G protein-coupled receptor

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G protein-coupled receptor topic overview

The analysis highlights History, Classification and Physiological roles as prominent areas in the source structure around G protein-coupled receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics: 303
Source areas: 12
Connected nodes: 316
Extracted relationships: 146
Concept neighborhoods: 65
Bridge connections: 316

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 73 topics

Mechanism · 53 topics

Physiological roles · 36 topics

Receptor regulation · 35 topics

Classification · 30 topics

Signaling · 22 topics

Structure–function relationships · 22 topics

Receptor structure · 10 topics

History and significance · 7 topics

Origin and diversification of the superfamily · 7 topics

Details of cAMP and PIP2 pathways · 6 topics

Receptor oligomerization · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold: IPR000276 · PF00001
Available protein structures:: IPR000276 · PF00001
CDD: cd14964
ECOD: 5001.1.1
InterPro: IPR000276
OPM protein: 1gzm

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Group of evolutionarily related proteins Protein family
Cell surface receptors Cell surface receptor
Molecules Molecule
Cell Cell (biology)
G protein
Cell membrane
Ligand
N-terminal N-terminus
C-terminal
Amino acid residues Amino acid residue
Rhodopsin
Agonists Agonist
Eukaryotes Eukaryote
Yeast
Choanoflagellates Choanoflagellate
Ligands Ligand (biochemistry)
Odors Odor
Pheromones Pheromone
Hormones Hormone
Neurotransmitters Neurotransmitter
Peptides Peptide
Proteins Protein
CAMP Cyclic adenosine monophosphate
Phosphatidylinositol
GEFs Guanine nucleotide exchange factor
GDP Guanosine diphosphate
GTP Guanosine triphosphate
Gαs Gs alpha subunit
Gαi/o Gi alpha subunit
Gαq/11 Gq alpha subunit
Gα12/13 G12/G13 alpha subunits
Cyclic-adenosine monophosphate Cyclic amp
Adenylate cyclase Adenylyl cyclase
Tissue Tissue (biology)
Catalyze
Cytosolic
Adenosine triphosphate
Ion channels Cyclic nucleotide-gated ion channel
Ser/thr-specific Serine/threonine-specific protein kinase
Protein kinase A
Second messenger Second messenger system
Effector Effector (biology)
Phospholipase C-β Phospholipase C
Phosphatidylinositol 4,5-bisphosphate
Inositol (1,4,5) trisphosphate Inositol trisphosphate
Diacylglycerol Diglyceride
IP3 receptors Inositol trisphosphate receptor
Endoplasmic reticulum
Ca2+
Plasma membrane
Protein kinase C
Allosterically
Calmodulins Calmodulin
Small GTPase
Rho Rho family of GTPases
Cytoskeleton
Rho-kinase Rho-associated protein kinase
Gβγ G beta-gamma complex
G-protein-regulated inwardly rectifying K+ channels G protein-coupled inwardly-rectifying potassium channel
N-type N-type calcium channel
Voltage-gated Ca2+ channels Voltage-dependent calcium channel
Phosphoinositide-3-kinase PI3K
ERK2 MAPK1
Slime mold
D. discoideum Dictyostelium discoideum
Bradykinin receptor B2
ITIM Immunoreceptor tyrosine-based inhibitory motif
Integrins
Receptor tyrosine kinases
Cytokine receptors
JAK/STATs JAK-STAT signaling pathway
Guanine-nucleotide dissociation inhibitors Guanosine nucleotide dissociation inhibitors
Protein phosphatases

History and significance

Crystal structure
Cryogenic electron microscopy
Nobel Prize in Chemistry
Brian Kobilka
Robert Lefkowitz
Advair Diskus Fluticasone propionate/salmeterol
Abilify Aripiprazole

