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Actin: Movements, History, Applications & Research

Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.

Language: English [EN]
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Actin topic overview

The analysis highlights Movements, History, Applications and Research as prominent areas in the source structure around Actin.

Related topics
374
Source areas
10
Connected nodes
384
Extracted relationships
266
Concept neighborhoods
50
Bridge connections
384

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 102 topics
Molecular pathology · 75 topics
Structure · 74 topics
Function · 43 topics
History · 19 topics
Assembly dynamics · 16 topics
Evolution · 15 topics
Genetics · 12 topics
Applications · 9 topics
Research · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR004000 · PF00022
Available protein structures:
IPR004000 · PF00022
InterPro
IPR004000
PDB
IPR004000 PF00022 (ECOD; PDBsum)
Pfam
PF00022
PROSITE
PDOC00340

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Assembly dynamics

Genetics

Evolution

Molecular pathology

Applications

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Actin connects Entity context

The extracted context around Actin shows recurring relationship patterns in the source. For example, Actin → ABPs, Arp2/3, Burkholderia, Different, DNA, Each, Ena/VASP, In, Listeria, Many, Mycobacterium, Other, Pseudomonas, Rickettsia, Shigella, Some, The, This, Through, Two Another extracted example is Actin → Albert Szent-Györgyi's, ATP, Banga's, Brunó Ferenc Straub, Building, Following, Halliburton, However, Hungary, Ilona Banga, Institute, Medical Chemistry, Realizing, Since Straub's, Straub, Straub's, Szeged, Szent-Györgyi, University. Use these groups to spot repeated connection types before inspecting the individual relationships.

Actin

Top relations

related to Other pathological mechanisms · 21
Actin → ABPs, Arp2/3, Burkholderia, Different, DNA, Each, Ena/VASP, In, Listeria, Many, Mycobacterium, Other, Pseudomonas, Rickettsia, Shigella, Some, The, This, Through, Two
related to history · 19
Actin → Albert Szent-Györgyi's, ATP, Banga's, Brunó Ferenc Straub, Building, Following, Halliburton, However, Hungary, Ilona Banga, Institute, Medical Chemistry, Realizing, Since Straub's, Straub, Straub's, Szeged, Szent-Györgyi, University
related to ATPase's catalytic mechanism · 14
Actin → ADP, Although, ATP, ATP's, ATPase, ATPase's, Glu137, It, Its, Pi, QM/MM, The, Then, This
related to Equivalents in prokaryotes · 14
Actin → AlfA, Bacteria, DNA, F-actin, FtsA, FtsZ, Furthermore, G-actin, However, MamK, MreB, ParM, ParMs, The
related to Evolution · 13
Actin → Arp1, Arp11, Arps, Bacteria, Earth, FtsA, Humans, In, Many, MreB, ParM, Some, The
related to Structure · 13
Actin → ADP, ATP, ATPase, Binding, Da, G-actin, GTP-binding, Its, Kabsch, Monomeric, The, The G-actin, The X-ray
related to F-actin · 12
Actin → As F-actin, At, ATP-binding, Conversely, F-actin, G-actin, In F-actin, Some, The, These, These F-actin, Under
related to Molecular pathology · 11
Actin → ACTA1, ACTA2, ACTB, ACTC1, ACTG1, ACTG2, F-actin, HIV, Of, The, This
related to Actin binding proteins · 10
Actin → Arp2/3, ATP, Branches, Formins, G-actin, Nucleation, The, Then, These, They
related to Folding · 10
Actin → ATP-dependent, CCT, Eubacteria, GroEL, However, II, It, Nevertheless, Substrates, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cell proteins filaments protein also cells myosin muscle cytoskeleton two found different polymerization form mutations microfilaments filament structure processes molecules

Actin relationships Subject–Predicate–Object triples

TTTA extracted 266 structured relationships around Actin. Examples in this analysis include Actin → AlphaFold → IPR004000 and Actin → AlphaFold → PF00022. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ActinAlphaFoldIPR0040001.00infobox
ActinAlphaFoldPF000221.00infobox
ActinAvailable protein structures:IPR0040001.00infobox
ActinAvailable protein structures:PF000221.00infobox
ActinInterProIPR0040001.00infobox
ActinPDBIPR004000 PF00022 (ECOD; PDBsum)1.00infobox
ActinPfamPF000221.00infobox
ActinPROSITEPDOC003401.00infobox
ActinSCOP22btf / SCOPe / SUPFAM1.00infobox
ActinSymbolActin1.00infobox
Actincausesdiseases0.90text
Actinis afamily of globular multi-functional proteins that form microfilaments in the cytoskeleton0.90text
Actinis amolecule that integrates cytoplasmic and nuclear signal transduction pathways0.90text
Actinis amost abundant protein found in human tissue0.90text
Actinlocated inthe smooth muscle0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Actin bring nearby vocabulary together. In this analysis, examples include Filaments, Proteins and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Actin
    • Filaments
    • Proteins
    • Cell
    • Myosin
    • Protein
    • Nuclear
    • Muscle
    • Filament
    • End
    • Different
    • Nucleus
    • Cells
  • actin
    • Filaments
    • Proteins
    • Cell
    • Myosin
    • Protein
    • Nuclear
    • Muscle
    • Filament
    • End
    • Different
    • Nucleus
    • Cells
  • microfilaments
    • Called
    • Protein
    • Cell
    • Two
    • Polymerization
    • Cytoskeleton
    • Involved
    • Proteins
    • Filaments
    • Muscle
    • Role
    • Membrane
  • cytoskeleton
    • Cell
    • Also
    • Processes
    • Proteins
    • Microfilaments
    • Muscle
    • Two
    • Actin's
    • Involved
    • Form
    • Cells
    • Membrane
  • thin filaments
    • Cells
    • Proteins
    • Myosin
    • Membrane
    • Muscle
    • Microfilaments
    • End
    • Cell
    • Filament
    • Protein
    • F-actin
    • Polymerization
  • muscle fibrils
    • Myosin
    • Cells
    • Found
    • Present
    • Protein
    • Isoforms
    • Two
    • Also
    • Membrane
    • Nuclear
    • One
    • Processes
  • eukaryotic cells
    • Muscle
    • Cell
    • Found
    • Present
    • Filaments
    • Role
    • Form
    • Microfilaments
    • Cytoskeleton
    • Protein
    • Many
    • Membrane
  • muscle cells
    • Myosin
    • Cells
    • Muscle
    • Cell
    • Found
    • Present
    • Filaments
    • Role
    • Protein
    • Isoforms
    • Form
    • Microfilaments

Connections between topic areas Semantic bridges

For Actin, one of the stronger structural bridges in this analysis connects Actin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ActinOverview · splits 282 ⟂ 103
ActinMolecular pathology · splits 309 ⟂ 76
ActinStructure · splits 310 ⟂ 75
ActinFunction · splits 341 ⟂ 44
ActinHistory · splits 365 ⟂ 20
ActinAssembly dynamics · splits 368 ⟂ 17
ActinEvolution · splits 369 ⟂ 16
ActinGenetics · splits 372 ⟂ 13
ActinApplications · splits 375 ⟂ 10
ActinResearch · splits 375 ⟂ 10

Map overview Semantic statistics

Actin

Nodes385
Edges384
Triples266
Avg. degree1.99
Density0.005195
Components1

Source & methodology

TTTA analyzes the structure around Actin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Movements, History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Actin · EN edition · Analysis: TopicsToTalkAbout

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