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CDC42

Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of…

Interactions, Role in cancer & Function

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3.6.5.2
↗
Aliases
CDC42, CDC42Hs, G25K, TKS, cell division cycle 42
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK,…
Band
1p36.12 · 4 D3|4 69.83 cM
Bgee
monocyte · islet of Langerhans · rectum · ganglionic eminence · gallbladder
BioGPS
More reference expression data

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Overview

Function

Structure

Role in cancer

Takenouchi-Kosaki syndrome

Interactions

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CDC42

Nodes57
Edges56
Triples271
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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CDC42

Top relations

Gene ontology · 137
CDC42 → actin cytoskeleton organization, actin filament branching, actin filament bundle assembly, actin filament organization, adherens junction organization, apical part of cell, apolipoprotein A-I receptor binding, blood coagulation, canonical Wnt signaling pathway, cardiac conduction system development, Cdc42 protein signal transduction, cell cortex, cell differentiation, cell junction assembly, cell periphery, cell projection, cell projection assembly, cell-cell junction, centrosome, cytoplasm
related to Interactions · 25
CDC42 → Aldrich, ARHGAP1, ARHGDIA, BAIAP2, BNIP2, BNIPL, CDC42EP2, CDC42EP3, ERRFI1, GDI1, IQGAP1, IQGAP2, ITSN1, MAP3K10, MAP3K11, PAK1, PAK2, PAK4, PAK7, PARD6A
Bgee · 20
CDC42 → aortic valve, ascending aorta, dermis, endothelial cell of lymphatic vessel, Epithelium of choroid plexus, epithelium of colon, gallbladder, ganglionic eminence, granulocyte, islet of Langerhans, medullary collecting duct, molar, monocyte, olfactory zone of nasal mucosa, rectum, renal corpuscle, smooth muscle tissue, stroma of bone marrow, ventricular zone, vestibular sensory epithelium
RNA expression pattern · 20
CDC42 → aortic valve, ascending aorta, dermis, endothelial cell of lymphatic vessel, Epithelium of choroid plexus, epithelium of colon, gallbladder, ganglionic eminence, granulocyte, islet of Langerhans, medullary collecting duct, molar, monocyte, olfactory zone of nasal mucosa, rectum, renal corpuscle, smooth muscle tissue, stroma of bone marrow, ventricular zone, vestibular sensory epithelium
related to Structure · 11
CDC42 → GAPs, GDP, GDP-bound, GEFs, GTP, GTP-binding, GTP-bound, GTPase, Its, P-loop, This
related to Takenouchi-Kosaki syndrome · 9
CDC42 → Alleic, Arg66Gly, Cys81Phe, Glu171Lys, Ile21Thr, Mutations, Ser83Pro, Takenouchi-Kosaki, Tyr64Cys
related to External links · 8
CDC42 → CDC42 Info, Cell Migration GatewayHuman CDC42, GTP-Binding, Medicine Medical Subject Headings, MeSH, National Library, Protein, UCSC Genome Browser
related to Role in cancer · 8
CDC42 → Elevated, G1-S, It, NFkB, Recently, Several, SRF, STAT3
related to Function · 7
CDC42 → Activated Cdc42, GTPase, Human Cdc42, PAK1, PAK2, Rho, Rho GTPases
Band · 2
CDC42 → 1p36.12, 4 D3|4 69.83 cM

Important terminology Word statistics

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Important terminology

cell cancer cells migration gene endothelial human bp protein chr band division gtpase adhesion signaling integrin chromosome expression location treatment

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CDC423.6.5.2↗1.00infobox
CDC42AliasesCDC42, CDC42Hs, G25K, TKS, cell division cycle 421.00infobox
CDC42Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK,…1.00infobox
CDC42Band1p36.121.00infobox
CDC42Band4 D3|4 69.83 cM1.00infobox
CDC42Bgeemonocyte1.00infobox
CDC42Bgeeislet of Langerhans1.00infobox
CDC42Bgeerectum1.00infobox
CDC42Bgeeganglionic eminence1.00infobox
CDC42Bgeegallbladder1.00infobox
CDC42Bgeeepithelium of colon1.00infobox
CDC42Bgeesmooth muscle tissue1.00infobox
CDC42Bgeeolfactory zone of nasal mucosa1.00infobox
CDC42Bgeegranulocyte1.00infobox
CDC42Bgeeventricular zone1.00infobox
CDC42Bgeeascending aorta1.00infobox
CDC42Bgeeaortic valve1.00infobox
CDC42BgeeEpithelium of choroid plexus1.00infobox
CDC42Bgeeendothelial cell of lymphatic vessel1.00infobox
CDC42Bgeestroma of bone marrow1.00infobox
CDC42Bgeemedullary collecting duct1.00infobox
CDC42Bgeerenal corpuscle1.00infobox
CDC42Bgeemolar1.00infobox
CDC42Bgeevestibular sensory epithelium1.00infobox
CDC42Bgeedermis1.00infobox
CDC42BioGPSMore reference expression data1.00infobox
CDC42Chr.Chromosome 1 (human)1.00infobox
CDC42Chr.Chromosome 4 (mouse)1.00infobox
CDC42DatabasesNCBI: entry; OMA: entry1.00infobox
CDC42End22,101,360 bp1.00infobox

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