Classification

Human
Genes
Protein-coding Protein biosynthesis
Genome
Sequence analysis
Sequence homology
Olfactory receptors Olfactory receptor
Endogenous
Compounds Chemical compound
Orphan receptors Orphan receptor
Structure Protein tertiary structure
Signal transduction
Rhodopsin-like Rhodopsin-like receptors
Class A Class A GPCR
Class B Class B GPCR
Secretin receptor family
Class C Class C GPCR
Glutamate Metabotropic glutamate receptor
Class D Class D GPCR?action=edit&redlink=1
Fungal mating pheromone receptors
Class E Class E GPCR?action=edit&redlink=1
Cyclic AMP receptors
Class F Class F GPCR?action=edit&redlink=1
Frizzled
Smoothened
GRAFS
Adhesion Adhesion G protein-coupled receptor
Taste2 Taste receptor
Secretin Secretin receptor
Pseudo amino acid composition

Receptor oligomerization

Origin and diversification of the superfamily

Multicellularity Multicellular organism
Fungi
Eukaryotic
Dictyostelium
Opisthokonts Opisthokont
Nematodes Nematode
Pfam

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How G protein-coupled receptor connects Entity context

The extracted context around G protein-coupled receptor shows recurring relationship patterns in the source. For example, G protein-coupled receptor → Application, April, Archived, August, Basic, Biology Network Center, British Journal, Clinical Pharmacology, Data, Edinburgh, February, G-protein, G-protein-coupled, GPCR, GPCR Cell Line Archived, GPCR-I-TASSER, GPCRdb, GPCRs, Harpsøe, Hauser AS Another extracted example is G protein-coupled receptor → America, April, Archived, August, Bibcode, Chemistry, GPCR Reference Library, Hohmann JG, Li, Mortrud MT, National Academy, October, PDF, PMC, PMID, Proceedings, Ranchalis JE, Reference, Retrieved, Sciences. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to External links · 51

G protein-coupled receptor → Application, April, Archived, August, Basic, Biology Network Center, British Journal, Clinical Pharmacology, Data, Edinburgh, February, G-protein, G-protein-coupled, GPCR, GPCR Cell Line Archived, GPCR-I-TASSER, GPCRdb, GPCRs, Harpsøe, Hauser AS

related to Further reading · 25

G protein-coupled receptor → America, April, Archived, August, Bibcode, Chemistry, GPCR Reference Library, Hohmann JG, Li, Mortrud MT, National Academy, October, PDF, PMC, PMID, Proceedings, Ranchalis JE, Reference, Retrieved, Sciences

related to Physiological roles · 24

G protein-coupled receptor → Adrenergic, AMPAR, Autonomic, Behavioral, Both, Cell, GABA, GABAA, GCPRs, GPCR, GPCRs, Homeostasis, HT3, Involved, NMDAR, Notable, Receptors, Regulation, Rhodopsin, Some

related to Phosphorylation by GRKs · 9

G protein-coupled receptor → Activity, G-protein-coupled, GPCR, GPCRs, GRKs, GRKs-mediated, Phosphorylation, The, They

related to Mechanism · 5

G protein-coupled receptor → Further, GTPase, RGS, The, This

see also · 5

G protein-coupled receptor → D12, GPCRsReceptor, GPCRsTOG, MeSH, Metabotropic

AlphaFold · 2

G protein-coupled receptor → IPR000276, PF00001

Available protein structures: · 2

G protein-coupled receptor → IPR000276, PF00001

CDD · 1

G protein-coupled receptor → cd14964

ECOD · 1

G protein-coupled receptor → 5001.1.1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor proteins gpcrs receptors gpcr protein also may signaling signal membrane structure g-protein camp ligand activated binding protein-coupled phosphorylation kinase

