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AKT2: Art, Function & Clinical significance

AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.

Language: English [EN]
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AKT2 topic overview

The analysis highlights Art, Function and Clinical significance as prominent areas in the source structure around AKT2.

Related topics
24
Source areas
4
Connected nodes
28
Extracted relationships
143
Concept neighborhoods
14
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Clinical significance · 6 topics
Interactions · 4 topics
Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
Aliases
AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D
Band
19q13.2 · 7 A3|7 15.94 cM
Bgee
right uterine tube · right hemisphere of cerebellum · right lobe of thyroid gland · left lobe of thyroid gland · left ovary
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How AKT2 connects Entity context

The extracted context around AKT2 shows recurring relationship patterns in the source. For example, AKT2 → activation of GTPase activity, apoptotic process, ATP binding, carbohydrate metabolic process, carbohydrate transport, cell cortex, cellular response to high light intensity, cellular response to insulin stimulus, cytoplasm, cytosol, early endosome, endosome, fat cell differentiation, glucose metabolic process, glycogen biosynthetic process, glycogen metabolic process, insulin receptor signaling pathway, intracellular anatomical structure, intracellular membrane-bounded organelle, intracellular protein transmembrane transport Another extracted example is AKT2 → aortic valve, ascending aorta, body of uterus, canal of the cervix, choroid plexus of fourth ventricle, gastrocnemius muscle, genital tubercle, granulocyte, lactiferous gland, left lobe of thyroid gland, left ovary, lip, muscle of thigh, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, right uterine tube, tail of embryo, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

AKT2

Top relations

Gene ontology · 59
AKT2 → activation of GTPase activity, apoptotic process, ATP binding, carbohydrate metabolic process, carbohydrate transport, cell cortex, cellular response to high light intensity, cellular response to insulin stimulus, cytoplasm, cytosol, early endosome, endosome, fat cell differentiation, glucose metabolic process, glycogen biosynthetic process, glycogen metabolic process, insulin receptor signaling pathway, intracellular anatomical structure, intracellular membrane-bounded organelle, intracellular protein transmembrane transport
Bgee · 19
AKT2 → aortic valve, ascending aorta, body of uterus, canal of the cervix, choroid plexus of fourth ventricle, gastrocnemius muscle, genital tubercle, granulocyte, lactiferous gland, left lobe of thyroid gland, left ovary, lip, muscle of thigh, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, right uterine tube, tail of embryo, yolk sac
RNA expression pattern · 19
AKT2 → aortic valve, ascending aorta, body of uterus, canal of the cervix, choroid plexus of fourth ventricle, gastrocnemius muscle, genital tubercle, granulocyte, lactiferous gland, left lobe of thyroid gland, left ovary, lip, muscle of thigh, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, right uterine tube, tail of embryo, yolk sac
related to External links · 8
AKT2 → Human AKT2, Overview, P31751, PDB, PDBe-KB, RAC-beta, UCSC Genome Browser, UniProt
related to Function · 8
AKT2 → AKT, AKT1, In, It, SH2-like, Src, The, This
related to Clinical significance · 3
AKT2 → Mice, Overexpression, The
Band · 2
AKT2 → 19q13.2, 7 A3|7 15.94 cM
Chr. · 2
AKT2 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
AKT2 → 27,340,251 bp, 40,285,536 bp
related to Interactions · 2
AKT2 → APPL1, SH3RF1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp insulin chr band serine kinase pathway chromosome 19 signal transduction location mouse glucose rac-beta oncogene threonine 15

