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Dopamine transporter: Geography, Location and distribution & Genetics and regulation

The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.…

Language: English [EN]
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Dopamine transporter topic overview

The analysis highlights Geography, Location and distribution and Genetics and regulation as prominent areas in the source structure around Dopamine transporter.

Related topics
195
Source areas
10
Connected nodes
205
Extracted relationships
173
Concept neighborhoods
38
Bridge connections
205

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 69 topics
Ligands and modulators · 36 topics
Genetics and regulation · 22 topics
Location and distribution · 20 topics
Mechanism · 19 topics
Biological role and disorders · 9 topics
Interactions · 7 topics
Pharmacology · 6 topics
Protein structure · 6 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
Band
5p15.33 · 13 C1|13 40.1 cM
Bgee
substantia nigra · testicle · gonad · left lobe of thyroid gland · right ovary
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Mechanism

Protein structure

Location and distribution

Genetics and regulation

Biological role and disorders

Pharmacology

Interactions

Ligands and modulators

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dopamine transporter connects Entity context

The extracted context around Dopamine transporter shows recurring relationship patterns in the source. For example, Dopamine transporter → adenohypophysis development, ageing, axon, cell surface, cytoplasm, dopamine binding, dopamine biosynthetic process, dopamine catabolic process, dopamine transport, dopamine uptake, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, dopaminergic synapse, flotillin complex, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, lactation, locomotory behavior Another extracted example is Dopamine transporter → arcuate nucleus, body of uterus, canal of the cervix, central gray substance of midbrain, embryo, epithelium of lens, epithelium of small intestine, gonad, hypothalamus, left lobe of thyroid gland, left ovary, olfactory bulb, renal cortex, right lobe of thyroid gland, right ovary, substantia nigra, suprachiasmatic nucleus, testicle, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dopamine transporter

Top relations

Gene ontology · 51
Dopamine transporter → adenohypophysis development, ageing, axon, cell surface, cytoplasm, dopamine binding, dopamine biosynthetic process, dopamine catabolic process, dopamine transport, dopamine uptake, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, dopaminergic synapse, flotillin complex, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, lactation, locomotory behavior
Bgee · 19
Dopamine transporter → arcuate nucleus, body of uterus, canal of the cervix, central gray substance of midbrain, embryo, epithelium of lens, epithelium of small intestine, gonad, hypothalamus, left lobe of thyroid gland, left ovary, olfactory bulb, renal cortex, right lobe of thyroid gland, right ovary, substantia nigra, suprachiasmatic nucleus, testicle, ventral tegmental area
RNA expression pattern · 19
Dopamine transporter → arcuate nucleus, body of uterus, canal of the cervix, central gray substance of midbrain, embryo, epithelium of lens, epithelium of small intestine, gonad, hypothalamus, left lobe of thyroid gland, left ovary, olfactory bulb, renal cortex, right lobe of thyroid gland, right ovary, substantia nigra, suprachiasmatic nucleus, testicle, ventral tegmental area
related to External links · 16
Dopamine transporter → Associations, Clinical TrialsDopamine, Dopamine, Drosophila, Experiments, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Publications, Q7K4Y6, Sodium-dependent, Transporter, UniProt
related to Pharmacology · 13
Dopamine transporter → Amphetamine, CAMKIIα-mediated, Cocaine, DAT, DAT-coupled L-type, In, Once, Phosphorylated DAT, TAAR1, TAAR1-independent, The, VMAT2, When
related to Biological role and disorders · 10
Dopamine transporter → Additionally, ADHD, An, DAT, Data, Differences, The, These, This, VNTR
related to DAT–Cav coupling · 9
Dopamine transporter → As, CAMKII, CAMKII-mediated, Cav, Cav1, DAT, L-type, Preliminary, This
related to Protein structure · 9
Dopamine transporter → DAT, Drosophila, Further, GABA, The, These, TMD, TMDs, X-ray
related to Interactions · 4
Dopamine transporter → Alpha-synuclein, Dopamine, PICK1, Synaptogyrin-3
Band · 2
Dopamine transporter → 13 C1|13 40.1 cM, 5p15.33

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dopamine dat transporter protein gene membrane also amphetamine reuptake human may chromosome bp disorders synaptic neurotransmitter slc6a3 sodium transport chr