G protein-coupled receptor relationships Subject–Predicate–Object triples

TTTA extracted 146 structured relationships around G protein-coupled receptor. Examples in this analysis include G protein-coupled receptor → AlphaFold → IPR000276 and G protein-coupled receptor → AlphaFold → PF00001. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
G protein-coupled receptor	AlphaFold	IPR000276	1.00	infobox
G protein-coupled receptor	AlphaFold	PF00001	1.00	infobox
G protein-coupled receptor	Available protein structures:	IPR000276	1.00	infobox
G protein-coupled receptor	Available protein structures:	PF00001	1.00	infobox
G protein-coupled receptor	CDD	cd14964	1.00	infobox
G protein-coupled receptor	ECOD	5001.1.1	1.00	infobox
G protein-coupled receptor	InterPro	IPR000276	1.00	infobox
G protein-coupled receptor	OPM protein	1gzm	1.00	infobox
G protein-coupled receptor	OPM superfamily	6	1.00	infobox
G protein-coupled receptor	PDB	IPR000276 PF00001 (ECOD; PDBsum)	1.00	infobox
G protein-coupled receptor	Pfam	PF00001	1.00	infobox
G protein-coupled receptor	Pfam clan	CL0192	1.00	infobox
G protein-coupled receptor	PROSITE	PDOC00210	1.00	infobox
G protein-coupled receptor	Symbol	7tm_1	1.00	infobox
G protein-coupled receptor	TCDB	9.A.14	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around G protein-coupled receptor bring nearby vocabulary together. In this analysis, examples include Receptors, Phosphorylation and Activation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

G protein-coupled receptor
- Receptors
- Phosphorylation
- Activation
- May
- Gpcrs
- Cell
- Two
- Domain
- Ligand
- Receptor
- Activated
- Subunits
g protein-coupled receptor
- Receptors
- Protein
- G-protein
- Signal
- Phosphorylation
- Activation
- Signaling
- May
- Gpcrs
- Cell
- Two
- Domain
group of evolutionarily related proteins
- Signaling
- May
- Receptors
- Intracellular
- G-protein
- Protein
- Bound
- Signal
- Gtp
- Subunits
- Called
- Binding
cell surface receptors
- Membrane
- Receptors
- Bind
- Molecules
- Pathway
- Extracellular
- Protein-coupled
- Receptor
- Signal
- Ligand
- Called
- Rhodopsin
cell
- Membrane
- Receptors
- Bind
- Molecules
- Pathway
- Extracellular
- Protein-coupled
- Ligand
- G-protein
- Gpcrs
- Gtp
- Ligands
cell membrane
- Membrane
- Called
- Molecules
- Receptor
- Receptors
- Two
- Bind
- Pathway
- Extracellular
- Protein-coupled
- Ligand
- Signal
ligand
- Binding
- Activated
- Structure
- Change
- Rhodopsin
- Gpcr
- Receptor
- Called
- Molecules
- Signaling
- Phosphorylation
- Pathways
proteins
- Signaling
- May
- Receptors
- Intracellular
- G-protein
- Protein
- Bound
- Signal
- Gtp
- Subunits
- Called
- Binding

Connections between topic areas Semantic bridges

For G protein-coupled receptor, one of the stronger structural bridges in this analysis connects G protein-coupled receptor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

G protein-coupled receptor — Overview · splits 243 ⟂ 74

G protein-coupled receptor — Mechanism · splits 263 ⟂ 54

G protein-coupled receptor — Physiological roles · splits 280 ⟂ 37

G protein-coupled receptor — Receptor regulation · splits 281 ⟂ 36

G protein-coupled receptor — Classification · splits 286 ⟂ 31

G protein-coupled receptor — Structure–function relationships · splits 294 ⟂ 23

G protein-coupled receptor — Signaling · splits 294 ⟂ 23

G protein-coupled receptor — Receptor structure · splits 306 ⟂ 11

G protein-coupled receptor — History and significance · splits 309 ⟂ 8

G protein-coupled receptor — Origin and diversification of the superfamily · splits 309 ⟂ 8

G protein-coupled receptor — Details of cAMP and PIP2 pathways · splits 310 ⟂ 7

G protein-coupled receptor — Receptor oligomerization · splits 313 ⟂ 4

Map overview Semantic statistics

G protein-coupled receptor

Nodes317

Edges316

Triples146

Avg. degree1.99

Density0.006309

Components1

Source & methodology

TTTA analyzes the structure around G protein-coupled receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Classification & Physiological roles, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — G protein-coupled receptor · EN edition · Analysis: TopicsToTalkAbout