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Bupropion

Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder and seasonal affective disorder and to support smoking cessation. It is a norepinephrine–dopamine reuptake inhibitor (NDRI). Some evidence-based guidelines support…

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3D model (JSmol)
Interactive image
Addiction liability
Low
AHFS/Drugs.com
Monograph
ATC code
N06AX12 (WHO)
Bioavailability
Unknown
CAS Number
34911-55-2 Y[PubChem] 31677-93-7 (HCl)905818-69-1 HBr) · 31677-93-7 (HCl) · 905818-69-1 HBr)

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

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Map overview Semantic statistics

Bupropion

Nodes284
Edges283
Triples237
Avg. degree1.99
Density0.007042
Components1

How this topic connects Entity context

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Bupropion

Top relations

related to history · 19
Bupropion → Burroughs Wellcome, Canada, December, Drug Administration, FDA, GlaxoSmithKline, However, In, It, Nariman Mehta, Subsequently, United States, US, US Food, Wellbutrin, Wellbutrin SR, Wellbutrin XL, XL, Zyban
related to Analogues · 17
Bupropion → CC, CMC, CpC, It, N-cyclopropyl, N-cyclopropylcathinone, N-methyl, N-tert-butyl, NDRIs, PAL-433, RTI-6037-39, SNDRAs, SNDRI, SRA, The, These, They
related to Interactions · 16
Bupropion → Additionally, As, CYP2B6, CYP2D6, For, However, Indeed, Interactions, MDMA, Ritonavir, Since, St John's, The, This, Ticlopidine, When
related to Pharmacodynamics · 12
Bupropion → DAT, DRIs, For, However, In, NDRI, PET, Pharmacological, S-hydroxybupropion, The, These, VMAT2
related to Pharmacokinetics · 12
Bupropion → Absolute, After, AKR7A2/AKR7A3, As, CYP2B6, CYP2C19, P450, S-hydroxybupropion, SR, Sustained-release, The, XL
related to Psychiatric · 12
Bupropion → Considered, Drug Administration, FAERS, FDA, FDA Adverse Event Reporting, For, However, Other, System, The, The US Food, This
related to Chemistry · 10
Bupropion → Although, C13H18ClNO, It, N-tert-butyl-β-keto-α-methylphenethylamine, N-tert-butyl-β-ketoamphetamine, N-tert-butylcathinone, Pharmaceutically, R-bupropion, S-bupropion, The
Legal status · 9
Bupropion → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, EU: Rx-only, In general: Prescription only, SE: Rx-only, SE: Rx-onlyIn general: Prescription only, UK: POM (Prescription only), US: ℞-only
related to Attention deficit hyperactivity disorder · 8
Bupropion → ADHD, American Academy, In, Pediatrics, Similarly, Systematic, This, United States
related to Recreational use · 8
Bupropion → Canada, Case, Europe, However, Recreational, There, United States, While

Important terminology Word statistics

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Important terminology

effects dopamine treatment use also norepinephrine antidepressants hydroxybupropion drug may fda reuptake disorder however approved smoking wellbutrin associated risk depression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Bupropion3D model (JSmol)Interactive image1.00infobox
BupropionAddiction liabilityLow1.00infobox
BupropionAHFS/Drugs.comMonograph1.00infobox
BupropionATC codeN06AX12 (WHO)1.00infobox
BupropionBioavailabilityUnknown1.00infobox
BupropionCAS Number34911-55-2 Y[PubChem] 31677-93-7 (HCl)905818-69-1 HBr)1.00infobox
BupropionCAS Number31677-93-7 (HCl)1.00infobox
BupropionCAS Number905818-69-1 HBr)1.00infobox
BupropionChEBICHEBI:3219 Y1.00infobox
BupropionChEMBLChEMBL894 Y1.00infobox
BupropionChemSpider431 Y1.00infobox
BupropionChiralityRacemic mixture1.00infobox
BupropionCompTox Dashboard (EPA)DTXSID70227061.00infobox
BupropionDrug classNorepinephrine–dopamine reuptake inhibitor (NDRI); antidepressant1.00infobox
BupropionDrugBankDB01156 Y1.00infobox
BupropionElimination half-lifeBupropion: alpha: 0.5–1.04 beta: 11 h1.00infobox
BupropionElimination half-lifealpha: 0.5–1.041.00infobox
BupropionElimination half-lifebeta: 11 h1.00infobox
BupropionElimination half-lifeHydroxybupropion: 20 h1.00infobox
BupropionElimination half-lifeThreohydrobupropion: 37 h1.00infobox
BupropionElimination half-lifeErythrohydrobupropion: 33 h1.00infobox
BupropionExcretionUrine: 87% (0.5% unchanged)1.00infobox
BupropionExcretionFeces: 10%1.00infobox
BupropionFormulaC13H18ClNO1.00infobox
BupropionIUPHAR/BPS71351.00infobox
BupropionKEGGD07591 Y1.00infobox
BupropionKEGGas HCl: D00817 Y1.00infobox
BupropionLegal statusAU: S4 (Prescription only)1.00infobox
BupropionLegal statusBR: Class C1 (Other controlled substances)1.00infobox
BupropionLegal statusCA: ℞-only1.00infobox

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