Dopamine transporter relationships Subject–Predicate–Object triples

TTTA extracted 173 structured relationships around Dopamine transporter. Examples in this analysis include Dopamine transporter → Aliases → SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1 and Dopamine transporter → Band → 5p15.33. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dopamine transporterAliasesSLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS11.00infobox
Dopamine transporterBand5p15.331.00infobox
Dopamine transporterBand13 C1|13 40.1 cM1.00infobox
Dopamine transporterBgeesubstantia nigra1.00infobox
Dopamine transporterBgeetesticle1.00infobox
Dopamine transporterBgeegonad1.00infobox
Dopamine transporterBgeeleft lobe of thyroid gland1.00infobox
Dopamine transporterBgeeright ovary1.00infobox
Dopamine transporterBgeecanal of the cervix1.00infobox
Dopamine transporterBgeeleft ovary1.00infobox
Dopamine transporterBgeeright lobe of thyroid gland1.00infobox
Dopamine transporterBgeebody of uterus1.00infobox
Dopamine transporterBgeerenal cortex1.00infobox
Dopamine transporterBgeeventral tegmental area1.00infobox
Dopamine transporterBgeeembryo1.00infobox
Dopamine transporterBgeehypothalamus1.00infobox
Dopamine transporterBgeearcuate nucleus1.00infobox
Dopamine transporterBgeeepithelium of small intestine1.00infobox
Dopamine transporterBgeeepithelium of lens1.00infobox
Dopamine transporterBgeecentral gray substance of midbrain1.00infobox
Dopamine transporterBgeesuprachiasmatic nucleus1.00infobox
Dopamine transporterBgeeolfactory bulb1.00infobox
Dopamine transporterBioGPSMore reference expression data1.00infobox
Dopamine transporterChr.Chromosome 5 (human)1.00infobox
Dopamine transporterChr.Chromosome 13 (mouse)1.00infobox
Dopamine transporterDatabasesNCBI: entry; OMA: entry1.00infobox
Dopamine transporterEnd1,445,440 bp1.00infobox
Dopamine transporterEnd73,726,791 bp1.00infobox
Dopamine transporterEnsemblENSG00000142319 ENSG000002769961.00infobox
Dopamine transporterEntrez65311.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dopamine transporter bring nearby vocabulary together. In this analysis, examples include Transporter, Dat and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dopamine transporter
    • Transporter
    • Dat
    • Protein
    • Reuptake
    • Function
    • Amphetamine
    • Also
    • Membrane
    • Efflux
    • Neurotransmitter
    • Sodium
    • May
  • dopamine transporter
    • Transporter
    • Dat
    • Protein
    • Efflux
    • Reuptake
    • Function
    • Amphetamine
    • Also
    • Membrane
    • Neurotransmitter
    • Sodium
    • May
  • gene
    • Chromosome
    • Protein
    • Slc6a3
    • Location
    • Known
    • Bp
    • Chr
    • Expression
    • Neurotransmitter
    • Human
    • Band
    • Positive
  • neurotransmitter
    • Slc6a3
    • Location
    • Mechanism
    • Positive
    • Regulation
    • Bp
    • Chr
    • Chromosome
    • Function
    • Human
    • Synaptic
    • Sodium
  • dopamine
    • Transporter
    • Dat
    • Protein
    • Reuptake
    • Function
    • Amphetamine
    • Also
    • Membrane
    • Efflux
    • Neurotransmitter
    • Sodium
    • May
  • chromosome 5
    • Bp
    • Chr
    • Human
    • Location
    • Band
    • Gene
    • Dat1
    • Positive
    • Regulation
    • Slc6a3
    • Neurotransmitter
    • Function
  • dopamine releasing agent
    • Transporter
    • Dat
    • Protein
    • Reuptake
    • Function
    • Amphetamine
    • Also
    • Membrane
    • Efflux
    • Neurotransmitter
    • Sodium
    • May
  • integral membrane protein
    • Sodium
    • Gene
    • Slc6a3
    • Positive
    • Regulation
    • Neurotransmitter
    • Transporter
    • Chromosome
    • Disorders
    • Function
    • Ions
    • Neuron

Connections between topic areas Semantic bridges

For Dopamine transporter, one of the stronger structural bridges in this analysis connects Dopamine transporter with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dopamine transporter — Overview · splits 136 ⟂ 70
Dopamine transporter — Ligands and modulators · splits 169 ⟂ 37
Dopamine transporter — Genetics and regulation · splits 183 ⟂ 23
Dopamine transporter — Location and distribution · splits 185 ⟂ 21
Dopamine transporter — Mechanism · splits 186 ⟂ 20
Dopamine transporter — Biological role and disorders · splits 196 ⟂ 10
Dopamine transporter — Interactions · splits 198 ⟂ 8
Dopamine transporter — Protein structure · splits 199 ⟂ 7
Dopamine transporter — Pharmacology · splits 199 ⟂ 7

Map overview Semantic statistics

Dopamine transporter

Nodes206
Edges205
Triples173
Avg. degree1.99
Density0.009709
Components1

Source & methodology

TTTA analyzes the structure around Dopamine transporter to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Geography, Location and distribution & Genetics and regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dopamine transporter · EN edition · Analysis: TopicsToTalkAbout

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