,264,461 bp1.00infobox

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