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Narcolepsy

Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. The symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. People with narcolepsy…

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Key facts & relationships

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Causes
Loss of hypocretin-producing neurons in type 1, often unclear in type 2
Complications
Motor vehicle collisions, falls
Diagnostic method
Based on the symptoms, sleep studies(PSG + MSLT) NT1: genetic testing and/or lumbar puncture
Differential diagnosis
Sleep apnea, major depressive disorder, anemia, heart failure, drinking alcohol, idiopathic hypersomnia, sleep deprivation, Kleine-Levin syndrome
Duration
Lifelong
Frequency
0.2 to 600 per 100,000

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Overview

Signs and symptoms

Causes

Pathophysiology

Diagnosis

Treatment

Epidemiology

Society and culture

Research

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Map overview Semantic statistics

Narcolepsy

Nodes174
Edges173
Triples256
Avg. degree1.99
Density0.011494
Components1

How this topic connects Entity context

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Narcolepsy

Top relations

related to Medications · 42
Narcolepsy → Additional, Amitriptyline, As, Atomoxetine, August, Drug Administration, EDS, European Commission, European Medicines Agency, FDA, Food, France, GHB, H3, Imipramine, In, Internationally, It, June, Milnacipran
related to Diagnosis · 16
Narcolepsy → Diagnostic, Diseases, DSM-5, For, ICD-11, ICSD-3, In, International Classification, Mental Disorders, REM, Sleep Disorders, SOREMPs, Statistical Manual, The, The DSM-5, This
related to Tests · 16
Narcolepsy → Diagnosis, Epworth Sleepiness Scale, ESS, Individuals, Measuring, MSLT, Polysomnography, PSG, REM, Sleep, The, The Epworth Sleepiness Scale, These, This, Three, When
related to Genetics · 15
Narcolepsy → Another, Cathepsin, EIF3G, HLA, HLA DQB1, HLA DRB1, HLA-DQA1, HLA-DQB1, IDs, P2RY11-DNMT1, Specific, The, These, TNFSF4, TRAC
related to H1N1 influenza · 14
Narcolepsy → DQ0602, Finland's National Institute, Genes, GlaxoSmithKline's H1N1, H1N1, Health, HLA, In, Pandemrix, T-cells, TRAJ24, TRBV4-2, Type, Welfare
related to Epidemiology · 13
Narcolepsy → Americans, Cognitive, Estimates, For, In, Israel, Japan, Research, The, There, These, United States, While
related to Signs and symptoms · 13
Narcolepsy → Additionally, Daytime, Drowsiness, Excessive, Many, Narcoleptics, Other, REM, The, There, These, They, Vivid
related to Loss of neurons · 10
Narcolepsy → Cerebrospinal, HCRT-1/OX-A, HCRT/OX, In, Loss, Orexin, REM, Selective, The, Those
has cause · 9
Narcolepsy → Family, H1N1, In, It, REM, Some, T-cells, The, There
related to Animal models · 7
Narcolepsy → An, Animal, Hypocretin/Orexin, In, More, The, These

Important terminology Word statistics

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Important terminology

sleep cataplexy may rem orexin people also disorder daytime symptoms sleepiness medications treatment neurons type used excessive occur brain include

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NarcolepsyCausesLoss of hypocretin-producing neurons in type 1, often unclear in type 21.00infobox
NarcolepsyComplicationsMotor vehicle collisions, falls1.00infobox
NarcolepsyDiagnostic methodBased on the symptoms, sleep studies(PSG + MSLT) NT1: genetic testing and/or lumbar puncture1.00infobox
NarcolepsyDifferential diagnosisSleep apnea, major depressive disorder, anemia, heart failure, drinking alcohol, idiopathic hypersomnia, sleep deprivation, Kleine-Levin syndrome1.00infobox
NarcolepsyDurationLifelong1.00infobox
NarcolepsyFrequency0.2 to 600 per 100,0001.00infobox
NarcolepsyMedicationStimulants (modafinil, pitolisant, solriamfetol, methylphenidate, amphetamine), sodium oxybate, mixed oxybate salts, serotonin reuptake inhibitors1.00infobox
NarcolepsyPronunciation/ˈnɑːrkəˌlɛpsi/1.00infobox
NarcolepsyRisk factorsFamily history, immune triggers in genetically susceptible people, and injury or disease affecting sleep-regulating brain regions in secondary narcolepsy1.00infobox
NarcolepsySpecialtySleep medicine, neurology1.00infobox
NarcolepsySymptomsExcessive daytime sleepiness, involuntary sleep episodes, sudden loss of muscle strength, sleep-related hallucinations1.00infobox
NarcolepsyTreatmentBehavioural strategies, planned naps, safety counselling, medication1.00infobox
NarcolepsyTypesType 1 narcolepsy, type 2 narcolepsy, secondary narcolepsy1.00infobox
NarcolepsyUsual onsetAdolescence1.00infobox
Narcolepsyis achronic neurological disorder that impairs the ability to regulate sleep0.90text
Narcolepsyis aclinical syndrome of hypothalamic disorder0.90text

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