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Baclofen

Baclofen, sold under the brand name Lioresal among others, is a central nervous system (CNS) depressant and derivative of the inhibitory neurotransmitter, gamma-Aminobutyric acid (GABA). Baclofen is a potent GABAB receptor agonist, antispasmodic, and skeletal muscle relaxant used to treat chronic muscle spasms and muscle spasticity, such as from a spinal…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M03BX01 (WHO)
Bioavailability
Well-absorbed
CAS Number
1134-47-0
ChEBI
CHEBI:2972

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Overview

Medical uses

Adverse effects

Overdose

Pharmacology

History

Society and culture

Research

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Map overview Semantic statistics

Baclofen

Nodes112
Edges111
Triples82
Avg. degree1.98
Density0.017857
Components1

How this topic connects Entity context

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Baclofen

Top relations

related to history · 12
Baclofen → Ciba-Geigy, Drug Administration, FDA, Heinrich Keberle, Historically, In, Intrathecal, It, Its, Swiss, This, US Food
related to Research · 10
Baclofen → ANSM, Charcot, CMT, Evidence, French, In, It, Marie, Marketing Authorization, Tooth
related to Withdrawal · 6
Baclofen → Abrupt, Acute, Discontinuation, The, Thus, Withdrawal
Legal status · 5
Baclofen → AU: S4 (Prescription only), CA: ℞-only, NZ: Prescription only, UK: POM (Prescription only), US: ℞-only
related to Pharmacodynamics · 5
Baclofen → Agonism, Baclofen's, For, GABAB, GHB
related to Medical uses · 3
Baclofen → Intrathecal, Parkinson's, Use
related to Overdose · 3
Baclofen → Overdose, Reports, Symptoms
related to Pharmacokinetics · 3
Baclofen → Biotransformation, It, The
is a · 2
Baclofen → effective medication for the treatment of severe, potent GABAB receptor agonist
related to Routes of administration · 2
Baclofen → At, Intrathecal

Important terminology Word statistics

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Important terminology

use effects alcohol may withdrawal spasticity symptoms used spinal also intrathecal administration drug doses gabab seizures treatment side receptor dizziness

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Baclofen3D model (JSmol)Interactive image1.00infobox
BaclofenAHFS/Drugs.comMonograph1.00infobox
BaclofenATC codeM03BX01 (WHO)1.00infobox
BaclofenBioavailabilityWell-absorbed1.00infobox
BaclofenCAS Number1134-47-01.00infobox
BaclofenChEBICHEBI:29721.00infobox
BaclofenChEMBLChEMBL7011.00infobox
BaclofenChemSpider21971.00infobox
BaclofenChiralityRacemic mixture1.00infobox
BaclofenCompTox Dashboard (EPA)DTXSID50226411.00infobox
BaclofenDependence liabilityModerate–high1.00infobox
BaclofenDrug classGABAB receptor agonist, antispasmodic1.00infobox
BaclofenDrugBankDB001811.00infobox
BaclofenECHA InfoCard100.013.1701.00infobox
BaclofenElimination half-life2.5–7 hours1.00infobox
BaclofenExcretionKidney (70–80%)1.00infobox
BaclofenFormulaC10H12ClNO21.00infobox
BaclofenIUPHAR/BPS10841.00infobox
BaclofenKEGGD002411.00infobox
BaclofenLegal statusAU: S4 (Prescription only)1.00infobox
BaclofenLegal statusCA: ℞-only1.00infobox
BaclofenLegal statusNZ: Prescription only1.00infobox
BaclofenLegal statusUK: POM (Prescription only)1.00infobox
BaclofenLegal statusUS: ℞-only1.00infobox
BaclofenLicense dataUS DailyMed: Baclofen1.00infobox
BaclofenMedlinePlusa6825301.00infobox
BaclofenMetabolism85% excreted in urine/faeces unchanged. 15% metabolised by deamination1.00infobox
BaclofenMetabolitesβ-(p-chlorophenyl)-4-hydroxybutyric acid (γ-hydroxybaclofen)1.00infobox
BaclofenMolar mass213.66 g·mol−11.00infobox
BaclofenOther namesBaclophen, β-(4-chlorophenyl)-γ-aminobutyric acid, β-(4-chlorophenyl)-GABA1.00infobox

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