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Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.
The analysis highlights Overview, Ethnic factors in variability and Gene as prominent areas in the source structure around CYP2D6.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CYP2D6 shows recurring relationship patterns in the source. For example, CYP2D6 → alkaloid catabolic process, alkaloid metabolic process, arachidonic acid metabolic process, aromatase activity, coumarin metabolic process, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, heme binding, heterocycle metabolic process, intracellular membrane-bounded organelle, iron ion binding, isoquinoline alkaloid metabolic process, lipid metabolism, long-chain fatty acid biosynthetic process, membrane, metal ion binding, mitochondrion, monooxygenase activity, monoterpenoid metabolic process Another extracted example is CYP2D6 → anterior pituitary, cerebellar cortex, duodenum, extraocular muscle, left lobe of liver, left lobe of thyroid gland, lumbar subsegment of spinal cord, muscle of thigh, neural layer of retina, nucleus accumbens, pituitary gland, primary visual cortex, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, right uterine tube, sciatic nerve, superior frontal gyrus, sural nerve, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
may gene enzyme ultrarapid drugs function human metabolism metabolized bp substrates one cytochrome chromosome drug also allele p450 chr band
TTTA extracted 144 structured relationships around CYP2D6. Examples in this analysis include CYP2D6 → Aliases → CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6 and CYP2D6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CYP2D6 | Aliases | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6 | 1.00 | infobox |
| CYP2D6 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ | 1.00 | infobox |
| CYP2D6 | Band | 22q13.2 | 1.00 | infobox |
| CYP2D6 | Band | 15|15 E1 | 1.00 | infobox |
| CYP2D6 | Bgee | right lobe of liver | 1.00 | infobox |
| CYP2D6 | Bgee | duodenum | 1.00 | infobox |
| CYP2D6 | Bgee | sural nerve | 1.00 | infobox |
| CYP2D6 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| CYP2D6 | Bgee | right uterine tube | 1.00 | infobox |
| CYP2D6 | Bgee | pituitary gland | 1.00 | infobox |
| CYP2D6 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| CYP2D6 | Bgee | left lobe of thyroid gland | 1.00 | infobox |
| CYP2D6 | Bgee | nucleus accumbens | 1.00 | infobox |
| CYP2D6 | Bgee | anterior pituitary | 1.00 | infobox |
| CYP2D6 | Bgee | left lobe of liver | 1.00 | infobox |
| CYP2D6 | Bgee | extraocular muscle | 1.00 | infobox |
| CYP2D6 | Bgee | cerebellar cortex | 1.00 | infobox |
| CYP2D6 | Bgee | sciatic nerve | 1.00 | infobox |
| CYP2D6 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| CYP2D6 | Bgee | superior frontal gyrus | 1.00 | infobox |
| CYP2D6 | Bgee | primary visual cortex | 1.00 | infobox |
| CYP2D6 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| CYP2D6 | Bgee | neural layer of retina | 1.00 | infobox |
| CYP2D6 | Bgee | muscle of thigh | 1.00 | infobox |
| CYP2D6 | BioGPS | More reference expression data | 1.00 | infobox |
| CYP2D6 | Chr. | Chromosome 22 (human) | 1.00 | infobox |
| CYP2D6 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| CYP2D6 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CYP2D6 | End | 42,130,865 bp | 1.00 | infobox |
| CYP2D6 | End | 82,264,461 bp | 1.00 | infobox |
The concept neighborhoods around CYP2D6 bring nearby vocabulary together. In this analysis, examples include Function, One and Allele. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CYP2D6, one of the stronger structural bridges in this analysis connects CYP2D6 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CYP2D6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Ethnic factors in variability & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CYP2D6 · EN edition · Analysis: TopicsToTalkAbout