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Atomoxetine

Atomoxetine, sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor (sNRI) medication used to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser extent, cognitive disengagement syndrome (CDS). It may be used alone or along with psychostimulant medication. It enhances the executive functions of…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06BA09 (WHO)
Bioavailability
2D6Tooltip CYP2D6 EMsTooltip extensive metabolizers: 94% 2D6Tooltip CYP2D6 PMsTooltip poor metabolizers: 63%
CAS Number
83015-26-3 Y · as HCl: 82248-59-7
ChEBI
CHEBI:127342 Y · as HCl: CHEBI:331697

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Overview

Medical uses

Contraindications

Side effects

Interactions

Pharmacology

History

Society and culture

Research

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Map overview Semantic statistics

Atomoxetine

Nodes306
Edges305
Triples182
Avg. degree1.99
Density0.006536
Components1

How this topic connects Entity context

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Atomoxetine

Top relations

related to Names · 34
Atomoxetine → Atentah, Atominex, Attentin, Attera, Attex, Auroxetyn, Axepta, Axetra, Canada, Czech Republic, France, In, In Australia, In Brazil, In France, In India, In Indonesia, In Iran, In Poland, In Turkey
related to history · 19
Atomoxetine → ADHD, August, Company, Eli Lilly, FDA, HCl, In, It, Its, July, Lilly, May, On, September, Strattera, Sun Pharmaceutical's Chairman, Sun Pharmaceuticals, United States, US
related to Interactions · 16
Atomoxetine → Bupropion, Concurrent, CYP1A2, CYP2C9, CYP2D6, CYP3A, CYP3A4, CYP450, Dosage, Findings, It, N-desmethylatomoxetine, O-glucuronide, P-glycoprotein, P450, Similarly
related to Pharmacodynamics · 11
Atomoxetine → Atomoxetine's, Conversely, DAT, DRI, However, In, NET, PET, SERT, Subsequently, Supporting
related to Research · 11
Atomoxetine → ADHD, Alzheimer's, Besides, Company, Eli Lilly, However, It, Parkinson's, SSRIs, The, Though
related to Attention deficit hyperactivity disorder · 9
Atomoxetine → ADHD, Doctors, However, In, It, Meta-analyses, One, The, While
Legal status · 7
Atomoxetine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, EU: Rx-only, NZ: Prescription only, UK: POM (Prescription only), US: ℞-only
has effect · 5
Atomoxetine → ADHD, As, Common, CYP2D6, The
related to Contraindications · 5
Atomoxetine → Any, Contraindications, MAOIs, Moderate, Narrow-angle
CAS Number · 2
Atomoxetine → 83015-26-3 Y, as HCl: 82248-59-7

Important terminology Word statistics

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Important terminology

cyp2d6 metabolizers poor adhd extensive found may effects levels treatment exposure used 4-hydroxyatomoxetine hours increase inhibitors drug metabolism however brand

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Atomoxetine3D model (JSmol)Interactive image1.00infobox
AtomoxetineAHFS/Drugs.comMonograph1.00infobox
AtomoxetineATC codeN06BA09 (WHO)1.00infobox
AtomoxetineBioavailability2D6Tooltip CYP2D6 EMsTooltip extensive metabolizers: 94% 2D6Tooltip CYP2D6 PMsTooltip poor metabolizers: 63%1.00infobox
AtomoxetineCAS Number83015-26-3 Y1.00infobox
AtomoxetineCAS Numberas HCl: 82248-59-71.00infobox
AtomoxetineChEBICHEBI:127342 Y1.00infobox
AtomoxetineChEBIas HCl: CHEBI:3316971.00infobox
AtomoxetineChEMBLChEMBL641 Y1.00infobox
AtomoxetineChEMBLas HCl: ChEMBL17021.00infobox
AtomoxetineChemSpider49516 Y1.00infobox
AtomoxetineChemSpideras HCl: 495151.00infobox
AtomoxetineCompTox Dashboard (EPA)DTXSID90442971.00infobox
AtomoxetineDrug classNorepinephrine reuptake inhibitor (NRI)1.00infobox
AtomoxetineDrugBankDB00289 Y1.00infobox
AtomoxetineDrugBankas HCl: DBSALT0012071.00infobox
AtomoxetineECHA InfoCard100.120.3061.00infobox
AtomoxetineElimination half-life2D6Tooltip CYP2D6 EMsTooltip extensive metabolizers: 4.5–5.3 h 2D6Tooltip CYP2D6 PMsTooltip poor metabolizers: 19–22 h1.00infobox
AtomoxetineExcretion2D6Tooltip CYP2D6 EMsTooltip extensive metabolizers: urine (>96%), feces (1–2%) 2D6Tooltip CYP2D6 PMsTooltip poor metabolizers: urine (80%), feces (13–22%)1.00infobox
AtomoxetineFormulaC17H21NO1.00infobox
AtomoxetineIUPHAR/BPS71181.00infobox
AtomoxetineKEGGD07473 Y1.00infobox
AtomoxetineKEGGas HCl: D025741.00infobox
AtomoxetineLegal statusAU: S4 (Prescription only)1.00infobox
AtomoxetineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
AtomoxetineLegal statusCA: ℞-only1.00infobox
AtomoxetineLegal statusNZ: Prescription only1.00infobox
AtomoxetineLegal statusUK: POM (Prescription only)1.00infobox
AtomoxetineLegal statusUS: ℞-only1.00infobox
AtomoxetineLegal statusEU: Rx-only1.00infobox

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