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Galectin-9: Standards, Function & Clinical significance

Galectin-9 was first isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein. Human galectin-9 is encoded by the LGALS9 gene.

Language: English [EN]
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Galectin-9 topic overview

The analysis highlights Standards, Function and Clinical significance as prominent areas in the source structure around Galectin-9.

Related topics
30
Source areas
3
Connected nodes
33
Extracted relationships
176
Concept neighborhoods
9
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 25 topics
Clinical significance · 4 topics
Overview · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LGALS9, HUAT, LGALS9A, galectin 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV6
Band
17q11.2 · 11|11 B5
Bgee
monocyte · granulocyte · mucosa of transverse colon · rectum · gallbladder
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Galectin-9 connects Entity context

The extracted context around Galectin-9 shows recurring relationship patterns in the source. For example, Galectin-9 → carbohydrate binding, cellular response to interferon-gamma, chemotaxis, cytoplasm, cytosol, disaccharide binding, enzyme binding, ERK1 and ERK2 cascade, extracellular exosome, extracellular region, extracellular space, female pregnancy, galactose binding, immune system process, inflammatory response, intracellular anatomical structure, maternal process involved in female pregnancy, mature conventional dendritic cell differentiation, natural killer cell tolerance induction, negative regulation of activated T cell proliferation Another extracted example is Galectin-9 → AMPK, CD137, CD40, CLEC7A, For, Galectin-8-based, HAVCR2, However, K63, LAMP1, LAMP2, MAP3K7, Mild, SCRAB2, T-cells, TAK1, The, This, TIM-3, TMEM192. Use these groups to spot repeated connection types before inspecting the individual relationships.

Galectin-9

Top relations

Gene ontology · 53
Galectin-9 → carbohydrate binding, cellular response to interferon-gamma, chemotaxis, cytoplasm, cytosol, disaccharide binding, enzyme binding, ERK1 and ERK2 cascade, extracellular exosome, extracellular region, extracellular space, female pregnancy, galactose binding, immune system process, inflammatory response, intracellular anatomical structure, maternal process involved in female pregnancy, mature conventional dendritic cell differentiation, natural killer cell tolerance induction, negative regulation of activated T cell proliferation
related to Function · 22
Galectin-9 → AMPK, CD137, CD40, CLEC7A, For, Galectin-8-based, HAVCR2, However, K63, LAMP1, LAMP2, MAP3K7, Mild, SCRAB2, T-cells, TAK1, The, This, TIM-3, TMEM192
Bgee · 19
Galectin-9 → appendix, crypt of lieberkuhn of small intestine, duodenum, epithelium of colon, epithelium of stomach, gallbladder, gastric mucosa, granulocyte, left lobe of liver, lymph node, monocyte, mucosa of transverse colon, mucous cell of stomach, pyloric antrum, pylorus, rectum, seminal vesicula, spleen, thymus
RNA expression pattern · 19
Galectin-9 → appendix, crypt of lieberkuhn of small intestine, duodenum, epithelium of colon, epithelium of stomach, gallbladder, gastric mucosa, granulocyte, left lobe of liver, lymph node, monocyte, mucosa of transverse colon, mucous cell of stomach, pyloric antrum, pylorus, rectum, seminal vesicula, spleen, thymus
related to Clinical significance · 10
Galectin-9 → AML, CLL, HAVCR2, Hodgkin's, MDS, Moreover, T-cell, The, Therefore, This
related to External links · 5
Galectin-9 → O00182, Overview, PDB, PDBe-KB, UniProt
Band · 2
Galectin-9 → 11|11 B5, 17q11.2
Chr. · 2
Galectin-9 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Galectin-9 → 27,649,560 bp, 78,875,772 bp
Aliases · 1
Galectin-9 → LGALS9, HUAT, LGALS9A, galectin 9

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene chr band tumor ampk chromosome 17 mouse lgals9 lysosomal function expression protein location immune cell intracellular regulation

