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Tyramine

Tyramine (/ˈtaɪrəmiːn/ TY-rə-meen) (also spelled tyramin), also known under several other names, is a naturally occurring trace amine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent. Notably, it is unable to cross the blood-brain barrier, resulting in only non-psychoactive peripheral sympathomimetic effects…

Occurrence, Biological activity & Overview

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3D model (JSmol)
Interactive image
ATC code
none
Boiling point
206 °C (403 °F) at 25 mmHg; 166 °C at 2 mmHg
CAS Number
51-67-2 Y
ChEBI
CHEBI:15760 Y
ChEMBL
ChEMBL11608 Y

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Overview

Occurrence

Biological activity

Biosynthesis

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Map overview Semantic statistics

Tyramine

Nodes101
Edges100
Triples60
Avg. degree1.98
Density0.019802
Components1

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Tyramine

Top relations

related to In animals · 15
Tyramine → Agrotis, Anopheles, Apis, Bombyx, Caenorhabditis, Chilo, Drosophila, Heliothis, In, Locusta, Mamestra, Papilio, Periplaneta, Phormia, Rhipicephalus
related to Biological activity · 13
Tyramine → Additionally, CYP2D6, DBH, Evidence, FMO3, Human, If, MAO-A, MAOIs, NDRA, PNMT, TAAR1, The TAAR1
related to Biosynthesis · 5
Tyramine → Biochemically, N-dimethyltyramine, N-methyltyramine, N-trimethyltyramine, TyramineN-MethyltyramineN
related to Occurrence · 3
Tyramine → Foods, In, Specific
3D model (JSmol) · 1
Tyramine → Interactive image
ATC code · 1
Tyramine → none
Boiling point · 1
Tyramine → 206 °C (403 °F) at 25 mmHg; 166 °C at 2 mmHg
CAS Number · 1
Tyramine → 51-67-2 Y
ChEBI · 1
Tyramine → CHEBI:15760 Y
ChEMBL · 1
Tyramine → ChEMBL11608 Y

Important terminology Word statistics

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Important terminology

monoamine norepinephrine foods oxidase tyrosine dopamine including also inhibitors ingestion octopamine found sympathomimetic activity response migraine crisis trace releasing agent

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tyramine3D model (JSmol)Interactive image1.00infobox
TyramineATC codenone1.00infobox
TyramineBoiling point206 °C (403 °F) at 25 mmHg; 166 °C at 2 mmHg1.00infobox
TyramineCAS Number51-67-2 Y1.00infobox
TyramineChEBICHEBI:15760 Y1.00infobox
TyramineChEMBLChEMBL11608 Y1.00infobox
TyramineChemSpider5408 Y1.00infobox
TyramineCompTox Dashboard (EPA)DTXSID20438741.00infobox
TyramineDensity1.103 g/cm3 predicted1.00infobox
TyramineDrug classSympathomimetic; Trace amine-associated receptor 1 agonist; Norepinephrine-dopamine releasing agent; Monoaminergic activity enhancer1.00infobox
TyramineECHA InfoCard100.000.1061.00infobox
TyramineFormulaC8H11NO1.00infobox
TyramineIUPHAR/BPS21501.00infobox
TyramineKEGGC00483 Y1.00infobox
TyramineMelting point164.5 °C (328.1 °F)1.00infobox
TyramineMetabolismCYP2D6, flavin-containing monooxygenase 3, monoamine oxidase A, monoamine oxidase B, phenylethanolamine N-methyltransferase, dopamine β-hydroxylase, others1.00infobox
TyramineMetabolites4-Hydroxyphenylacetaldehyde, dopamine, N-methyltyramine, octopamine1.00infobox
TyramineMolar mass137.182 g·mol−11.00infobox
TyramineOther namesTyramin; 4-Hydroxyphenethylamine; para-Tyramine; p-Tyramine; 4-Tyramine; Mydrial; Uteramin1.00infobox
TyraminePronunciation/ˈtaɪrəmiːn/ TY-rə-meen1.00infobox
TyraminePubChem CID56101.00infobox
TyramineUNIIX8ZC7V0OX31.00infobox
Tyramineis afull agonist of the TAAR1 in rodents and humans.Tyramine is physiologically metabolized by monoamine oxidases0.90text

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