AKT2 relationships Subject–Predicate–Object triples

TTTA extracted 143 structured relationships around AKT2. Examples in this analysis include AKT2 → 2.7.11.1 → ↗ and AKT2 → Aliases → AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
AKT22.7.11.11.00infobox
AKT2AliasesAKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 21.00infobox
AKT2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D1.00infobox
AKT2Band19q13.21.00infobox
AKT2Band7 A3|7 15.94 cM1.00infobox
AKT2Bgeeright uterine tube1.00infobox
AKT2Bgeeright hemisphere of cerebellum1.00infobox
AKT2Bgeeright lobe of thyroid gland1.00infobox
AKT2Bgeeleft lobe of thyroid gland1.00infobox
AKT2Bgeeleft ovary1.00infobox
AKT2Bgeeright ovary1.00infobox
AKT2Bgeebody of uterus1.00infobox
AKT2Bgeemuscle of thigh1.00infobox
AKT2Bgeecanal of the cervix1.00infobox
AKT2Bgeegastrocnemius muscle1.00infobox
AKT2Bgeechoroid plexus of fourth ventricle1.00infobox
AKT2Bgeegenital tubercle1.00infobox
AKT2Bgeelip1.00infobox
AKT2Bgeegranulocyte1.00infobox
AKT2Bgeeascending aorta1.00infobox
AKT2Bgeeaortic valve1.00infobox
AKT2Bgeetail of embryo1.00infobox
AKT2Bgeelactiferous gland1.00infobox
AKT2Bgeeyolk sac1.00infobox
AKT2BioGPSMore reference expression data1.00infobox
AKT2Chr.Chromosome 19 (human)1.00infobox
AKT2Chr.Chromosome 7 (mouse)1.00infobox
AKT2DatabasesNCBI: entry; OMA: entry1.00infobox
AKT2End40,285,536 bp1.00infobox
AKT2End27,340,251 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around AKT2 bring nearby vocabulary together. In this analysis, examples include Insulin, Gene and Mice. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • AKT2
    • Insulin
    • Gene
    • Mice
    • Normal
    • Receptor
    • Glucose
    • Location
    • Pathway
    • Signal
    • Transduction
    • Kinase
    • Serine
  • akt2
    • Insulin
    • Gene
    • Mice
    • Normal
    • Receptor
    • Glucose
    • Location
    • Pathway
    • Signal
    • Transduction
    • Kinase
    • Serine
  • gene
    • Location
    • Serine
    • Human
    • Threonine
    • Chromosome
    • Bp
    • Chr
    • Kinase
    • Function
    • Search
    • Cell
    • Mouse
  • insulin signal transduction pathway
    • Transduction
    • Pathway
    • Signal
    • Receptor
    • Signaling
    • Part
    • Transport
    • Glucose
    • Mice
    • Normal
    • Phenotype
    • Function
  • insulin signaling pathway
    • Pathway
    • Signal
    • Transduction
    • Receptor
    • Signaling
    • Part
    • Transport
    • Glucose
    • Mice
    • Normal
    • Phenotype
    • Uniprot
  • insulin resistance
    • Pathway
    • Signal
    • Transduction
    • Receptor
    • Part
    • Signaling
    • Mice
    • Normal
    • Phenotype
    • Transport
    • Glucose
    • Function
  • insulin receptor
    • Pathway
    • Signal
    • Transduction
    • Signaling
    • Receptor
    • Mice
    • Normal
    • Phenotype
    • Part
    • Transport
    • Glucose
    • Search
  • serine/threonine kinases
    • Threonine
    • Function
    • P31751
    • Pdb
    • Search
    • Threonine-protein
    • Uniprot
    • Oncogene
    • Protein
    • Chromosome
    • Location
    • Bp

Connections between topic areas Semantic bridges

For AKT2, one of the stronger structural bridges in this analysis connects AKT2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AKT2Function · splits 17 ⟂ 12
AKT2Clinical significance · splits 22 ⟂ 7
AKT2Interactions · splits 24 ⟂ 5
AKT2Overview · splits 25 ⟂ 4

Map overview Semantic statistics

AKT2

Nodes29
Edges28
Triples143
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around AKT2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — AKT2 · EN edition · Analysis: TopicsToTalkAbout

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