Galectin-9 relationships Subject–Predicate–Object triples

TTTA extracted 176 structured relationships around Galectin-9. Examples in this analysis include Galectin-9 → Aliases → LGALS9, HUAT, LGALS9A, galectin 9 and Galectin-9 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Galectin-9AliasesLGALS9, HUAT, LGALS9A, galectin 91.00infobox
Galectin-9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV61.00infobox
Galectin-9Band17q11.21.00infobox
Galectin-9Band11|11 B51.00infobox
Galectin-9Bgeemonocyte1.00infobox
Galectin-9Bgeegranulocyte1.00infobox
Galectin-9Bgeemucosa of transverse colon1.00infobox
Galectin-9Bgeerectum1.00infobox
Galectin-9Bgeegallbladder1.00infobox
Galectin-9Bgeespleen1.00infobox
Galectin-9Bgeeepithelium of colon1.00infobox
Galectin-9Bgeelymph node1.00infobox
Galectin-9Bgeepylorus1.00infobox
Galectin-9Bgeeappendix1.00infobox
Galectin-9Bgeegastric mucosa1.00infobox
Galectin-9Bgeemucous cell of stomach1.00infobox
Galectin-9Bgeeepithelium of stomach1.00infobox
Galectin-9Bgeepyloric antrum1.00infobox
Galectin-9Bgeeseminal vesicula1.00infobox
Galectin-9Bgeeleft lobe of liver1.00infobox
Galectin-9Bgeeduodenum1.00infobox
Galectin-9Bgeecrypt of lieberkuhn of small intestine1.00infobox
Galectin-9Bgeethymus1.00infobox
Galectin-9BioGPSMore reference expression data1.00infobox
Galectin-9Chr.Chromosome 17 (human)1.00infobox
Galectin-9Chr.Chromosome 11 (mouse)1.00infobox
Galectin-9DatabasesNCBI: entry; OMA: entry1.00infobox
Galectin-9End27,649,560 bp1.00infobox
Galectin-9End78,875,772 bp1.00infobox
Galectin-9EnsemblENSG000001689611.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Galectin-9 bring nearby vocabulary together. In this analysis, examples include Ampk, Tumor and Various. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Human
    • Lgals9
    • Location
    • Chromosome
    • Bp
    • Chr
    • End
    • Search
    • Structure
    • Mouse
    • Band
    • Function
  • function
    • Links
    • Search
    • Structure
    • Intracellular
    • Lgals9
    • Location
    • Signaling
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Human
  • Galectin-9
    • Ampk
    • Tumor
    • Various
    • Lysosomal
    • Immune
    • Intracellular
    • Kinase
    • Regulation
    • Signaling
    • Expression
    • Function
    • Clinical
  • galectin-9
    • Ampk
    • Tumor
    • Various
    • Lysosomal
    • Immune
    • Intracellular
    • Kinase
    • Regulation
    • Signaling
    • Expression
    • Function
    • Clinical
  • immune
    • Tumor
    • Metformin
    • O00182
    • Protein
    • Search
    • Structure
    • Uniprot
    • Intracellular
    • Kinase
    • Lgals9
    • Location
    • Mouse
  • clinical significance
    • External
    • Links
    • Pdb
    • Search
    • Structure
    • Lgals9
    • Location
    • Chromosome
    • Expression
    • Function
    • Bp
    • Chr
  • ampk
    • Lysosomal
    • Metformin
    • Kinase
    • Galectin-9
    • Immune
    • Intracellular
    • Regulation
    • Signaling
    • Various
  • lysosomal
    • Metformin
    • Regulation
    • Signaling

Connections between topic areas Semantic bridges

For Galectin-9, one of the stronger structural bridges in this analysis connects Galectin-9 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Galectin-9Function · splits 8 ⟂ 26
Galectin-9Clinical significance · splits 29 ⟂ 5

Map overview Semantic statistics

Galectin-9

Nodes34
Edges33
Triples176
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around Galectin-9 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Galectin-9 · EN edition · Analysis: TopicsToTalkAbout

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